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Atividade física regular preserva a função pulmonar em pacientes com espondilite anquilosante sem doença pulmonar prévia; Regular physical activity preserves the lung function in patients with ankylosing spondylitis without previous lung alterations

GOYA, Karin M.; SIQUEIRA, Luciana T.; COSTA, Renata Alqualo; GALLINARO, Andréa Lopes; GONÇALVES, Celio Roberto; CARVALHO, Jozélio Freire de
Fonte: Elsevier Editora Ltda Publicador: Elsevier Editora Ltda
Tipo: Artigo de Revista Científica
Português
Relevância na Pesquisa
67.13%
A espondilite anquilosante é uma doença inflamatória que influencia de maneira restritiva a mecânica respiratória por meio do acometimento das articulações da coluna, bem como das alterações posturais decorrentes desse processo como o aumento da cifose torácica. OBJETIVO: O objetivo deste estudo foi avaliar a alteração pulmonar dos pacientes portadores de espondilite anquilosante e relacioná-la à atividade física, verificando a influência na capacidade respiratória. MÉTODOS:Foram recrutados para este estudo 104 pacientes. Apenas 15 preenchiam os critérios de inclusão e exclusão, sendo divididos em dois grupos: grupo I, composto por indivíduos sedentários, e o grupo II, composto por pacientes que praticam uma atividade física regular moderada. RESULTADOS:Os dois grupos não diferiram em relação à média da idade (49,6 ± 11,6 versus 43,3 ± 13,2 anos, p = 0,19), peso (70,9 ± 9,7 versus 74,1 ± 12,1 kg, p = 0,30) e a altura (164,6 ± 3,5 versus 167,6 ± 6,9 cm, p = 0,16). Entretanto, o tempo médio de doença foi significantemente maior no grupo I comparado ao grupo de ativos (20,1 ± 6,9 vs. 9,6 ± 3,4, p = 0,004). Como tema de interesse, observou-se que o volume minuto foi significativamente maior no grupo ativo que no inativo (4...

Comparison of the Clinical Expression of Patients with Ankylosing Spondylitis from Europe and Latin America

Benegas, Mariana; Munoz-Gomariz, Elisa; Font, Pilar; Burgos-Vargas, Ruben; Chaves, Jose; Palleiro, Daniel; Maldonado Cocco, Jose; Gutierrez, Miguel; Saenz, Ricardo; Steckmen, Ivan; Rillo, Oscar; Mulero, Juan; Sampaio-Barros, Percival; Barcelos, Anabela; V
Fonte: J RHEUMATOL PUBL CO; TORONTO Publicador: J RHEUMATOL PUBL CO; TORONTO
Tipo: Artigo de Revista Científica
Português
Relevância na Pesquisa
66.89%
Objective. To compare the clinical, demographic, and serologic characteristics and the treatment of patients diagnosed with ankylosing spondylitis (AS) from Europe (EU) and Latin America (LA). Methods. We included 3439 patients from national registries: the Spanish Registry of Spondyloarthritis (REGISPONSER), the Belgian registry (ASPECT), and the Latin American Registry of Spondyloarthropathies (RESPONDIA). We selected patients with diagnosis of AS who met the modified New York classification criteria. Demographic, clinical, disease activity, functional, and metrological measurement data were recorded. Current treatment was recorded. The population was classified into 2 groups: patients with disease duration < 10 years and those with disease duration >= 10 years. A descriptive and comparative analysis of variables of both groups was carried out. Results. There were 2356 patients in EU group and 1083 in LA group. Prevalence of HLA-B27 was 71% in LA group and 83% in EU group (p < 0.001). We found a greater frequency of peripheral arthritis and enthesitis (p < 0.001) in the LA population; prevalence of arthritis was 57% in LA and 42% in EU, and for enthesitis, 54% and 38%. Except for treatment with anti-tumor necrosis factor (anti-TNF)...

Sexual activity in ankylosing spondylitis

Gallinaro, Andrea Lopes; Akagawa, Lilian Lie; Ichiba Otuzi, Mariana Hissami; Sampaio-Barros, Percival Degrava; Goncalves, Celio Roberto
Fonte: ELSEVIER SCIENCE INC; NEW YORK Publicador: ELSEVIER SCIENCE INC; NEW YORK
Tipo: Artigo de Revista Científica
Português
Relevância na Pesquisa
67.26%
Objective: To assess the sexual activity of patients with ankylosing spondylitis, correlating it with disease activity and functional indices. Patients and methods: Thirty-two patients with ankylosing spondylitis and 32 healthy controls were assessed regarding pain, fatigue, sexual activity (by use of pictures of seven sexual positions), disease activity (by use of Bath Ankylosing Spondylitis Disease Activity Index - BASDAI), and functional capacity (by use of Bath Ankylosing Spondylitis Functional Index - BASFI). After the interview, the patients were divided into two groups: group A (with sexual activity) and group B (no sexual activity). Results: Group B showed statistical association with longer disease duration (P = 0.01), and higher BASFI (P = 0.0007) and BASDAI (P = 0.03) scores. No correlation was observed between age and functional capacity. Man lying on his back and woman on top was the most frequent, enjoyable and least painful position. The position with the woman on her back and a man lying on top was the least chosen. Control individuals reported a higher frequency of sexual activity, longer duration of intercourse, and less pain and fatigue; the reported frequency of orgasms, however, was similar in both groups. Conclusion: The chronic nature of ankylosing spondylitis...

Equilíbrio estático e dinâmico no indivíduo com espondilite anquilosante: revisão da literatura; Static and dynamic balance in subjects with ankylosing spondylitis: literature review

Pompeu, José Eduardo; Romano, Renata Sorroche Lourenço; Pompeu, Sandra Maria Alvarenga Anti; Lima, Sônia Maria Anti Loduca
Fonte: Elsevier Editora Ltda Publicador: Elsevier Editora Ltda
Tipo: Artigo de Revista Científica
Português
Relevância na Pesquisa
66.89%
Com o objetivo de analisar as alterações musculoesqueléticas dos indivíduos com espondilite anquilosante (EA) e suas repercussões sobre o controle postural, realizou-se uma revisão bibliográfica nas bases de dados da BIREME e EBSCO HOTS e no site Pubmed com as palavras-chave: "ankylosing spondylitis", "postural balance" e "posture". Foram selecionados artigos envolvendo seres humanos e que analisavam o controle postural e a biomecânica dos indivíduos com EA, nos idiomas inglês e português, publicados no período entre 1999 e 2010. Do total de artigos encontrados, apenas quatro preencheram os requisitos. Desses, três compararam os resultados de pacientes com EA com os dados obtidos de indivíduos saudáveis, e um analisou apenas indivíduos com EA. Nenhum artigo continha o mesmo método de análise postural. Para avaliação do equilíbrio foram utilizadas a Escala de Equilíbrio de Berg, a Plataforma de Força e a Magnometria. Os principais desvios posturais encontrados foram aumento da cifose torácica e flexão do quadril, que levam a uma anteriorização do centro de gravidade corporal, apresentando flexão do joelho e plantiflexão do tornozelo como compensação para manter o equilíbrio. Apenas um autor encontrou piora do equilíbrio funcional nos sujeitos com EA. Todos os métodos de avaliação utilizados foram considerados capazes de mensurar o equilíbrio...

Adaptação cultural cruzada e validação da versão do Índice Funcional de Espondilite Anquilosante de Bath (BASFI) para o português do Brasil; Cross-cultural adaptation and validation of the Brazilian-Portuguese version of the Bath Ankylosing Spondylitis Functional Index (BASFI)

Cusmanich, Karla Garcez; Kowalski, Sérgio Candido; Gallinaro, Andréa Lopes; Goldenstein-Schainberg, Claudia; Souza, Lilian Avila Lima e; Gonçalves, Célio Roberto
Fonte: Elsevier Editora Ltda Publicador: Elsevier Editora Ltda
Tipo: Artigo de Revista Científica
Português
Relevância na Pesquisa
66.89%
OBJETIVO: Conduzir uma adaptação cultural cruzada do Índice Funcional de Espondilite Anquilosante de Bath (BASFI, Bath Ankylosing Spondylitis Functional Index) para o português do Brasil e avaliar suas propriedades de medição. MéTODOS: O BASFI foi traduzido por quatro reumatologistas e três professores de língua inglesa. O questionário traduzido foi aplicado a pacientes com espondilite anquilosante por observadores treinados e autoaplicado em três momentos, dias 1, 2 e 14. A validade foi estimada analisando-se a associação do BASFI e as medidas de capacidade funcional (rotação cervical, distância intermaleolar, teste de Schober e distância occipito-parede). A consistência interna foi testada pelo coeficiente α de Cronbach, e a confiabilidade pelo teste-reteste (coeficiente de correlação intraclasse [CCI]). RESULTADOS: Foram incluídos 60 pacientes com espondilite anquilosante: 85% do gênero masculino, com idade média de 47 ± 12 anos e duração média da doença de 20 ± 11 anos. A confiabilidade intraobservador no teste-reteste (intervalo de duas semanas) revelou alto ICC (0,999; 95% IC: 0,997-0,999), além de alta consistência interna (coeficiente α de Cronbach: 0,86; 95% IC: 0,80-0,90). Considerando-se a validade...

Avaliação da função gonadal em homens com espondilite anquilosante; Gonadal function in male patients with ankylosing spondylitis

Nukumizu, Lúcia Akemi
Fonte: Biblioteca Digitais de Teses e Dissertações da USP Publicador: Biblioteca Digitais de Teses e Dissertações da USP
Tipo: Tese de Doutorado Formato: application/pdf
Publicado em 03/04/2012 Português
Relevância na Pesquisa
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Objetivo: Avaliar a função testicular em pacientes do sexo masculino com espondilite anquilosante (EA). Métodos: Vinte pacientes com EA e vinte e quatro adultos masculinos saudáveis foram avaliados quanto às características demográficas, exame urológico, ultrassonografia testicular, avaliações dos espermatozóides, anticorpo anti-espermatozóide e perfil hormonal. Critérios de seleção foram: período de pelo menos 3 meses sem o uso de sulfasalazina e metotrexato e nunca terem usado agentes biológicos ou imunossupressores. As avaliações da EA incluíram investigações clínica e laboratorial. Resultados: A mediana da idade atual foi similar no grupo controle e EA (p=0,175). A freqüência de varicocele foi significantemente maior nos pacientes com EA em comparação com os controles (40% vs 8%, p=0,027). A mediana das formas normais de espermatozóides foi similar em pacientes com EA versus controles [17,25 (2-32,5) vs. 22,5 (1,5-45)%, p=0,215], assim como os outros parâmetros dos espermatozóides (p>0,05). Em contraste, a mediana das formas normais de espermatozóides foi significantemente menor em pacientes com EA com varicocele versus aqueles sem varicocele [13,5 (2-27) vs. 22 (10-32,5)%, p=0,049]. Reforçando esse achado...

Baixos níveis de esclerostina: preditor de processo inflamatório persistente em pacientes com espondilite anquilosante sob terapia anti-TNFα; Low sclerostin levels: a predictive marker of persistent inflammation in ankylosing spondylitis during anti-TNF therapy

Saad, Carla Gonçalves Schahin
Fonte: Biblioteca Digitais de Teses e Dissertações da USP Publicador: Biblioteca Digitais de Teses e Dissertações da USP
Tipo: Tese de Doutorado Formato: application/pdf
Publicado em 28/11/2012 Português
Relevância na Pesquisa
66.89%
Introdução: Baixas concentrações séricas de esclerostina foram descritas em pacientes com Espondilite Anquilosante (EA). No entanto, não existem dados sobre a importância deste inibidor da via de sinalização Wnt em pacientes com EA durante o tratamento com anti fator de necrose tumoral alfa (TNFa). Objetivos: Avaliar longitudinalmente os níveis séricos de esclerostina e sua associação com inflamação e densidade mineral óssea (DMO) em pacientes com EA em tratamento com anti-TNFa. Métodos: Trinta pacientes com EA em atividade foram avaliados no início, 6 e 12 meses, após terapia anti-TNFa em relação aos parâmetros clínicos (BASDAI, BASFI, BASMI e ASQoL), marcadores inflamatórios e dano radiológico basal (mSASSS). Trinta indivíduos saudáveis pareados por idade e sexo constituíram o grupo controle. As análises laboratoriais de esclerostina e da ligação de esclerostina ao receptor LRP6 e a DMO foram realizadas nos pacientes nos mesmos períodos de avaliação e comparadas aos controles. Resultados: Na avaliação inicial, pacientes com EA apresentavam menores concentrações séricas de esclerostina [60,5 (32,7) vs. 96,7 (52,9) pmol/l,P=0,002] e níveis similares de ligação de esclerostina ao receptor LRP6 (P=0...

Influence of TNF-alpha blockers on the oral prevalence of opportunistic microorganisms in ankylosing spondylitis patients

Pereira, D. F. A.; Pinheiro, M. M.; Silva, P. N. F.; Teodoro, G. R.; Brighenti, F. L.; Koga-Ito, C. Y.
Fonte: Clinical & Exper Rheumatology Publicador: Clinical & Exper Rheumatology
Tipo: Artigo de Revista Científica Formato: 679-685
Português
Relevância na Pesquisa
66.89%
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP); Processo FAPESP: 08/57631-4; Processo FAPESP: 08/56485-4; ObjectivesTo compare the oral prevalence and antimicrobial susceptibility of candida spp. staphylococci, enterobacteriaceae, and pseudomonas spp. from ankylosing spondylitis (AS) patients receiving conventional and anti-TNF-alpha therapy.MethodsThe study included 70 AS patients, diagnosed according to the modified New York criteria (1984). The volunteers were divided into 2 groups: a biological group (AS BioG) (n=35) (on anti-TNF-a therapy) and a conventional group (AS ConvG) (n=35). The control group (ContG) (n=70) was made up of healthy individuals matched for age, gender, and oral conditions. After clinical examination, oral rinse samples were collected and plated in specific culture media. The number of colony-forming units per milliliter (cfu/ml) was obtained, and isolates were identified using the API system. Antimicrobial susceptibility tests were performed according to the NCCLS guidelines. Prevalence and counts of microorganisms were statistically compared between the 3 groups, using the Mann-Whitney and Chi-square tests. Significance level was set at 5%.ResultsIn both the AS BioG and the AS ConvG, staphylococci counts were higher than that in the ContG (p<0.0001).Candida albicans and staphylococcus epidermidis were the most commonly found species in all the groups. Serratia marcescens and klebsiella oxytoca were more prevalent in the AS BioG and the AS ConvG...

Influence of TNF-α blockers on the oral prevalence of opportunistic microorganisms in ankylosing spondylitis patients

Pereira, D. F A; Pinheiro, M. M.; Silva, P. N F; Teodoro, G. R.; Brighenti, F. L.; Koga-Ito, C. Y.
Fonte: Universidade Estadual Paulista Publicador: Universidade Estadual Paulista
Tipo: Artigo de Revista Científica Formato: 679-685
Português
Relevância na Pesquisa
67.13%
Objectives: To compare the oral prevalence and antimicrobial susceptibility of Candida spp., staphylococci, enterobacteriaceae, and pseudomonas spp.from ankylosing spondylitis (AS) patients receiving conventional and anti-TNF-α therapy. Methods: The study included 70 AS patients, diagnosed according to the modified New York criteria (1984). The volunteers were divided into 2 groups: a biological group (AS BioG) (n=35) (on anti-TNF-α therapy) and a conventional group (AS ConvG) (n=35). The control group (ContG) (n=70) was made up of healthy individuals matched for age, gender, and oral conditions. After clinical examination, oral rinse samples were collected and plated in specific culture media. The number of colony-forming units per milliliter (cfu/ml) was obtained, and isolates were identified using the API system. Antimicrobial susceptibility tests were performed according to the NCCLS guidelines. Prevalence and counts of microorganisms were statistically compared between the 3 groups, using the Mann-Whitney and Chi-square tests. Significance level was set at 5%. Results: In both the AS BioG and the AS ConvG, staphylococci counts were higher than that in the ContG (p<0.0001). Candida albicans and staphylococcus epidermidis were the most commonly found species in all the groups. Serratia marcescens and klebsiella oxytoca were more prevalent in the AS BioG and the AS ConvG...

Osteoclast activity in ankylosing spondylitis patients before and after TNF-blocking therapy

Raposeiro, Rita Maria Mendes
Fonte: Universidade Nova de Lisboa Publicador: Universidade Nova de Lisboa
Tipo: Dissertação de Mestrado
Publicado em /10/2014 Português
Relevância na Pesquisa
66.89%
Ankylosing spondylitis (AS) is a chronic inflammatory rheumatic disease of the axial skeleton. The major outcome of this disease is defined by new bone formation, commonly observed in the ligaments of the intervertebral joints, that can lead to the formation of bony spurs, known as syndesmophytes. Previous studies have shown that serum levels of TNF, IL-6 and IL-17 are increased in AS patients and may be implicated in the development of secondary osteoporosis, since these cytokines are able to induce osteoclast (OC) differentiation and, therefore, bone resorption. In this work we aimed to assess the effects of TNF-blocking therapy in the systemic inflammatory environment of AS patients with active disease as well as in OC differentiation and activity. To accomplish this objective, we cultured circulating monocytes from AS patients, before and after therapy, under osteoclastogenic conditions and we performed two functional assays (TRAP staining and resorption pit assay) and analyzed the expression of osteoclast specific genes. We have shown that AS patients with active disease have increased levels of pro-inflammatory cytokines when compared with healthy subjects. We also found that IL-17, TGF-β and osteoprotegerin are decreased after TNF-blocking therapy. Interestingly...

Ankylosing spondylitis and central core disease: case report

Scola,Rosana Herminia; Lin,Kátia; Iwamoto,Fábio Massaiti; Arruda,Walter Oleschko; Werneck,Lineu Cesar
Fonte: Academia Brasileira de Neurologia - ABNEURO Publicador: Academia Brasileira de Neurologia - ABNEURO
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/09/2003 Português
Relevância na Pesquisa
66.89%
Ankylosing spondylitis (AS) is an inflammatory disorder of unknown cause that primarily affects the axial skeleton. Neurological manifestations of AS are usually related to spinal deformities. Previous studies of the paraspinal muscles of AS patients showed muscle fiber atrophy, and core fibers. On the other hand, central core disease (CCD) is a genetic condition that primarily involves the skeletal muscles, but can present articular deformities secondary to muscular weakness. We report the case of a 45-year-old man with clinical and radiological diagnosis of AS and proximal muscular weakness in the lower limbs. Needle electromyography showed myopathic features and nerve conduction study was normal. Muscle biopsy disclosed almost complete predominance of type-1 fibers, and fibers with central cores. This is the first report of AS and CCD. Whether central core myopathy is coincidental or a new association with AS is discussed.

Evaluation of serum paraoxonase and arylesterase activities in ankylosing spondylitis patients

Erdem,Fazile Hatipoglu; Karatay,Saliha; Yildirim,Kadir; Kiziltunc,Ahmet
Fonte: Faculdade de Medicina / USP Publicador: Faculdade de Medicina / USP
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/01/2010 Português
Relevância na Pesquisa
67.42%
OBJECTIVES: The aim of this study was to investigate the activities of serum paraoxonase and arylesterase in patients with ankylosing spondylitis with respect to those of healthy controls, to assess whether these enzyme levels are related to disease activity and functional capacity. METHODS: The study included 32 patients with ankylosing spondylitis whose diagnoses were made according to the modified New York criteria as well as 25 healthy controls matched for age and sex. The Bath Ankylosing Spondylitis Disease Activity Index and the Bath Ankylosing Spondylitis Functional Index were applied to the ankylosing spondylitis patients. As laboratory parameters, the erythrocyte sedimentation rate and serum C-reactive protein level were measured in patients and control subjects. Paraoxonase and arylesterase enzyme activities were measured using appropriate methods. RESULTS: No statistically significant differences (p>0.05) were found between the ankylosing spondylitis patients and controls in terms of serum paraoxonase or arylesterase levels. Furthermore, there was no correlation between clinical and laboratory parameters in patients with ankylosing spondylitis. CONCLUSION: Serum paraoxonase and arylesterase levels in ankylosing spondylitis patients may not differ from those of healthy controls...

Gender differences in ankylosing spondylitis-associated cumulative healthcare utilization: a population-based cohort study

Chen,Hsin-Hua; Chen,Tzeng-Ji; Chen,Yi-Ming; Ying-Ming,Chiu; Chen,Der-Yuan
Fonte: Faculdade de Medicina / USP Publicador: Faculdade de Medicina / USP
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/01/2011 Português
Relevância na Pesquisa
66.89%
BACKGROUND: Ankylosing spondylitis (AS) is one of the most common rheumatic diseases with gender differences in prevalence and clinical presentation. This study aimed to examine whether such gender differences are correlated with cumulative healthcare utilization in Taiwan. METHODS: The National Health Insurance Research Database supplied claim records of one million individuals from 1996 to 2007. Selected cases included patients aged >16 years. Certified rheumatologists diagnosed the patients in three or more visits and gave prescriptions for AS. Multivariate adjusted logistic regression analyses were used to calculate the influence of gender on cumulative healthcare utilization associated with AS. RESULTS: The study included 228 women and 636 men. After adjustment for potential confounding factors, men had more cumulative outpatient visits associated with AS (odds ratio, 1.59; 95% confidence interval, 1.13 -2.23; p = 0.008). Men also exhibited a trend for higher frequency of AS-related hospitalization (p = 0.054). CONCLUSION: Men are more likely to have high cumulative AS-associated healthcare utilization than women. Further investigation of the causal factors is warranted.

Is there a relationship between endothelial nitric oxide synthase gene polymorphisms and ankylosing spondylitis?

Sari,Ismail; Igci,Yusuf Ziya; Can,Gercek; Taylan,Ali; Solmaz,Dilek; Gogebakan,Bulent; Akar,Servet; Eslik,Zeynep; Bozkaya,Giray; Akkoc,Nurullah
Fonte: Faculdade de Medicina / USP Publicador: Faculdade de Medicina / USP
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/01/2013 Português
Relevância na Pesquisa
67.3%
OBJECTIVE: Nitric oxide is produced by endothelial nitric oxide synthase, and its production can be influenced by polymorphisms of the endothelial nitric oxide synthase gene. Because candidate genes responsible for susceptibility to ankylosing spondylitis are mostly unknown and available data suggest that there may be problems related to the nitric oxide pathway, such as endothelial dysfunction and increased asymmetric dimethylarginine, this study aimed to assess the association of common endothelial nitric oxide synthase gene polymorphisms with ankylosing spondylitis. METHODS: One hundred ninety-four unrelated Turkish ankylosing spondylitis patients and 113 healthy without apparent cardiovascular disease, hypertension or diabetes mellitus were included. All individuals were genotyped by PCR-RFLP for two single-nucleotide polymorphisms, namely 786T>C (rs2070744, promoter region) and 786 Glu298Asp (rs1799983, exon 7). Variable numbers of tandem repeat polymorphisms in intron 4 were also studied and investigated by direct electrophoresis on agarose gel following polymerase chain reaction analysis. The Bath ankylosing spondylitis metrology index of the patients was calculated, and human leukocyte antigen B27 was studied. RESULTS: All studied polymorphisms satisfied Hardy-Weinberg equilibrium. Sex distributions were similar between the patient and control groups. No significant differences were found in the distributions of allele and genotype frequencies of the studied endothelial nitric oxide synthase polymorphisms between patients and controls. There were no correlations between endothelial nitric oxide synthase polymorphisms...

Fetuin-A is related to syndesmophytes in patients with ankylosing spondylitis: a case control study

Tuylu,Tugba; Sari,Ismail; Solmaz,Dilek; Kozaci,Didem Leyla; Akar,Servet; Gunay,Necati; Onen,Fatos; Akkoc,Nurullah
Fonte: Faculdade de Medicina / USP Publicador: Faculdade de Medicina / USP
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/12/2014 Português
Relevância na Pesquisa
67.2%
OBJECTIVES: New bone formation is one of the hallmark characteristics of ankylosing spondylitis, which is thereby associated with syndesmophytes. Fetuin-A is a molecule that is abundantly found in calcified tissues and it shows high affinity for calcium phosphate minerals and related compounds. Considering the role of fetuin-A in the regulation of calcified matrix metabolism, we compared the fetuin-A levels in ankylosing spondylitis patients with syndesmophytes with those in patients without syndesmophytes and in healthy controls. We also studied other biomarkers that are thought to be related to syndesmophytes. METHODS: Ninety-four patients (49 patients without syndesmophytes, 67.3% male, 40.7±8.7 years; 45 patients with syndesmophytes, 71.1% M, 43.9±9.9 years) and 68 healthy controls (44.2±10.6 years and 70.6% male) were included in this study. Syndesmophytes were assessed on the lateral radiographs of the cervical and lumbar spine. The serum levels of fetuin-A, dickkopf-1, sclerostin, IL-6, high-sensitivity C-reactive protein and bone morphogenetic protein-7 were measured with an enzyme-linked immunosorbent assay. RESULTS: Patients with syndesmophytes had significantly higher levels of fetuin-A compared with patients without syndesmophytes and controls (1.16±0.13...

Intrazelluläre Zytokine bei Morbus Behçet im Verlauf unter einer Therapie mit Interferon-alpha2a - Vergleich mit HLA-B27-assoziierten Spondarthritiden -; Cytokine patterns in Behcet's Disease in comparison to Ankylosing Spondylitis – influence of treatment with interferon-alpha2a

Groll, Stefanie Philippine
Fonte: Universität Tübingen Publicador: Universität Tübingen
Tipo: Dissertation; info:eu-repo/semantics/doctoralThesis
Português
Relevância na Pesquisa
66.96%
Ziel: Die Behandlung von aktivem M. Behcet (MB) mit humanem rekombinantem Interferon-alpha2a (IFNa2a) ist klinisch wirksam. Der genaue Wirkmechanismus ist unbekannt. Dies ist die erste Arbeit, die den Einfluss von IFNa2a auf intrazelluläre Zytokine in T-Zellen von MB Patienten im Vergleich zu gesunden Kontrollen und Patienten mit Spondylitis ankylosans (SA) untersucht. Methoden: Die intrazelluläre Zytokinproduktion von T-Zellen wurde bei 10 Patienten mit MB vor, sowie 4 und 12 Wochen nach Beginn einer Therapie mit IFNa2a untersucht. 10 Patienten mit SA und 10 gesunde Probanden dienten als Kontrollen. Mononukleäre Zellen des peripheren Blutes wurden stimuliert und die Oberflächenmarker der T-Zellen CD3, CD8 und CD4 mit fluoreszierenden Antikörpern markiert. Parallel erfolgte die Markierung der intrazellulären Zytokine Interleukin 2 (IL 2), Tumornekrosefaktor-alpha (TNFa), Interferon-gamma (IFNg) und Interleukin 4 (IL 4). Die Zellen wurden durchflusszytometrisch gemessen und ausgewertet. Ergebnisse: IL2-produzierende CD3+ und CD4+ T-Zellen waren bei Patienten mit MB und AS im Vergleich zu gesunden Probanden signifikant erniedrigt (p=0,02 bzw. 0,007). Die Anzahl von IFNg-produzierenden CD3+ T-Zellen bei Patienten mit MB war vor Therapiebeginn erhöht im Vergleich zu Patienten mit AS und gesunden Kontrollen (p=0...

Influência da fisioterapia aquática na função pulmonar de pacientes com espondilite anquilosante: série de casos; Influence of aquatic physical therapy on lung function in patients with ankylosing spondylitis: case series

Hernandes, Nidia Aparecida; Ide, Maiza Ritomy; Buosi, Damaris Franzini
Fonte: Universidade de São Paulo. Faculdade de Medicina Publicador: Universidade de São Paulo. Faculdade de Medicina
Tipo: info:eu-repo/semantics/article; info:eu-repo/semantics/publishedVersion; ; Formato: application/pdf
Publicado em 31/12/2006 Português
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66.89%
Espondilite anquilosante (EA) é uma patologia reumática caracterizada porcomprometimento progressivo da coluna vertebral e articulações, com envolvimento pulmonar que leva a um padrão ventilatório restritivo, geralmente assintomático. A cinesioterapia aquática é recomendada, pois os princípios físicos da água auxiliam a redução de sintomas e a realização de exercícios. Este estudo visou avaliar os efeitos de um programa de fisioterapia aquática na função pulmonar de pacientes com EA, por meio de análise de parâmetros espirométricos (CVF= capacidade vital forçada, VEF = volume expiratório forçado, VVM = ventilação voluntária máxima). Quatro pacientes com EA (três homens e uma mulher, com idade média de 33,25 anos) foram submetidos à avaliação da capacidade funcional pulmonar antes e após a intervenção. Um programa de fisioterapia aquática foi aplicado três vezes por semana durante 10 semanas. A CVF aumentou em um sujeito, o VEF aumentou em um e diminuiu em outro, permanecendo inalterado nos demais. O índice de Tiffeneau apresentou redução em um sujeito e aumento em dois. A VVM aumentou em um, reduziu-se em outro e permaneceu inalterada nos demais sujeitos. Vê-se pois que os resultados da avaliação espirométrica não foram uniformes nos quatro participantes...

Evaluation of serum paraoxonase and arylesterase activities in ankylosing spondylitis patients

Erdem, Fazile Hatipoglu; Karatay, Saliha; Yildirim, Kadir; Kiziltunc, Ahmet
Fonte: Universidade de São Paulo. Faculdade de Medicina Publicador: Universidade de São Paulo. Faculdade de Medicina
Tipo: info:eu-repo/semantics/article; info:eu-repo/semantics/publishedVersion; ; ; ; ; ; Formato: application/pdf
Publicado em 01/01/2010 Português
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67.42%
OBJECTIVES: The aim of this study was to investigate the activities of serum paraoxonase and arylesterase in patients with ankylosing spondylitis with respect to those of healthy controls, to assess whether these enzyme levels are related to disease activity and functional capacity. METHODS: The study included 32 patients with ankylosing spondylitis whose diagnoses were made according to the modified New York criteria as well as 25 healthy controls matched for age and sex. The Bath Ankylosing Spondylitis Disease Activity Index and the Bath Ankylosing Spondylitis Functional Index were applied to the ankylosing spondylitis patients. As laboratory parameters, the erythrocyte sedimentation rate and serum C-reactive protein level were measured in patients and control subjects. Paraoxonase and arylesterase enzyme activities were measured using appropriate methods. RESULTS: No statistically significant differences (p>;0.05) were found between the ankylosing spondylitis patients and controls in terms of serum paraoxonase or arylesterase levels. Furthermore, there was no correlation between clinical and laboratory parameters in patients with ankylosing spondylitis. CONCLUSION: Serum paraoxonase and arylesterase levels in ankylosing spondylitis patients may not differ from those of healthy controls...

Is there a relationship between endothelial nitric oxide synthase gene polymorphisms and ankylosing spondylitis?

Sari, Ismail; Igci, Yusuf Ziya; Can, Gercek; Taylan, Ali; Solmaz, Dilek; Gogebakan, Bulent; Akar, Servet; Eslik, Zeynep; Bozkaya, Giray; Akkoc, Nurullah
Fonte: Universidade de São Paulo. Faculdade de Medicina Publicador: Universidade de São Paulo. Faculdade de Medicina
Tipo: info:eu-repo/semantics/article; info:eu-repo/semantics/publishedVersion; ; Formato: application/pdf
Publicado em 01/01/2013 Português
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67.3%
OBJECTIVE: Nitric oxide is produced by endothelial nitric oxide synthase, and its production can be influenced by polymorphisms of the endothelial nitric oxide synthase gene. Because candidate genes responsible for susceptibility to ankylosing spondylitis are mostly unknown and available data suggest that there may be problems related to the nitric oxide pathway, such as endothelial dysfunction and increased asymmetric dimethylarginine, this study aimed to assess the association of common endothelial nitric oxide synthase gene polymorphisms with ankylosing spondylitis. METHODS: One hundred ninety-four unrelated Turkish ankylosing spondylitis patients and 113 healthy without apparent cardiovascular disease, hypertension or diabetes mellitus were included. All individuals were genotyped by PCR-RFLP for two single-nucleotide polymorphisms, namely 786T>;C (rs2070744, promoter region) and 786 Glu298Asp (rs1799983, exon 7). Variable numbers of tandem repeat polymorphisms in intron 4 were also studied and investigated by direct electrophoresis on agarose gel following polymerase chain reaction analysis. The Bath ankylosing spondylitis metrology index of the patients was calculated, and human leukocyte antigen B27 was studied. RESULTS: All studied polymorphisms satisfied Hardy-Weinberg equilibrium. Sex distributions were similar between the patient and control groups. No significant differences were found in the distributions of allele and genotype frequencies of the studied endothelial nitric oxide synthase polymorphisms between patients and controls. There were no correlations between endothelial nitric oxide synthase polymorphisms...

Fluoroscopy-guided intra-articular sacroiliac joint steroid injection for sacroiliitis in ankylosing spondylitis: a Case Report

Dawson,PUA; Dewar,NA; Tulloch-Reid,D
Fonte: West Indian Medical Journal Publicador: West Indian Medical Journal
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/01/2014 Português
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67.13%
Sacroiliitis, a condition commonly seen in ankylosing spondylitis, is well known to be one of the main pain generators of low back pain, which may result in difficulty with walking. A 20-year old male with history of ankylosing spondylitis presented to the University Hospital of the West Indies, Physical Medicine and Rehabilitation Clinic, with a two-year history of right buttock, low back and groin pain. Radiographic evaluation revealed increased sclerosis and erosive changes in bilateral sacroiliac joints, right greater than left. Right intra-articular sacroiliac joint steroid injection was administered under fluoroscopy guidance. Post-injection visual analogue pain scale (VAS) score with activity improved from 8 to 1 and Oswestry Disability Index improved from 40% moderate disability to 16% minimal disability. The patient's overall assessment was 95% perceived improvement in pain. This case report illustrates the effectiveness of intra-articular sacroiliac joint steroid injection in treating sacroiliitis in ankylosing spondylitis.