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Investigation of Adenovirus Occurrence in Pediatric Tumor Entities▿

Kosulin, Karin; Haberler, Christine; Hainfellner, Johannes A.; Amann, Gabriele; Lang, Susanna; Lion, Thomas
Fonte: American Society for Microbiology Publicador: American Society for Microbiology
Tipo: Artigo de Revista Científica
Português
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Adenoviruses (AdVs) contain genes coding for proteins with transforming potential, and certain AdV serotypes have been shown to induce tumors in rodents. However, data on the possible oncogenicity of AdVs in humans are scarce. We have therefore employed a real-time quantitative PCR (RQ-PCR) assay permitting highly sensitive detection of all 51 currently known human AdV serotypes to screen more than 500 tumor specimens derived from 17 different childhood cancer entities including leukemias, lymphomas, and solid tumors. Most tumor entities analyzed showed no evidence for the presence of AdV sequences, but AdV DNA was detected by RQ-PCR in different brain tumors including 25/30 glioblastomas, 22/30 oligodendrogliomas, and 20/30 ependymomas. Nonmalignant counterparts of AdV-positive brain tumors, including specimens of ependymal cells, plexus choroideus, and periventricular white matter, were screened for control purposes and revealed the presence of AdV DNA in most specimens tested. Identification of the AdV types present in positive malignant and nonmalignant brain tissue specimens revealed predominantly representatives of species B and D and, less commonly, C. To exclude contamination as a possible cause of false-positive results, specimens with AdV sequences detectable by PCR were subsequently analyzed by in situ hybridization...

Rapidly Fatal Acanthamoeba Encephalitis and Treatment of Cryoglobulinemia

Meersseman, Wouter; Lagrou, Katrien; Sciot, Raf; de Jonckheere, Johan; Haberler, Christine; Walochnik, Julia; Peetermans, Willy E.; van Wijngaerden, Eric
Fonte: Centers for Disease Control and Prevention Publicador: Centers for Disease Control and Prevention
Tipo: Artigo de Revista Científica
Publicado em /03/2007 Português
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We describe a 66-year-old woman with therapy-refractory cryoglobulinemia treated with rituximab, plasmapheresis, and steroids; a case of fatal meningoencephalitis caused by Acanthamoeba spp. then developed. Such infections are rare and show an unusually rapid course (possibly related to rituximab).

Prognostic classification of pediatric medulloblastoma based on chromosome 17p loss, expression of MYCC and MYCN, and Wnt pathway activation

Park, Ae Kyung; Lee, Seung-Jun; Phi, Ji Hoon; Wang, Kyu-Chang; Kim, Dong Gyu; Cho, Byung-Kyu; Haberler, Christine; Fattet, Sarah; Dufour, Christelle; Puget, Stéphanie; Sainte-Rose, Christian; Bourdeaut, Franck; Grill, Jacques; Delattre, Olivier; Kim, Seu
Fonte: Oxford University Press Publicador: Oxford University Press
Tipo: Artigo de Revista Científica
Português
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Pediatric medulloblastoma is considered a highly heterogeneous disease and a new strategy of risk stratification to optimize therapeutic outcomes is required. We aimed to investigate a new risk-stratification approach based on expression profiles of medulloblastoma cohorts. We analyzed gene expression profiles of 30 primary medulloblastomas and detected strong evidence that poor survival outcome was significantly associated with mRNA expression profiles of 17p loss. However, it was not supported in independent cohorts from previously published data (n = 100). We speculated that this discrepancy might come from complex conditions of two important prognostic determinants: loss of tumor suppressors (chromosome 17p) and high expression of oncogenes c-myc (MYCC) or N-myc (MYCN). When patients were stratified into 5 or 7 subgroups based on simultaneous consideration of these 2 factors while defining the Wnt group as independent, obviously different survival expectancies were detected between the subgroups. For instance, predicted 5-year survival probabilities ranged from 19% to 81% in the 5 subgroups. We also found that age became a significant prognostic marker after adjusting for 17p, MYCC, and MYCN status. Diminished survival in age <3 years was more substantial in subgroups with high expression of MYCC...

Atypical teratoid rhabdoid tumor: improved long-term survival with an intensive multimodal therapy and delayed radiotherapy. The Medical University of Vienna Experience 1992–2012

Slavc, Irene; Chocholous, Monika; Leiss, Ulrike; Haberler, Christine; Peyrl, Andreas; Azizi, Amedeo A; Dieckmann, Karin; Woehrer, Adelheid; Peters, Christina; Widhalm, Georg; Dorfer, Christian; Czech, Thomas
Fonte: John Wiley & Sons Ltd. Publicador: John Wiley & Sons Ltd.
Tipo: Artigo de Revista Científica
Português
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Atypical teratoid rhabdoid tumors (ATRTs) are recently defined highly aggressive embryonal central nervous system tumors with a poor prognosis and no definitive guidelines for treatment. We report on the importance of an initial correct diagnosis and disease-specific therapy on outcome in 22 consecutive patients and propose a new treatment strategy. From 1992 to 2012, nine patients initially diagnosed correctly as ATRT (cohort A, median age 24 months) were treated according to an intensive multimodal regimen (MUV-ATRT) consisting of three 9-week courses of a dose-dense regimen including doxorubicin, cyclophosphamide, vincristine, ifosfamide, cisplatin, etoposide, and methotrexate augmented with intrathecal therapy, followed by high-dose chemotherapy (HDCT) and completed with local radiotherapy. Thirteen patients were treated differently (cohort B, median age 30 months) most of whom according to protocols in use for their respective diagnoses. As of July 2013, 5-year overall survival (OS) and event-free survival (EFS) for all 22 consecutive patients was 56.3 ± 11.3% and 52.9 ± 11.0%, respectively. For MUV-ATRT regimen-treated patients (cohort A) 5-year OS was 100% and EFS was 88.9 ± 10.5%. For patients treated differently (cohort B) 5-year OS and EFS were 28.8 ± 13.1%. All nine MUV-ATRT regimen-treated patients are alive for a median of 76 months (range: 16–197)...

P03-013 - Symptomatic neuromuscular sarcoidosis

Mulazzani, M; Haberler, C; Zimprich, F; Hartl, EV; Cetin, H
Fonte: BioMed Central Publicador: BioMed Central
Tipo: Artigo de Revista Científica
Publicado em 08/11/2013 Português
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Clinical Neuropathology practice news 2-2014: ATRX, a new candidate biomarker in gliomas

Haberler, Christine; Wöhrer, Adelheid
Fonte: Dustri-Verlag Dr. Karl Feistle Publicador: Dustri-Verlag Dr. Karl Feistle
Tipo: Artigo de Revista Científica
Português
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Genome-wide molecular approaches have substantially elucidated molecular alterations and pathways involved in the oncogenesis of brain tumors. In gliomas, several molecular biomarkers including IDH mutation, 1p/19q co-deletion, and MGMT promotor methylation status have been introduced into neuropathological practice. Recently, mutations of the ATRX gene have been found in various subtypes and grades of gliomas and were shown to refine the prognosis of malignant gliomas in combination with IDH and 1p/19q status. Mutations of ATRX are associated with loss of nuclear ATRX protein expression, detectable by a commercially available antibody, thus turning ATRX into a promising prognostic candidate biomarker in the routine neuropathological setting.

Early treatment with IgM-enriched intravenous immunoglobulin does not mitigate critical illness polyneuropathy and/or myopathy in patients with multiple organ failure and SIRS/sepsis: a prospective, randomized, placebo-controlled, double-blinded trial

Brunner, Richard; Rinner, Walter; Haberler, Christine; Kitzberger, Reinhard; Sycha, Thomas; Herkner, Harald; Warszawska, Joanna; Madl, Christian; Holzinger, Ulrike
Fonte: BioMed Central Publicador: BioMed Central
Tipo: Artigo de Revista Científica
Português
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16.95%

Response to imatinib as a function of target kinase expression in recurrent glioblastoma

Hassler, Marco Ronald; Vedadinejad, Mariam; Flechl, Birgit; Haberler, Christine; Preusser, Matthias; Hainfellner, Johannes Andreas; Wöhrer, Adelheid; Dieckmann, Karin Ute; Rössler, Karl; Kast, Richard; Marosi, Christine
Fonte: Springer International Publishing Publicador: Springer International Publishing
Tipo: Artigo de Revista Científica
Publicado em 25/02/2014 Português
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16.95%

In search of a canonical history of macroeconomics in the interwar period: Haberler's Prosperity and Depression revisited

Boianovsky,Mauro
Fonte: Fundação Getúlio Vargas Publicador: Fundação Getúlio Vargas
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/09/2000 Português
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The article investigates the methodological foundations of Gottfried Haberler's 1937 classic Prosperity and Depression and their influence on Haberler's assessment of theories prevailing before The General Theory and of Keynes's impact on macroeconomics. It is argued that Haberler was influenced by the ideas of the philosopher of social sciences Felix Kaufmann, whose 1936 book on methodology was instrumental in Haberler's emphasis on the distinction between tautological and empirical statements in economics. Haberler's cristicism of Hayek's capital shortage explanation of the crisis, as well as his rejection of Keynes' equilibrating mechanism through income changes and his scepticism towards econometric modelling of the business cycle, stem in large part from his views on method.