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PubMed é um banco de dados que possibilita a pesquisa bibliográfica em mais de 17 milhões de referências de artigos médicos publicados em cerca de 3.800 revistas científicas .

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Primary leiomyosarcoma of the submandibular gland: a case report

El Ochi, Mohamed Reda; Chahdi, Hafsa; Rharrassi, Issam; Albouzidi, Abderrahman; Oukabli, Mohamed
Fonte: BioMed Central Publicador: BioMed Central
Tipo: Text
Publicado em 15/12/2015 Português

ChromContact: A web tool for analyzing spatial contact of chromosomes from Hi-C data

Sato, Tetsuya; Suyama, Mikita
Fonte: BioMed Central Publicador: BioMed Central
Tipo: Text
Publicado em 15/12/2015 Português

Magnetic resonance imaging-based cerebral tissue classification reveals distinct spatiotemporal patterns of changes after stroke in non-human primates

Bouts, Mark. J. R. J.; Westmoreland, Susan. V.; de Crespigny, Alex J.; Liu, Yutong; Vangel, Mark; Dijkhuizen, Rick M.; Wu, Ona; D’Arceuil, Helen E.
Fonte: BioMed Central Publicador: BioMed Central
Tipo: Text
Publicado em 15/12/2015 Português

Dark chocolate supplementation reduces the oxygen cost of moderate intensity cycling

Patel, Rishikesh Kankesh; Brouner, James; Spendiff, Owen
Fonte: BioMed Central Publicador: BioMed Central
Tipo: Text
Publicado em 15/12/2015 Português

Management and outcomes in patients with Staphylococcus aureus bacteremia after implementation of mandatory infectious diseases consult: a before/after study

Martin, Leslie; Harris, Miriam Tova; Brooks, Annie; Main, Cheryl; Mertz, Dominik
Fonte: BioMed Central Publicador: BioMed Central
Tipo: Text
Publicado em 15/12/2015 Português

Registering prostate external beam radiotherapy with a boost from high-dose-rate brachytherapy: a comparative evaluation of deformable registration algorithms

Moulton, Calyn R.; House, Michael J.; Lye, Victoria; Tang, Colin I.; Krawiec, Michele; Joseph, David J.; Denham, James W.; Ebert, Martin A.
Fonte: BioMed Central Publicador: BioMed Central
Tipo: Text
Publicado em 14/12/2015 Português

Targeting the indoleamine 2,3-dioxygenase pathway in cancer

Moon, Yong Wha; Hajjar, Joud; Hwu, Patrick; Naing, Aung
Fonte: BioMed Central Publicador: BioMed Central
Tipo: Text
Publicado em 15/12/2015 Português
Tumor cells escape the immune surveillance system of the host through a process called immune tolerance. Immunotherapy targets molecules that serve as checks and balances in the regulation of immune response. Indoleamine-2,3-dioxygenase (IDO) is an intracellular enzyme, which through the process of tryptophan depletion exerts an immunosuppressive effect, facilitating immune escape of tumors. This review summarizes our current knowledge on IDO expression in malignancies, the IDO inhibitors that are currently available and those under clinical development.

Development and characterization of a eukaryotic expression system for human type II procollagen

Wieczorek, Andrew; Rezaei, Naghmeh; Chan, Clara K.; Xu, Chuan; Panwar, Preety; Brömme, Dieter; Merschrod S., Erika F.; Forde, Nancy R.
Fonte: BioMed Central Publicador: BioMed Central
Tipo: Text
Publicado em 15/12/2015 Português

A novel RING finger in the C-terminal domain of the coatomer protein α-COP

Kaur, Gurmeet; Subramanian, Srikrishna
Fonte: BioMed Central Publicador: BioMed Central
Tipo: Text
Publicado em 14/12/2015 Português
The C-terminal domain of α-COP, an essential subunit of the COPI coatomer complex, is composed of an all α-helical region and a small β-sheet domain. We show that this β-sheet domain is a Really Interesting New Gene (RING)-like treble clef zinc finger. The zinc-binding residues are substituted by other aminoacids in many homologs including the structurally-characterized proteins from Saccharomyces cerevisiae and Bos taurus. This RING-like domain is possibly related to those of other vesicle membrane-associated complexes, such as CORVET, HOPS and SEA, and likely mediates interactions with Dsl1p and assist in coat oligomerization.

Intracellular chloride concentration of the mouse vomeronasal neuron

Kim, SangSeong; Ma, Limei; Unruh, Jay; McKinney, Sean; Yu, C. Ron
Fonte: BioMed Central Publicador: BioMed Central
Tipo: Text
Publicado em 15/12/2015 Português

A simple method for identifying parameter correlations in partially observed linear dynamic models

Li, Pu; Vu, Quoc Dong
Fonte: BioMed Central Publicador: BioMed Central
Tipo: Text
Publicado em 14/12/2015 Português

Cytoplasmic levels of cFLIP determine a broad susceptibility of breast cancer stem/progenitor-like cells to TRAIL

French, Rhiannon; Hayward, Olivia; Jones, Samuel; Yang, William; Clarkson, Richard
Fonte: BioMed Central Publicador: BioMed Central
Tipo: Text
Publicado em 15/12/2015 Português

Framework of behavioral indicators evaluating TB health promotion outcomes: a modified Delphi study of TB policymakers and health workers

Li, Ying; Ehiri, John; Hu, Daiyu; Oren, Eyal; Cao, Jia
Fonte: BioMed Central Publicador: BioMed Central
Tipo: Text
Publicado em 15/12/2015 Português

Smoking and body weight: evidence from China health and nutrition survey

Wang, Qing
Fonte: BioMed Central Publicador: BioMed Central
Tipo: Text
Publicado em 14/12/2015 Português

Recognizing and reporting domestic violence: attitudes, experiences and behavior of Dutch dentists

van Dam, Brigitte A. F. M.; van der Sanden, Wil J. M.; Bruers, Josef J. M.
Fonte: BioMed Central Publicador: BioMed Central
Tipo: Text
Publicado em 15/12/2015 Português

Erythema nodosum as a result of estrogen patch therapy for prostate cancer: a case report

Coyle, Christopher; Mangar, Stephen; Abel, Paul; Langley, Ruth E.
Fonte: BioMed Central Publicador: BioMed Central
Tipo: Text
Publicado em 14/12/2015 Português

Building-related health impacts in European and Chinese cities: a scalable assessment method

Tuomisto, Jouni T.; Niittynen, Marjo; Pärjälä, Erkki; Asikainen, Arja; Perez, Laura; Trüeb, Stephan; Jantunen, Matti; Künzli, Nino; Sabel, Clive E.
Fonte: BioMed Central Publicador: BioMed Central
Tipo: Text
Publicado em 14/12/2015 Português

Counselling practices in community pharmacies in Riyadh, Saudi Arabia: a cross-sectional study

Alaqeel, Sinaa; Abanmy, Norah O.
Fonte: BioMed Central Publicador: BioMed Central
Tipo: Text
Publicado em 15/12/2015 Português

Problem-based learning in resource-poor settings: lessons from a medical school in Ghana

Amoako-Sakyi, Daniel; Amonoo-Kuofi, Harold
Fonte: BioMed Central Publicador: BioMed Central
Tipo: Text
Publicado em 14/12/2015 Português
Problem-based learning (PBL) is arguably one of the most important innovations in medical education in the last century. The evident benefits of PBL and the changing face of medicine and medical education have led many institutions including those in resource-poor settings to consider the adoption of PBL curricula. However, experts are uncertain about how successful PBL will be in such settings, as literature on the implementation of PBL in resource-poor settings appears to be inadequate. The University of Cape Coast is located in a resource-poor setting, however, its medical school has used PBL curriculum since 2007. In a descriptive prose, this article discusses the PBL implementation processes, the challenges faced, the mitigation strategies employed, and the lessons learned at University of Cape Coast School of Medical Sciences (UCCSMS). The arguments fall under the broad themes of curricular structure, resource constraints, faculty development, and assessment. The peculiar socioeconomic situation of Ghana, challenges in funding of tertiary education, and the resource implications of PBL provided the context for the arguments. It emerged out of the discussion that PBL has to be implemented as whole curriculum to be effective. Regular faculty development activities on PBL and the alignment of assessment methods with PBL also emerged as important issues in the discussion. The article argues that in spite of its cost implication...

Deciphering the role of interleukin-22 in metabolic alterations

Sabat, Robert; Wolk, Kerstin
Fonte: BioMed Central Publicador: BioMed Central
Tipo: Text
Publicado em 15/12/2015 Português
Inflammatory processes and metabolic alterations are supposed to substantially interact. Recently, cumulating reports describe a profound role of interleukin(IL)-22 in this relationship. IL-22 is a particular kind of immune mediator that is produced by certain lymphocyte populations and regulates the function of several tissue cells but not immune cells. So far, IL-22 was known to plays a fundamental role in the elimination of bacterial infections at border surfaces of the body and to protect tissues from damage. This research highlight article arranges the facts regarding the effects of IL-22 in the context of adiposity and metabolic alterations and postulates a new function of the immune system.