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Metronidazole-containing gel for the treatment of periodontitis: an in vivo evaluation

SATO, Sandra; FONSECA, Maria José Vieira; CIAMPO, José Orestes Del; JABOR, José Roberto; PEDRAZZI, Vinícius
Fonte: Sociedade Brasileira de Pesquisa Odontológica Publicador: Sociedade Brasileira de Pesquisa Odontológica
Tipo: Artigo de Revista Científica
Português
Relevância na Pesquisa
37.29%
The aim of this investigation was to monitor metronidazole concentrations in the gingival crevicular fluid (GCF) collected from periodontal pockets of dogs after treatment with an experimental 15% metronidazole gel. Five dogs had periodontitis induced by cotton ligatures placed subgingivally and maintained for a 30-day period. After the induction period, only pockets with 4 mm or deeper received the gel. Each pocket was filled up to the gingival margin by means of a syringe with a blunt-end needle. GCF was collected in paper strips and quantified in an electronic device before and after 15 minutes, 1 h, 6 h, 24 h and 48 h of gel administration. The GCF samples were assayed for metronidazole content by means of a high performance liquid chromatography method. Concentrations of metronidazole in the GCF of the 5 dogs (mean ± SD, in µg/mL) were 0 ± 0 before gel application and 47,185.75 ± 24,874.35 after 15 minutes, 26,457.34 ± 25,516.91 after 1 h, 24.18 ± 23.11 after 6 h, 3.78 ± 3.45 after 24 h and 3.34 ± 5.54 after 48 h. A single administration of the 15% metronidazole gel released the drug in the GCF of dogs in levels several-fold higher than the minimum inhibitory concentration for some periodontopathogens grown in subgingival biofilms for up to one hour...

Metronidazole Immediate Release Formulations: A Fasting Randomized Open-Label Crossover Bioequivalence Study in Healthy Volunteers

Silva, M. de Freitas; Schramm, S. G.; Kano, Eunice Kazue; Koono, E. E. M.; Manfio, J. L.; Porta, Valentina; Serra, Cristina Helena dos Reis
Fonte: GEORG THIEME VERLAG KG; STUTTGART Publicador: GEORG THIEME VERLAG KG; STUTTGART
Tipo: Artigo de Revista Científica
Português
Relevância na Pesquisa
37.2%
Metronidazole is a BCS (Biopharmaceutics Classification System) class 1 drug, traditionally considered the choice drug in the infections treatment caused by protozoa and anaerobic microorganisms. This study aimed to evaluate bioequivalence between 2 different marketed 250 mg metronidazole immediate release tablets. A randomized, open-label, 2 x 2 crossover study was performed in healthy Brazilian volunteers under fasting conditions with a 7-day washout period. The formulations were administered as single oral dose and blood was sampled over 48 h. Metronidazole plasma concentrations were determined by a liquid chromatography mass spectrometry (LC-MS/MS) method. The plasma concentration vs. time profile was generated for each volunteer and the pharmacokinetic parameters C-max, T-max, AUC(0-t), AUC(0-infinity), k(e), and t(1/2) were calculated using a noncompartmental model. Bioequivalence between pharmaceutical formulations was determined by calculating 90% CIs (Confidence Intervall) for the ratios of C-max, AUC(0-t), and AUC(0-infinity) values for test and reference using log-transformed data. 22 healthy volunteers (11 men, 11 women; mean (SD) age, 28 (6.5) years [range, 21-45 years]; mean (SD) weight, 66 (9.3) kg [range, 51-81 kg]; mean (SD) height...

Detecção precoce de bactérias periodontopatogênicas e a ação de um gel de metronidazol 25% em crianças com Diabetes mellitus tipo I; Early detection of periodontopathogenic bacteria and the effect of a topic metronidazole 25% gel in children with type I Diabetes mellitus

Prestes, Marcelo Pires
Fonte: Biblioteca Digitais de Teses e Dissertações da USP Publicador: Biblioteca Digitais de Teses e Dissertações da USP
Tipo: Tese de Doutorado Formato: application/pdf
Publicado em 05/09/2007 Português
Relevância na Pesquisa
37.13%
A Diabetes mellitus do tipo I (IDDM), doença metabólica caracterizada pela deficiência na produção de insulina, causa profundas alterações sistêmicas, incluindo a cavidade bucal. A doença periodontal, que se apresenta mais agressiva em pacientes diabéticos, até mesmo na infância, tem como agentes etiológicos microrganismos denominados periodontopatógenos, dentre eles o Aggregatibacter actinomycetemcomitans (A. actinomycetemcomitans), anteriormente chamado Actinobacillus actinomycetemcomitans, que em associação às alterações na resposta imune e inflamatória decorrentes da diabetes, poderá causar maior reabsorção do osso alveolar precocemente em crianças. A identificação precoce destes agressores poderá ser extremamente útil para a instituição de medidas preventivas e terapêuticas que possam inibir ou minimizar os efeitos nocivos da IDDM e suas conseqüências para a cavidade bucal. Para este fim, métodos moleculares de investigação estão sendo cada vez mais utilizados, destacando-se a Reação em Cadeia da Polimerase em Tempo Real (Real-Time PCR) com alta especificidade e sensibilidade para detectar e quantificar microrganismos, mesmo em pequeno número e em meios, até então, pouco explorados como a saliva. Por fim...

Determinação da bioequivalência do metronidazol a partir de comprimidos revestidos; Bioequivalence determination of metronidazole from coated tablets

Silva, Marina de Freitas
Fonte: Biblioteca Digitais de Teses e Dissertações da USP Publicador: Biblioteca Digitais de Teses e Dissertações da USP
Tipo: Dissertação de Mestrado Formato: application/pdf
Publicado em 20/08/2009 Português
Relevância na Pesquisa
37.33%
O metronidazol é usado no tratamento de infecções causadas por protozoários e naquelas causadas por microrganismos anaeróbicos, no tratamento das formas intestinais e extra-intestinais de amebíase, em tricomoníase e em infecções bacterianas aeróbicas graves. Após administração oral, a absorção é rápida e completa sendo amplamente distribuído, atinge concentração plasmática máxima em 1-2 horas. A meia-vida de eliminação do metronidazol é de 6-12 horas. O objetivo deste trabalho foi avaliar a equivalência terapêutica por meio da bioequivalêmcia entre duas formulações de comprimidos revestidos contendo metronidazol, produzidos por dois fabricantes distintos, permitindo assim a intercambiabilidade entre as formulações. O ensaio de bioequivalência entre o produto teste (FUNED metronidazol) e o produto referência (Flagyl® - Aventis Pharma Ltda.) foi do tipo randomizado, cruzado e aberto. O medicamento foi administrado em dose única de 250 mg de metronidazol aos 24 voluntários sadios. Amostras de sangue foram coletadas até 48 horas após a administração e analisadas por método, desenvolvido e validado, de cromatografia líquida de alta eficiência acoplada à espectrometria de massas (CLAE- MS/MS). As curvas de decaimento plasmático obtidas para o produto teste (FUNED metronidazol) e para o produto referência (Flagyl® - Aventis Pharma Ltda.) foram semelhantes...

Avaliação de um gel contendo metronidazol para o tratamento adjuvante da periodontite crônica; Evaluation of a gel containing metronidazole for the adjuvant treatment of chronic periodontitis

Miani, Paola Kirsten
Fonte: Biblioteca Digitais de Teses e Dissertações da USP Publicador: Biblioteca Digitais de Teses e Dissertações da USP
Tipo: Tese de Doutorado Formato: application/pdf
Publicado em 19/11/2010 Português
Relevância na Pesquisa
37.29%
Sistemas poliméricos para a liberação de fármacos associados à terapêutica periodontal convencional têm sido desenvolvidos e aplicados com algumas vantagens em comparação ao debridamento mecânico isolado. Um dispositivo de liberação lenta para uso em bolsas periodontais contendo metronidazol como princípio ativo, foi desenvolvido e testado quanto à sua eficácia no tratamento de pacientes com periodontite crônica. Dezesseis pacientes foram selecionados e aleatoriamente alocados aos seguintes tratamentos com 8 indivíduos por grupo: 1) raspagem e alisamento radicular (controle ativo) ou 2) raspagem e alisamento radicular + aplicação de gel contendo metronidazol a 15% (experimental). Os efeitos dos tratamentos foram avaliados pelo acompanhamento longitudinal de parâmetros clínicos (profundidade do sulco gengival à sondagem e nível clínico de inserção) e microbiológicos (análise da microbiota subgengival pela técnica da hibridização DNA-DNA Checkerboard). O monitoramento das concentrações de metronidazol no fluido gengival colhido dos pacientes que receberem o gel foi realizado pela cromatografia líquida de alta eficiência. Os resultados da análise das concentrações de metronidazol na bolsa periodontal demonstraram que o gel só pôde ser detectado em concentrações efetivas até uma hora depois da aplicação. Em relação à análise microbiológica...

Ensaio terapêutico na infecção por Giardia muris em camundongo com metronidazole, tinidazole, secnidazole e furazolidone

Cruz, Claudia Cristina Pedigone; Ferrari, Lilian; Sogayar, Roberto
Fonte: Sociedade Brasileira de Medicina Tropical - SBMT Publicador: Sociedade Brasileira de Medicina Tropical - SBMT
Tipo: Artigo de Revista Científica Formato: 223-228
Português
Relevância na Pesquisa
37.29%
Foi testado in vivo a sensibilidade de Giardia muris a quatro drogas comumente usadas no tratamento da giardíase humana. Foram utilizados 7 grupos de animais, com 12 camundongos cada, sendo que o grupo controle recebeu apenas solução salina 0,15M (0,5ml/animal). Os demais grupos receberam em dose única: metronidazole e furazolidone (500mg/kg), tinidazole e secnidazole (200mg/kg). A eficácia das drogas foi avaliada através da contagem de cistos nas fezes e pela ausência de trofozoítos no intestino. O metronidazole foi a droga mais eficaz. Os cortes histológicos mostraram diferenças entre o padrão da mucosa intestinal de animais normais e parasitados. No entanto, não se observou diferença entre o padrão de mucosa de animais infectados tratados e não tratados, o que sugere que estas alterações podem ser causadas pelo parasito e não pelas drogas.; A comparative study about the effectiveness of metronidazole, tinidazole, secnidazole and furazolidone was performed on Giardia muris from mice naturally infected. Groups of 12 animals each was constituted: the control treated with saline; one treated with metronidazole; one treated with furazolidone; one treated with tinidazole; one treated with secnidazole; histological normal control; histological infected. Samples of three stools were examined before and after treatment with quantification of cysts. Animals were cured when the trophozoites was not seen in the small bowel. The curative activity of drugs was 58.3% for metronidazole...

Systemic use of metronidazole in the treatment of chronic periodontitis: a pilot study using clinical, microbiological, and enzymatic evaluation.

Vergani, Solange Alonso; Silva, Emílio Barbosa e; Vinholis, Adriana Helena; Marcantonio, Rosemary Adriana Chierici
Fonte: Universidade Estadual Paulista Publicador: Universidade Estadual Paulista
Tipo: Artigo de Revista Científica Formato: 121-127
Português
Relevância na Pesquisa
37.25%
The aim of the present parallel, double-blind investigation was to evaluate the effect of using systemic metronidazole alone or associated to scaling and root planing on adult chronic periodontal disease, monitored at baseline, 30, 60 and 90 days. Twelve subjects were divided into three groups: the first group (Group I - 22 sites) was submitted to scaling and root planing (SRP) alone; the second group (Group II - 30 sites) received SRP and 250 mg of metronidazole (3 times a day for 10 days), and the third group (Group III - 31 sites) was treated with metronidazole alone. The clinical parameters evaluated were probing depth (PD), clinical attachment level (CAL), plaque index (PlI), gingival index (GI) and bleeding upon probing (BP). Microbiological (BANA test) and enzymatic (Pocket Watch) tests were also performed. All three proposed treatments produced significant improvements in clinical conditions of subjects, from baseline, 30, 60 and 90-day period, except for clinical attachment level. The results obtained by microbiological and enzymatic tests did not show statistical differences among the groups for the 90-day period (r = 0.7924 and r = 0.7757, respectively). In relation to clinical parameters, statistical differences among groups were observed only for the gingival index (p = 0.0261) between Groups I and II...

Clinical evaluation of an ointment with 10% metronidazole and 2% lidocaine in the treatment of alveolitis.

Silva, L. J.; Poi, Wilson Roberto; Panzarini, S. R.; Rodrigues, T. S.; Simonato, L. E.
Fonte: Universidade Estadual Paulista Publicador: Universidade Estadual Paulista
Tipo: Artigo de Revista Científica Formato: 431-436
Português
Relevância na Pesquisa
37.13%
AIM: In this study, the authors evaluate the use of a 10% metronidazole and 2% lidocaine ointment, using a lanolin base and mint as flavoring, to treat alveolitis in humans. METHODS: Twenty-five patients, with a diagnosis of alveolitis, were treated in the following way: locoregional anesthesia; surgical cleaning of the socket with alveolar curettes; saline solution irrigation with a 20 ml disposable syringe; and complete filling of the socket with the ointment. RESULTS: The analysis of the results showed that the painful symptoms were severe before and on the day of the treatment in 17 (68%) of the 25 patients treated. Post-treatment analysis presented 2 patients (18%) with severe painful symptoms after 24 h of the treatment and complete remission of painful symptoms after 48 h of the treatment with the ointment. CONCLUSIONS: Based on the results, it is possible to conclude that the 10% metronidazole and 2% lidocaine ointment, with mint flavoring and lanolin as a base, can be used to treat alveolitis.

Nanostructured screen-printed electrodes modified with self-assembled monolayers for determination of metronidazole in different matrices

Huayhuas-chipana, Bryan C.; Gomero, Juan C. M.; Sotomayor, Maria D. P. T.
Fonte: Sociedade Brasileira de Química Publicador: Sociedade Brasileira de Química
Tipo: Artigo de Revista Científica Formato: 1737-1745
Português
Relevância na Pesquisa
37.13%
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP); Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq); Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES); This paper describes the development of a sensor for the determination of metronidazole using a simple method involving the creation of nanoporous structures on gold electrodes followed by modification with self-assembled monolayers (SAMs) of thiols. The initial formation of oxidized gold species at pH 7.0 was followed by potentiodynamic reduction in order to obtain a nanostructured surface that was then modified with a SAM of cysteine. The sensor was characterized by scanning electron microscopy (SEM), atomic force microscopy (AFM), and electrochemical techniques. Quantification of metronidazole was performed using optimized square wave voltammetry. Under the best analytical conditions, the sensor operated at -0.36 V showed a linear range of 50-300 µmol L-1 and a limit of detection (LOD) of 2.6 µmol L-1. Evaluation of selectivity demonstrated that the electrode provided higher sensitivity towards nitroimidazoles. The sensor responses showed that it could be used for detection of metronidazole in different types of matrix.; Neste trabalho é descrito o desenvolvimento de um sensor para detecção de metronidazol...

THE RADIO SENSITIZING EFFECT OF METRONIDAZOLE IN MAIZE

VICCINI,LYDERSON FACIO; SARAIVA,LUIZ SÉRGIO; ALMEIDA FILHO,JOSÉ DE; CRUZ,COSME DAMIÃO; ANDRADE,ROGÉRIO ALVAREZ DE
Fonte: Instituto Agronômico de Campinas Publicador: Instituto Agronômico de Campinas
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/01/1997 Português
Relevância na Pesquisa
37.13%
The identification of chemical substances which increase the efficiency of radiation is important to make easier the obtention of plants with structural chromosome aberrations which may be used in an alternative program for hybrid maize production. The present work was carried out to investigate the effect of the chemical substance metronidazole in maize seedlings submitted to gamma radiation. Several treatments were done, soaking the seeds in solutions with varied concentrations of the active substance combined with solution filtration and gamma radiation. On the third day of the experiment, germination percentage, root and stem lengths were evaluated. At a high concentration (1,250 mg/50 mL) metronidazole behaved as a radiosensibilizer in the presence of radiation. Even at a low concentration (250 mg/50 mL; 750 mg/50 mL) and in the absence of radiation, metronidazole behaved as toxic substance.

Plasma hydroxy-metronidazole/ metronidazole ratio in hepatitis C virus-induced liver disease

Marchioretto,M.A.M.; Ecclissato,C.; Silva,C.M.F. da; Cassiano,N.M.; Calafatti,S.A.; Mendonça,S.; Ribeiro,M.L.; Bernasconi,G.C.R.; Degger,M.F.; Piovesan,H.; Pedrazzoli Jr.,J.
Fonte: Associação Brasileira de Divulgação Científica Publicador: Associação Brasileira de Divulgação Científica
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/03/2005 Português
Relevância na Pesquisa
37.4%
It has been suggested that the measurement of metronidazole clearance is a sensitive method for evaluating liver function. The aim of this study was to evaluate the usefulness of plasma hydroxy-metronidazole/metronidazole ratios as indicators of dynamic liver function to detect changes resulting from the various forms of chronic hepatitis C virus (HCV) infection. A total of 139 individuals were studied: 14 healthy volunteers, 22 healthy, asymptomatic, consecutive anti-HCV-positive HCV-RNA negative subjects, 81 patients with chronic hepatitis C (49 with moderate/severe chronic hepatitis and 34 with mild hepatitis), and 20 patients with cirrhosis of the liver. HCV status was determined by the polymerase chain reaction. Plasma concentrations of metronidazole and its hydroxy-metabolite were measured by reverse-phase high-performance liquid chromatography with ultraviolet detection in a blood sample collected 10 min after the end of a metronidazole infusion. Anti-HCV-positive HCV-RNA-negative individuals demonstrated a significantly reduced capacity to metabolize intravenously infused metronidazole compared to healthy individuals (0.0478 ± 0.0044 vs 0.0742 ± 0.0232). Liver cirrhosis patients also had a reduced plasma hydroxy-metronidazole/metronidazole ratio when compared to the other groups of anti-HCV-positive individuals (0.0300 ± 0.0032 vs 0.0438 ± 0.0027 (moderate/severe chronic hepatitis) vs 0.0455 ± 0.0026 (mild chronic hepatitis) and vs 0.0478 ± 0.0044 (anti-HCV-positive...

Randomized clinical trial comparing the efficacy of the vaginal use of metronidazole with a Brazilian pepper tree (Schinus) extract for the treatment of bacterial vaginosis

Leite,S.R.R.F.; Amorim,M.M.R.; Sereno,P.F.B.; Leite,T.N.F.; Ferreira,J.A.C.; Ximenes,R.A.A.
Fonte: Associação Brasileira de Divulgação Científica Publicador: Associação Brasileira de Divulgação Científica
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/03/2011 Português
Relevância na Pesquisa
37.25%
A 7.4% vaginal extract of the Brazilian pepper tree (Schinus terebinthifolius Raddi) was compared with 0.75% vaginal metronidazole, both manufactured by the Hebron Laboratory, for the treatment of bacterial vaginosis, used at bedtime for 7 nights. The condition was diagnosed using the combined criteria of Amsel and Nugent in two groups of 140 and 137 women, aged between 18 and 40 years. Intention-to-treat analysis was performed. Women were excluded from the study if they presented delayed menstruation, were pregnant, were using or had used any topical or systemic medication, presented any other vaginal infections, presented hymen integrity, or if they reported any history suggestive of acute pelvic inflammatory disease. According to Amsel’s criteria separately, 29 patients (21.2%) treated with the extract and 87 (62.1%) treated with metronidazole were considered to be cured (P < 0.001). According to Nugent’s score separately, 19 women (13.9%) treated with the extract and 79 (56.4%) treated with metronidazole were considered to be cured (P < 0.001). Using the two criteria together, the so-called total cure was observed in 17 women (12.4%) treated with the extract and in 79 women (56.4%) treated with metronidazole (P < 0.001). In conclusion...

Voltammetric Behaviour of Metronidazole at Mercury Electrodes

La-Scalea,Mauro A.; Serrano,Silvia H.P.; Gutz,Ivano G.R.
Fonte: Sociedade Brasileira de Química Publicador: Sociedade Brasileira de Química
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/01/1999 Português
Relevância na Pesquisa
37.25%
Metronidazole is the most important drug of the group of 5-nitroimidazoles and possesses toxicity to anaerobic micro-organisms DNA being the main target for their biological action. The mechanism of biological action of metronidazole is dependent upon the nitro group reduction process. The reduction of metronidazole is pH dependent in acid medium and four electrons are involved in the complete reduction to the hydroxylamine derivative. In aprotic medium the reduction of the metronidazole occurs in two steps, the first involving one electron to form the nitro radical and the second step involving three more electrons until the formation of the hydroxylamine derivative. In this paper the mechanism of reduction of metronidazole was studied by using the voltammetric techniques: d.c. polarography, differential pulse polarography and cyclic voltammetry using the mercury drop as the working electrode.

Toxic concentrations of metronidazole to Microcystis protocystis

Magalhães,SMS; Brêtas,CM; Brêtas,JM; Pianetti,GA; Franco,MW; Barbosa,FAR
Fonte: Instituto Internacional de Ecologia Publicador: Instituto Internacional de Ecologia
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/08/2014 Português
Relevância na Pesquisa
37.2%
Antimicrobials are among the most commonly used drugs and have become a class of contaminants with great environmental importance. Metronidazole is an antimicrobial used for the therapeutic management of several human diseases. The toxicity of antimicrobials on aquatic species may affect sensitive microorganisms and reduce metabolic processes. Cyanobacteria is a group of organisms that are of great ecological importance in aquatic environments. Studies indicate that cyanobacteria are very sensitive to some antimicrobials. Therefore, it is necessary to evaluate the effects of metronidazole contamination on phytoplankton. The aim of this study was to investigate the effects of metronidazole on the growth of the cyanobacterium Microcystis protocystis and to evaluate the stability of this antimicrobial agent in the culture medium over a period of 96 hours. M. protocystis was resistant to growth inhibition by metronidazole. The EC50 of this antimicrobial for M. protocystis was 117.3 mg L–1. Under the growth inhibition test conditions, neither a significant change in the MNZ concentration nor the presence of drug metabolites or degradation products was observed. These results indicate low cellular uptake of the antimicrobial agent and its persistence in the culture medium.

Systemic use of metronidazole in the treatment of chronic periodontitis: a pilot study using clinical, microbiological, and enzymatic evaluation

Vergani,Solange Alonso; Silva,Emílio Barbosa e; Vinholis,Adriana Helena; Marcantonio,Rosemary Adriana Chiérici
Fonte: Sociedade Brasileira de Pesquisa Odontológica - SBPqO Publicador: Sociedade Brasileira de Pesquisa Odontológica - SBPqO
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/06/2004 Português
Relevância na Pesquisa
37.2%
The aim of the present parallel, double-blind investigation was to evaluate the effect of using systemic metronidazole alone or associated to scaling and root planing on adult chronic periodontal disease, monitored at baseline, 30, 60 and 90 days. Twelve subjects were divided into three groups: the first group (Group I - 22 sites) was submitted to scaling and root planing (SRP) alone; the second group (Group II - 30 sites) received SRP and 250 mg of metronidazole (3 times a day for 10 days), and the third group (Group III - 31 sites) was treated with metronidazole alone. The clinical parameters evaluated were probing depth (PD), clinical attachment level (CAL), plaque index (PlI), gingival index (GI) and bleeding upon probing (BP). Microbiological (BANA test) and enzymatic (Pocket Watch) tests were also performed. All three proposed treatments produced significant improvements in clinical conditions of subjects, from baseline, 30, 60 and 90-day period, except for clinical attachment level. The results obtained by microbiological and enzymatic tests did not show statistical differences among the groups for the 90-day period (r = 0.7924 and r = 0.7757, respectively). In relation to clinical parameters, statistical differences among groups were observed only for the gingival index (p = 0.0261) between Groups I and II...

Metronidazole-containing gel for the treatment of periodontitis: an in vivo evaluation

Sato,Sandra; Fonseca,Maria José Vieira; Ciampo,José Orestes Del; Jabor,José Roberto; Pedrazzi,Vinícius
Fonte: Sociedade Brasileira de Pesquisa Odontológica - SBPqO Publicador: Sociedade Brasileira de Pesquisa Odontológica - SBPqO
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/06/2008 Português
Relevância na Pesquisa
37.29%
The aim of this investigation was to monitor metronidazole concentrations in the gingival crevicular fluid (GCF) collected from periodontal pockets of dogs after treatment with an experimental 15% metronidazole gel. Five dogs had periodontitis induced by cotton ligatures placed subgingivally and maintained for a 30-day period. After the induction period, only pockets with 4 mm or deeper received the gel. Each pocket was filled up to the gingival margin by means of a syringe with a blunt-end needle. GCF was collected in paper strips and quantified in an electronic device before and after 15 minutes, 1 h, 6 h, 24 h and 48 h of gel administration. The GCF samples were assayed for metronidazole content by means of a high performance liquid chromatography method. Concentrations of metronidazole in the GCF of the 5 dogs (mean ± SD, in µg/mL) were 0 ± 0 before gel application and 47,185.75 ± 24,874.35 after 15 minutes, 26,457.34 ± 25,516.91 after 1 h, 24.18 ± 23.11 after 6 h, 3.78 ± 3.45 after 24 h and 3.34 ± 5.54 after 48 h. A single administration of the 15% metronidazole gel released the drug in the GCF of dogs in levels several-fold higher than the minimum inhibitory concentration for some periodontopathogens grown in subgingival biofilms for up to one hour...

A meta-analysis of metronidazole and vancomycin for the treatment of Clostridium difficile infection, stratified by disease severity

Di,Xiuzhen; Bai,Nan; Zhang,Xin; Liu,Bin; Ni,Wentao; Wang,Jin; Wang,Kai; Liang,Beibei; Liu,Youning; Wang,Rui
Fonte: Brazilian Society of Infectious Diseases Publicador: Brazilian Society of Infectious Diseases
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/08/2015 Português
Relevância na Pesquisa
37.33%
The aim of this meta-analysis was to compare the efficacy of metronidazole and vancomycin for the treatment of Clostridium difficileinfection, especially to investigate which agent was superior for treating either mild or severe C. difficileinfection. A meta-analysis of randomized controlled trials and cohort studies identified in Pubmed, Embase, and the Cochrane Library was conducted. Four randomized controlled trials and two cohort studies involving 1218 patients were included in this meta-analysis. Metronidazole was inferior to vancomycin for treating C. difficileinfection in terms of both initial clinical cure rates (risk ratio, RR = 0.91, 95% confidence interval, CI = 0.84-0.98, p= 0.02) and sustained cure rates (RR = 0.88, 95% CI = 0.82-0.96, p= 0.003). For mild C. difficileinfection, the efficacy of metronidazole and vancomycin resulted in similar clinical cure rates (RR = 0.94, 95% CI = 0.84-1.04, p= 0.21) and sustained cure rates (RR = 0.93, 95% CI = 0.83-1.05, p= 0.26). For severe C. difficileinfection the efficacy of vancomycin was superior to metronidazole in terms of clinical cure rates (RR = 0.81, 95% CI = 0.69-0.95, p= 0.009), whereas sustained cure rates were similar (RR = 0.86...

Association of calcium hydroxide and metronidazole in the treatment of dog's teeth with chronic periapical lesion

Panzarini,Sônia Regina; Souza,Valdir; Holland,Roberto; Dezan Júnior,Eloi
Fonte: Faculdade De Odontologia De Bauru - USP Publicador: Faculdade De Odontologia De Bauru - USP
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/10/2006 Português
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37.29%
One of the primary objectives of endodontic treatment of teeth with pulp necrosis is the elimination of microorganisms from the root canal system, as effectively as possible, especially in cases with chronic periapical lesions. AIM: The purpose of this study was to analyze the response of the periapical tissue of dogs' teeth with chronic periapical lesions to endodontic treatment performed with utilization of metronidazole, calcium hydroxide, and an association of both as root canal dressings. METHODOLOGY: Forty root canals were submitted to pulpectomy and the root canals were kept exposed to the oral environment for 6 months. Then, they were submitted to biomechanical preparation and divided into 4 study groups with 10 specimens: group I - no root canal dressing; group II - calcium hydroxide; group III - metronidazole; group IV - calcium hydroxide associated to metronidazole. After 15 days, the root canals were filled with Fill Canal sealer. After 90 days, the animals were killed and the especimens processed for histological analysis. RESULTS: Calcium hydroxide dressing provided a significantly better outcome compared to other experimental groups (alpha = 0.01). Also, the results of the association of metronidazole and calcium hydroxide were similar to those observed for the metronidazole group. The worst results were obtained by the no root canal dressing group. CONCLUSION: The use of metronidazole alone or associated with Calcium hydroxide...

Associação do hidróxido de cálcio e metronidazol no tratamento de dentes de cães com lesão periapical crônica; Association of calcium hydroxide and metronidazole in the treatment of dog's teeth with chronic periapical lesion

Panzarini, Sônia Regina; Souza, Valdir; Holland, Roberto; Dezan Júnior, Eloi
Fonte: Universidade de São Paulo. Faculdade de Odontologia de Bauru Publicador: Universidade de São Paulo. Faculdade de Odontologia de Bauru
Tipo: info:eu-repo/semantics/article; info:eu-repo/semantics/publishedVersion; ; Formato: application/pdf
Publicado em 01/10/2006 Português
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Um dos principais objetivos do tratamento endodôntico de dentes com polpa necrosada é a eliminação máxima possível dos microrganismos presentes no sistema de canal radicular, principalmente nos casos que apresentam lesões periapicais crônicas. OBJETIVO: O presente trabalho teve como objetivo analisar a resposta dos tecidos periapicais de dentes de cães com lesão periapical crônica ao tratamento endodôntico utilizando como curativo de demora o metronidazol, o hidróxido de cálcio e a associação das duas substâncias. METODOLOGIA: Foram empregados 44 canais radiculares de 2 cães adultos, portadores de lesão periapical crônica induzida experimentalmente. Após o preparo biomecânico os dentes foram divididos em quatro grupos experimentais de acordo com o curativo de demora empregado: Grupo I - controle - sem curativo de demora; Grupo II - hidróxido de cálcio; Grupo III - associação de hidróxido de cálcio e metronidazol e Grupo IV - metronidazol. Após 15 dias todos os canais foram obturados com cimento Fill Canal e passados 90 dias os animais foram sacrificados. RESULTADOS: Os dados obtidos evidenciaram que o hidróxido de cálcio apresentou resultado superior aos demais tratamentos, com diferença estatísticamente significante (alfa = 0.01) e o metronidazol resultado semelhante à associação do hidróxido de cálcio com o metronidazol. Os piores resultados foram obtidos pelo grupo sem curativo de demora. CONCLUSÃO: O uso de metronidazol ou da sua associação com hidróxido de cálcio...

Efficacy of metronidazole versus placebo in pain control after hemorrhoidectomy: results of a controlled clinical trial

Solorio-López,Sergio; Palomares-Chacón,Ulises Rodrigo; Guerrero-Tarín,Jesús Enrique; González-Ojeda,Alejandro; Cortés-Lares,José Antonio; Rendón-Félix,Jorge; García-Rentería,Jesús; Chávez-Tostado,Mariana; Cuesta-Márquez,Lizbeth; Salazar-Parr
Fonte: Revista Española de Enfermedades Digestivas Publicador: Revista Española de Enfermedades Digestivas
Tipo: info:eu-repo/semantics/article; journal article; info:eu-repo/semantics/publishedVersion Formato: text/html; application/pdf
Publicado em 01/11/2015 Português
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Introduction: Hemorrhoidal disease occurs in 50% of people aged > 40 years and is the most common reason for anorectal surgery. Pain is the main complication. Multiple topical and systemic drugs have been investigated for pain control, but there is no ideal treatment. Metronidazole has been shown to decrease postoperative pain but is not used widely. Objective: To evaluate the effect of oral metronidazole versus placebo and to assess postoperative pain following hemorrhoidectomy. Material and methods: Controlled clinical trial in adult patients who underwent elective hemorrhoidectomy for grade III/IV hemorrhoids. Patients were assigned to receive metronidazole (500 mg q8 h orally; study group, SG) or placebo (control group, CG) for 7 days after surgery. Pain was assessed using a visual analog scale after surgery. Analgesic administration (time and use of analgesics) and resumption of daily life activities were also assessed. Results: Forty-four patients were included, 22 in each group. Postoperative pain differed significantly between the SG and CG at 6 h (3.86 ± 0.56, 6.64 ± 1.49), 12 h (5.59 ± 1.33, 8.82 ± 0.79), 24 h (6.86 ± 1.49, 9.73 ± 0.45), day 4 (5.32 ± 2.10, 9.50 ± 0.59), day 7 (3.14 ± 1.03, 7.36 ± 1.39), and day 14 (2.14 ± 0.46...