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Fine-needle aspiration biopsy of disseminated sporotrichosis: A case report

GERHARD, Rene; MOSCOSO, Patricia Carrasco de; GABBI, Tatiana Villas Boas; VALENTE, Neusa Yuriko Sakai
Fonte: WILEY-LISS Publicador: WILEY-LISS
Tipo: Artigo de Revista Científica
Português
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In this report, we describe a case of disseminated sporotrichosis that was diagnosed by fine-needle aspiration biopsy (FNAB). The cytologic smears exhibited a large number of macrophages, few polymorphonuclear neutrophils and numerous round or oval, sometimes elongated, isolated and scattered yeast-like structures localized extracellularly or inside macrophages. These structures were clearly visualized by Giemsa and Papanicolaou methods. Cultures from skin biopsy material revealed,fungal colonies which were subsequently identified as Sporothrix schenckii. The cytologic aspects, the correlation with histologic findings and the differential cytologic diagnosis were reviewed.

Avaliação da virulência e da resposta imune de diferentes espécies de Sporothrix sp. na esporotricose experimental; Immune response and virulence evaluation from different species of Sporothrix sp. in experimental sporotrichosis

Almeida, José Roberto Fogaça de
Fonte: Biblioteca Digitais de Teses e Dissertações da USP Publicador: Biblioteca Digitais de Teses e Dissertações da USP
Tipo: Dissertação de Mestrado Formato: application/pdf
Publicado em 27/11/2013 Português
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Esporotricose é uma micose subcutânea, causada principalmente pelo fungo Sporothrix schenckii e a nova espécie Sporothrix brasiliensis. Foi relatado na literatura que os camundongos infectados com a cepa de S. schenckii M-64 produziu uma resposta imune mista, em que o soro dos camundongos infectados reagiram apenas com uma glicoproteína de 70 kDa (gp70), identificada como importante fator de virulência. Assim o presente trabalho visa avaliar a importância à virulência e eficácia do anticorpo monoclonal P6E7 em outras cepas do complexo Sporothrix. Camundongos foram infectados com as cepas de S. schenckii (1099-18 e 15383) e S. brasiliensis (5110 e 17943). Cada 7 dias, o baço e fígado foram retirados para a análise do UFC e citocinas. Foi realizado western blot com o soro dos camundongos infectados e com anticorpo monoclonal P6E7 utilizando o exoantígenos das diferentes cepas. Foi realizado protocolo de tratamento com o anticorpo P6E7 nos camundongos infectados, para a avaliação da carga fúngica no baço e no fígado. Análise de citocinas mostrou que as cepas de S. schenckii induziram uma resposta mista Th1/Th2, entretanto nos camundongos infectados com as cepas de S. brasiliensis, não foi observada produção significativa de citocinas. No western blot realizado com exoantígenos das cepas de Sporothrix sp. foi observado diferentes componentes antigênicos...

Efficacy of terbinafine and itraconazole on a experimental model of systemic sporotrichosis

Meinerz, Ana Raquel Mano; Xavier, Melissa Orzechowski; Cleff, Marlete Brum; Madrid, Isabel Martins; Nobre, Márcia de Oliveira; Meireles, Mário Carlos Araújo; Mello, Joao Roberto Braga de
Fonte: Universidade Federal do Rio Grande do Sul Publicador: Universidade Federal do Rio Grande do Sul
Tipo: Artigo de Revista Científica Formato: application/pdf
Português
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Itraconazole is currently considered the drug of choice to treat the diverse clinical presentation of sporotrichosis. On the other hand terbinafine by virtue of its excellent in vitro activity is under comparative evaluation for its therapeutic potential for a wide range of fungal infections. In this study, our aim was to determine the in vivo efficacy of terbinafine and itraconazole on a experimental model of systemic sporotrichosis. 120 rats Wistar received an injection of 2x103 S. schenckii cells by via the lateral tail vein. After 3 days the animals were treated with terbinafine (250mg/kg) and itraconazole (100 mg/kg) and their respective diluents. In our model, terbinafine and itraconazole were effective in reducing the number of clinical lesions and positive organ cultures. There was statistical difference between the groups treated with the antifungals in relation to the control groups (p<0,05) concerning the clinical alterations, anatomic-pathological findings and in the positive organ cultures of the agent, being that the treated animals resulted in the absence and/or reduction of all the evaluated parameters. As for the treatments, terbinafine showed similar or higher activity that itraconazole in the evaluation of the testicle alteration (p=0...

Sucesso terapêutico da terbinafina em um caso de esporotricose; Sucessful treatment of terbinafine in a case of sporotrichosis

Heidrich, Daiane; Senter, Luciana; Silva, Patrícia Valente da; Stopiglia, Cheila Denise Ottonelli; Vettorato, Gerson; Scroferneker, Maria Lucia
Fonte: Universidade Federal do Rio Grande do Sul Publicador: Universidade Federal do Rio Grande do Sul
Tipo: Artigo de Revista Científica Formato: application/pdf; application/pdf
Português
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A esporotricose e uma infeccao subaguda ou cronica, causada por fungos pertencentes ao Complexo Sporothrix. Relato do caso: esporotricose de localizacao nasal foi tratada com iodeto de potassio e como nao se obteve sucesso, reiniciou-se o tratamento com associacao de iodeto de potassio e itraconazol. Porem, ocorreu nova recidiva. As culturas dos exames micologicos foram submetidas a ensaios de atividade antifungica in vitro para auxiliar no tratamento. A terbinafina foi o antifungico que apresentou melhores resultados, por isso, o tratamento foi reiniciado com este antifungico e, apos dois anos do termino do mesmo, nao recidivou. Adicionalmente, ambas as culturas foram comparadas por RAPD, obtendo padroes de fragmentos distintos, indicando que os isolados sao diferentes ou demonstrando um processo microevolutivo do microrganismo.; Sporotrichosis is a chronic subacute infection caused by fungi belonging to the Sporothrix Complex. In the present clinical case, nasal sporotrichosis was treated with potassium iodide. This was unsuccessful, and the treatment was restarted with a combination of potassium iodide and itraconazole. This however resulted in a further recurrence of the infection. The mycological cultures were tested in vitro for antifungal activity to assist in treatment. Terbinafine...

Esporotricose sistêmica experimental: Avaliação in vivo da β (1-3) glucana em associação ao itraconazol em modelo murino; Experimental systemic sporotrichosis: evaluation in vivo _ (1-3) glucan and in association to itraconazole in murine model

Martins, Anelise Afonso
Fonte: Universidade Federal do Rio Grande do Sul Publicador: Universidade Federal do Rio Grande do Sul
Tipo: Tese de Doutorado Formato: application/pdf
Português
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A esporotricose, micose subcutânea causada pelo fungo dimórfico Sporothrix schenckii, acomete o homem e várias espécies de animais, sendo os felinos domésticos a espécie mais comumente envolvida nos relatos zoonóticos da enfermidade. Considerando as dificuldades terapêuticas no tratamento da micose, incluindo toxicidade e o desenvolvimento de resistência aos antifúngicos disponíveis, o estudo objetivou avaliar a eficácia in vivo do imunomodulador (1-3) glucana e em associação ao Itraconazol no tratamento da esporotricose sistêmica experimental, além de avaliar a presença do S. schenckii na cavidade oral e a produção de óxido nítrico. Foram utilizados 96 ratos Wistar, machos, os quais foram divididos em seis grupos de 16 animais, sendo eles G1: 0,5mg de glucana previamente (três doses) e pós a inoculação; G2: 0,5 mg glucana pós inoculação; G3: grupo controle; G4: 0,5mg de glucana associada a 10mg/kg de itraconazol; G5: 10mg/kg de itraconazol; e grupo G6: duas doses de 0,5mg de glucana associado a 10mg/kg de itraconazol. Os animais foram inoculados com 0,1ml do inóculo fúngico pela via intraperitoneal e veia lateral da cauda, após uma semana iniciou-se o tratamento dos grupos, quando estes apresentavam sinais clínicos da enfermidade. Após acompanhamento clínico durante a cinco semanas de tratamento e isolamento do agente na cavidade oral dos animais...

Localized lymphatic sporotrichosis after fish-induced injury (Tilapia sp.)

Haddad, V; Miot, H. A.; Bartoli, L. D.; Cardoso, A. D.; De Camargo, RMP
Fonte: B I O S Scientific Publishers Ltd Publicador: B I O S Scientific Publishers Ltd
Tipo: Artigo de Revista Científica Formato: 425-427
Português
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Localized lymphatic sporotrichosis generally develops after the fungus Sporothrix schenckii is traumatically introduced into skin or mucosa by contaminated plant material. An 18-year-old male fisherman was injured by spines of the dorsal fin of a fish on the left third finger. The lesion became ulcerated, edematous and suppurative and did not respond to tetracycline and cephalexin. Fifteen days after the accident, a nodular lymphangitic pattern of swelling was observed. Histopathological findings and an intradermal test were suggestive of sporotrichosis and mycological cultures confirmed the diagnosis. The lesions resolved after oral treatment with potassium iodide. Sporotrichosis is a common subcutaneous mycosis in Brazil, and there is a previous report in the literature of this disease being acquired via trauma involving fish spines.

Human sporotrichosis: Transmitted by feline

Marques, Silvio Alencar; De Camargo, Rosangela Maria Pires; Haddad Jr., Vidai; Marques, Mariangela Esther Alencar; Franco, Sonia Regina Verdi Silva; Rocha, Noeme Souza
Fonte: Universidade Estadual Paulista Publicador: Universidade Estadual Paulista
Tipo: Artigo de Revista Científica Formato: 559-562
Português
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The authors present two cases of human sporotrichosis, the lymphangitic and the fixed cutaneous form, observed in the owners of an infected domestic cat. Feline sporotrichosis has been related with higher frequency and shows zoonotic significance due to inter and intraspecies transmission risk. This is thought to occur as consequence of the high number of fungi in cutaneous lesions of this animal species.

Sporotrichosis in an HIV-positive man with oral lesions: A case report

Fontes, Patrícia Campos; Kitakawa, Dárcio; Carvalho, Yasmin Rodarte; Brandão, Adriana Aigotti Haberbeck; Cabral, Luiz Antonio Guimaraẽs; Almeida, Janete Dias
Fonte: Universidade Estadual Paulista Publicador: Universidade Estadual Paulista
Tipo: Artigo de Revista Científica Formato: 648-650
Português
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Background: Sporotrichosis is a granulomatous fungal infection caused by Sporothrix schenckii, which frequently causes cutaneous or lymphocutaneous lesions and rarely has oral manifestations. Case: A 38-year-old, white, HIV-positive man complained of a 5.0-cm, symptomatic, ulcerated lesion with thin, superficial granulation in the soft palate extending to the uvula. Exfoliative cytology of this oral lesion showed chronic granulomatous inflammatory alterations and extracellular fungal structures consisting of periodic acid-Schiff-positive budding cells and spherical or elongated (cigar bodies) free spore forms. Conclusion: The clinical and cytologic findings allowed the diagnosis of sporotrichosis, demonstrating the importance of cytodiagnosis in fungal diseases. © The International Academy of Cytology.

Sporothrix schenckii and sporotrichosis

Lopes-Bezerra,Leila M.; Schubach,Armando; Costa,Rosane O.
Fonte: Academia Brasileira de Ciências Publicador: Academia Brasileira de Ciências
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/06/2006 Português
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For a long time sporotrichosis has been regarded to have a low incidence in Brazil; however, recent studies demonstrate that not only the number of reported cases but also the incidence of more severe or atypical clinical forms of the disease are increasing. Recent data indicate that these more severe forms occur in about 10% of patients with confirmed diagnosis. The less frequent forms, mainly osteoarticular sporotrichosis, might be associated both with patient immunodepression and zoonotic transmission of the disease. The extracutaneous form and the atypical forms are a challenge to a newly developed serological test, introduced as an auxiliary tool for the diagnosis of unusual clinical forms of sporotrichosis.

Cutaneous sporotrichosis treatment with potassium iodide: a 24 year experience in São Paulo state, Brazil

Yamada,Karin; Zaitz,Clarisse; Framil,Valéria Maria De Souza; Muramatu,Laura Hitomi
Fonte: Instituto de Medicina Tropical Publicador: Instituto de Medicina Tropical
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/04/2011 Português
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BACKGROUND: Sporotrichosis is a subacute or chronic disease caused by a dimorphic fungus, Sporothrix schenckii. The first and most traditional treatment is potassium iodide in satured solution (SSKI) used by DE BEURMANN in 1907. For its effectiveness, it is still used for cutaneous sporotrichosis. OBJECTIVE: To evaluate the treatment of cutaneous sporotrichosis with SSKI in relation to clinical cure, side effects, length of treatment and reactivation. METHODS: We conducted a retrospective analysis of medical records over a 24-year period (1981-2005). Patients of all ages who were treated in the hospital´s division of dermatology were included in the study providing that they had a positive culture of S. schenckii. Satured solution of potassium iodide (3 to 6g per day) was the treatment prescribed. For children, half of the dose was prescribed. RESULTS: The lymphocutaneous disease was prevalent, the cure rate was 94.7%, side effects were described in 5.5% of the cases, mean length of treatment was 3.5 months and possible reactivation was observed in 11.1%. CONCLUSION: SSKI is an effective drug, with many side effects, but with low frequency. Resolution was for maximum six months of treatment. SSKI has been found to be a very effective drug in this retrospective study of culture-proven cases of cutaneous and lymphocutaneous sporotrichosis. It should be used as first drug of choice especially in resource-limited settings.

Disseminated cutaneous sporotrichosis in a patient with AIDS: report of a case

Carvalho,Miriam Tomoko Mitsuno; Castro,Adriana Pinheiro de; Baby,Cristiane; Werner,Betina; Filus Neto,José; Queiroz-Telles,Flávio
Fonte: Sociedade Brasileira de Medicina Tropical - SBMT Publicador: Sociedade Brasileira de Medicina Tropical - SBMT
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/12/2002 Português
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We describe a case report of disseminated cutaneous sporotrichosis as the initial presentation of AIDS in a 24-year-old HIV-positive male patient. He presented multiple ulcerated skin lesions distributed over the face, thorax, legs and arms. Biopsy of one of the cutaneous lesions was suggestive of sporotrichosis and culture isolated Sporothrix schenckii. Itraconazole was started and the lesions progressively resolved after 15 days of medication. The patient was discharged with this medication but he did not return for follow-up. He died three months later in another hospital. Therapy of sporotrichosis in HIV-infected patients remains unclear and the response to therapy is variable. Itraconazole is highly concentrated in the skin and is one of the options for treatment of disseminated sporotrichosis.

The epidemiological scenario of feline sporotrichosis in Rio de Janeiro, State of Rio de Janeiro, Brazil

Pereira,Sandro Antonio; Gremião,Isabella Dib Ferreira; Kitada,Amanda Akemi Braga; Boechat,Jéssica Sepulveda; Viana,Paula Gonçalves; Schubach,Tânia Maria Pacheco
Fonte: Sociedade Brasileira de Medicina Tropical - SBMT Publicador: Sociedade Brasileira de Medicina Tropical - SBMT
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/06/2014 Português
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Introduction Sporotrichosis is a mycosis affecting both humans and animals. Within the context of the ongoing sporotrichosis epidemic in the State of Rio de Janeiro, Brazil, sick cats plays an important role in the zoonotic transmission. The aim of this study was to update the number of feline cases diagnosed at the Fundação Oswaldo Cruz (2005-2011). Methods The medical records of the cats followed were reviewed; the inclusion criterion was the isolation of Sporothrix spp. in culture. Results In total, 2,301 feline cases were identified. Conclusions These results should alert sanitary authorities to the difficulties associated with sporotrichosis control.

Immune reconstitution inflammatory syndrome in HIV and sporotrichosis coinfection: report of two cases and review of the literature

Lyra,Marcelo Rosandiski; Nascimento,Maria Letícia Fernandes Oliveira; Varon,Andréa Gina; Pimentel,Maria Inês Fernandes; Antonio,Liliane de Fátima; Saheki,Maurício Naoto; Bedoya-Pacheco,Sandro Javier; Valle,Antonio Carlos Francesconi do
Fonte: Sociedade Brasileira de Medicina Tropical - SBMT Publicador: Sociedade Brasileira de Medicina Tropical - SBMT
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/12/2014 Português
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We report 2 cases of patients with immune reconstitution inflammatory syndrome (IRIS) associated with cutaneous disseminated sporotrichosis and human immunodeficiency virus (HIV) coinfection. The patients received specific treatment for sporotrichosis. However, after 4 and 5 weeks from the beginning of antiretroviral therapy, both patients experienced clinical exacerbation of skin lesions despite increased T CD4+ cells (T cells cluster of differentiation 4 positive) count and decreased viral load. Despite this exacerbation, subsequent mycological examination after systemic corticosteroid administration did not reveal fungal growth. Accordingly, they were diagnosed with IRIS. However, the sudden withdrawal of the corticosteroids resulted in the recurrence of IRIS symptoms. No serious adverse effects could be attributed to prednisone. We recommend corticosteroid treatment for mild-to-moderate cases of IRIS in sporotrichosis and HIV coinfection with close follow-up.

Sporotrichosis: an emergent zoonosis in Rio de Janeiro

Barros,Mônica Bastos de Lima; Schubach,Tânia Maria Pacheco; Gutierrez Galhardo,Maria Clara; Schubach,Armando de Oliveira; Monteiro,Paulo Cezar Fialho; Reis,Rosani Santos; Zancopé-Oliveira,Rosely Maria; Lazéra,Márcia dos Santos; Cuzzi-Maya,Tullia; Bla
Fonte: Instituto Oswaldo Cruz, Ministério da Saúde Publicador: Instituto Oswaldo Cruz, Ministério da Saúde
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/08/2001 Português
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During the period from 1987 to 1998, 13 cases of human sporotrichosis were recorded at the Research Center Evandro Chagas Hospital (CPqHEC) in Rio de Janeiro. Two of these patients related scratch by a sick cat. During the subsequent period from July 1998 to July 2000, 66 human, 117 cats and 7 dogs with sporotrichosis were diagnosed at the CPqHEC. Fifty-two humans (78.8%) reported contact with cats with sporotrichosis, and 31 (47%) of them reporting a history of a scratch or bite. This epidemic, unprecedented in the literature, involving cats, dogs and human beings may have started insidiously before 1998.

Molecular identification of Sporothrix species involved in the first familial outbreak of sporotrichosis in the state of Espírito Santo, southeastern Brazil

Oliveira,Manoel Marques Evangelista; Maifrede,Simone Bravim; Ribeiro,Mariceli Araújo; Zancope-Oliveira,Rosely Maria
Fonte: Instituto Oswaldo Cruz, Ministério da Saúde Publicador: Instituto Oswaldo Cruz, Ministério da Saúde
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/11/2013 Português
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Sporotrichosis is a widespread subcutaneous mycosis caused by the dimorphic fungi now known as the Sporothrix schenckii complex. This complex is comprised of at least six species, including Sporothrix albicans, Sporothrix brasiliensis, Sporothrix globosa, Sporothrix luriei, Sporothrix mexicana and S. schenckii. Cases of sporotrichosis have significantly increased in Brazil over the past decade, especially in the state of Rio de Janeiro (RJ), where an epidemic among cat owners has been observed. The zoonotic transmission from cats to humans suggests a common source of infection and indicates that animals can act as vectors. We performed a molecular characterisation of samples collected during the first outbreak of familial sporotrichosis caused by S. brasiliensis in the state of Espírito Santo, Brazil. These results represent the first description of such an outbreak outside the endemic area of zoonotic sporotrichosis in RJ.

Acute dacryocystitis: another clinical manifestation of sporotrichosis

Freitas,Dayvison Francis Saraiva; Lima,Iluska Augusta Rocha; Curi,Carolina Lemos; Jordão,Livia; Zancopé-Oliveira,Rosely Maria; Valle,Antonio Carlos Francesconi do; Galhardo,Maria Clara Gutierrez; Curi,Andre Luiz Land
Fonte: Instituto Oswaldo Cruz, Ministério da Saúde Publicador: Instituto Oswaldo Cruz, Ministério da Saúde
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/04/2014 Português
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Sporotrichosis associated with exposure to domestic cats is hyperendemic in Rio de Janeiro, Brazil. A review of the clinical records at our institute revealed four patients with clinical signs of dacryocystitis and a positive conjunctival culture for Sporothrix who were diagnosed with Sporothrix dacryocystitis. Three patients were children (< 13 years of age) and one patient was an adult. Two patients reported contact with a cat that had sporotrichosis. Dacryocystitis was associated with nodular, ulcerated lesions on the face of one patient and with granulomatous conjunctivitis in two patients; however, this condition manifested as an isolated disease in another patient. All of the patients were cured of the fungal infections, but three patients had chronic dacryocystitis and one patient developed a cutaneous fistula. Sporotrichosis is usually a benign disease, but may cause severe complications when the eye and the adnexa are affected. Physicians, especially ophthalmologists in endemic areas, should be aware of the ophthalmological manifestations and complications of sporotrichosis.

Efficacy of terbinafine and itraconazole on a experimental model of systemic sporotrichosis

Meinerz,Ana Raquel Mano; Xavier,Melissa O.; Cleff,Marlete Brum; Madrid,Isabel Martins; Nobre,Márcia Oliveira; Meireles,Mário Carlos Araújo; Mello,João Roberto Braga de
Fonte: Sociedade Brasileira de Microbiologia Publicador: Sociedade Brasileira de Microbiologia
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/12/2008 Português
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Itraconazole is currently considered the drug of choice to treat the diverse clinical presentation of sporotrichosis. On the other hand terbinafine by virtue of its excellent in vitro activity is under comparative evaluation for its therapeutic potential for a wide range of fungal infections. In this study, our aim was to determine the in vivo efficacy of terbinafine and itraconazole on a experimental model of systemic sporotrichosis. 120 rats Wistar received an injection of 2x10³ S. schenckii cells by via the lateral tail vein. After 3 days the animals were treated with terbinafine (250mg/kg) and itraconazole (100 mg/kg) and their respective diluents. In our model, terbinafine and itraconazole were effective in reducing the number of clinical lesions and positive organ cultures. There was statistical difference between the groups treated with the antifungals in relation to the control groups (p<0,05) concerning the clinical alterations, anatomic-pathological findings and in the positive organ cultures of the agent, being that the treated animals resulted in the absence and/or reduction of all the evaluated parameters. As for the treatments, terbinafine showed similar or higher activity that itraconazole in the evaluation of the testicle alteration (p=0...

Recurrence of sporotrichosis in cats with zoonotic involvement

Nobre, M??rcia de Oliveira; Castro, Angela P??tter de; Caetano, Dilma; Souza, Lorena Leonardo de; Meireles, M??rio Carlos Ara??jo; Ferreiro, Laerte
Fonte: Universidade Federal do Rio Grande Publicador: Universidade Federal do Rio Grande
Tipo: Artigo de Revista Científica
Português
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Este trabajo tuvo como objetivo describir la presencia de esporotricosis en una poblaci??n de gatos y en su propietaria. En mayo de 1997 fueron atendidos en una cl??nica veterinaria de la ciudad de Rio Grande (Estado de Rio Grande do Sul, Brasil), cuatro felinos que presentaban un estado caqu??ctico y lesiones ulcerativas en cabeza, nariz y miembros. Fueron recolectados exudados y costras para el diagn??stico microbiol??gico. La propietaria volvi?? a la cl??nica informando que otros 11 felinos presentaban lesiones semejantes a las anteriores y ella misma presentaba una lesi??n ulcerada en la mano y linfangitis ascendente, siendo recomendada su atenci??n m??dica y la toma de secreciones y costras de las lesiones. Las muestras recolectadas fueron cultivadas y se aisl?? Sporothrix schenckii. Tres a??os despu??s, la misma propietaria busc?? atenci??n veterinaria para otros siete gatos con lesiones similares a las descritas anteriormente, siendo de nuevo comprobada la presencia de S. schenckii. El tratamiento con yoduro de potasio fue efectivo para la cura de la esporotricosis humana, mientras que en los felinos el tratamiento fue efectivo solamente en un animal, teniendo efecto t??xico en los dem??s, los cuales sufrieron una progresi??n de la enfermedad o murieron. Se destaca la posibilidad de mantenimento del hongo S. schenckii en poblaciones de gatos por largos per??odos de tiempo.; The aim of this work is to describe the prevalence of the disease in the same cattery after three years...

Esporotricose óssea e cutânea em canino; Cutaneos and osseous sporotrichosis in dog

Madrid, Isabel Martins; Xavier, Melissa Orzechowski; Mattei, Antonella Souza; Carapeto, Luiz Paiva; Antunes, Tatiana de Ávila; Santos Júnior, Ronaldo; Nobre, Márcia de Oliveira; Meireles, Mário Carlos Araújo
Fonte: Universidade de São Paulo. Faculdade de Medicina Veterinária e Zootecnia Publicador: Universidade de São Paulo. Faculdade de Medicina Veterinária e Zootecnia
Tipo: info:eu-repo/semantics/article; info:eu-repo/semantics/publishedVersion; ; ; ; ; ; Formato: application/pdf
Publicado em 01/01/2007 Português
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A esporotricose é uma micose subcutânea causada pelo fungo dimórfico Sporothrix schenckii. Este artigo descreve o primeiro caso de esporotricose óssea e cutânea, em canino, na cidade de Pelotas, Rio Grande do Sul. O animal apresentava lesões ulceradas e crostosas, há aproximadamente três anos no plano nasal e membro torácico direito, dispnéia e apatia. Para confirmação do diagnóstico, foram realizados exames micológico, histopatológico, radiológico e hematológico. O animal foi tratado durante três meses com 10mg/kg de itraconazol, por via oral, obtendo-se a cura das lesões. Este estudo alerta clínicos de pequenos animais para a ocorrência desta micose em caninos na região de Pelotas, RS.; The sporotrichosis is a subcutaneous mycosis caused by dimorphic fungus Sporothrix schenckii. This article describes the first cutaneous and osseous sporotrichosis case in canine in the Pelotas city, Rio Grande do Sul. The animal presented crusts and ulcerated lesions, approximately the three years in the nasal plan and right hind-foot, dispneic and apathy. Mycological, histopathological, radiological and hematological diagnosis was realized. The animal was treated by three months with itraconazole, administered orally at a dosage of 10mg/kg...

Tratamento da esporotricose cutânea com sski: experiência de 24 anos no estado de São Paulo, Brasil.; Cutaneous sporotrichosis treatment with potassium iodide: a 24 year experience in São Paulo state, Brazil

Yamada, Karin; Zaitz, Clarisse; Framil, Valéria Maria De Souza; Muramatu, Laura Hitomi
Fonte: Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo Publicador: Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo
Tipo: info:eu-repo/semantics/article; info:eu-repo/semantics/publishedVersion; ; ; ; ; Formato: application/pdf
Publicado em 01/04/2011 Português
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FUNDAMENTOS: Esporotricose é doença subaguda ou crônica causada pelo fungo dimórfico Sporothrix schenckii. O primeiro e mais tradicional tratamento é o iodeto de potássio em solução saturada (SSKI) usado por De Beurmann em 1907. Por ser eficaz,ainda é muito utilizada no nosso meio para o tratamento da esporotricose cutânea. OBJETIVOS: Avaliar o tratamento da esporotricose cutânea com SSKI em relação à cura clínica, efeitos colaterais, tempo de tratamento e recidiva. MÉTODOS: A partir da revisão dos resultados de exames do laboratório de Micologia da Clínica de Dermatologia da Santa Casa de SP, durante 1981 a 2005, foram incluídos pacientes de qualquer idade com lesão cutânea sugestiva de esporotricose e cultura positiva para S. schenckii. Em todos pacientes o tratamento prescrito foi SSKI na dose de 3 a 6g/dia para adultos, por um período de até duas semanas após cura clínica. Em crianças foi utilizada a metade da dose. RESULTADOS: Houve predomínio da forma cutânea localizada, taxa de cura de 94,7%, efeitos colaterais em 5,5%, média de tempo de tratamento de 3,5 meses e 11,1% de provável recidiva. CONCLUSÃO: A SSKI é eficaz, com diversos efeitos colaterais, porém de baixa frequência, permanecendo indicada para as formas cutâneas da esporotricose.; BACKGROUND: Sporotrichosis is a subacute or chronic disease caused by a dimorphic fungus...