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Valor da captura híbrida para o papilomavírus humano (HPV) no seguimento de pacientes submetidos à conização do colo uterino devido a lesão intraepitelial de alto grau por cirurgia de alta frequência (CAF); The value of the HPV DNA test on the follow-up of the patients treated for high grade cervical intraepithelial lesions by conization with large loop excision of the transformation zone (LLETZ)

Roncaglia, Maria Teresa
Fonte: Biblioteca Digitais de Teses e Dissertações da USP Publicador: Biblioteca Digitais de Teses e Dissertações da USP
Tipo: Tese de Doutorado Formato: application/pdf
Publicado em 22/05/2012 Português
Relevância na Pesquisa
75.86%
INTRODUÇÃO: A lesão intraepitelial cervical de alto grau causada pelo HPV, precursora do câncer cervical, é facilmente diagnosticada e seu tratamento pode ser realizado de maneira ambulatorial, sem muitas complicações. Mesmo assim, o seguimento das pacientes tratadas deve ser feito de maneira criteriosa e sistemática para que a recorrência ou persistência da doença não passe despercebida. Conseguir identificar o grupo de pacientes com maior probabilidade de recorrência ou persistência da doença facilitaria sobremaneira esse seguimento, diminuindo o ônus econômico e psicológico que o seguimento generalizado produz. O objetivo deste trabalho é identificar marcadores que possam indicar o grupo de pacientes com maior possibilidade de recorrência da lesão intraepitelial cervical de alto grau. MÉTODOS: Neste estudo 114 mulheres com diagnóstico de lesão intraepitelial cervical de alto grau foram submetidas à conização cervical por cirurgia de alta frequência (CAF) no Setor de Patologia do Trato Genital Inferior (PTGI) da Divisão da Clínica Ginecológica do Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (HC-FMUSP) no período entre março de 2006 e maio de 2009. O seguimento foi realizado a cada seis meses durante o período de 24 meses. No seguimento foi coletada a citologia cervical...

Avaliação da função global e regional pela ressonância magnética com a técnica dos marcadores miocárdicos em pacientes na fase tardia do infarto da parede anterior do ventrículo esquerdo em acompanhamento clínico; Evaluation by magnetic resonance with myocardial tagging technique of global and regional function of left ventricle in patients with chronic anterior myocardial infarction during clinical follow-up

Florenzano, Sérgio Domingos
Fonte: Biblioteca Digitais de Teses e Dissertações da USP Publicador: Biblioteca Digitais de Teses e Dissertações da USP
Tipo: Tese de Doutorado Formato: application/pdf
Publicado em 05/07/2004 Português
Relevância na Pesquisa
75.9%
O infarto agudo do miocárdio (IAM) é definido como uma necrose do miocárdio resultante de um comprometimento agudo de sua irrigação sang?ínea. As manifestações de insuficiência cardíaca (ICC) são comuns em pacientes com doença arterial coronariana (DAC) aguda ou crônica, acarretando significativa morbidade e mortalidade. O objetivo foi avaliar a função global e regional do ventrículo esquerdo (VE), através da Ressonância Magnética (IRM) com a técnica dos marcadores miocárdicos na evolução clínica dos pacientes na fase tardia do infarto da parede anterior do VE. Foi realizado seguimento longitudinal prospectivo da evolução da função da parede do ventrículo esquerdo. Foram avaliadas e comparadas entre si as várias etapas evolutivas de pacientes encaminhados pela Unidade Clínica de Coronariopatia Crônica e Unidade de Cirurgia Torácica e Cardiovascular do Incor-FMUSP. Entre dezembro de 2000 e fevereiro de 2003, estudamos 24 pacientes (19 homens e cinco mulheres), idade média de 54,33 ± 10,11 anos. Os estudos foram realizados na inclusão do paciente no protocolo, após 4 meses e 10 meses de seguimento. Os estudos foram realizados em repouso (rep) e durante o estímulo inotrópico com baixa dose de dobutamina (dob) (10 mcg/kg/ml). Nenhum paciente desenvolveu sintomas durante a infusão de dobutamina. Foram estudados os volumes diastólico (VDF) e sistólico (VSF) finais e a fração de ejeção (FE) com a técnica de cine ressonância...

Three-year follow-up of Interleukin 6 and C-reactive protein in chronic obstructive pulmonary disease

Ferrari, Renata; Tanni, Suzana E.; Caram, Laura M.O.; Corrêa, Corina; Corrêa, Camila R.; Godoy, Irma
Fonte: Universidade Estadual Paulista Publicador: Universidade Estadual Paulista
Tipo: Artigo de Revista Científica
Português
Relevância na Pesquisa
85.82%
Background: Past studies have shown that mean values of Interleukin-6 (IL-6) and C-reactive protein (CRP) do not change significantly in COPD patients over a one-year period. However, longer period follow-up studies are still lacking. Thus, the aim of this study is to evaluate plasma CRP and IL-6 concentration over three years in COPD patients and to test the association between these inflammatory mediators and disease outcome markers. Methods: A cohort of 77 outpatients with stable COPD was evaluated at baseline, and 53 (mean FEV1, 56% predicted) were included in the prospective study. We evaluated Interleukin-6 (IL-6), C-reactive protein (CRP), six-minute walking distance (6MWD), and body mass index (BMI) at baseline and after three years. Plasma concentration of IL-6 was measured by high sensitivity ELISA, and CRP was obtained by high sensitivity particle-enhanced immunonephelometry. Results: IL-6 increased significantly after 3 years compared to baseline measurements [0.8 (0.5-1.3) vs 2.4 (1.3-4.4) pg/ml; p < 0.001] and was associated with worse 6MWD performance. In the Cox regression, increased IL-6 at baseline was associated with mortality [Hazard Ratio (95% CI) = 2.68 (0.13, 1.84); p = 0.02]. CRP mean values did not change [5 (1.6-7.9) vs 4.7 (1.7-10) pg/L; p = 0.84]...

Cognitive-behavioral therapy for anxiety disorders in children and adolescents: a systematic review of follow-up studies

Davis,Roberta; Souza,Maria Augusta Mansur de; Rigatti,Roberta; Heldt,Elizeth
Fonte: Instituto de Psiquiatria da Universidade Federal do Rio de Janeiro Publicador: Instituto de Psiquiatria da Universidade Federal do Rio de Janeiro
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/12/2014 Português
Relevância na Pesquisa
85.9%
Objective To conduct a systematic review about the long-term response to cognitive-behavioral therapy (CBT) for anxiety disorders (ADs) in children and adolescents. Methods The PubMed and ISI Web of Science databases were consulted. Search in the databases was performed in November 2012 and included cohort studies after CBT for ADs in children and adolescents with a follow-up period over 12 months. Results A total of 10 papers met the inclusion criteria. The follow-up period ranged from 12 months to 13 years and the results generally showed maintenance of the short-term benefits with CBT. However, the studies presented limitations, especially regarding methods, such as lack of a control group and losses to follow-up. Conclusion The long-term benefits of CBT were identified, however it would be interesting to conduct other studies with more frequent assessment periods, in order to minimize losses to follow-up, in addition to evaluating children and adolescents in the various stages of their development.

Oral health follow-up studies in the 1993 Pelotas (Brazil) birth cohort study: methodology and principal results

Peres,Marco A.; Barros,Aluísio Jardim; Peres,Karen Glazer; Araújo,Cora Luiza; Menezes,Ana M. B.; Hallal,Pedro C.; Victora,Cesar G.
Fonte: Escola Nacional de Saúde Pública Sergio Arouca, Fundação Oswaldo Cruz Publicador: Escola Nacional de Saúde Pública Sergio Arouca, Fundação Oswaldo Cruz
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/10/2010 Português
Relevância na Pesquisa
75.79%
The aim of this study was to describe oral health follow-up studies nested in a birth cohort. A population-based birth cohort was launched in 1993 in Pelotas, Rio Grande do Sul State, Brazil. Two oral health follow-up studies were conducted at six (n = 359) and 12 (n = 339) years of age. A high response rate was observed at 12 years of age; 94.4% of the children examined at six years of age were restudied in 2005. The mean DMF-T index at age 12 was 1.2 (SD = 1.6) for the entire sample, ranging from 0.6 (SD = 1.1) for children that were caries-free at age six, 1.3 (SD = 1.5) for those with 1-3 carious teeth at six years, and 1.8 (SD = 1.8) for those with 4-19 carious teeth at six years (p < 0.01). The number of individuals with severe malocclusions at 12 years was proportional to the number of malocclusions at six years. Oral health problems in early adolescence were more prevalent in individuals with dental problems at six years of age.

Follow-up of women with atypical squamous cells cannot exclude high-grade squamous intraepithelial lesions (ASC-H)

Lopez-Alegria,Fanny; De Lorenzi,Dino Soares; Quezada,Orlando Poblete
Fonte: Associação Paulista de Medicina - APM Publicador: Associação Paulista de Medicina - APM
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/01/2014 Português
Relevância na Pesquisa
75.82%
CONTEXT AND OBJECTIVE: The concept that the presence of atypical squamous cells cannot exclude high-grade squamous intraepithelial lesions (ASC-H) was introduced in the 2001 Bethesda System of cervical cytology classification. This nomenclature defines cervical cancer precursor lesions. The objective of this study was to investigate the colpocytological-histological results from a three-year follow-up conducted on a cohort of women with reports of ASC-H who were attended during 2005-2006 at clinics of the Southern Metropolitan Healthcare Service of Santiago, Chile. DESIGN AND SETTING: Prospective cohort study at primary healthcare clinics in Santiago, Chile. METHODS : Colpocytological-histological follow-up was conducted over a three-year period on 92 women with cytological reports of ASC-H who were attended at primary healthcare clinics during 2005-2006. RESULTS : At the end of the follow-up period, high-grade lesions were evaluated and the following outcomes were observed: seven women presented invasive cancer (7.6%), 49 presented high-grade lesions (53.3%), 26 presented low-grade lesions (28.2%) and 10 presented normal results (10.9%). The "Conditional Probabilities Tree Diagram" was used to show the results from tests and the times of lesion detection. It demonstrated that...

Basal cell carcinoma treated with Mohs surgery in Australia - II. Outcome at 5-year follow-up

Leibovitch, I.; Huilgol, S.; Selva-Nayagam, D.; Richards, S.; Paver, R.
Fonte: Mosby Inc Publicador: Mosby Inc
Tipo: Artigo de Revista Científica
Publicado em //2005 Português
Relevância na Pesquisa
75.83%
BACKGROUND: Long-term follow-up is essential to evaluate the role of Mohs micrographic surgery (MMS) in the treatment for cutaneous basal cell carcinoma (BCC). OBJECTIVE: Our purpose was to report the 5-year follow-up outcome of patients treated with MMS for BCC. METHOD: This prospective, multicenter case series included all patients in Australia treated with MMS for BCC, who were monitored by the Skin and Cancer Foundation between 1993 and 2002. Parameters recorded were patient demographics, duration of tumor, site, preoperative tumor size, recurrences before MMS, histologic classification of malignancy, postoperative defect size, and 5-year recurrence after MMS. RESULTS: Three thousand three hundred seventy (3370) patients (1594 female and 1776 male patients) completed a 5-year follow-up period. Fifty-six percent of the tumors were primary and 44% were previously recurrent. Most of them (98.4%) were located on the head and neck, and the most common histologic subtypes were nodulocystic (29.3%) and infiltrating (28.3%). Recurrence at 5 years was diagnosed in 1.4% of primary and in 4% of recurrent tumors. Previous tumor recurrence (P < .001), longer tumor duration before MMS (P = .015), infiltrating histology (P = .13), and more levels for tumor (P < .001) were the main predictors for tumor recurrence after MMS. LIMITATION: Data were missing for some outcome measures. CONCLUSION: The low 5-year recurrence rate of BCC with MMS emphasizes the importance of margin-controlled excision.

Gain and loss of gastrointestinal symptoms in diabetes mellitus: associations with psychiatric disease, glycemic control, and autonomic neuropathy over 2 years of follow-up

Quan, C.; Talley, N.; Jones, M.; Spies, J.; Horowitz, M.
Fonte: Blackwell Publishing Ltd Publicador: Blackwell Publishing Ltd
Tipo: Artigo de Revista Científica
Publicado em //2008 Português
Relevância na Pesquisa
75.8%
OBJECTIVE: To prospectively determine the turnover (gain or loss) of gastrointestinal (GI) symptoms in diabetic subjects in relation to glycemic control, autonomic neuropathy and psychiatric disease over a 2-year follow-up. METHODS: Type 1 and type 2 diabetic subjects were recruited from the community, as were community controls. Individual GI symptoms were examined by a validated questionnaire and classified as diarrhea, irritable bowel syndrome, upper GI symptoms, and any GI symptoms at baseline, 12 and 24 months. Glycemic control (glycated hemoglobin), autonomic function (using standardized tests), and psychiatric disease (using the Composite International Diagnostic Interview) were also assessed at these time points. RESULTS: Baseline and 2-year follow-up data were available for 139 diabetic subjects and 55 controls. Glycated hemoglobin at baseline was 7.7% (plusminus1.36) in the diabetic group; 5% had severe autonomic dysfunction. There was a significantly higher prevalence of diarrhea in the diabetic subjects. GI symptom turnover varied between 15% and 25% in the diabetic group and was not significantly different from the controls. There was no clear association between turnover of GI symptoms and either glycemic control or autonomic neuropathy. The appearance of depression was associated with gaining of most symptoms apart from irritable bowel syndrome...

Baseline factors predictive of serious suicidality at follow-up: findings focussing on age and gender from a community-based study

Fairweather-Schmidt, A.; Anstey, K.; Salim, A.; Rodgers, B.
Fonte: BioMed Central Ltd. Publicador: BioMed Central Ltd.
Tipo: Artigo de Revista Científica
Publicado em //2010 Português
Relevância na Pesquisa
75.85%
Background: Although often providing more reliable and informative findings relative to other study designs, longitudinal investigations of prevalence and predictors of suicidal behaviour remain uncommon. This paper compares 12-month prevalence rates for suicidal ideation and suicide attempt at baseline and follow-up; identifies new cases and remissions; and assesses the capacity of baseline data to predict serious suicidality at follow-up, focusing on age and gender differences. Methods: 6,666 participants aged 20-29, 40-49 and 60-69 years were drawn from the first (1999-2001) and second (2003-2006) waves of a general population survey. Analyses involved multivariate logistic regression. Results: At follow-up, prevalence of suicidal ideation and suicide attempt had decreased (8.2%-6.1%, and 0.8%-0.5%, respectively). However, over one quarter of those reporting serious suicidality at baseline still experienced it four years later. Females aged 20-29 never married or diagnosed with a physical illness at follow-up were at greater risk of serious suicidality (OR = 4.17, 95% CI = 3.11-5.23; OR = 3.18, 95% CI = 2.09-4.26, respectively). Males aged 40-49 not in the labour force had increased odds of serious suicidality (OR = 4.08, 95% CI = 1.6-6.48) compared to their equivalently-aged and employed counterparts. Depressed/anxious females aged 60-69 were nearly 30% more likely to be seriously suicidal. Conclusions: There are age and gender differentials in the risk factors for suicidality. Life-circumstances contribute substantially to the onset of serious suicidality...

Five-year follow-up of a multicenter, double-blind randomized clinical trial of laparoscopic Nissen vs anterior 90 degrees partial fundoplication

Nijjar, R.; Watson, D.; Jamieson, G.; Archer, S.; Bessell, J.; Booth, M.; Cade, R.; Cullingford, G.; Devitt, P.; Fletcher, D.; Hurley, J.; Kiroff, G.; Martin, I.; Nathanson, L.; Windsor, J.
Fonte: Amer Medical Assoc Publicador: Amer Medical Assoc
Tipo: Artigo de Revista Científica
Publicado em //2010 Português
Relevância na Pesquisa
75.9%
Hypothesis: Laparoscopic 90° anterior partial fundoplication for gastroesophageal reflux disease achieves equivalent results to laparoscopic Nissen fundoplication. Design: A multicenter, prospective, double-blind randomized clinical trial with a minimum of 5 years’ followup. Setting: Nine university teaching hospitals in 6 major cities throughout Australia and New Zealand. Participants: One hundred twelve patients undergoing primary antireflux surgery were randomized to undergo either laparoscopic Nissen fundoplication (52 patients) or anterior 90° partial fundoplication (60 patients). Interventions: Laparoscopic Nissen fundoplication with division of the short gastric vessels or laparoscopic anterior 90° partial fundoplication. Main Outcome Measures: Blinded assessment at 1 and 5 years’ follow-up of clinical outcome for postoperative heartburn, dysphagia, gas-related symptoms, and satisfaction with the surgical outcome. Analog scales ranging from 0 to 10 were used to assess symptom severity. Results: Ninety-seven patients underwent follow-up at 5 years. Three others died during follow-up, 4 refused follow-up, and 8 were lost to follow-up; 89% remained at 5-years’ follow-up. At 5 years’ follow-up, mean analog scores for heartburn were 2.2 for anterior fundoplication vs 0.9 for Nissen fundoplication (P=.003). There were no significant differences between the groups for dysphagia scores. The mean score for outcome satisfaction was 7.1 after anterior fundoplication vs 8.1 after Nissen fundoplication (P=.18). Eighty-eight percent reported a good or excellent outcome following Nissen fundoplication vs 77% following anterior fundoplication. Conclusions: Laparoscopic Nissen and anterior 90° partial fundoplication achieve similar levels of patient satisfaction at 5 years’ follow-up...

A study of depression in attempted suicide: initial assessment, short-term follow-up and prediction of persistent depression.

Davis, Anthony T.
Fonte: Universidade de Adelaide Publicador: Universidade de Adelaide
Tipo: Tese de Doutorado
Publicado em //2012 Português
Relevância na Pesquisa
75.79%
Depression, no matter how it is categorized, is the most common psychiatric disorder in patients who attempt suicide. However, there are conflicting views about the nature, extent and significance of depression in this group. Further-more, there is minimal information available concerning the short term course of depression following attempted suicide and therefore the optimal clinical management of depressed suicidal patients. These patients carry a high risk for repeated attempted suicide or suicide. The study aimed to provide a detailed analysis of several conceptualizations of depression in adults who have attempted suicide and to examine short-term changes in mood state following the suicide attempt. It further aimed to identify predictors of depression one week following attempted suicide, with a view to assisting clinicians in the initial identification of patients who could be at risk for ongoing suicidal behaviour. To achieve these aims a three year multi-phasic study was designed, utilizing a range of measures of depression. Initially, the extent of the problem of attempted suicide at the Royal Adelaide Hospital was established and then, according to self-report measures of depression, the frequency and type of depression in the patients who had attempted suicide was defined. Having identified a cohort of suicidal patients with a depressive disorder...

Mycophenolate versus azathioprine for kidney transplantation: a 15-year follow-up of a randomized trial

Clayton, P.; McDonald, S.; Chapman, J.; Chadban, S.
Fonte: Lippincott Williams & Wilkins Publicador: Lippincott Williams & Wilkins
Tipo: Artigo de Revista Científica
Publicado em //2012 Português
Relevância na Pesquisa
75.78%
BACKGROUND: The use of mycophenolate mofetil (MMF) is associated with less acute rejection than azathioprine (AZA) early after kidney transplantation. However, the long-term impact of MMF versus AZA is less well studied. METHODS: The Tricontinental Mycophenolate Mofetil Renal Transplantation Study was a double-blind randomized placebo-controlled trial of MMF versus AZA, together with cyclosporine and steroids, first reported in 1996. We analyzed the long-term outcomes of the Australian cohort of patients enrolled in this study using follow-up data from the Australia and New Zealand Dialysis and Transplant Registry. Patient and graft survival, cancer incidence, and estimated kidney function were compared on an intention-to-treat basis. RESULTS: A total of 133 Australian patients participated in the study: 45 were randomized to AZA, 44 were randomized to MMF 2 g/d, and 44 were randomized to MMF 3 g/d. Baseline characteristics were similar between the groups. Median follow-up was 13.8 years, during which there were 97 graft failures, 75 deaths, and 1 lost to follow-up. There were no statistically significant differences between the groups in long-term patient or graft survival, cancer incidence, or kidney function. Death-censored graft survival was best in the group with 3 g/d MMF and worst in the group with 2 g/d MMF. By 5 years...

Inadequate riboflavin intake and anemia risk in a Chinese population: five-year follow up of the Jiangsu Nutrition Study

Shi, Z.; Zhen, S.; Wittert, G.; Yuan, B.; Zuo, H.; Taylor, A.
Fonte: Public Library of Science Publicador: Public Library of Science
Tipo: Artigo de Revista Científica
Publicado em //2014 Português
Relevância na Pesquisa
75.88%
Objectives: Riboflavin (vitamin B2) has been shown in animal studies to affect the absorption and metabolism of iron. Cross-sectional population studies show a relationship between riboflavin intake and anemia but prospective population studies are limited. The aim of the study was to determine the relationship between riboflavin intake and the risk of anemia in a Chinese cohort. Method: The study used data from 1253 Chinese men and women who participated in two waves of the Jiangsu Nutrition Study (JIN), five years apart, in 2002 and 2007. Riboflavin intake and hemoglobin (Hb) were quantitatively assessed together with dietary patterns, lifestyle, socio-demographic and health-related factors. Results: At baseline, 97.2% of participants had inadequate riboflavin intake (below the estimate average requirement). Riboflavin intake was positively associated with anemia at baseline, but low riboflavin intake was associated with an increased risk of anemia at follow-up among those anemic at baseline. In the multivariate model, adjusting for demographic and lifestyle factors and dietary patterns, the relative risk and 95% confidence interval for anemia at follow-up, across quartiles of riboflavin intake were: 1, 0.82(0.54–1.23), 0.56(0.34–0.93)...

Five-year follow-up after comparing bipolar endometrial ablation with hydrothermablation for menorrhagia

Penninx, J.; Herman, M.; Mol, B.; Bongers, M.
Fonte: Lippincott, Williams & Wilkins Publicador: Lippincott, Williams & Wilkins
Tipo: Artigo de Revista Científica
Publicado em //2011 Português
Relevância na Pesquisa
75.8%
OBJECTIVE: To evaluate the results of a previous study comparing bipolar radiofrequency endometrial ablation with hydrothermablation for the treatment of menorrhagia at 5-year follow-up. METHOD: A double-blind, randomized, controlled trial was performed in a large teaching hospital in the Netherlands between March 2005 and August 2007. One-hundred sixty women with menorrhagia were randomly allocated to bipolar ablation or hydrothermablation. The results of follow-up at 12 months were previously reported. At 4–5 years of follow-up, a questionnaire was sent to all the participants to register amenorrhea rates, reinterventions, and patient satisfaction. RESULTS: At 5-year follow-up, response rates were 90% and 83% in the bipolar group and hydrotherm group, respectively. Amenorrhea rates were 55.4% and 35.3% in the bipolar group and the hydrotherm group, respectively (relative risk [RR] 1.5, 95% confidence interval [CI] 1.05–2.3). The number of surgical reinterventions was 11 compared with 23 (RR 0.43, 95% CI 0.23–0.80). Overall, more women were satisfied in the bipolar group compared with the hydrotherm group. CONCLUSION: After treatment, bipolar radiofrequency endometrial ablation system is more effective at 5 years than hydrothermablation in the treatment of menorrhagia. LEVEL OF EVIDENCE: II; Josien P. Penninx...

Preditores à taxa de resposta em estudos de follow-up a consumidores de drogas: uma meta-análise

Candeias, Pedro; Henriques, Susana
Fonte: CIES-IUL Publicador: CIES-IUL
Tipo: Trabalho em Andamento
Publicado em //2015 Português
Relevância na Pesquisa
85.89%
Os estudos de follow-up a consumidores de drogas permitem conhecer fatores como alterações nos padrões de consumo, a efetividade de intervenções, entre outros. Contudo, um dos principais problemas subjacentes a esta técnica é conseguir taxas de resposta satisfatórias. Com base numa meta-análise bibliográfica o presente artigo pretende: 1) descrever uma amostra de 220 artigos internacionais de follow-up a consumidores de drogas; 2) testar preditores para a taxa de resposta nesta amostra. Conclui-se que existe uma relação significativa entre a taxa de resposta e a existência de intervalos regulares entre as vagas do follow-up, e que a existência de intervenção, isto é, a tentativa de alterar comportamentos dos participantes, não tem efeito na taxa de resposta.; Follow-up studies applied to drug users allow us to know factors such as changes in consumption patterns, the effectiveness of interventions, among others. However, one of the main problems behind this technique is to get satisfactory response rates. Based on a literature meta-analysis this article aims: 1) to describe a sample of 220 international articles of drug users follow-up; 2) to test the predictors for the response rate in this sample. It follows that there is a significant relationship between response rate and the existence of regular pauses between the waves of the follow-up...

The Australian Mohs database, part II - Periocular basal cell carcinoma outcome at 5-year follow-up

Malhotra, R.; Huilgol, S.; Huynh, N.; Selva-Nayagam, D.
Fonte: Elsevier Science Inc Publicador: Elsevier Science Inc
Tipo: Artigo de Revista Científica
Publicado em //2004 Português
Relevância na Pesquisa
75.83%
OBJECTIVE: To report the outcome with 5-year strict follow-up (only cases where 5-year follow-up is available) of all patients with periocular basal cell carcinoma (BCC) treated with Mohs' micrographic surgery (MMS) in Australia between 1993 and 1996. DESIGN: Prospective, noncomparative, multicenter, interventional case series. METHODS: A prospective series of 819 patients, undergoing MMS for periocular BCC over a 3-year period (1993-1996). INCLUSION CRITERIA: Periocular BCC referred for MMS. MAIN OUTCOME MEASURES: Recurrence, site, size, prior occurrence, defect size, histologic subtype, and presence of perineural invasion. RESULTS: Eight hundred nineteen patients had 257 (54%) lower eyelid, 195 (41%) medial canthus, and 22 (5%) upper eyelid BCCs. The most common histologic subtypes were nodulocystic (43%) and infiltrating (30%) (P = 0.0003). Sixty-eight percent were primary and 32% were recurrent tumors. Five-year follow-ups for cases between 1993 and 1996 were available in 347 (42%) cases. There were 7 recurrences (2.0%; exact 95% confidence interval [CI]: 0.82%-4.1%), 5 of which were at the medial canthus and all of which were previously recurrent, with up to 3 recurrences before MMS. Previous recurrence (P<0.0001), infiltrating (5) or superficial (2) histologic subtype (P = 0.0882)...

The cost of long-term follow-up of high-risk infants for research studies

Doyle, L.W.; Clucas, L.; Roberts, G.; Davis, N.; Duff, J.; Callanan, C.; McDonald, M.; Anderson, P.J.; Cheong, J.L.Y.
Fonte: Wiley Publicador: Wiley
Tipo: Artigo de Revista Científica
Publicado em //2015 Português
Relevância na Pesquisa
75.88%
AIMS: Neonatal intensive care is expensive, and thus it is essential that its long-term outcomes are measured. The costs of follow-up studies for high-risk children who survive are unknown. This study aims to determine current costs for the assessment of health and development of children followed up in our research programme. METHODS: Costs were determined for children involved in the research follow-up programme at the Royal Women's Hospital, Melbourne, over the 6-month period between 1st January 2012 and 30th June 2012. The time required for health professionals involved in assessments in early and later childhood was estimated, and converted into dollar costs. Costs for equipment and data management were added. Estimated costs were compared with actual costs of running the research follow-up programme. RESULTS: A total of 134 children were assessed over the 6-month period. The estimated average cost per child assessed was $1184, much higher than was expected. The estimated cost to assess a toddler was $1149, whereas for an 11-year-old it was $1443, the difference attributable to the longer psychological and paediatric assessments. The actual average cost per child assessed was $1623. The shortfall of $439 between the actual and estimated average costs per child arose chiefly because of the need to pay staff even when participants were late or failed to attend. CONCLUSIONS: The average costs of assessing children at each age for research studies are much higher than expected. These data are useful for planning similar long-term follow-up assessments for high-risk children.; Lex W Doyle...

Calcium supplementation in pregnancy and its impact on blood pressure in children and women: Follow up of a randomised controlled trial

Hiller, J.; Crowther, C.; Moore, V.; Willson, K.; Robinson, J.
Fonte: Blackwell Publishing Asia Publicador: Blackwell Publishing Asia
Tipo: Artigo de Revista Científica
Publicado em //2007 Português
Relevância na Pesquisa
75.83%
Background: Follow up of participants in trials of antenatal calcium supplementation has reported an impact on blood pressure among mothers and children. Aims: To determine whether blood pressure at 4–7 years follow up would be lower for calcium-supplemented mothers in the Australian Calcium Trial (ACT) and for their children. Methods: This follow up targeted 414 of the original ACT participants with liveborn infants who lived in South Australia. Mothers and their children attended the Women's and Children's Hospital for anthropomorphic examination. Information on lifestyle factors was collected by questionnaire. Descriptive statistics examined differences between respondents and non-respondents and multiple regression models examined associations with blood pressure. Results: Blood pressure and body measurements were available on 45 and 43% of eligible women and children, respectively; questionnaire data were available on 50% of this cohort. At follow up, there were no differences between treatment groups in blood pressure in the women or their children. Both children of women who had high blood in pregnancy (pre-eclampsia or pregnancy-induced hypertension) and the women themselves had higher systolic and diastolic blood pressure at follow up. Among children...

A 7 year follow-up of children and adolescents with obsessive-compulsive disorder: an analysis of predictive factors in a clinical prospective study

Becker Nissen,Judith; Hesselberg Nikolajsen,Kathrine; Hove Thomsen,Per
Fonte: The European Journal of Psychiatry Publicador: The European Journal of Psychiatry
Tipo: info:eu-repo/semantics/article; journal article; info:eu-repo/semantics/publishedVersion Formato: text/html; application/pdf
Publicado em 01/09/2014 Português
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75.81%
Background and Objectives: Obsessive compulsive disorder (OCD) is a frequent psychiatric disorder. Despite its significant influence on personal development, little is known about its long-term course in children and adolescents. The aim was to follow children and adolescents with OCD for 7 years and to compare patients gaining remission with patients experiencing symptoms. Methods: The study was a prospective follow-up study in which the patients were interviewed 7 years after their initial contact with the healthcare system. The patients had been described at baseline. Results: Among the 95 participants, 53 participants described symptoms at follow-up and 44 participants described remission. More patients with persistent symptoms described an anxious personality trait. The schizoid/compulsive personality traits were represented at a higher rate in the group with persistent symptoms than in the group with remission symptoms. Important predictive factors included predisposition to OCD, the occurrence of comorbid disorders and older referral age. The occurrence of magic obsessions and repetitive compulsions increased the risk of OC symptoms at follow-up. The group “late responders” differed from the non-responder group by predisposition to depression. Conclusions: The present clinical study is one of the longest follow-up studies conducted in children and adolescents with OCD. In addition to confirming several previous findings...

Oral health follow-up studies in the 1993 Pelotas (Brazil) birth cohort study: methodology and principal results

Peres,Marco A.; Barros,Aluísio Jardim; Peres,Karen Glazer; Araújo,Cora Luiza; Menezes,Ana M. B.; Hallal,Pedro C.; Victora,Cesar G.
Fonte: Escola Nacional de Saúde Pública Sergio Arouca, Fundação Oswaldo Cruz Publicador: Escola Nacional de Saúde Pública Sergio Arouca, Fundação Oswaldo Cruz
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/10/2010 Português
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The aim of this study was to describe oral health follow-up studies nested in a birth cohort. A population-based birth cohort was launched in 1993 in Pelotas, Rio Grande do Sul State, Brazil. Two oral health follow-up studies were conducted at six (n = 359) and 12 (n = 339) years of age. A high response rate was observed at 12 years of age; 94.4% of the children examined at six years of age were restudied in 2005. The mean DMF-T index at age 12 was 1.2 (SD = 1.6) for the entire sample, ranging from 0.6 (SD = 1.1) for children that were caries-free at age six, 1.3 (SD = 1.5) for those with 1-3 carious teeth at six years, and 1.8 (SD = 1.8) for those with 4-19 carious teeth at six years (p < 0.01). The number of individuals with severe malocclusions at 12 years was proportional to the number of malocclusions at six years. Oral health problems in early adolescence were more prevalent in individuals with dental problems at six years of age.