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Análise da distribuição das doses ocupacionais em operações de manutenção e intervenção em áreas restritas do Centro de Radiofarmácia do IPEN; Ocupational doses distribuition analysis in operation of maintenance and interventions in restricted areas at Radiofarmacy Center of IPEN

Machado, Jessica Soares
Fonte: Biblioteca Digitais de Teses e Dissertações da USP Publicador: Biblioteca Digitais de Teses e Dissertações da USP
Tipo: Dissertação de Mestrado Formato: application/pdf
Publicado em 21/02/2013 Português
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Este estudo foi desenvolvido no Instituto de Pesquisas Energéticas e Nucleares - IPEN mais especificamente, no Centro de Radiofarmácia - CR que realiza pesquisa e processamento de radiosótopos como o 99Mo, 131I, 123I, 67Ga, 201Tl, 18F, 177Lu e 153Sm para uso em medicina nuclear. Os radioisótopos são produzidos em escala industrial e a instalação foi projetada para atender aos padrões de segurança radiológica e às exigências da Garantia de qualidade. No CR há profissionais qualificados que realizam as tarefas de manutenção dos equipamentos e instrumentos, instalados nas celas de processamento de radiofármacos, sem os quais não é possível conduzir a produção com segurança e qualidade. Neste estudo foi realizada uma pesquisa denominada Pesquisa de Variáveis, baseada nas operações de manutenções e intervenções em áreas restritas do CR e no levantamento da distribuição de doses nessas tarefas no período de 2005 a 2011. Esta pesquisa tem por objetivo identificar e determinar as principais variáveis que tem impacto sobre a dose do trabalhador. Os resultados obtidos foram apresentados para variável Indivíduo Ocupacionalmente Exposto - IOE, variável Operação, variável Área/Cela, variável Tipo de Tarefa e variável Duração de Operação...

Consumo alimentar de beneficiários do programa Bolsa Família; Food consumption of "Bolsa Família" Program beneficiaries

Sartori, Alan Giovanini de Oliveira
Fonte: Biblioteca Digitais de Teses e Dissertações da USP Publicador: Biblioteca Digitais de Teses e Dissertações da USP
Tipo: Dissertação de Mestrado Formato: application/pdf
Publicado em 20/01/2014 Português
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A expansão do consumo de alimentos submetidos a elevado grau de processamento em países em desenvolvimento é notória. Em paralelo, observa-se o aumento na prevalência de excesso de peso e de comorbidades associadas. O fenômeno também tem sido observado em famílias consideradas pobres que recebem benefício financeiro de programa federal de transferência condicionada de renda. O objetivo geral foi analisar o consumo alimentar de beneficiários do Programa Bolsa Família (PBF). Foi elaborado um sistema de classificação de alimentos, de acordo com o propósito e grau de processamento. Os dados utilizados são provenientes do módulo de consumo alimentar pessoal da Pesquisa de Orçamentos Familiares (n = 34.003; 7.600 beneficiários), conduzida pelo Instituto Brasileiro de Geografia e Estatística (IBGE) entre os anos de 2008 e 2009. As observações foram classificadas em três faixas etárias: crianças e adolescentes (10 a 18 anos), adultos (19 a 59 anos) e idosos (60 ou mais anos). Os integrantes da amostra também foram discriminados de acordo com o local do domicílio: regiões Norte, Sul, Nordeste, Centro-Oeste, estado de São Paulo e grupamento dos estados de Minas Gerais, Rio de Janeiro e Espírito Santo. Para estimar o conteúdo de carotenoides presente na dieta um banco de dados foi construído e a composição dessas substâncias nos alimentos foi obtida...

Strand-specific miR-28-5p and miR-28-3p have distinct effects in colorectal cancer cells

Almeida, Maria L.; Nicoloso, Milena S.; Zeng, Lizhi; Ivan, Cristina; Spizzo, Riccardo; Gafà, Roberta; XIiao, LIianchun; Zhang, Xinna; Vanninii, Ivan; Fanini, Francesca; Fabbri, Muller; Lanza, GIiovanni; Reis, R. M.; Zweidler-Mckay, Patrick; Calin, Georg
Fonte: WB Saunders Publicador: WB Saunders
Tipo: Artigo de Revista Científica
Publicado em /04/2012 Português
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The authors thank Sue Moreau from the Department of Scientific Publications at The University of Texas MD Anderson Cancer Center for English language editing of the manuscript. Author contributions: Study concept and design: M.I.A., P.A.Z, G.A.C. Acquisition of data: M.I.A., L.Z., X.Z. Drafting of the manuscript: M.I.A., M.N., R.S., M.F., R.M.R., P.A.Z, G.A.C. Analysis and interpretation of data: M.I.A., M.N., R.S., R.M., P.A.Z, G.A.C. Critical revision of the manuscript for important intellectual content: M.I.A., M.N., R.S., M.F., R.M.R., P.A.Z, G.A.C. Statistical analysis: M.I.A., C.I., L.X. Obtained funding: G.A.C. Administrative, technical, or material support: R.G., I.V., F.F., M.F., G.L. Study supervision: G.A.C. Drs Nicoloso and Spizzo are currently at the Division of Experimental Oncology, CRO, National Cancer Institute, Aviano, Italy; Background & Aims MicroRNAs (miRNAs) can promote or inhibit tumor growth and are therefore being developed as targets for cancer therapies. They are diverse not only in the messenger RNAs (mRNA) they target, but in their production; the same hairpin RNA structure can generate mature products from each strand, termed 5p and 3p, that can bind different mRNAs. We analyzed the expression, functions...

Unpressurized light aviation aircrafts flight and psysiological data acquisition system

Marques, André Emanuel Castro
Fonte: Universidade da Beira Interior Publicador: Universidade da Beira Interior
Tipo: Dissertação de Mestrado
Publicado em /10/2012 Português
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Special thanks to FCT (Fundação para a Ciência e Tecnologia) for the MSc Grant under AIRDEV (Business Models for Airport Development and Management) Project in partnership with MIT – Portugal Program (Reference: MIT- PT-TSAAs/0046/2008). Special thanks to Nonin Medical Inc. for supporting this work with the cerebral oximetry equipment. Special thanks to the OMNI Aviation Training Center for the assistance and availability for flight tests. Special thanks to the Portuguese Air Force for the authorization to conduct Hypobaric Chamber tests in the Aeronautical Medical Center. Special thanks to the Department of Sport Sciences of the University of Beira Interior for the Garmin Forerunner 305. Special thanks to the Department of Informatics of the University of Beira Interior and to the Informatics Engineering Department of the Superior School of Technology of the Polytechnics Institute of Tomar for the assembly of the Atmospheric Sensors Board and the creation of specific software.; The majority of light aviation aircrafts have non pressurized cabins that may pose risks for the safety of both pilots and passengers. As altitude increases partial oxygen pressure decreases and this situation may lead to early stages of hypoxia affecting pilot’s capabilities to perform simple tasks. In addition temperature also changes as altitude increases. All these factors combined in several ways may affect significantly the capability of a pilot to conduct a safe flight. Some work has been developed in this area and results show that even small changes in altitude can decrease pilot’s oxygen level significantly. Thus...

Lateral interactions in visual perception of temporal signals: cortical and subcortical components

Teixeira,Claudio E. C.; Silveira,Luiz Carlos L.; Kremers,Jan
Fonte: Pontificia Universidade Católica do Rio de Janeiro; Universidade de Brasília; Universidade de São Paulo Publicador: Pontificia Universidade Católica do Rio de Janeiro; Universidade de Brasília; Universidade de São Paulo
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/06/2011 Português
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The aim of this work was to isolate and investigate subcortical and cortical lateral interactions involved in flicker perception. We quantified the perceived flicker strength (PFS) in the center of a test stimulus which was simultaneously modulated with a surround stimulus (50% Michelson contrast in both stimuli). Subjects were requested to adjust the modulation depth of a separate matching stimulus that was physically identical to the center of the test stimulus but without the surround. Using LCD goggles, synchronized to the frame rate of a CRT screen, the center and surround could be presented monoptically or dichoptically. In the monoptic condition, center-surround interactions can have both subcortical and cortical origins. In the dichoptic condition, center-surround interactions cannot occur in the retina and the LGN, therefore isolating a cortical mechanism. Results revealed both a strong monoptic (subcortical plus cortical) lateral interaction and a weaker dichoptic (cortical) lateral interaction. Subtraction of the dichoptic from the monoptic data revealed a subcortical mechanism of the lateral interaction. While the modulation of the cortical PFS component showed a low-pass temporal-frequency tuning, the modulation of the subcortical PFS component was maximal at 6 Hz. These findings are consistent with two separate temporal channels influencing the monoptic PFS...

BRIGEP—the BRIDGE-based genome–transcriptome–proteome browser

Goesmann, A.; Linke, B.; Bartels, D.; Dondrup, M.; Krause, L.; Neuweger, H.; Oehm, S.; Paczian, T.; Wilke, A.; Meyer, F.
Fonte: Oxford University Press Publicador: Oxford University Press
Tipo: Artigo de Revista Científica
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The growing amount of information resulting from the increasing number of publicly available genomes and experimental results thereof necessitates the development of comprehensive systems for data processing and analysis. In this paper, we describe the current state and latest developments of our BRIGEP bioinformatics software system consisting of three web-based applications: GenDB, EMMA and ProDB. These applications facilitate the processing and analysis of bacterial genome, transcriptome and proteome data and are actively used by numerous international groups. We are currently in the process of extensively interconnecting these applications. BRIGEP was developed in the Bioinformatics Resource Facility of the Center for Biotechnology at Bielefeld University and is freely available. A demo project with sample data and access to all three tools is available at . Code bundles for these and other tools developed in our group are accessible on our FTP server at .

Sequential processing in vision: The interaction of sensitivity regulation and temporal dynamics

Smith, Vivianne C.; Pokorny, Joel; Lee, Barry B.; Dacey, Dennis M.
Fonte: PubMed Publicador: PubMed
Tipo: Artigo de Revista Científica
Português
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The goal of this work was to describe the interaction of sensitivity regulation and temporal dynamics through the primate retina. A linear systems model was used to describe the temporal amplitude sensitivity at different retinal illuminances. Predictions for the primate H1 horizontal cell were taken as the starting point. The H1 model incorporated an early time-dependent stage of sensitivity regulation by the cones. It was adjusted to reduce the effects of gap junction input and then applied as input to a model describing temporal amplitude sensitivity of Parvocellular and Magnocellular pathway retinal ganglion cells. The ganglion cell model incorporated center–surround subtraction. The H1 based model required little modification to describe the Parvocellular data. The Magnocellular data required a further time-dependent stage of sensitivity regulation that resulted in Weber’s Law. Psychophysical data reflect the sensitivity regulation of the retinal ganglion cell pathways but show a decline in temporal resolution that is most pronounced for the post-retinal processing of Parvocellular signals.

A General Purpose Feature Extractor for Light Detection and Ranging Data

Li, Yangming; Olson, Edwin B.
Fonte: Molecular Diversity Preservation International (MDPI) Publicador: Molecular Diversity Preservation International (MDPI)
Tipo: Artigo de Revista Científica
Publicado em 17/11/2010 Português
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Feature extraction is a central step of processing Light Detection and Ranging (LIDAR) data. Existing detectors tend to exploit characteristics of specific environments: corners and lines from indoor (rectilinear) environments, and trees from outdoor environments. While these detectors work well in their intended environments, their performance in different environments can be poor. We describe a general purpose feature detector for both 2D and 3D LIDAR data that is applicable to virtually any environment. Our method adapts classic feature detection methods from the image processing literature, specifically the multi-scale Kanade-Tomasi corner detector. The resulting method is capable of identifying highly stable and repeatable features at a variety of spatial scales without knowledge of environment, and produces principled uncertainty estimates and corner descriptors at same time. We present results on both software simulation and standard datasets, including the 2D Victoria Park and Intel Research Center datasets, and the 3D MIT DARPA Urban Challenge dataset.

Bilateral Collicular Interaction: Modulation of Auditory Signal Processing in Amplitude Domain

Mei, Hui-Xian; Cheng, Liang; Tang, Jia; Fu, Zi-Ying; Wang, Xin; Jen, Philip H.-S.; Chen, Qi-Cai
Fonte: Public Library of Science Publicador: Public Library of Science
Tipo: Artigo de Revista Científica
Publicado em 24/07/2012 Português
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In the ascending auditory pathway, the inferior colliculus (IC) receives and integrates excitatory and inhibitory inputs from many lower auditory nuclei, intrinsic projections within the IC, contralateral IC through the commissure of the IC and from the auditory cortex. All these connections make the IC a major center for subcortical temporal and spectral integration of auditory information. In this study, we examine bilateral collicular interaction in modulating amplitude-domain signal processing using electrophysiological recording, acoustic and focal electrical stimulation. Focal electrical stimulation of one (ipsilateral) IC produces widespread inhibition (61.6%) and focused facilitation (9.1%) of responses of neurons in the other (contralateral) IC, while 29.3% of the neurons were not affected. Bilateral collicular interaction produces a decrease in the response magnitude and an increase in the response latency of inhibited IC neurons but produces opposite effects on the response of facilitated IC neurons. These two groups of neurons are not separately located and are tonotopically organized within the IC. The modulation effect is most effective at low sound level and is dependent upon the interval between the acoustic and electric stimuli. The focal electrical stimulation of the ipsilateral IC compresses or expands the rate-level functions of contralateral IC neurons. The focal electrical stimulation also produces a shift in the minimum threshold and dynamic range of contralateral IC neurons for as long as 150 minutes. The degree of bilateral collicular interaction is dependent upon the difference in the best frequency between the electrically stimulated IC neurons and modulated IC neurons. These data suggest that bilateral collicular interaction mainly changes the ratio between excitation and inhibition during signal processing so as to sharpen the amplitude sensitivity of IC neurons. Bilateral interaction may be also involved in acoustic-experience-dependent plasticity in the IC. Three possible neural pathways underlying the bilateral collicular interaction are discussed.

Automated Extraction of BI-RADS Final Assessment Categories from Radiology Reports with Natural Language Processing

Sippo, Dorothy A.; Warden, Graham I.; Andriole, Katherine P.; Lacson, Ronilda; Ikuta, Ichiro; Birdwell, Robyn L.; Khorasani, Ramin
Fonte: Springer US Publicador: Springer US
Tipo: Artigo de Revista Científica
Português
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The objective of this study is to evaluate a natural language processing (NLP) algorithm that determines American College of Radiology Breast Imaging Reporting and Data System (BI-RADS) final assessment categories from radiology reports. This HIPAA-compliant study was granted institutional review board approval with waiver of informed consent. This cross-sectional study involved 1,165 breast imaging reports in the electronic medical record (EMR) from a tertiary care academic breast imaging center from 2009. Reports included screening mammography, diagnostic mammography, breast ultrasound, combined diagnostic mammography and breast ultrasound, and breast magnetic resonance imaging studies. Over 220 reports were included from each study type. The recall (sensitivity) and precision (positive predictive value) of a NLP algorithm to collect BI-RADS final assessment categories stated in the report final text was evaluated against a manual human review standard reference. For all breast imaging reports, the NLP algorithm demonstrated a recall of 100.0 % (95 % confidence interval (CI), 99.7, 100.0 %) and a precision of 96.6 % (95 % CI, 95.4, 97.5 %) for correct identification of BI-RADS final assessment categories. The NLP algorithm demonstrated high recall and precision for extraction of BI-RADS final assessment categories from the free text of breast imaging reports. NLP may provide an accurate...

Integrating a Hive Triangle Pattern with Subpixel Analysis for Noncontact Measurement of Structural Dynamic Response by Using a Novel Image Processing Scheme

Lu, Yung-Chi; Hung, Shih-Lin; Lin, Tzu-Hsuan
Fonte: Hindawi Publishing Corporation Publicador: Hindawi Publishing Corporation
Tipo: Artigo de Revista Científica
Português
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This work presents a digital image processing approach with a unique hive triangle pattern by integrating subpixel analysis for noncontact measurement of structural dynamic response data. Feasibility of proposed approach is demonstrated based on numerical simulation of a photography experiment. According to those results, the measured time-history displacement of simulated image correlates well with the numerical solution. A small three-story frame is then mounted on a small shaker table, and a linear variation differential transformation (LVDT) is set on the second floor. Experimental results indicate that the relative error between data from LVDT and analyzed data from digital image correlation is below 0.007%, 0.0205 in terms of frequency and displacement, respectively. Additionally, the appropriate image block affects the estimation accuracy of the measurement system. Importantly, the proposed approach for evaluating pattern center and size is highly promising for use in assigning the adaptive block for a digital image correlation method.

The Offshore Services Value Chain : Developing Countries and the Crisis

Gereffi, Gary; Fernandez-Stark, Karina
Fonte: Banco Mundial Publicador: Banco Mundial
Português
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This paper analyzes the recent evolution and impact of the global economic crisis on the offshore services industry. Using a global value chains framework, the authors classify the offshore services sector in a comprehensive set of general and industry-specific activities that correspond to different segments and stages in the value-adding process for services. Through an analysis of the impact of the economic crisis on the industry, a small decline in demand was found; however this did not cause any structural changes in the market. The crisis has created two opposing effects: general contraction of demand by existing customers due to the recession; and, at the same time, a substitution effect by which new services are being moved from developed countries to emerging economies in search of cost reduction. The paper concludes that the offshore services industry will continue to offer growth opportunities for developing countries not only among existing market players, but also a range of new countries. The industry has the potential to become an important source for employment and economic growth around the globe.

An analysis of sensor data path as a "game changer" at the operational level of war

Albrant, Jeremiah; Buchholz, Raymond; Clulow, Brian; Held, Raymond; Khatra, Amrik; Miller , Todd; Minor, Ira; Nguyen, Peter; Ramirez ,Luis; Renteria, David
Fonte: Monterey, California. Naval Postgraduate School Publicador: Monterey, California. Naval Postgraduate School
Tipo: Tese de Doutorado
Português
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Approved for public release; distribution is unlimited; This project describes a Systems Engineering approach to validate that variation of the sensor data path at the Operational Level of War (OLW) represents a "game changing" concept to improve Fleet Battle Management through the Naval Planning Process (NPP) in the Maritime Operations Center. The team used Vitech's CORE Model Based Systems Engineering tool to model and simulate the baseline and hypothesized data paths and information processes derived from two mission threads: Counter-Piracy and Humanitarian Assistance/Disaster Relief. Considerations for time-sensitive sensor data included key decisions on tasking, collection, processing, exploitation, fusion, analysis, and dissemination. Modeling and simulation results show that Unmanned Aerial Systems (UASs) at the OLW provides only a minor improvement to the overall performance of the NPP and a moderate improvement to the number of information requests the Maritime Intelligence Operations Center can fulfill. The results are significant in that they appear to validate an Operational Commander's decision not to directly use UAS to support the OLW. Future research should be directed towards the determination of the capacity of such "game changing" technology to effectively support mature operational environments or be the linkage for other sources of information for mission achievement.

Streamlining Non-Tariff Measures : A Toolkit for Policy Makers

Cadot, Olivier; Malouche, Mariem; Sáez, Sebastián
Fonte: Washington, DC: World Bank Publicador: Washington, DC: World Bank
Tipo: Publications & Research :: Publication; Publications & Research :: Publication
Português
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This volume is organized as follows. Chapter one discusses the newly revamped non-tariff measure (NTM) classification system, the data collection effort so far, and the key characteristics of the data. It also highlights the private-sector view that NTMs should support domestic firms' competitiveness across countries. Chapter two describes the analytics of an NTM review, step by step through the key questions, for example, is there a market failure, which market is affected, what are the costs of regulatory action vs. the risks of deregulation, and explains how to answer these questions and how to go about quantification when it is possible. Chapter three focuses on the institutional setup and key principles required to successfully pursue the streamlining of regulations. Since the mid-1990s, developed countries have introduced new regulatory approaches aimed at improving the quality of the decision-making process by enhancing both the analytical framework used by policy makers and the participation of interested parties in the regulatory process. Finally...

Unpressurized light aviation aircrafts flight and psysiological data acquisition system

Marques, André Emanuel Castro
Fonte: Universidade da Beira Interior Publicador: Universidade da Beira Interior
Tipo: Dissertação de Mestrado
Publicado em /10/2012 Português
Relevância na Pesquisa
25.62%
Special thanks to FCT (Fundação para a Ciência e Tecnologia) for the MSc Grant under AIRDEV (Business Models for Airport Development and Management) Project in partnership with MIT – Portugal Program (Reference: MIT- PT-TSAAs/0046/2008). Special thanks to Nonin Medical Inc. for supporting this work with the cerebral oximetry equipment. Special thanks to the OMNI Aviation Training Center for the assistance and availability for flight tests. Special thanks to the Portuguese Air Force for the authorization to conduct Hypobaric Chamber tests in the Aeronautical Medical Center. Special thanks to the Department of Sport Sciences of the University of Beira Interior for the Garmin Forerunner 305. Special thanks to the Department of Informatics of the University of Beira Interior and to the Informatics Engineering Department of the Superior School of Technology of the Polytechnics Institute of Tomar for the assembly of the Atmospheric Sensors Board and the creation of specific software.; The majority of light aviation aircrafts have non pressurized cabins that may pose risks for the safety of both pilots and passengers. As altitude increases partial oxygen pressure decreases and this situation may lead to early stages of hypoxia affecting pilot’s capabilities to perform simple tasks. In addition temperature also changes as altitude increases. All these factors combined in several ways may affect significantly the capability of a pilot to conduct a safe flight. Some work has been developed in this area and results show that even small changes in altitude can decrease pilot’s oxygen level significantly. Thus...

Regulatory Administrative Databases in FDA's Center for Biologics Evaluation and Research: Convergence Toward a Unified Database

Smith, Jeffrey K.
Fonte: Springer US Publicador: Springer US
Tipo: Artigo de Revista Científica
Publicado em 27/12/2012 Português
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Regulatory administrative database systems within the Food and Drug Administration's (FDA) Center for Biologics Evaluation and Research (CBER) are essential to supporting its core mission, as a regulatory agency. Such systems are used within FDA to manage information and processes surrounding the processing, review, and tracking of investigational and marketed product submissions. This is an area of increasing interest in the pharmaceutical industry and has been a topic at trade association conferences (Buckley 2012). Such databases in CBER are complex, not for the type or relevance of the data to any particular scientific discipline but because of the variety of regulatory submission types and processes the systems support using the data. Commonalities among different data domains of CBER's regulatory administrative databases are discussed. These commonalities have evolved enough to constitute real database convergence and provide a valuable asset for business process intelligence. Balancing review workload across staff, exploring areas of risk in review capacity, process improvement, and presenting a clear and comprehensive landscape of review obligations are just some of the opportunities of such intelligence. This convergence has been occurring in the presence of usual forces that tend to drive information technology (IT) systems development toward separate stovepipes and data silos. CBER has achieved a significant level of convergence through a gradual process...

Setting up a STAR Tier 2 Site at Golias/Prague Farm

Chaloupka, Petr; Jakl, Pavel; Kapitán, Jan; Lauret, Jérôme; Zerola, Michal
Fonte: Universidade Cornell Publicador: Universidade Cornell
Tipo: Artigo de Revista Científica
Português
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High Energy Nuclear Physics (HENP) collaborations' experience show that the computing resources available at a single site are often neither sufficient nor satisfy the need of remote collaborators. From latencies in the network connectivity to the lack of interactivity, work at distant computing centers is often inefficient. Having fully functional software stack on local resources is a strong enabler of science opportunities for any local group who can afford the time investment. Prague's heavy-ions group participating in STAR experiment at RHIC has been a strong advocate of local computing as the most efficient means of data processing and physics analyses. Tier 2 computing center was set up at a Regional Computing Center for Particle Physics called "Golias". We report on our experience in setting up a fully functional Tier 2 center and discuss the solutions chosen to address storage space and analysis issues and the impact on the farms overall functionality. This includes a locally built STAR analysis framework, integration with a local DPM system (a cost effective storage solution), the influence of the availability and quality of the network connection to Tier 0 via a dedicated CESNET/ESnet link and the development of light-weight yet fully automated data transfer tools allowing the movement of entire datasets from BNL (Tier 0) to Golias (Tier 2).; Comment: To appear in proceedings of Computing in High Energy and Nuclear Physics 2009

Genes implicated in stem-cell identity and temporal-program are directly targeted by Notch in neuroblast tumours; Notch targets in Neuroblasts

Zacharioudaki, Evanthia; Housden, Benjamin E.; Garinis, George; Stojnic, Robert; Delidakis, Christos; Bray, Sarah
Fonte: Company of Biologists Publicador: Company of Biologists
Tipo: Article; accepted version
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This is the author accepted manuscript. The final version is available from Company of Biologists via http://dx.doi.org/10.1242/dev.126326; Notch signalling is involved in a multitude of developmental decisions and its aberrant activation is linked to many diseases, including cancers. One such example is the neural stem cell tumours that arise from constitutive Notch activity in Drosophila neuroblasts. To investigate how hyper-activation of Notch in larval neuroblasts leads to tumours, we combined results from profiling the upregulated mRNAs and mapping the regions bound by Su(H) (the core Notch pathway transcription factor). This identified 246 putative direct Notch targets. These genes were highly enriched for transcription factors (TFs) and overlapped significantly with a previously identified regulatory programme dependent on the proneural transcription factor Asense. Included were genes associated with the neuroblast maintenance and self-renewal programme that we validated as Notch regulated in vivo. Another group were the so-called temporal transcription factors, which have been implicated in neuroblast maturation. Normally expressed in specific time windows, several temporal transcription factors were ectopically expressed in the stem cell tumours...

ACE Data from the ACE Science Center

Davis, A. J.; Hemple, S. J.; Sears, S. R.
Fonte: International Union of Pure and Applied Physics Publicador: International Union of Pure and Applied Physics
Tipo: Book Section; PeerReviewed Formato: application/pdf
Publicado em //1999 Português
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The purpose of the ACE Science Center (ASC) is to perform level 1 processing of data from the nine science instruments aboard the Advanced Composition Explorer (ACE) spacecraft and to facilitate access to all ACE data by both the instrument investigators and the space physics community. We describe the ACE data products available from the ASC and the methods by which users may access the data.

The Nuclear Spectroscopic Telescope Array (NuSTAR)

Harrison, Fiona A.; Bhalereo, Varun; Cook, W. Rick; Grefenstette, Brian W.; Kitaguchi, Takeo; Madsen, Kristin Kruse; Mao, Peter; Miyasaka, Hiromasa; Rana, Vikram
Fonte: Society of Photo-optical Instrumentation Engineers (SPIE) Publicador: Society of Photo-optical Instrumentation Engineers (SPIE)
Tipo: Book Section; PeerReviewed Formato: application/pdf
Publicado em //2010 Português
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The Nuclear Spectroscopic Telescope Array (NuSTAR) is a NASA Small Explorer mission that will carry the rst focusing hard X-ray (6 - 80 keV) telescope to orbit. NuSTAR will oer a factor 50 - 100 sensitivity improvement compared to previous collimated or coded mask imagers that have operated in this energy band. In addition, NuSTAR provides sub-arcminute imaging with good spectral resolution over a 12-arcminute eld of view. After launch, NuSTAR will carry out a two-year primary science mission that focuses on four key programs: studying the evolution of massive black holes through surveys carried out in elds with excellent multiwavelength coverage, understanding the population of compact objects and the nature of the massive black hole in the center of the Milky Way, constraining the explosion dynamics and nucleosynthesis in supernovae, and probing the nature of particle acceleration in relativistic jets in active galactic nuclei. A number of additional observations will be included in the primary mission, and a guest observer program will be proposed for an extended mission to expand the range of scientic targets. The payload consists of two co-aligned depth-graded multilayer coated grazing incidence optics focused onto a solid state CdZnTe pixel detectors. To be launched in early 2012 on a Pegasus rocket into a low-inclination Earth orbit...