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Caracterização por RM cardíaca e técnica de realce tardio de um pseudoaneurisma do ventrículo esquerdo; Left ventricular false aneurysm characterized by cardiovascular magnetic resonance and late enhancement technique

Andrade, LC; Donato, P; Ferreira, MJ; Caseiro-Alves, F
Fonte: Centro Hospitalar e Universitário de Coimbra Publicador: Centro Hospitalar e Universitário de Coimbra
Tipo: Artigo de Revista Científica
Publicado em //2014 Português
Left ventricular pseudoaneurysm is a rare complication of myocardial infarction. Differentiation between true and false aneurysms, although difficult, is crucial, because of the different treatment options they entail. We present a rare case of a giant pseudoaneurysm of the left ventricle related with a previous myocardial infarction. The present case highlights the pivotal role of magnetic resonance imaging for differential diagnosis between these entities.

Adult abdominal Burkitt lymphoma with isolated peritoneal involvement

Oliveira, C; Matos, H; Serra, P; Catarino, R; Estevão, A
Fonte: Centro Hospitalar e Universitário de Coimbra Publicador: Centro Hospitalar e Universitário de Coimbra
Tipo: Artigo de Revista Científica
Publicado em //2014 Português
Burkitt lymphoma is a fast-growing high grade B-cell neoplasm that rarely affects adults. Three clinical variants are described in the World Health Organization classification: endemic, sporadic, and immunodeficiency-associated. The non-endemic form typically presents as an abdominal mass in children. Symptoms usually occur due to mass effect or direct intestinal involvement. We describe a very unusual presentation of a sporadic Burkitt lymphoma case in a 61-year-old male with diffuse peritoneal and omental involvement, without lymphadenopathies, mimicking peritoneal carcinomatosis.

Intervenção transtorácica pulmonar guiada por TC aspirativa por agulha fina e biópsia; Percutaneous CT-guided lung intervention: fine-needle aspiration and core biopsy

Oliveira, C; Candelária, I; Dias, C; Couto, T; Estevão, A
Fonte: Centro Hospitalar e Universitário de Coimbra Publicador: Centro Hospitalar e Universitário de Coimbra
Tipo: Artigo de Revista Científica
Publicado em //2014 Português

Cardiovascular magnetic resonance imaging assessment of diastolic dysfunction in a population without heart disease: a gender-based study

Graça, B; Ferreira, MJ; Donato, P; Castelo-Branco, M; Caseiro-Alves, F
Fonte: Springer Publicador: Springer
Tipo: Artigo de Revista Científica
Publicado em //2014 Português
OBJECTIVES: Asymptomatic left ventricular (LV) diastolic dysfunction is increasingly recognised as an important diagnosis. Our goal was to study the prevalence and gender differences in subclinical LV diastolic dysfunction, using cardiovascular magnetic resonance imaging (CMR) at 3 T. METHODS: We prospectively studied 48 volunteers (19 male and 29 female, mean age 49 ± 7 years) with no evidence of cardiovascular disease. We used CMR to measure left atrium (LA) and LV volumes, LV peak filling rate and transmitral flow. RESULTS: The overall prevalence of LV diastolic dysfunction in our cohort varied between 20 % (based on evaluation of LV filing profiles) and 24 % (based on the evaluation of the transmitral flow). The prevalence of diastolic dysfunction was higher in men than in women, independently of the criteria used (P between 0.004 and 0.022). Indexed LV end-diastolic volume, indexed LV stroke volume, indexed LV mass, indexed LA minimum volume and indexed LA maximum volume were significantly greater in men than in women (P < 0.05). All the subjects had LV ejection fractions within the normal range. CONCLUSIONS: It is clinically feasible to study diastolic flow and LV filling with CMR. CMR detected diastolic dysfunction in asymptomatic men and women. KEY POINTS: • CMR imaging offers new possibilities in assessing left ventricular diastolic function. • The prevalence of diastolic dysfunction is higher in men than in women. • The prevalence of some diastolic dysfunction in a normal population is 24 %.

Usefulness of Liver and Spleen Acoustic Radiation Force Impulse (ARFI) for the evaluation of cirrhotic patients

Barbosa, L; Oliveira, C; Fernandes, A; Marques, M; Pereira, J; Sofia, C; Caseiro-Alves, F; Noruegas, MJ
Fonte: Centro Hospitalar e Universitário de Coimbra Publicador: Centro Hospitalar e Universitário de Coimbra
Tipo: Artigo de Revista Científica
Publicado em //2014 Português
Objective: To evaluate the correlation between ARFI and Child-Pugh classification. Secondary Aims: 1) To compare ARFI values (hepatic, splenic and spleno-hepatic index) from cirrhotic to normal population; 2) To correlate biochemical parameters of liver function and ARFI. Materials and Methods: 58 cirrhotic patients (referenced to US for surveillance or to clarify any hepatic decompensation) were included in this prospective study, as well as 38 healthy subjects who underwent ultrasonography for other reasons than hepatic evaluation. All had ARFI liver and spleen evaluation on ACUSON S2000 ARFI equipment. The best cut-off liver and spleen values for the diagnosis of cirrhosis in comparison to the normal subjects were determined using SPSS® v20. Results: Mean liver ARFI values in controls and cirrhotic patients were respectively 1.18 ± 0.22 m/s and 2.93 ± 0.50 m/s. The ROC curve demonstrated an AUC 0.998 and the best cut-off was 1.89. Mean spleen ARFI values in controls and cirrhotic patients were respectively 2.60 ± 0.42 m/s and 3.03 ± 0.71. The ROC curve demonstrated an AUC 0.766 and the best cut-off was 2.73 m/s. The splenohepatic index showed a worse AUC than ARFI liver. A weak correlation was found between the ARFI liver and Child-Pugh. We found no statistically significant differences for spleen ARFI values and Child-Pugh. We found a statistically significant correlation between liver ARFI and bilirubin...

Phenotypic expression in hypertrophic cardiomyopathy and late gadolinium enhancement on cardiac magnetic resonance; Expressão fenotípica da miocardiopatia hipertrófica e realce tardio na ressonância magnética cardíaca

Caetano, F; Botelho, A; Trigo, J; Silva, J; Almeida, I; Venâncio, M; Pais, J; Sanches, C; Leitão-Marques, A
Fonte: Centro Hospitalar e Universitário de Coimbra Publicador: Centro Hospitalar e Universitário de Coimbra
Tipo: Artigo de Revista Científica
Publicado em //2014 Português
INTRODUCTION AND AIM: The prognostic value of late gadolinium enhancement (LGE) for risk stratification of hypertrophic cardiomyopathy (HCM) patients is the subject of disagreement. We set out to examine the association between clinical and morphological variables, risk factors for sudden cardiac death and LGE in HCM patients. METHODS: From a population of 78 patients with HCM, we studied 53 who underwent cardiac magnetic resonance. They were divided into two groups according to the presence or absence of LGE. Ventricular arrhythmias and morbidity and mortality during follow-up were analyzed. RESULTS: Patients with LGE were younger at the time of diagnosis (p=0.046) and more often had a family history of sudden death (p=0.008) and known coronary artery disease (p=0.086). On echocardiography they had greater maximum wall thickness (p=0.007) and left atrial area (p=0.037) and volume (p=0.035), and more often presented a restrictive pattern of diastolic dysfunction (p=0.011) with a higher E/É ratio (p=0.003) and left ventricular systolic dysfunction (p=0.038). Cardiac magnetic resonance supported the association between LGE and previous echocardiographic findings: greater left atrial area (p=0.029) and maximum wall thickness (p<0.001) and lower left ventricular ejection fraction (p=0.056). Patients with LGE more often had an implantable cardioverter-defibrillator (ICD) (p=0.015). At follow-up...

Left Ventricular Diastolic Function in Type 2 Diabetes Mellitus and the Association With Coronary Artery Calcium Score: A Cardiac MRI Study

Graça, B; Donato, P; Ferreira, MJ; Castelo-Branco, M; Caseiro-Alves, F
Fonte: Centro Hospitalar e Universitário de Coimbra Publicador: Centro Hospitalar e Universitário de Coimbra
Tipo: Artigo de Revista Científica
Publicado em //2014 Português
OBJECTIVE: The purpose of this study was to compare cardiac MRI-derived parameters of left ventricular (LV) diastolic function between uncomplicated type 2 diabetes mellitus (DM2) and normoglycemic control subjects and to evaluate whether these parameters of LV diastolic function are related to coronary atherosclerosis. SUBJECTS AND METHODS: We prospectively studied 41 subjects with DM2 and 21 normoglycemic control subjects (30 women and 32 men; mean age, 57.2 ± 7.1 [SD] years) with no evidence of overt cardiovascular disease. We used cardiac MRI to measure LV volumes, LV peak filling rate (PFR), and transmitral flow and CT to determine coronary artery calcium scores. RESULTS: Absolute values of the peak filling rate (PFR) were significantly lower in DM2 patients than in control subjects (mean ± SD, 293.2 ± 51.7 vs 375.7 ± 102.8 mL/s, respectively; p < 0.001). Mitral peak E velocities (mean ± SD, 42.8 ± 10.7 vs 48.8 ± 10.4 cm/s; p = 0.040) and peak E velocity-to-peak A velocity ratios (0.88 ± 0.3 vs 1.1 ± 0.3; p = 0.002) were also lower in DM2 patients compared with control subjects. DM2 patients with coronary artery calcification showed a lower PFR normalized to stroke volume (SV) (mean ± SD, 4.4 ± 1.0 vs 5.3 ± 1.4...

Giant colonic diverticulum presenting with painless rectal bleeding and diagnosed at angiography.

Costa-Andrade, L; Baptista, M; Costa, JF; Caseiro-Alves, F
Fonte: Centro Hospitalar e Universitário de Coimbra Publicador: Centro Hospitalar e Universitário de Coimbra
Tipo: Artigo de Revista Científica
Publicado em //2014 Português

Left atrial dysfunction in type 2 diabetes mellitus: insights from cardiac MRI

Graça, B; Ferreira, MJ; Donato, P; Castelo-Branco, M; Caseiro-Alves, F
Fonte: Springer Publicador: Springer
Tipo: Artigo de Revista Científica
Publicado em //2014 Português
OBJECTIVES: The left atrium (LA) modulates left ventricular filling through reservoir, conduit and booster pump functions. Only limited data exist on LA involvement in type 2 diabetes mellitus (DM2). This study sought to assess LA function in asymptomatic DM2 with cardiac MRI. We hypothesized that cardiac MRI can detect LA dysfunction in asymptomatic DM2. METHODS: Forty-five patients with asymptomatic DM2 and 24 normoglycaemic controls were studied. MRI cine imaging was performed to measure LA maximal and minimal volumes. A flow-sensitive phase-contrast gradient-echo sequence was used for flow measurements perpendicular to the orifice of the mitral valve, to quantify active LA stroke volume. LA total, passive and active emptying volumes and fractions were calculated. RESULTS: LA reservoir function, namely LA total ejection fraction, was significantly greater in controls compared to patients with DM2 (62.2 ± 5.2 vs 57.0 ± 7.6 %, P = 0.004). LA passive ejection fraction was also greater in the controls (26.2 ± 9.5 vs 16.1 ± 11.0 %, P < 0.001). Regarding parameters of LA booster pump function, LA active ejection fraction was not significantly different between groups. DM2 was demonstrated to be an independent determinant of LA function. CONCLUSIONS: Cardiac MRI enables the detection of LA dysfunction in asymptomatic DM2...

Anti-MuSK-positive myasthenia gravis diagnosed during pregnancy: New challenges for an old disease

Neves, AR; Monteiro, P; Matos, A; Santos-Silva, I
Fonte: Centro Hospitalar e Universitário de Coimbra Publicador: Centro Hospitalar e Universitário de Coimbra
Tipo: Artigo de Revista Científica
Publicado em //2015 Português
Myasthenia gravis is an autoimmune disorder affecting predominantly women in their reproductive age. The course of the disease during pregnancy is unpredictable, although it is more difficult to manage earlier in the gestation. Myasthenia gravis with antibodies against the muscle-specific receptor tyrosine kinase (anti-MuSK) has been described as a subtype of disease with more localised clinical features and a poorer response to treatment than acetylcholine receptor antibody (anti-AChR)-positive patients. Few cases have been reported in pregnant women, with deliveries being performed mainly by caesarean section. We report a successful case of vaginal delivery and describe our experience providing the first review of the management of this subtype of disease during pregnancy.

Adaptação cultural e propriedades psicométricas da versão portuguesa da escala Pain Assessment in Advanced Dementia; Cultural adaptation and psychometric properties of the portuguese version of the Pain Assessment in Advanced Dementia Scale

Batalha, LM; Antunes-Duarte, CI; Rosário, RA; Pereira da Costa, MF; Pereira, VJ; Morgado, T
Fonte: Centro Hospitalar e Universitário de Coimbra Publicador: Centro Hospitalar e Universitário de Coimbra
Tipo: Artigo de Revista Científica
Publicado em //2012 Português

Let's Go Publishing!

Marinho, RT; Sousa, C; Donato, H; Massano, J; Crespo, J
Fonte: Centro Hospitalar e Universitário de Coimbra Publicador: Centro Hospitalar e Universitário de Coimbra
Tipo: Artigo de Revista Científica
Publicado em //2014 Português

Evaluation of the anti-inflammatory, anti-catabolic and pro-anabolic effects of E-caryophyllene, myrcene and limonene in a cell model of osteoarthritis

Rufino, AT; Ribeiro, M; Sousa, C; Judas, F; Salgueiro, L; Cavaleiro, C; Mendes, AF
Fonte: Elsevier Publicador: Elsevier
Tipo: Artigo de Revista Científica
Publicado em //2015 Português
Osteoarthritis is a progressive joint disease and a major cause of disability for which no curative therapies are yet available. To identify compounds with potential anti-osteoarthritic properties, in this study, we screened one sesquiterpene, E-caryophyllene, and two monoterpenes, myrcene and limonene, hydrocarbon compounds for anti-inflammatory, anti-catabolic and pro-anabolic activities in human chondrocytes. At non-cytotoxic concentrations, myrcene and limonene inhibited IL-1β-induced nitric oxide production (IC50=37.3μg/ml and 85.3µg/ml, respectively), but E-caryophyllene was inactive. Myrcene, and limonene to a lesser extent, also decreased IL-1β-induced NF-κB, JNK and p38 activation and the expression of inflammatory (iNOS) and catabolic (MMP-1 and MMP-13) genes, while increasing the expression of anti-catabolic genes (TIMP-1 and -3 by myrcene and TIMP-1 by limonene). Limonene increased ERK1/2 activation by 30%, while myrcene decreased it by 26%, relative to IL-1β-treated cells. None of the compounds tested was able to increase the expression of cartilage matrix-specific genes (collagen II and aggrecan), but both compounds prevented the increased expression of the non-cartilage specific, collagen I, induced by IL-1β. These data show that myrcene has significant anti-inflammatory and anti-catabolic effects in human chondrocytes and...

Tendinopatia patelar Tratamento cirúrgico

Fonseca, F
Fonte: Centro Hospitalar e Universitário de Coimbra Publicador: Centro Hospitalar e Universitário de Coimbra
Tipo: Conferência ou Objeto de Conferência
Publicado em //2015 Português

A technique to remove a stable all-polyethylene cemented acetabular liner in revision hip arthroplasty: A case report

Judas, F; Lucas, FM; Fonseca, RL
Fonte: Elsevier Publicador: Elsevier
Tipo: Artigo de Revista Científica
Publicado em //2015 Português
INTRODUCTION: The removal of a well-fixed acetabular component in a total hip arthroplasty can cause bone fractures, excessive bleeding, as well as extended bone loss. The reimplantation of a new acetabular component may be compromised. PRESENTATION OF CASE:We report a technique using 2 cork-screws for removal a stable cemented acetabular component for the treatment of a recurrent dislocation of a cemented total hip arthroplasty, due to acetabular malposition. DISCUSSION: A diversity of approaches and tools has been used for extraction ofthe acetabular prosthesis. Using 2 cork-screws it is possible to create fissures and fractures into the cement mantle, and greater manual control is obtained facilitating the manipulation of the acetabular component in different directions. The cup-cemented bond can be disrupted, the host bone is preserved and the risks of complications are minimized. CONCLUSION: This technique is simple, available in any environment, reproducible, non-costly, nontiming consuming and safe.

Luxação de próteses totais da anca: causas e tratamento.

Pato, T; Lucas, F; Judas, F
Fonte: Centro Hospitalar e Universitário de Coimbra Publicador: Centro Hospitalar e Universitário de Coimbra
Tipo: Parte de Livro
Publicado em //2015 Português
A luxação de próteses totais da anca (PTA) continua a ser uma das complicações mais comuns e temidas. Pode ser um evento único, recidivante, precoce ou tardio. O risco de nova luxação aumenta significativamente após o primeiro episódio. Os fatores de risco são diversos: cirurgia prévia da anca, cirurgia de revisão da PTA, via de abordagem e técnica cirúrgica, experiência do cirurgião, má orientação dos componentes, conflito dos componentes ou da estrutura óssea, má colaboração do paciente. Quando ocorre luxação é fundamental um estudo sistematizado e rigoroso para avaliar a sua causa e programar a abordagem terapêutica. Normalmente a redução fechada é eficaz. Quando a redução por meios fechados não é possível, quando existe instabilidade, componentes malposicionados ou inadequada tensão dos tecidos moles, poderá recorrer-se à cirurgia. Existem várias alternativas cirúrgicas: colocação de rebordo acetabular antiluxante, reposicionamento dos componentes, resseção de osteófitos, aumento do tamanho da cabeça femoral, uso de acetábulo restritivo ou prótese bipolar. Quando estes procedimentos falham, a artroplastia tipo Girdlestone poderá estar indicada.

Cuidar Humanitude: Enfermagemneurorrelacional

Simões, M
Fonte: Centro Hospitalar e Universitário de Coimbra Publicador: Centro Hospitalar e Universitário de Coimbra
Tipo: Livro
Publicado em //2014 Português

Five-year review of an international clinical research-training program

Suemoto, CK; Ismail, S; Corrêa, PC; Khawaja, F; Jerves, T; Pesantez, L; Germani, AC; Zaina, F; Santos Júnior, AC; Oliveira-Ferreira, RJ
Fonte: Centro Hospitalar e Universitário de Coimbra Publicador: Centro Hospitalar e Universitário de Coimbra
Tipo: Artigo de Revista Científica
Publicado em //2015 Português
The exponential increase in clinical research has profoundly changed medical sciences. Evidence that has accumulated in the past three decades from clinical trials has led to the proposal that clinical care should not be based solely on clinical expertise and patient values, and should integrate robust data from systematic research. As a consequence, clinical research has become more complex and methods have become more rigorous, and evidence is usually not easily translated into clinical practice. Therefore, the instruction of clinical research methods for scientists and clinicians must adapt to this new reality. To address this challenge, a global distance-learning clinical research-training program was developed, based on collaborative learning, the pedagogical goal of which was to develop critical thinking skills in clinical research. We describe and analyze the challenges and possible solutions of this course after 5 years of experience (2008-2012) with this program. Through evaluation by students and faculty, we identified and reviewed the following challenges of our program: 1) student engagement and motivation, 2) impact of heterogeneous audience on learning, 3) learning in large groups, 4) enhancing group learning, 5) enhancing social presence...

Contributo de fatores individuais, sociais e ambientais para a decisão de prosseguir uma gravidez não planeada na adolescência: Um estudo caracterizador da realidade portuguesa

Pires, R; Pereira, J; Araújo Pedrosa, A; Vilar, D; Vicente, L; Canavarro, MC
Fonte: Centro Hospitalar e Universitário de Coimbra Publicador: Centro Hospitalar e Universitário de Coimbra
Tipo: Artigo de Revista Científica
Publicado em //2015 Português

Fabry’s disease, an eye-kidney disease review; Doença de Fabry, revisão de uma doença olho-rim

Guedes-Marques, M; Mira, F; Ferreira, E; Pinto, H; Maia, P; Mendes, T; Carreira, A; Campos, M
Fonte: Centro Hospitalar e Universitário de Coimbra Publicador: Centro Hospitalar e Universitário de Coimbra
Tipo: Artigo de Revista Científica
Publicado em //2015 Português
Fabry’s disease is a recessive X -linked disorder that results from a deficiency of the hydrolase alpha- -galactosidase A (α -Gal A). The absence of α -Gal A enzyme activity leads to accumulation of glycosphingolipid globotryaosylceramide (GL -3) in the lysosomes of a variety of cell types. It can cause skin and ocular lesions, progressive renal, cardiac or cerebrovascular disorders. The authors report the case of a 39 -year -old female who was referred to a nephrology appointment by her ophthalmologist, after the diagnosis of cornea verticillata and posterior subcapsular cataract. This case illustrates the importance of a multidisciplinary evaluation to an effective clinical screening. In males, most symptoms begin in childhood; in females the onset can be observed later and presentation is more variable. Various manifestations often lead to misdiagnosis or are frequently delayed for many years. Enzyme replacement therapy highlights the importance of early diagnosis so that treatment can be initiated before irreversible organ damage occurs.