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Vírus respiratório sincicial humano em crianças hospitalizadas por infecções agudas das vias aéreas inferiores; Human respiratory syncytial virus in children hospitalized for acute lower respiratory infection

SALOMÃO JUNIOR, João B; GARDINASSI, Luiz G. A; SIMAS, Paulo V. M; BITTAR, Cintia O; SOUZA, Fátima P; RAHAL, Paula; ZANETTA, Dirce M. T
Fonte: Sociedade Brasileira de Pediatria Publicador: Sociedade Brasileira de Pediatria
Tipo: Artigo de Revista Científica
Português
Relevância na Pesquisa
56.12%
OBJETIVO: Avaliar a prevalência e a sazonalidade do vírus respiratório sincicial humano (VRSH) em crianças de 0 a 6 anos hospitalizadas por infecção aguda das vias aéreas inferiores (IVAI) em São José do Rio Preto (SP) e a associação entre faixa etária, diagnóstico e VRSH. MÉTODOS: Entre maio de 2004 e setembro de 2005, foram estudados 290 episódios consecutivos de IVAI adquiridos na comunidade em crianças de 0 a 6 anos internadas no Hospital de Base de São José do Rio Preto. Para identificação do VRSH, foram coletadas amostras de secreção de nasofaringe e realizou-se análise molecular por meio da técnica de RT-PCR. RESULTADOS: A prevalência de VRSH foi de 29,3% nos episódios de IVAI hospitalizados. A IVAI foi frequente em lactentes (mediana de idade = 13,5 meses). O VRSH foi mais frequente nos casos de bronquiolite (64%) e no primeiro ano de vida (35%). Os episódios de infecção por VRSH ocorreram entre o outono e a primavera, com frequência maior em 2004 do que em 2005. Os critérios clínicos e radiológicos não foram suficientes para o diagnóstico de infecção pelo VRSH. Em 78,8% dos episódios de VRSH, houve tratamento com antibiótico. CONCLUSÕES: A prevalência do VRSH em crianças de 0 a 6 anos hospitalizadas por IVAI foi elevada...

Respiratory infection, exposure to mouse allergen and breastfeeding: role in recurrent wheezing in early life

RULLO, V.E.V; ARRUDA, L. K; CARDOSO, Maria Regina Alves; VALENTE, V.; ZAMPOLO, A. S.; NOBREGA, F; NASPITZ, C K; SOLÉ, D
Fonte: Basel Publicador: Basel
Tipo: Artigo de Revista Científica
Português
Relevância na Pesquisa
66.07%
Background: Environmental factors may influence the development of allergen sensitization and asthma. The aim of this study was to evaluate the role of endotoxin and allergen exposure in early life as a risk factor for recurrent wheezing. Methods: One hundred and four infants from low-income families, at high risk of asthma, were enrolled at birth. Dust samples were collected from the bedding and bedroom floor within 6 months after birth. Recurrent wheezing was defined as 3 or more wheezing episodes in the past year. Endotoxin was determined by Limulus amebocyte lysate assay, and major indoor allergens were quantitated by ELISA in dust extracts. IgE antibodies were measured by ImmunoCAP at 30 months of age. Results: At 30 months, 51 of the 99 infants who completed the study (51.5 per cent) had recurrent wheezing. Respiratory infection was strongly associated with recurrent wheezing (OR 6.67, 95 per cent CI 1.96-22.72), whereas exclusive breastfeeding for at least 1 month was a protective factor (OR 0.09, 95 per cent CI 0.01-0.51). Exposure to high levels of mouse allergen was more frequent among non-recurrent wheezers, approaching significance (OR 0.12, 95 per cent CI 0.01-1.13; p = 0.064). None of the children were sensitized to mouse. Sensitization to mite was found in 26/90 (28.8 per cent) children...

Respiratory Infection, Exposure to Mouse Allergen and Breastfeeding: Role in Recurrent Wheezing in Early Life

RULLO, Vera E. V.; ARRUDA, L. Karla; CARDOSO, M. Regina; VALENTE, Vivien; ZAMPOLO, Alessandra S.; NOBREGA, Fernando; NASPITZ, Charles K.; SOLE, Dirceu
Fonte: KARGER Publicador: KARGER
Tipo: Artigo de Revista Científica
Português
Relevância na Pesquisa
66.07%
Background: Environmental factors may influence the development of allergen sensitization and asthma. The aim of this study was to evaluate the role of endotoxin and allergen exposure in early life as a risk factor for recurrent wheezing. Methods: One hundred and four infants from low-income families, at high risk of asthma, were enrolled at birth. Dust samples were collected from the bedding and bedroom floor within 6 months after birth. Recurrent wheezing was defined as 3 or more wheezing episodes in the past year. Endotoxin was determined by Limulus amebocyte lysate assay, and major indoor allergens were quantitated by ELISA in dust extracts. IgE antibodies were measured by ImmunoCAP at 30 months of age. Results: At 30 months, 51 of the 99 infants who completed the study (51.5%) had recurrent wheezing. Respiratory infection was strongly associated with recurrent wheezing (OR 6.67, 95% CI 1.96-22.72), whereas exclusive breastfeeding for at least 1 month was a protective factor (OR 0.09, 95% CI 0.01-0.51). Exposure to high levels of mouse allergen was more frequent among non-recurrent wheezers, approaching significance (OR 0.12, 95% CI 0.01-1.13; p=0.064). None of the children were sensitized to mouse. Sensitization to mite was found in 26/90 (28.8%) children...

Duration of day-care attendance and acute respiratory infection; Tempo de permanência na creche e infecção respiratória aguda

Fuchs, Sandra Cristina Pereira Costa; Maynart, Rita de Cassia; Costa, Lenara Ferreira da; Cardozo, Adriana; Schierholt, Rejane Cristina
Fonte: Universidade Federal do Rio Grande do Sul Publicador: Universidade Federal do Rio Grande do Sul
Tipo: Artigo de Revista Científica Formato: application/pdf
Português
Relevância na Pesquisa
66.07%
A freqüência à creche associa-se com maior número de episódios de infecção respiratória e hospitalizações. Além da creche, a idade, a presença de irmãos e a aglomeração do ambiente são outras características identificadas como fatores de risco. Neste estudo investigou-se a associação entre infecção aguda do trato respiratório (IRA) e o número de horas que a criança permanecia na creche. Investigou-se a prevalência de IRA entre crianças freqüentadoras da creche e entre aquelas cuidadas em casa através de um estudo transversal. Selecionou-se a amostra entre filhos de funcionários de um hospital com disponibilidade de creche. Infecção respiratória foi definida pela presença de pelo menos dois sinais ou sintomas ocorridos nas duas últimas semanas. Crianças expostas à creche por 12 a 50 horas semanais apresentaram um risco aproximadamente três a cinco vezes maior de ter uma infecção respiratória aguda. Este efeito mostrou-se independente do nível sócio-econômico dos pais, da presença de irmãos e da idade da criança. Outros estudos caracterizaram o risco decorrente da exposição à creche, contudo neste detectou-se o efeito relacionado a permanência prolongada. Alternativas como as creches familiares americanas são pouco difundidas em nosso meio...

Human respiratory syncytial virus in children hospitalized for acute lower respiratory infection

Salomão Junior, João Batista; Gardinassi, Luiz G. A.; Simas, Paulo V. M.; Bittar, Cintia O.; Souza, Fátima Pereira de; Rahal, Paula; Zanetta, Dirce M. T.
Fonte: Sociedade Brasileira de Pediatria Publicador: Sociedade Brasileira de Pediatria
Tipo: Artigo de Revista Científica Formato: 219-224
Português
Relevância na Pesquisa
56.12%
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP); Processo FAPESP: 04/06883-2; Objective: To evaluate the prevalence and seasonality of human respiratory syncytial virus (HRSV) in children aged 0 to 6 years, hospitalized with acute lower respiratory infection (ALRI) in Sao Jose do Rio Preto, SP, Brazil, and the association between age, diagnosis, and HRSV.Methods: Between May 2004 and September 2005, we studied 290 consecutive episodes of community-acquired ALRI in children aged 0 to 6 years admitted to the Hospital de Base of Sao Jose do Rio Preto. In order to detect HRSV, nasopharyngeal secretion samples were collected and RT-PCR molecular analysis was performed.Results: The HRSV prevalence was 29.3% for the cases of hospitalized patients with ALRI. ALRI was common in infants (median age = 13.5 months). HRSV was more frequent in cases of bronchiolitis (64%) and during the first year of life (35%). Episodes of HRSV infection occurred between fall and spring, showing higher frequency in 2004 than in 2005. Clinical and radiological criteria were not sufficient to establish the diagnosis of infection with HRSV. Antibiotic therapy was used in 78.8% of episodes of HRSV.Conclusions: There was a high prevalence of HRSV in children aged 0 to 6 years who were hospitalized for ALRI...

Analysis of Climatic Factors Impact on RSV Infection Distribution in Children Attending Childcare at Northwest Region of São Paulo, Brazil

Simas, Paulo Vitor Marques; Gardinassi, Luiz Gustavo Araujo; Nogueira, Felipe Cavassan; Bonfim, Caroline Measso; Gomes, Deriane Elias; Lacerda, Mauricio Nogueira; Durigon, Edison Luiz; Rahal, Paula; Souza, Fátima Pereira de
Fonte: Universidade Estadual Paulista Publicador: Universidade Estadual Paulista
Tipo: Artigo de Revista Científica Formato: 1-6
Português
Relevância na Pesquisa
56.07%
Respiratory syncytial virus (RSV) was detected in samples collected from children from 0 to 6 years of age with acute respiratory infection, attending public childcare on Northwest region of São Paulo, Brazil. RSV distribution was associated to seasonal climatic variables as temperature, rainfall and relative air humidity. We utilized samples of nasopharyngeal aspirate collected during the period of July 2003 to September 2005. RT-PCR was the chosen method for viral identification. Results showed that from the 817 samples (collected from 179 children), 7.7% (63/817) were RSV positive. In 2003, RSV was detected from July until October. In 2004, RSV infections occurred in March, May, June, July, October, November, and December. In 2005, RSV was detected in March, April, May, August, and September. RSV circulation patterns in childcare children showed seasonal distribution associated to decreases in temperature and relative air humidity. RSV was detected in childcare children as an important viral agent causing respiratory infections, with varying patterns of circulation into the cohort during the study period. Moreover, RSV distribution showed to be associated with the dry season on Northwest region of São Paulo, Brazil.

Outbreak of acute respiratory infection among infants in Lisbon, Portugal, caused by human adenovirus serotype 3 and a new 7/3 recombinant strain

Rebelo-de-Andrade, H; Pereira, C; Gíria, M; Prudêncio, E; Brito, MJ; Calé, E; Taveira, N
Fonte: American Society for Microbiology Publicador: American Society for Microbiology
Tipo: Artigo de Revista Científica
Publicado em //2010 Português
Relevância na Pesquisa
66.03%
Human adenoviruses (AdVs) typically cause mild illnesses in otherwise healthy hosts. We investigated a pediatric outbreak of acute respiratory infection with fatal outcomes that occurred in Lisbon, Portugal, in 2004. Biological specimens were collected from 83 children attending two nurseries, a kinesiotherapy clinic, and the household of a nanny. Adenovirus infection was confirmed in 48 children by PCR and virus isolation. Most (96%) isolates were classified as being of subspecies B1. Phylogenetic analysis of fiber and hexon gene sequences revealed that most infants were infected with AdV serotype 3 (AdV3) strains. Infants attending one nursery harbored a new recombinant strain containing an AdV serotype 7 hexon and serotype 3 fiber (AdV7/3). Both the AdV3 and the AdV7/3 strains caused fatal infections. Two different serotype 3 strains were circulating in Lisbon in 2004, and the new AdV7/3 recombinant type originated from only one of those strains. These results demonstrate that recombination leads to the emergence of new adenovirus strains with epidemic and lethal potential.

Human adenovirus detection among immunocompetent and immunocompromised patients presenting acute respiratory infection

Watanabe,Aripuana; Carraro,Emerson; Camargo,Clarice; Puerari,Diane; Guatura,Sandra; Granato,Celso; Bellei,Nancy
Fonte: Sociedade Brasileira de Medicina Tropical - SBMT Publicador: Sociedade Brasileira de Medicina Tropical - SBMT
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/04/2013 Português
Relevância na Pesquisa
66.09%
INTRODUCTION: Human adenoviruses (HAdV) play an important role in the etiology of severe acute lower respiratory infection, especially in immunocompromised individuals. The aim of the present study was detect the HAdV through different methods: direct fluorescence assay (DFA) and nested-polymerase chain reaction (PCR-nested) from patients with acute respiratory infection (ARI) up to 7 days of symptoms onset. METHODS: Samples (n=643) were collected from different risk groups during from 2001 to 2010: 139 adults attended in an Emergency Room Patients (ERP); 205 health care workers (HCW); 69 from Renal Transplant Outpatients (RTO); 230 patients in hematopoietic stem cell transplantation (HSCT) program. RESULTS: Among all patients (n=643) adenovirus was detected on 13.2% by DFA and/or PCR: 6/139 (4.3%) adults from ERP, 7/205 (3.4%) from HCW samples, 4/69 (5.8%) from RTO and 68/230 (29.5%) from HSCT patients. Nested PCR showed higher detection (10%) compared to DFA test (3.8%) (p < 0.001). HSCT patients presented significantly higher prevalence of HAdV infection. CONCLUSIONS: Adenovirus detection through nested-PCR assay was higher. However the inclusion of molecular method in laboratorial routine diagnostic should be evaluated considering the reality of each specific health service.

Duration of day-care attendance and acute respiratory infection

Fuchs,Sandra Costa; Maynart,Rita de Cássia; Costa,Lenara Ferreira da; Cardozo,Adriana; Schierholt,Rejane
Fonte: Escola Nacional de Saúde Pública Sergio Arouca, Fundação Oswaldo Cruz Publicador: Escola Nacional de Saúde Pública Sergio Arouca, Fundação Oswaldo Cruz
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/09/1996 Português
Relevância na Pesquisa
66.07%
Day-care attendance accounts for an increased frequency of acute respiratory infections (ARI), in numbers of both episodes and hospitalizations. In addition to day-care exposure, risk factors include age, siblings, and crowding. The purpose of this study was to investigate a possible association between duration of day-care exposure and ARI. A cross-sectional study was carried out to compared ARI rates for children exposed to day care and children cared for at home. Children with at least one parent working in a hospital were sampled from the hospital-run day-care center and those cared for at home. An acute respiratory infection was defined as the presence of two or more signs or symptoms in the previous two weeks. Children exposed to the day-care center for 12 to 50 hours a week had a three to five times greater risk of developing ARI than those staying at home. This risk was assessed independently, taking socioeconomic status, age, and number of siblings into account. Risk of respiratory illness and day-care attendance has been described elsewhere, but this study presents original findings related to duration of exposure. With a view towards reducing risk of ARI, improvements should be made in institutional day-care centers in Brazil...

Mask-wearing and respiratory infection in healthcare workers in Beijing, China

Yang,Peng; Seale,Holly; MacIntyre,C Raina; Zhang,Haiyan; Zhang,Zhen; Zhang,Yi; Wang,Xiaoli; Li,Xinyu; Pang,Xinghuo; Wang,Quanyi
Fonte: Brazilian Society of Infectious Diseases Publicador: Brazilian Society of Infectious Diseases
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/04/2011 Português
Relevância na Pesquisa
56.24%
OBJECTIVES: The aim of the study was to determine rates of mask-wearing, of respiratory infection and the factors associated with mask-wearing and of respiratory infection in healthcare workers (HCWs) in Beijing during the winter of 2007/2008. METHODS: We conducted a survey of 400 HCWs working in eight hospitals in Beijing by face to face interview using a standardized questionnaire. RESULTS: We found that 280/400 (70.0%) of HCWs were compliant with mask-wearing while in contact with patients. Respiratory infection occurred in 238/400 (59.5%) subjects from November, 2007 through February, 2008. Respiratory infection was higher among females (odds ratio [OR], 2.00 [95% confidence interval {CI}, 1.16-3.49]) and staff working in larger hospitals (OR, 1.72 [95% CI, 1.092.72]), but was lower among subjects with seasonal influenza vaccination (OR, 0.46 [95% CI, 0.280.76]), wearing medical masks (reference: cotton-yarn; OR, 0.60 [95% CI, 0.39-0.91]) or with good mask-wearing adherence (OR, 0.60 [95% CI, 0.37-0.98]). The risk of respiratory infection of HCWs working in low risk areas was similar to that of HCWs in high risk area. CONCLUSION: Our data suggest that female HCWs and staffs working in larger hospitals are the focus of prevention and control of respiratory infection in Beijing hospitals. Mask-wearing and seasonal influenza vaccination are protective for respiratory infection in HCWs; the protective efficacy of medical masks is better than that of cotton yarn ones; respiratory infection of HCWs working in low risk areas should also be given attention.

Dexamethasone for treatment of patients mechanically ventilated for lower respiratory tract infection caused by respiratory syncytial virus

van Woensel, J B M; van Aalderen, W M C; de Weerd, W; Jansen, N; van Gestel, J P J; Markhorst, D; van Vught, A J; Bos, A; Kimpen, J
Fonte: BMJ Group Publicador: BMJ Group
Tipo: Artigo de Revista Científica
Publicado em /05/2003 Português
Relevância na Pesquisa
56.07%
Background: A study was undertaken to evaluate the efficacy of dexamethasone in patients mechanically ventilated for lower respiratory infection caused by respiratory syncytial virus (RSV-LRTI).

Pesquisa de vírus respiratórios em crianças asmáticas (exacerbadas e não exacerbadas) e em crianças não asmáticas com sintomas de infecção respiratória aguda, em Goiânia-Goiás; Respiratory viruses research in asthmatic children (exacer-bated and non-exacerbated) and in non-asthmatic children with acute respiratory infection symptoms, Goiania-Goias

Costa, Lusmaia Damaceno Camargo
Fonte: Universidade Federal de Goiás; Brasil; UFG; Programa de Pós-graduação em Ciências da Saúde (FM); Faculdade de Medicina - FM (RG) Publicador: Universidade Federal de Goiás; Brasil; UFG; Programa de Pós-graduação em Ciências da Saúde (FM); Faculdade de Medicina - FM (RG)
Tipo: Tese de Doutorado Formato: application/pdf
Português
Relevância na Pesquisa
56.12%
Objective: to describe the prevalence of respiratory viruses in children with asthma during exacerbation and compare with those non-exacerbated and nonasthmatic children during acute respiratory infection. Methods: In this cross-sectional study nasopharyngeal aspirate/swab from children (4-14 years) was collected between August-2012 and August-2013 in a city (Goiânia) in Center-Brazil. There were 92 with exacerbated asthma (EA), 72 non-asthmatic with acute respiratory infection (ARI) in emergency room, and 61 non exacerbated asthmatic (NEA) treated in specialized clinics. The samples were tested to indirect immunofluorescence using the Respiratory Panel I (Chemicon. MA, USA) and RT-PCR kit rhinovirus. The study was approved by the ethics committee of the HC / UFG and statistical analysis performed with the SPSS v.20 software (SPSS Inc., Chicago, IL). The chi-square test was used to compare categorical variables and Kruskal-Wallis test to compare medians, pvalue< 0.05 was considered significant. Results: the sample consisted of 225 children, mostly male (59.5%) with median age of seven years. The viral prevalence was 91.1% and rhinovirus was the most commonly detected (67.6%), with no significant difference in incidence among all groups. Other viruses were identified: influenza A (13.2%)...

Parainfluenza virus as a cause of acute respiratory infection in hospitalized childrens

Pecchini,Rogério; Berezin,Eitan Naaman; Souza,Maria Cândida; Vaz-de-Lima,Lourdes de Andrade; Sato,Neuza; Salgado,Maristela; Ueda,Mirthes; Passos,Saulo Duarte; Rangel,Raphael; Catebelota,Ana
Fonte: Brazilian Society of Infectious Diseases Publicador: Brazilian Society of Infectious Diseases
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/08/2015 Português
Relevância na Pesquisa
56.16%
Background: Human parainfluenza viruses account for a significant proportion of lower respiratory tract infections in children.Objective: To assess the prevalence of Human parainfluenza viruses as a cause of acute respiratory infection and to compare clinical data for this infection against those of the human respiratory syncytial virus.Methods: A prospective study in children younger than five years with acute respiratory infection was conducted. Detection of respiratory viruses in nasopharyngeal aspirate samples was performed using the indirect immunofluorescence reaction. Length of hospital stay, age, clinical history and physical exam, clinical diagnoses, and evolution (admission to Intensive Care Unit or general ward, discharge or death) were assessed. Past personal (premature birth and cardiopathy) as well as family (smoking and atopy) medical factors were also assessed.Results: A total of 585 patients were included with a median age of 7.9 months and median hospital stay of six days. No difference between the HRSV+ and HPIV+ groups was found in terms of age, gender or length of hospital stay. The HRSV+ group had more fever and cough. Need for admission to the Intensive Care Unit was similar for both groups but more deaths were recorded in the HPIV+ group. The occurrence of parainfluenza peaked during the autumn in the first two years of the study.Conclusion: Parainfluenza was responsible for significant morbidity...

Outbreak of acute respiratory infection among infants in Lisbon, Portugal, caused by human adenovirus serotype 3 and a new 7/3 recombinant strain

Rebelo-de-Andrade, Helena; Pereia, C.; Giria, M.; Prudêncio, E.; Brito, M.J.; Calé, E.; Taveira, N.
Fonte: American Society for Microbiology Publicador: American Society for Microbiology
Tipo: Artigo de Revista Científica
Publicado em /04/2010 Português
Relevância na Pesquisa
66.03%
Human adenoviruses (AdVs) typically cause mild illnesses in otherwise healthy hosts. We investigated a pediatric outbreak of acute respiratory infection with fatal outcomes that occurred in Lisbon, Portugal, in 2004.Biological specimens were collected from 83 children attending two nurseries, a kinesiotherapy clinic, and the household of a nanny. Adenovirus infection was confirmed in 48 children by PCR and virus isolation. Most(96%) isolates were classified as being of subspecies B1. Phylogenetic analysis of fiber and hexon gene sequences revealed that most infants were infected with AdV serotype 3 (AdV3) strains. Infants attending one nursery harbored a new recombinant strain containing an AdV serotype 7 hexon and serotype 3 fiber (AdV7/3). Both the AdV3 and the AdV7/3 strains caused fatal infections. Two different serotype 3 strains were circulating in Lisbon in 2004, and the new AdV7/3 recombinant type originated from only one of those strains. These results demonstrate that recombination leads to the emergence of new adenovirus strains with epidemic and lethal potential; This research was funded by DGE of the European Commission (for the research project entitled Genomic inventory, forensic markers, and assessment of potential therapeutic and vaccine targets for viruses relevant in biological crime and terrorism...

Health transition research in the control of morbidity and mortality from acute respiratory infection.

Douglas, Robert M; D'ouza, Rennie
Fonte: Health Transition Centre, National Centre for Epidemiology and Population Health, The Australian National University Publicador: Health Transition Centre, National Centre for Epidemiology and Population Health, The Australian National University
Tipo: Artigo de Revista Científica Formato: 32218 bytes; application/pdf
Português
Relevância na Pesquisa
66.09%
The essence of health transition research is its multidisciplinary character and openness to broad theory. Theories of health transition provide the context in which classic epidemiological studies can, most effectively, contribute to population health improvement. Acute respiratory infections are a leading cause of morbidity in all countries, and a major cause of premature death in countries where mortality is high. The international ARI control program in childhood sponsored by the World Health Organization is built on conventional biomedical foundations. Health systems in Australia and Pakistan continue to be driven by this conventional model which has contributed to changes in mortality but probably not exclusively. A health transition approach forces us to step back, and place the gains of the biomedical model in a social and historical perspective. Using that perspective to move public health policy forward in the modern nation state requires adventurous lateral thinking. We review here the problem of acute respiratory infections in Australian and Pakistani children. In Australia, we focus on the large differences in respiratory infection severity and outcomes between Aboriginal children and Caucasians. We also draw attention to our current ignorance on what differentiates children who are prone to respiratory infections from those who are not. In Pakistan...

Clinical-epidemiological evaluation of respiratory syncytial virus infection in children attended in a public hospital in midwestern Brazil

Calegari,Tatiany; Queiroz,Divina A.O.; Yokosawa,Jonny; Silveira,Hélio L.; Costa,Lourenço F.; Oliveira,Thelma F.M.; Luiz,Lysa N.; Oliveira,Renata C.; Diniz,Francisco C.; Rossi,Lívia M.G.; Carvalho,Cláudio J; Lima,Ana Cláudia; Mantese,Orlando C
Fonte: Brazilian Society of Infectious Diseases Publicador: Brazilian Society of Infectious Diseases
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/04/2005 Português
Relevância na Pesquisa
56.11%
Respiratory syncytial virus (RSV) is responsible for annual respiratory infection outbreaks in infants and young children worldwide, frequently causing bronchiolitis and pneumonia. We evaluated clinical and epidemiological features of acute respiratory infections (ARIs) caused by respiratory syncytial virus (RSV) in children less than five years old. Nasopharyngeal aspirate samples from children with ARI symptoms, attended at the 'Hospital das Clínicas' - Federal University of Uberlândia, MG, Brazil, were collected and tested for RSV by the immunofluorescence assay (IFA). Patients' clinical and epidemiological data were also obtained. From April 2000 to June 2003, 317 nasopharyngeal samples were collected from children less than 54 months old. Seventy-six samples (24.0%) were positive for RSV, with 53% (40/76) obtained from male patients. Hospitalization occurred in 50% (38/76) of the cases, with an average period of 10.6 days, in most cases (87%, 33/38) occurring in children less than 12 months of age. Although an association between this age group and the presentation of more severe clinical symptoms was observed, such as bronchiolitis in 51% (27/53) of the patients and pneumonia in 19% (10/53), no patients died. RSV was found from February to August...

Bocavírus humano: características clínicas e epidemiológicas em crianças com sintomas respiratórios agudos.; Human bocavirus: clinical and epidemiological characteristics in children with acute respiratory symptoms.

Durigon, Giuliana Stravinskas
Fonte: Biblioteca Digitais de Teses e Dissertações da USP Publicador: Biblioteca Digitais de Teses e Dissertações da USP
Tipo: Tese de Doutorado Formato: application/pdf
Publicado em 15/09/2015 Português
Relevância na Pesquisa
56.09%
As infecções respiratórias agudas são responsáveis por elevados índices de morbimortalidade. Desde sua descoberta em 2005, foi relatada presença de bocavírus humano (HBoV) com prevalência variando de 1,5% a 19%. Durante o período de estudo foram detectadas 153 amostras positivas para HBoV (14%) de 1113 amostras coletadas, sendo sete HBoV positivos na unidade neonatal. O HBoV ocupou a terceira posição em frequência de vírus respiratórios detectados. As crianças positivas para HBoV eram mais velhas, utilizaram mais antibióticos e apresentaram o diagnóstico de pneumonia com maior frequência (independente da presença de outros vírus coinfectantes) do que as crianças negativas. O HBoV circulou ao longo de todos os meses, com maior prevalência entre maio a agosto. Houve uma elevada taxa de codetecção (84%) com os demais 20 vírus respiratórios pesquisados. A análise filogenética encontrou apenas HBoV1. Esse achado contribui para a consolidação do HBoV1 como causador de doença respiratória aguda.; It is well established that respiratory viruses are an important cause of hospitalizations in young children worldwide. Since its discovery in 2005, many authors have reported detection of human bocavirus (HBoV) in children with respiratory infection with prevalence varying from 1.5% to 19%. During the study period we detected HBoV in 153 samples (14%) from 1113-screened samples; seven were from the neonatal unit. HBoV was the third most frequently detected virus. Children infected with HBoV were significantly older...

Parental smoking and infant respiratory infection: How important is not smoking in the same room with the baby?

Blizzard, Leigh; Ponsonby, Anne-Louise; Dwyer, Terence; Venn, Alison; Cochrane, Jennifer
Fonte: American Public Health Association Publicador: American Public Health Association
Tipo: Artigo de Revista Científica
Português
Relevância na Pesquisa
56.09%
Objectives. We sought to quantify the effect of good smoking hygiene on infant risk of respiratory tract infection in the first 12 months of life. Methods. A cohort of 4486 infants in Tasmania, Australia, was followed from birth to 12 months of age for hospitalization with respiratory infection. Case ascertainment was 98.2%. Results. Relative to the infants of mothers who smoked postpartum but never in the same room with their infants, risk of hospitalization was 56% (95% confidence interval [Cl]=13%, 119%) higher if the mother smoked in the same room with the infant, 73% (95% Cl=18%, 157%) higher if the mother smoked when holding the infant, and 95% (95% Cl=28%, 298%) higher if the mother smoked while feeding the infant. Conclusions. Parents who smoke should not smoke with their infants present in the same room.

Rhinovirus detection by real-time RT-PCR in children with acute respiratory infection in Buenos Aires, Argentina

Marcone,Débora N; Videla,Cristina; Ricarte,Carmen; Carballal,Guadalupe; Vidaurreta,Santiago; Echavarría,Marcela
Fonte: Revista argentina de microbiología Publicador: Revista argentina de microbiología
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/12/2012 Português
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66.07%
Human rhinoviruses (HRV), the major cause of common colds, have a significant genetic diversity and are classified into 3 species (A, B, C) with more than 100 serotypes. HRV species C, described in 2006, can only be detected using molecular methods. The objectives of this paper were to adapt a real-time reverse transcription-polymerase chain reaction (RT-PCR) assay for HRV detection and to further determine the frequency of HRV in respiratory samples from children under 2 years of age, with acute respiratory infection (ARI), from Buenos Aires, Argentina. Two real-time RT-PCR assays amplifying the 207 base pair of the 5' non-coding region were compared. The original protocol includes locked nucleic acid analogues and a pyrimidine derivative in the forward primer, while the adapted protocol avoided those molecules. Of 67 respiratory samples, 17 (25.4 %) were positive with the original protocol, and 20 (29.9 %) with the adapted one. Discrepant results were confirmed by sequencing analysis. An expanded gold standard was defined to determine the performance of both assays, and was used to describe the clinical characteristics of positive patients. Better sensitivity and specificity were obtained with the adapted protocol. Considering the expanded gold standard...

Duration of day-care attendance and acute respiratory infection

Fuchs,Sandra Costa; Maynart,Rita de Cássia; Costa,Lenara Ferreira da; Cardozo,Adriana; Schierholt,Rejane
Fonte: Escola Nacional de Saúde Pública Sergio Arouca, Fundação Oswaldo Cruz Publicador: Escola Nacional de Saúde Pública Sergio Arouca, Fundação Oswaldo Cruz
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/09/1996 Português
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Day-care attendance accounts for an increased frequency of acute respiratory infections (ARI), in numbers of both episodes and hospitalizations. In addition to day-care exposure, risk factors include age, siblings, and crowding. The purpose of this study was to investigate a possible association between duration of day-care exposure and ARI. A cross-sectional study was carried out to compared ARI rates for children exposed to day care and children cared for at home. Children with at least one parent working in a hospital were sampled from the hospital-run day-care center and those cared for at home. An acute respiratory infection was defined as the presence of two or more signs or symptoms in the previous two weeks. Children exposed to the day-care center for 12 to 50 hours a week had a three to five times greater risk of developing ARI than those staying at home. This risk was assessed independently, taking socioeconomic status, age, and number of siblings into account. Risk of respiratory illness and day-care attendance has been described elsewhere, but this study presents original findings related to duration of exposure. With a view towards reducing risk of ARI, improvements should be made in institutional day-care centers in Brazil...