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Demande de projets de recherche: Programme de recherche 2009 ACG/IRSC/secteur industriel

Fonte: Pulsus Group Inc Publicador: Pulsus Group Inc
Tipo: Artigo de Revista Científica
Publicado em /08/2009 Português
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Genome-Wide SNP Detection, Validation, and Development of an 8K SNP Array for Apple

Chagné, David; Crowhurst, Ross N.; Troggio, Michela; Davey, Mark W.; Gilmore, Barbara; Lawley, Cindy; Vanderzande, Stijn; Hellens, Roger P.; Kumar, Satish; Cestaro, Alessandro; Velasco, Riccardo; Main, Dorrie; Rees, Jasper D.; Iezzoni, Amy; Mockler, Todd
Fonte: Public Library of Science Publicador: Public Library of Science
Tipo: Artigo de Revista Científica
Publicado em 21/02/2012 Português
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As high-throughput genetic marker screening systems are essential for a range of genetics studies and plant breeding applications, the International RosBREED SNP Consortium (IRSC) has utilized the Illumina Infinium® II system to develop a medium- to high-throughput SNP screening tool for genome-wide evaluation of allelic variation in apple (Malus×domestica) breeding germplasm. For genome-wide SNP discovery, 27 apple cultivars were chosen to represent worldwide breeding germplasm and re-sequenced at low coverage with the Illumina Genome Analyzer II. Following alignment of these sequences to the whole genome sequence of ‘Golden Delicious’, SNPs were identified using SoapSNP. A total of 2,113,120 SNPs were detected, corresponding to one SNP to every 288 bp of the genome. The Illumina GoldenGate® assay was then used to validate a subset of 144 SNPs with a range of characteristics, using a set of 160 apple accessions. This validation assay enabled fine-tuning of the final subset of SNPs for the Illumina Infinium® II system. The set of stringent filtering criteria developed allowed choice of a set of SNPs that not only exhibited an even distribution across the apple genome and a range of minor allele frequencies to ensure utility across germplasm...

Two sexes, one genome: the evolutionary dynamics of intralocus sexual conflict

Pennell, Tanya M; Morrow, Edward H
Fonte: Blackwell Publishing Ltd Publicador: Blackwell Publishing Ltd
Tipo: Artigo de Revista Científica
Português
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As the evolutionary interests of males and females are frequently divergent, a trait value that is optimal for the fitness of one sex is often not optimal for the other. A shared genome also means that the same genes may underlie the same trait in both sexes. This can give rise to a form of sexual antagonism, known as intralocus sexual conflict (IASC). Here, a tug-of-war over allelic expression can occur, preventing the sexes from reaching optimal trait values, thereby causing sex-specific reductions in fitness. For some traits, it appears that IASC can be resolved via sex-specific regulation of genes that subsequently permits sexual dimorphism; however, it seems that whole-genome resolution may be impossible, due to the genetic architecture of certain traits, and possibly due to the changing dynamics of selection. In this review, we explore the evolutionary mechanisms of, and barriers to, IASC resolution. We also address the broader consequences of this evolutionary feud, the possible interactions between intra- and interlocus sexual conflict (IRSC: a form of sexual antagonism involving different loci in each sex), and draw attention to issues that arise from using proxies as measurements of conflict. In particular, it is clear that the sex-specific fitness consequences of sexual dimorphism require characterization before making assumptions concerning how this relates to IASC. Although empirical data have shown consistent evidence of the fitness effects of IASC...

Identification of Pyrus Single Nucleotide Polymorphisms (SNPs) and Evaluation for Genetic Mapping in European Pear and Interspecific Pyrus Hybrids

Montanari, Sara; Saeed, Munazza; Knäbel, Mareike; Kim, YoonKyeong; Troggio, Michela; Malnoy, Mickael; Velasco, Riccardo; Fontana, Paolo; Won, KyungHo; Durel, Charles-Eric; Perchepied, Laure; Schaffer, Robert; Wiedow, Claudia; Bus, Vincent; Brewer, Lester
Fonte: Public Library of Science Publicador: Public Library of Science
Tipo: Artigo de Revista Científica
Publicado em 14/10/2013 Português
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We have used new generation sequencing (NGS) technologies to identify single nucleotide polymorphism (SNP) markers from three European pear (Pyrus communis L.) cultivars and subsequently developed a subset of 1096 pear SNPs into high throughput markers by combining them with the set of 7692 apple SNPs on the IRSC apple Infinium® II 8K array. We then evaluated this apple and pear Infinium® II 9K SNP array for large-scale genotyping in pear across several species, using both pear and apple SNPs. The segregating populations employed for array validation included a segregating population of European pear (‘Old Home’בLouise Bon Jersey’) and four interspecific breeding families derived from Asian (P. pyrifolia Nakai and P. bretschneideri Rehd.) and European pear pedigrees. In total, we mapped 857 polymorphic pear markers to construct the first SNP-based genetic maps for pear, comprising 78% of the total pear SNPs included in the array. In addition, 1031 SNP markers derived from apple (13% of the total apple SNPs included in the array) were polymorphic and were mapped in one or more of the pear populations. These results are the first to demonstrate SNP transferability across the genera Malus and Pyrus. Our construction of high density SNP-based and gene-based genetic maps in pear represents an important step towards the identification of chromosomal regions associated with a range of horticultural characters...

Le domaine des co-infections et des maladies concomitantes du Réseau canadien pour les essais VIH des IRSC : lignes directrices canadiennes pour la prise en charge et le traitement de la co-infection par le VIH et l’hépatite C chez les adultes

Hull, Mark; Giguère, Pierre; Klein, Marina; Shafran, Stephen; Tseng, Alice; Côté, Pierre; Poliquin, Marc; Cooper, Curtis
Fonte: Pulsus Group Inc Publicador: Pulsus Group Inc
Tipo: Artigo de Revista Científica
Publicado em //2014 Português
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Development and Validation of a 20K Single Nucleotide Polymorphism (SNP) Whole Genome Genotyping Array for Apple (Malus × domestica Borkh)

Bianco, Luca; Cestaro, Alessandro; Sargent, Daniel James; Banchi, Elisa; Derdak, Sophia; Di Guardo, Mario; Salvi, Silvio; Jansen, Johannes; Viola, Roberto; Gut, Ivo; Laurens, Francois; Chagné, David; Velasco, Riccardo; van de Weg, Eric; Troggio, Michela
Fonte: Public Library of Science Publicador: Public Library of Science
Tipo: Artigo de Revista Científica
Publicado em 10/10/2014 Português
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High-density SNP arrays for genome-wide assessment of allelic variation have made high resolution genetic characterization of crop germplasm feasible. A medium density array for apple, the IRSC 8K SNP array, has been successfully developed and used for screens of bi-parental populations. However, the number of robust and well-distributed markers contained on this array was not sufficient to perform genome-wide association analyses in wider germplasm sets, or Pedigree-Based Analysis at high precision, because of rapid decay of linkage disequilibrium. We describe the development of an Illumina Infinium array targeting 20K SNPs. The SNPs were predicted from re-sequencing data derived from the genomes of 13 Malus × domestica apple cultivars and one accession belonging to a crab apple species (M. micromalus). A pipeline for SNP selection was devised that avoided the pitfalls associated with the inclusion of paralogous sequence variants, supported the construction of robust multi-allelic SNP haploblocks and selected up to 11 entries within narrow genomic regions of ±5 kb, termed focal points (FPs). Broad genome coverage was attained by placing FPs at 1 cM intervals on a consensus genetic map, complementing them with FPs to enrich the ends of each of the chromosomes...

Serum Immunoglobulin G4 and Immunoglobulin G1 for Distinguishing Immunoglobulin G4-Associated Cholangitis From Primary Sclerosing Cholangitis

Boonstra, Kirsten; Culver, Emma L; de Buy Wenniger, Lucas Maillette; van Heerde, Marianne J; van Erpecum, Karel J; Poen, Alexander C; van Nieuwkerk, Karin MJ; Spanier, BW Marcel; Witteman, Ben JM; Tuynman, Hans ARE; van Geloven, Nan; van Buuren, Henk; Cha
Fonte: John Wiley & Sons, Ltd Publicador: John Wiley & Sons, Ltd
Tipo: Artigo de Revista Científica
Português
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The recent addition of immunoglobulin (Ig)G4-associated cholangitis (IAC), also called IgG4-related sclerosing cholangitis (IRSC), to the spectrum of chronic cholangiopathies has created the clinical need for reliable methods to discriminate between IAC and the more common cholestatic entities, primary (PSC) and secondary sclerosing cholangitis. The current American Association for the Study of Liver Diseases practice guidelines for PSC advise on the measurement of specific Ig (sIg)G4 in PSC patients, but interpretation of elevated sIgG4 levels remains unclear. We aimed to provide an algorithm to distinguish IAC from PSC using sIgG analyses. We measured total IgG and IgG subclasses in serum samples of IAC (n = 73) and PSC (n = 310) patients, as well as in serum samples of disease controls (primary biliary cirrhosis; n = 22). sIgG4 levels were elevated above the upper limit of normal (ULN = >1.4 g/L) in 45 PSC patients (15%; 95% confidence interval [CI]: 11-19). The highest specificity and positive predictive value (PPV; 100%) for IAC were reached when applying the 4× ULN (sIgG4 > 5.6 g/L) cutoff with a sensitivity of 42% (95% CI: 31-55). However, in patients with a sIgG4 between 1× and 2× ULN (n = 38/45), the PPV of sIgG4 for IAC was only 28%. In this subgroup...

Estrutura de Capital e Divulgação Voluntária de Informações de Responsabilidade Social Corporativa das Empresas Brasileiras

Almeida, Moisés Araújo; Santos, Joséte Florencio dos (Orientadora)
Fonte: Universidade Federal de Pernambuco Publicador: Universidade Federal de Pernambuco
Tipo: Tese de Doutorado
Português
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Este estudo tem por objetivo verificar se as divulgações voluntárias de informações de responsabilidade social corporativa influenciam a estrutura de capital das empresas listadas na BM&FBOVESPA, sob a ótica das teorias de Tradeoff e Pecking Order, no período de 2008 a 2012. A amostra foi composta pelas empresas não financeiras com informações disponíveis. Os dados foram coletados através de fontes secundárias, sendo as informações contábeis obtidas das bases de dados Economatica e Datastream e as informações sobre responsabilidade social corporativa obtidas dos relatórios de sustentabilidade publicados nos websites das empresas e no site da Comissão de Valores Mobiliários. Para mensurar a divulgação voluntária de informações de responsabilidade social corporativa, construiu-se um índice (IRSC) composto por 24 questões objetivas compreendendo aspectos de (i) estrutura de governança e sistemas de gestão, (ii) credibilidade, (iii) indicadores de desempenho ambiental e (iv) gastos ambientais. As empresas com maior pontuação no índice pertencem aos setores de exploração de petróleo e gás; geração, transmissão e distribuição de energia; indústria de papel e celulose; e, mineração de metais. A pontuação média das empresas se manteve em torno de 12 pontos. A análise foi feita com regressão múltipla de dados em painel desbalanceado com efeitos fixos e...

Nanonization of megestrol acetate by laser fragmentation in aqueous milieu

Sylvestre, Jean-Philippe; Tang, Marie-Christine; Furtos, Alexandra; Leclair, Grégoire; Meunier, Michel; Leroux, Jean-Christophe
Fonte: Université de Montréal Publicador: Université de Montréal
Tipo: Artigo de Revista Científica
Português
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Nanonization is a simple and effective method to improve dissolution rate and oral bioavailability of drugs with poor water solubility. There is growing interest to downscale the nanocrystal production to enable early preclinical evaluation of new drug candidates when compound availability is scarce. The purpose of the present study was to investigate laser fragmentation to form nanosuspensions in aqueous solution of the insoluble model drug megestrol acetate (MA) using very little quantities of the drug. Laser fragmentation was obtained by focusing a femtosecond (fs) or nanosecond (ns) laser radiation on a magnetically stirred MA suspension in water or aqueous solution of a stabilizing agent. The size distribution and physicochemical properties of the drug nanoparticles were characterized, and the in vitro dissolution and in vivo oral pharmacokinetics of a laser fragmented formulation were evaluated. A MA nanosuspension was also prepared by media milling for comparison purpose. For both laser radiations, smaller particles were obtained as the laser power was increased, but at a cost of higher degradation. Significant nanonization was achieved after a 30-min fs laser treatment at 250 mW and a 1-h ns laser treatment at 2500 mW. The degradation induced by the laser process of the drug was primarily oxidative in nature. The crystal phase of the drug was maintained...

Screening for adolescent idiopathic scoliosis: an information statement by the scoliosis research society international task force

Labelle, Hubert; Richards, Stephens B.; De Kleuver, Marinus; Grivas, Theodoros B.; Luk, Keith D.K.; Wong, Hee Kit; Thometz, John; Beauséjour, Marie; Turgeon, Isabelle; Fong, Daniel Y.T.
Fonte: Université de Montréal Publicador: Université de Montréal
Tipo: Artigo de Revista Científica
Português
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Background: Routine screening of scoliosis is a controversial subject and screening efforts vary greatly around the world. METHODS: Consensus was sought among an international group of experts (seven spine surgeons and one clinical epidemiologist) using a modified Delphi approach. The consensus achieved was based on careful analysis of a recent critical review of the literature on scoliosis screening, performed using a conceptual framework of analysis focusing on five main dimensions: technical, clinical, program, cost and treatment effectiveness. FINDINGS: A consensus was obtained in all five dimensions of analysis, resulting in 10 statements and recommendations. In summary, there is scientific evidence to support the value of scoliosis screening with respect to technical efficacy, clinical, program and treatment effectiveness, but there insufficient evidence to make a statement with respect to cost effectiveness. Scoliosis screening should be aimed at identifying suspected cases of scoliosis that will be referred for diagnostic evaluation and confirmed, or ruled out, with a clinically significant scoliosis. The scoliometer is currently the best tool available for scoliosis screening and there is moderate evidence to recommend referral with values between 5 degrees and 7 degrees. There is moderate evidence that scoliosis screening allows for detection and referral of patients at an earlier stage of the clinical course...

Gender-Specific Situational Correlates of Syringe Sharing during a Single Injection Episode

Hottes, Travis S.; Bruneau, Julie; Daniel, Mark
Fonte: Université de Montréal Publicador: Université de Montréal
Tipo: Pré-publication / Preprint
Português
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Ce document est la pré-publication d'un article paru dans AIDS and Behavior 2011; 15(1): 75-85 url: http://link.springer.com/journal/volumesAndIssues/10461; IRSC et FRSQ Réseau SIDA et maladies infectieuses

Association between neighbourhood socioeconomic characteristics and high-risk injection behaviour amongst injection drug users living in inner vs. other city areas in Montréal, Canada

Généreux, Mélissa; Bruneau, Julie; Daniel, Mark
Fonte: Université de Montréal Publicador: Université de Montréal
Tipo: Pré-publication / Preprint
Português
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Ce manuscrit est une pré-publication d'un article paru dans International Journal of Drug Policy 2010; 21(1): 49-55.; IRSC et FRSQ - Réseau SIDA et maladies infectieuses

Availability of body art facilities and body art piercing do not predict hepatitis C acquisition among injection drug users in Montreal, Canada: results from a cohort study

Bruneau, Julie; Daniel, Mark; Kestens, Yan; Abrahamowicz, Michal; Zang, Geng
Fonte: Université de Montréal Publicador: Université de Montréal
Tipo: Pré-publication / Preprint
Português
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Ce manuscrit est une pré-publication d'un article paru dans International Journal of Drug Policy 2010; 21(6): 477-484.; IRSC et FRSQ - Réseau SIDA et maladies infectieuses

The rising prevalence of prescription opioid injection and its association with hepatitis C incidence among street-drug users

Bruneau, Julie; Roy, Élise; Arruda, Nelson; Zang, Geng; Jutras-Aswad, Didier
Fonte: Université de Montréal Publicador: Université de Montréal
Tipo: Pré-publication / Preprint
Português
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Ce manuscrit est une pré-publication d'un article paru dans Addiction 2012; 107(7): 1318-1327 url: http://www.addictionjournal.org/; IRSC et FRSQ - Réseau SIDA et maladies infectieuses

Cannabis use correlates of syringe sharing among injection drug users

Jutras-Aswad, Didier; Bruneau, Julie; Zang, Geng
Fonte: Université de Montréal Publicador: Université de Montréal
Tipo: Pré-publication / Preprint
Português
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Ce manuscrit est une pré-publication d'un article paru dans The American Journal on Addictions 2010; 19(3): 231-237 url: http://onlinelibrary.wiley.com/doi/10.1111/ajad.2010.19.issue-3/issuetoc; IRSC et FRSQ - Réseau SIDA et maladies infectieuses

Increased Degranulation of Natural Killer Cells during Acute HCV Correlates with the Magnitude of Virus-specific T cell Responses

Pelletier, Sandy; Drouin, Christian; Bédard, Nathalie; Khakoo, Salim I.; Bruneau, Julie; Shoukry, Naglaa H.
Fonte: Université de Montréal Publicador: Université de Montréal
Tipo: Pré-publication / Preprint
Português
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Ce manuscrit est une pré-publication d'un article paru dans Journal of Hepatology 2010; 53(5): 805-816.; IRSC et FRSQ - Réseau SIDA et maladies infectieuses

Inhibitory Killer Immunoglobulin-like receptors to self HLA-B and HLA-C ligands contribute differentially to Natural Killer cell functional potential in HIV infected Slow Progressors

Kamya, Philomena; Tallon, Benjamin; Melendez-Pena, Carlos; Migueles, Stephen A.; Connors, Mark; Tremblay, Cécile L.; Bruneau, Julie; Bernard, Nicole F.
Fonte: Université de Montréal Publicador: Université de Montréal
Tipo: Pré-publication / Preprint
Português
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Ce manuscrit est une pré-publication d'un article paru dans Clinical Immunology 2012; 143(3): 246-255 url: http://www.journals.elsevier.com/clinical-immunology/; IRSC et FRSQ - Réseau SIDA et maladies infectieuses

Recherche et développement dans les sciences de l’environnement : l’Université entre impératifs scientifico-techniques, économiques et socio-politiques. Le cas du Réseau de centres d’excellence ArcticNet.

Coussot, Caroline
Fonte: Université de Montréal Publicador: Université de Montréal
Tipo: Thèse ou Mémoire numérique / Electronic Thesis or Dissertation
Português
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Cette thèse cible l’étude d’une organisation sociotechnique pluraliste, le Réseau de centres d’excellence ArcticNet, établi depuis 2003 au sein de l’Université Laval et financé par le programme fédéral des Réseaux de centres d’excellence (RCE). Ce programme, effectif depuis 1988, est issu d’une initiative du ministère de l’Industrie Canada et des trois Conseils fédéraux de financement de la recherche scientifique (CRSNG, CRSH et IRSC). Par sa dimension interdisciplinaire et interinstitutionnelle, le RCE ArcticNet sollicite la mise en place de divers accommodements sur une thématique environnementale controversée, celle du développement de l’Arctique canadien côtier. Notre approche se concentre sur la description de ces collaborations pluralistes et l’analyse des stratégies de consensus mises en place par une organisation universitaire médiatrice. Si cette étude illustre le cas d’ArcticNet, elle questionne toutefois deux réalités d’ensemble: (1) D’un point de vue théorique, prépondérant dans cette thèse, les enjeux environnementaux et de développement durable s’inscrivent dans les nouvelles réalités de la production des connaissances portées par une coévolution entre science et société...

Le libre accès pour les bibliothèques de la santé : des ressources à découvrir

Attia, Audrey; Constantinescu, Teodora
Fonte: Institut universitaire de gériatrie de Montréal ; Hôpital général juif (Montréal, Québec) Publicador: Institut universitaire de gériatrie de Montréal ; Hôpital général juif (Montréal, Québec)
Tipo: Communication, présentation / Paper, Presentation
Português
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Cette présentation s’adresse aux spécialistes de l’information du milieu de la santé et aborde les points suivants : 1. Le monde du « libre accès » : définitions et statistiques; 2. Utiliser les ressources en libre accès; 3. Publier en libre accès (politiques d’accès aux résultats de la recherche des IRSC et du FRSQ); 4. Rôles et opportunités pour les bibliothèques de la santé.; This talk is aimed at health information specialists and discusses the following aspects of Open Access: 1. The world of Open Access: definitions and statistics; 2. Using the resources; 3. Open Access publishing (CIHR and FRSQ policies on access to research outputs); 4. Roles and opportunities for health libraries.; ABSAUM ; MMAHLA

Homophobia, coping strategies, and sexual identity formation among LGBT youths; Intimidation homophobe, stratégies d’adaptation et intégration de l’orientation sexuelle

Goyer, Marie-France; Université du Québec à Montréal; Blais, Martin; Université du Québec à Montréal; Hébert, Martine; Université du Québec à Montréal
Fonte: Eduff Publicador: Eduff
Tipo: ; ; Formato: application/pdf; application/pdf
Publicado em 26/11/2015 Português
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Sexual minority youths (SMY) face challenges in consolidating their sexual identity because of heterosexism. The role of homophobic bullying and coping strategies in the formation of sexual identity has been explored within a convenient sample of 262 sexual minority youths. Six dimensions of sexual identity formation have been tested, independent variables being: homophobic bullying, coping strategies (avoidance and problem-solving), age, gender, migration trajectory, residency, sexual attraction and time elapsed since the realization of the sexual identity difference. Homophobic bullying was associated with a lower score of sexual identity affirmation and higher scores of identity concealment, internalized homo/bi-phobia, acceptance concern, identity uncertainty and process difficulty. Problem-solving coping strategies were associated with acceptance concerns. Avoidance coping strategies were associated with higher scores of acceptance concern and process difficulty in accepting non-heterosexual identity. Results confirm the importance of homo/bi-phobia prevention in order to help SMY in sexual identity consolidation.; Cette étude examine l’impact de l’intimidation homophobe et des stratégies d’adaptation sur 6 dimensions de l’intégration de l’orientation sexuelle (OS) à partir d’un échantillon de 262 jeunes LGBT. Un modèle de régression linéaire a été réalisé pour chaque dimension...