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Editorial: Recent Advances in HBV and HCV Immunology

Dustin, Lynn B.; Trehanpati, Nirupma
Fonte: Frontiers Media S.A. Publicador: Frontiers Media S.A.
Tipo: Artigo de Revista Científica
Publicado em 04/09/2015 Português
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Role of Murine Intestinal Interleukin-1 Receptor 1-Expressing Lymphoid Tissue Inducer-Like Cells in Salmonella Infection

Chen, Vincent L.; Surana, Neeraj K.; Duan, Jinyou; Kasper, Dennis L.
Fonte: Public Library of Science Publicador: Public Library of Science
Tipo: Artigo de Revista Científica
Português
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Interleukin (IL)-1 signaling plays a critical role in intestinal immunology. Here, we report that the major population of intestinal lamina propria lymphocytes expressing IL-1 receptor 1 (IL-1R1) is the lymphoid tissue inducer (LTi)-like cell, a type of innate lymphoid cell. These cells are significant producers of IL-22, and this IL-22 production depends on IL-1R1 signaling. LTi-like cells are required for defense against Salmonella enterica serovar Typhimurium. Moreover, colonic LTi-like cell numbers depend on the presence of the intestinal microbiota. LTi-like cells require IL-1R1 for production of protective cytokines and confer protection in infectious colitis, and their cell numbers in the colon depend upon having a microbiome.

HPVdb: a data mining system for knowledge discovery in human papillomavirus with applications in T cell immunology and vaccinology

Zhang, Guang Lan; Riemer, Angelika B.; Keskin, Derin B.; Chitkushev, Lou; Reinherz, Ellis L.; Brusic, Vladimir
Fonte: Oxford University Press Publicador: Oxford University Press
Tipo: Artigo de Revista Científica
Português
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High-risk human papillomaviruses (HPVs) are the causes of many cancers, including cervical, anal, vulvar, vaginal, penile and oropharyngeal. To facilitate diagnosis, prognosis and characterization of these cancers, it is necessary to make full use of the immunological data on HPV available through publications, technical reports and databases. These data vary in granularity, quality and complexity. The extraction of knowledge from the vast amount of immunological data using data mining techniques remains a challenging task. To support integration of data and knowledge in virology and vaccinology, we developed a framework called KB-builder to streamline the development and deployment of web-accessible immunological knowledge systems. The framework consists of seven major functional modules, each facilitating a specific aspect of the knowledgebase construction process. Using KB-builder, we constructed the Human Papillomavirus T cell Antigen Database (HPVdb). It contains 2781 curated antigen entries of antigenic proteins derived from 18 genotypes of high-risk HPV and 18 genotypes of low-risk HPV. The HPVdb also catalogs 191 verified T cell epitopes and 45 verified human leukocyte antigen (HLA) ligands. Primary amino acid sequences of HPV antigens were collected and annotated from the UniProtKB. T cell epitopes and HLA ligands were collected from data mining of scientific literature and databases. The data were subject to extensive quality control (redundancy elimination...

Antigen-specific immune modulation using an injectable biomaterial

Verbeke, Catia Stéphanie
Fonte: Harvard University Publicador: Harvard University
Tipo: Thesis or Dissertation
Português
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The field of immunology has advanced tremendously over the last 40 years, with seminal findings that have guided the development of powerful new therapies. However, the ability to induce safe and long-lasting antigen-specific tolerance has remained elusive. A therapy that could prevent the immune system from aberrantly destroying self-tissues, without impairing its capacity to eliminate dangerous pathogens, would be transformative for the treatment of autoimmune diseases. In addition, such a therapy could also greatly advance the field of organ transplantation by inducing antigen-specific tolerance to prevent graft rejection.; Engineering and Applied Sciences

Big Data Analytics in Immunology: A Knowledge-Based Approach

Zhang, Guang Lan; Sun, Jing; Chitkushev, Lou; Brusic, Vladimir
Fonte: Hindawi Publishing Corporation Publicador: Hindawi Publishing Corporation
Tipo: Artigo de Revista Científica
Português
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With the vast amount of immunological data available, immunology research is entering the big data era. These data vary in granularity, quality, and complexity and are stored in various formats, including publications, technical reports, and databases. The challenge is to make the transition from data to actionable knowledge and wisdom and bridge the knowledge gap and application gap. We report a knowledge-based approach based on a framework called KB-builder that facilitates data mining by enabling fast development and deployment of web-accessible immunological data knowledge warehouses. Immunological knowledge discovery relies heavily on both the availability of accurate, up-to-date, and well-organized data and the proper analytics tools. We propose the use of knowledge-based approaches by developing knowledgebases combining well-annotated data with specialized analytical tools and integrating them into analytical workflow. A set of well-defined workflow types with rich summarization and visualization capacity facilitates the transformation from data to critical information and knowledge. By using KB-builder, we enabled streamlining of normally time-consuming processes of database development. The knowledgebases built using KB-builder will speed up rational vaccine design by providing accurate and well-annotated data coupled with tailored computational analysis tools and workflow.

7.012 Introduction to Biology, Fall 2001; Introduction to Biology

Weinberg, Robert A. (Robert Allan), 1942-; Lander, Eric S.; Gardel, Claudette L.; Mischke, Michelle D.
Fonte: MIT - Massachusetts Institute of Technology Publicador: MIT - Massachusetts Institute of Technology
Formato: 16205 bytes; 14948 bytes; 27840 bytes; 21793 bytes; 14264 bytes; 15899 bytes; 11535 bytes; 16748 bytes; 11 bytes; 4586 bytes; 18637 bytes; 11602 bytes; 18220 bytes; 4755 bytes; 27322 bytes; 25313 bytes; 4039 bytes; 301 bytes; 354 bytes; 339 bytes; 180 byt
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Cell biology, immunology, neurobiology, and an exploration into current research in cancer, genomics, and molecular medicine.

Dewhurst Lab Manuals

Dewhurst, Stephen
Fonte: Universidade de Rochester Publicador: Universidade de Rochester
Tipo: Relatório
Português
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Basic Lab Methods and Procedures in Molecular Biology, Immunology, Neuroscience. Also, Lab Safety documents/plans, and basic information for new lab members.

The Role of the Wiskott-Aldrich Syndrome protein (WASp) in T helper cell differentiation and effector function

Morales-Tirado, Vanessa Marie ; Fowell, Deborah J.
Fonte: Universidade de Rochester Publicador: Universidade de Rochester
Tipo: Tese de Doutorado Formato: Number of Pages:xix, 236 leaves
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Thesis (Ph. D.)--University of Rochester. School of Medicine and Dentistry. Dept. of Microbiology and Immunology, 2008.; Naïve uncommitted CD4+ T lymphocytes can become effector T helper cells by signals derived from the T cell receptor (TCR) and the cytokine milieu. Each T helper subset has distinct functional and phenotypical characteristics and can determine the immune response against pathogens. The Th1 subset is characterized by the production of IL-2 and IFN-γ and is involved in cell-mediated inflammatory responses. The Th2 subset is characterized by the production of IL-4 and functionally, they combat extracellular pathogens, enhance antibody production and the response from innate immune cells. The mechanisms by which the CD4+ T cells differentiate into these polarized groups are not well understood. A number of studies suggest that upon T cell activation, actin-dependent signaling may be important for the intracellular signaling cascades leading to effector T cell development. The Wiskott-Aldrich Syndrome protein (WASp), through its role as a key regulator of the actin cytoskeleton, has been suggested to be the link between actin cytoskeleton movement and transcriptional activation of cells. Defects associated with this protein cause the Wiskott-Aldrich Syndrome (WAS) in humans; characterized by the triad of thrombocytopenia...

Evolution and Immune Functions of Nonclassical MHC Class Ib Genes in the Clawed Frogs Xenous laevis and Silurana tropicalis

Goyos, Ana S. ; Robert, Jacques
Fonte: Universidade de Rochester Publicador: Universidade de Rochester
Tipo: Tese de Doutorado
Português
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Thesis (Ph.D.)--University of Rochester. School of Medicine and Dentistry. Dept. of Microbiology and Immunology, 2010.; Major histocompatibility complex (MHC) class Ia (class Ia) are evolutionary conserved genes in jawed vertebrates encoding highly polymorphic and ubiquitously expressed surface molecules essential for the development and activation of CD8 T cells. By contrast, nonclassical MHC class Ib (class Ib) are a group of heterogeneous genes encoding molecules structurally similar to class Ia but with a more limited tissue distribution and polymorphism. In mammals, class Ibs have diverse, and often not well characterized, functions that include stress responses, detection of malignancy, immune regulation and the differentiation of CD8 T cells. Although class Ib genes have been identified in all taxa of jawed vertebrates, information about their function is even more limited and their phylogeny is uncertain. This is usually attributed to their fast rate of evolution. The subfamily Xenopodinae, including species of the clawed frog genera Xenopus and Silurana, which diverged from a common ancestor 80 million years ago (MYA), provides a powerful non-mammalian model to further investigate the evolution and immune functions of class Ib genes. Xenopus laevis is one of the best characterized and most widely used non-mammalian animal models to study immunity. We used this species to investigate the role of class Ib in early T cell ontogeny and in tumor immunity. The genome of the diploid Silurana tropicalis has been fully sequenced and annotated. We used this species to evaluate the genomic and molecular evolution of class Ib genes. Genomic...

Mechanisms of Vascular and Immune Alteration via Local Cytokine Treatment of Melanoma.

Sorensen, Elizabeth W. ; Lord, Edith M.
Fonte: Universidade de Rochester Publicador: Universidade de Rochester
Tipo: Tese de Doutorado
Português
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Thesis (Ph.D.)--University of Rochester. School of Medicine and Dentistry. Dept. of Microbiology and Immunology, 2010.; One of the earliest immunotherapies for the treatment of cancer involved the systemic administration of cytokines, and interestingly, both metastatic melanoma and renal cell carcinoma are particularly responsive to cytokine-based immunotherapies. However, although many cytokine treatments have been shown to be efficacious in animal models and in human clinical trials, the toxicity caused by high doses given systemically has been a barrier to their use in common clinical practice. The work presented in this thesis utilizes B16, a spontaneous mouse melanoma cell line, transfected to express the cytokines of interest (IL-12 or IL-2) to provide a system of constant, local production of cytokine within the tumor; a treatment modality that has been associated with increased anti-tumor response and decreased toxicity in both mice and humans. In this way, we have been able to elucidate the mechanisms by which these cytokines suppress tumor growth. IL-12 has been shown to be effective in enhancing anti-tumor responses by enhancing immunity and by limiting angiogenesis. However, how IL-12 exerts its anti-angiogenic effect is largely unknown. The majority of solid tumor vessels are chaotic and poorly formed...

Human Anergic B Cells: IgMlo

Quach, Tam Dan ; Sanz, Inaki
Fonte: Universidade de Rochester Publicador: Universidade de Rochester
Tipo: Tese de Doutorado
Português
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Thesis (Ph.D.)--University of Rochester. Dept. of Microbiology and Immunology, 2010.; B cell anergy represents an important mechanism of peripheral immunological tolerance which censors mature autoreactive B cells that escape central tolerance enforced by receptor editing and clonal deletion. While anergy has been well documented in mice, the extent of its participation in human B cell tolerance remains to be established. In this study, we characterize the functional behavior of strictly defined human naïve B cells separated on the basis of their levels of surface IgM (sIgM). We first observed that sIgM on B cells within the mature naïve pool in the periphery is broadly expressed ranging from as low as non-detectable to a density of high sIgM levels characteristic of transitional T1 B cells. We postulated that decreased sIgM expression was likely to reflect sustained IgM downregulation induced by chronic stimulation by ubiquitous self-antigens. Alternatively, low levels of sIgM could also be present in recently activated B cells due to BCR internalization induced by acute antigenic stimulation. The former hypothesis was however supported by the finding that upon B cell receptor (BCR) stimulation, cells with lower sIgM levels (IgMlo) are impaired in their ability to flux calcium in response to either anti-IgM or anti-IgD crosslinking. The results suggest that IgMlo cells represent an anergic B-cell population similar to those seen in several mouse models of B cell anergy including the best characterized autoreactive B-cell double transgenic model (hen egg lysozyme/anti-HEL). Of significant importance for our experimental model and conclusions...

Nonclassical MHC Class Ib Molecules: Critical Players in Tumor Immune Surveillance and Potential Immunotherapy Targets

Nedelkovska, Hristina ; Robert, Jacques
Fonte: University of Rochester Publicador: University of Rochester
Tipo: Tese de Doutorado
Português
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Thesis (Ph.D.)--University of Rochester. School of Medicine & Dentistry. Dept. of Microbiology and Immunology, 2012.; Nonclassical MHC class Ib (class Ib) molecules are increasingly implicated in tumorigenesis and tumor immunity, however, their function is not well understood. To investigate the fundamental role of class Ib genes in anti-tumor immune responses we capitalized on a well characterized comparative immuno-cancer model in Xenopus LG isogenetic clones. Previous work demonstrated the ability of the heat shock proteins gp96 and HSP70 to generate potent CD8 T cell responses against a transplantable thymic lymphoid tumor (15/0) that expresses several class Ib genes, but no classical MHC class Ia (class Ia) molecules. In the absence of class Ia, we hypothesized that HSP70 proteins can prime class Ib anti-tumor unconventional T cells in an antigen-dependent manner. To test this, we produced recombinant Xenopus inducible hsp72 and constitutive hsc73 from stable 15/0 tumor transfectants. Using a cross-presentation priming assay we showed that hsp72-Ag complexes, but neither hsc73-Ag nor Ag-negative HSP70s, elicit class Ib-mediated T cells responses resulting in protection from 15/0 tumor challenge. To further elucidate the role of class Ib molecules in anti-tumor immunity...

Genèse de l’immunopeptidome du CMH de classe I

Caron, Etienne
Fonte: Université de Montréal Publicador: Université de Montréal
Tipo: Thèse ou Mémoire numérique / Electronic Thesis or Dissertation
Português
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La différentiation entre le « soi » et le « non-soi » est un processus biologique essentiel à la vie. Les peptides endogènes présentés par les complexes majeurs d’histocompatibilité de classe I (CMH I) représentent le fondement du « soi » pour les lymphocytes T CD8+. On donne le nom d’immunopeptidome à l’ensemble des peptides présentés à la surface cellulaire par les molécules du CMH I. Nos connaissances concernant l’origine, la composition et la plasticité de l’immunopeptidome restent très limitées. Dans le cadre de cette thèse, nous avons développé une nouvelle approche par spectrométrie de masse permettant de définir avec précision : la nature et l’abondance relative de l’ensemble des peptides composant l’immunopeptidome. Nous avons trouvé que l’immunopeptidome, et par conséquent la nature du « soi » immun, est surreprésenté en peptides provenant de transcrits fortement abondants en plus de dissimuler une signature tissu-spécifique. Nous avons par la suite démontré que l’immunopeptidome est plastique et modulé par l’activité métabolique de la cellule. Nous avons en effet constaté que les modifications du métabolisme cellulaire par l’inhibition de mTOR (de l’anglais mammalian Target Of Rapamycin) provoquent des changements dynamiques dans la composition de l’immunopeptidome. Nous fournissons également la première preuve dans l’étude des systèmes que l’immunopeptidome communique à la surface cellulaire l’activité de certains réseaux biochimiques ainsi que de multiples événements métaboliques régulés à plusieurs niveaux à l’intérieur de la cellule. Nos découvertes ouvrent de nouveaux horizons dans les domaines de la biologie des systèmes et de l’immunologie. En effet...

Molecular Immunology & Immunogenetics Congress 2012 (MIMIC2012)

Sosa Molano, Ángela Catalina; Kariuki, Bárbara; Knutsen, Alan; Bellone, Clifford; Barrera A, Luis Alejandro; Tomatsu, Shunji; Montaño, Adriana
Fonte: Pontifícia Universidade Javeriana Publicador: Pontifícia Universidade Javeriana
Português
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Mucopolysaccharidosis type IVA (MPS IVA) or Morquio syndrome type A is an autosomal recessive disorder caused by mutations in the N-acetyl-galactosamine-6-sulfate sulfatase (GALNS) gene that results in the intralysosomal accumulation of keratan sulfate and chondroitin 6-sulfate. Like other lysosomal storage disorders (LSD), MPS IVA is a good candidate for enzyme replacement therapy (ERT). Preclinical studies for ERT in a Morquio syndrome type A mouse model have been established, and a clinical trial in Morquio syndrome type A patients is being carried out, however, current treatment for MPS IVA patients is not available. The immune response against the infused protein in ERT has been reported as the main obstacle in the effectiveness of the treatment. In the present study, our main goal is to determine the immunodominant sequences in GALNS protein. Two different bioinformatic tools (RANKPEP and Immune Epitope Data Base) were used for the prediction of potential T and B epitopes. Ten predicted peptides were selected and evaluated. Splenocytes of C57BL/6 mice treated by ERT were stimulated with individual peptides to determine cellular proliferation and cytokine secretion (IL-4, IL-5, IL-13 and IFN-α ). Three of the ten peptides elucidated strong cellular responses in the in-vitro assays. The identification of immunodominant peptides will allow the establishment of a peptidebased immunotherapy for Morquio syndrome type A and could be extrapolated to other LSD in which the immune response hinders the development of ERT.; Presentación de ponencia en evento científico o tecnológico; Turkish Society of Immunology

Characterisation of the immune responses of the koala / Ray Wilkinson.

Wilkinson, Ray, 1953-
Fonte: Universidade de Adelaide Publicador: Universidade de Adelaide
Tipo: Tese de Doutorado Formato: 274248 bytes; application/pdf
Publicado em //1996 Português
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Study undertaken to characterise both the humoral and cell-mediated immune responses of the koala to provide information upon which future disease investigations and immunological research can be based.; Thesis (Ph.D.)--University of Adelaide, Dept. of Microbiology and Immunology, 1996; Bibliography: leaves 218-252.; xvii, 252, [57] leaves, [21] leaves of plates : ill. (some col.) ; 30 cm.; Title page, contents and abstract only. The complete thesis in print form is available from the University Library.

Serotype conversion in Vibrio cholerae 01 / Uwe Horst Stroher.

Stroeher, Uwe Horst
Fonte: Universidade de Adelaide Publicador: Universidade de Adelaide
Tipo: Tese de Doutorado Formato: 489465 bytes; application/pdf
Publicado em //1992 Português
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Investigates the mechanism of serotype conversion between the Inaba and Ogawa serotypes of Vibrio cholerae 01.; Thesis (Ph.D.)--University of Adelaide, Dept. of Microbiology and Immunology, 1993?; Includes bibliographical references.; 1 v. (various foliations) : ill. ; 30 cm.; Title page, contents and abstract only. The complete thesis in print form is available from the University Library.

Transcription factors involved in regulation of immune and haemopoietic cytokine gene expression

Dunn, Stephanie May
Fonte: Adelaide Thesis (Ph.D.) -- University of Adelaide, Department of Microbiology and Immunology Publicador: Adelaide Thesis (Ph.D.) -- University of Adelaide, Department of Microbiology and Immunology
Tipo: Tese de Doutorado Formato: 63959 bytes; application/pdf
Publicado em //1993 Português
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Thesis (Ph.D.)--University of Adelaide, Dept. of Microbiology and Immunology, 1993

Molecular characterisation of the transcriptional activator, HLYU, of Vibrio cholerae O1/ Leanne R. Purins.

Purins, Leanne Roslyn
Fonte: Universidade de Adelaide Publicador: Universidade de Adelaide
Tipo: Tese de Doutorado Formato: 159652 bytes; application/pdf
Publicado em //2004 Português
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Thesis (Ph.D.)--University of Adelaide, School of Molecular and Biomedical Science, Discipline of Microbiology and Immunology, 2005; "May, 2004"; Includes corrigenda.; includes bibliographical references (leaves 118-156); [13], 155 leaves : ill. (some col.) ; 30 cm.; Title page, contents and abstract only. The complete thesis in print form is available from the University Library.

The physiology and immunology of the endocrine testis / by Simon Maddocks

Maddocks, Simon
Fonte: Universidade de Adelaide Publicador: Universidade de Adelaide
Tipo: Tese de Doutorado Formato: 77540 bytes; application/pdf
Publicado em //1987 Português
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Examines the immune priviledged status of the testis, and the likely mechanisms involved in providing this priviledged status. Some new concepts on the possible mechanisms that afford an immunologically protected environment in the rodent testis are presented.; Thesis (Ph.D.)--University of Adelaide, Dept. of Animal Sciences, 1987; Includes bibliographical references (leaves 343-403); xiii, 403 leaves : ill. (some col.) ; 30 cm.; Title page, contents and abstract only. The complete thesis in print form is available from the University Library.

Epidemiological studies on primipaternity and immunology in preeclampsia - a statement after twelve years of workshops

Robillard, P.Y.; Dekker, G.; Chaouat, G.; Hulsey, T.; Saftlas, A.
Fonte: Elsevier Sci Ireland Ltd Publicador: Elsevier Sci Ireland Ltd
Tipo: Artigo de Revista Científica
Publicado em //2011 Português
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Pierre-Yves Robillard, Gustaaf Dekker, Gérard Chaouat, Thomas C. Hulsey, Audrey Saftlas