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Obesity Decreases Time to Claudication and Delays Post-Exercise Hemodynamic Recovery in Elderly Peripheral Arterial Disease Patients

DIAS, Raphael Mendes Ritti; FORJAZ, Claudia Lucia de Moraes; CUCATO, Gabriel Grizzo; COSTA, Luis Augusto Riani; CAMARA, Lucas Caseri; WOLOSKER, Nelson; MARUCCI, Maria de Fatima Nunes
Fonte: KARGER Publicador: KARGER
Tipo: Artigo de Revista Científica
Português
Relevância na Pesquisa
56.44%
Background: Although obesity is usually observed in peripheral arterial disease (PAD) patients, the effects of the association between these diseases on walking capacity are not well documented. Objective: The main objectives of this study were to determine the effects of obesity on exercise tolerance and post-exercise hemodynamic recovery in elderly PAD patients. Methods: 46 patients with stable symptoms of intermittent claudication were classified according to their body mass index (BMI) into normal group (NOR) = BMI < 28.0 and obese or in risk of obesity group (OBE) = BMI >= 28.0. All patients performed a progressive graded treadmill test. During exercise, ventilatory responses were evaluated and pre- and post-exercise ankle and arm blood pressures were measured. Results: Exercise tolerance and oxygen consumption at total walking time were similar between OBE and NOR. However, OBE showed a lower claudication time (309 +/- 151 vs. 459 +/- 272 s, p = 0.02) with a similar oxygen consumption at this time. In addition, OBE presented a longer time for ankle brachial index recovery after exercise (7.8 +/- 2.8 vs. 6.3 +/- 2.6 min, p = 0.02). Conclusion: Obesity in elderly PAD patients decreased time to claudication, and delayed post-exercise hemodynamic recovery. These results suggest that muscle metabolic demand...

Efeito da ventilação assistida proporcional na capacidade ao exercício em pacientes com fibrose pulmonar idiopática; Effects of proportional assist ventilation on exercise capacity in idiopathic pulmonary fibrosis patients

Moderno, Eliana Vieira
Fonte: Biblioteca Digitais de Teses e Dissertações da USP Publicador: Biblioteca Digitais de Teses e Dissertações da USP
Tipo: Dissertação de Mestrado Formato: application/pdf
Publicado em 29/03/2007 Português
Relevância na Pesquisa
56.31%
O objetivo do presente estudo foi avaliar o efeito do suporte ventilatório com ventilação assistida proporcional (PAV) na capacidade ao exercício em pacientes com fibrose pulmonar idiopática (FPI). Dez pacientes foram submetidos a um teste cardiopulmonar de esforço máximo, prova de função pulmonar completa e 3 testes submáximos (60% da carga máxima): sem suporte ventilatório, com pressão positiva contínua nas vias aéreas (CPAP) e PAV. Foram avaliadas a capacidade de exercício, as adaptações cardiovasculares e ventilatórias e a percepção subjetiva de esforço. Uma amostra de lactato sanguíneo foi também obtida no repouso e no final do exercício. Nossos resultados mostram que a capacidade de exercício submáximo com suporte ventilatório PAV aumentou o tempo de exercício quando comparado com a CPAP e sem suporte ventilatório (respectivamente, 11,10±8,88 min, 5,60±4,74 e 4,50±3,84 min). O suporte ventilatório com PAV ocasionou uma menor demanda cardiovascular com redução do duplo produto e da freqüência cardíaca. Uma melhor oxigenação e uma menor percepção de esforço também foram observadas nos pacientes quando realizaram a atividade com PAV. Nossos resultados sugerem que o suporte ventilatório com PAV pode aumentar a tolerância ao exercício e reduzir a dispnéia em pacientes com fibrose pulmonar idiopática.; The objective of the present study was to evaluate the effect of ventilatory support using proportional assist ventilation (PAV) on exercise capacity in patients with idiopathic pulmonary fibrosis. Ten patients were submitted to a cardiopulmonary exercise testing...

Avaliação da musculatura estriada de membros inferiores na limitação funcional ao exercício em pacientes com hipertensão arterial pulmonar; Assessment of skeletal muscle of lower limb in functional exercise limitation in patients with pulmonary arterial hypertension

Breda, Ana Paula
Fonte: Biblioteca Digitais de Teses e Dissertações da USP Publicador: Biblioteca Digitais de Teses e Dissertações da USP
Tipo: Tese de Doutorado Formato: application/pdf
Publicado em 25/04/2011 Português
Relevância na Pesquisa
56.31%
Introdução: A hipertensão arterial pulmonar (HAP) é uma doença progressiva extremamente grave, que evolui com insuficiência cardíaca direita e morte. Apesar do avanço do tratamento farmacológico, o prognóstico permanece reservado com taxa de sobrevida de 86%, 70% e 55% em 1, 3 e 5 anos, respectivamente. A dispnéia progressiva e a intolerância ao exercício são as principais manifestações clínicas e refletem a falência do ventrículo direito. O músculo esquelético periférico parece ser também um dos principais determinantes desta limitação funcional, visto que a redução da oferta de oxigênio e alterações na extração/utilização do oxigênio pelo músculo são diretamente relacionados com a tolerância ao exercício. Existem dois mecanismos potencialmente envolvidos na regulação da oferta de oxigênio, e portanto, na capacidade de exercício: mecanismos centrais (função do coração, pulmão e sistema nervoso autônomo) e mecanismos periféricos (associado ao fluxo sanguíneo periférico e a função do músculo esquelético). Os pacientes com HAP geralmente apresentam baixo débito cardíaco e estado adrenérgico exacerbado. A combinação destas alterações pode resultar em alterações estruturais e funcionais da musculatura estriada periférica. Porém...

Efeito de um programa de treinamento físico aeróbio supervisionado em crianças com lúpus eritematoso sistêmico juvenil; Exercise training in childhood-onset systemic lupus erythematosus: a controlled randomized trial

Prado, Danilo Marcelo Leite do
Fonte: Biblioteca Digitais de Teses e Dissertações da USP Publicador: Biblioteca Digitais de Teses e Dissertações da USP
Tipo: Tese de Doutorado Formato: application/pdf
Publicado em 11/12/2013 Português
Relevância na Pesquisa
56.33%
INTRODUÇÃO: O treinamento físico é considerado como um importante recurso terapêutico no que concerne a melhora da disfunção física observada em adultos com lúpus eritematoso sistêmico. Entretanto, até o momento não há estudos longitudinais que avaliaram os possíveis efeitos terapêuticos de um programa de treinamento físico em crianças e adolescentes com lúpus eritematoso sistêmico juvenil (LES-J). OBJETIVO avaliar a segurança e a eficácia de um de um programa de treinamento físico aeróbio supervisionado de 12 semanas no aumento da capacidade cardiorrespiratória em pacientes com LES-J. MÉTODOS: Dezenove crianças e adolescentes com LES-J foram aleatoriamente randomizadas em dois grupos: treinamento físico aeróbio (LESJ TF, n=10; 12,9 + 2,3 anos) e grupo controle (LES-J C, n=9; 13,0 + 1,8 anos). Dez crianças saudáveis (CS) pareadas por idade e peso corporal foram recrutadas como controle. As crianças foram submetidas a um teste de esforço cardiorrespiratório máximo em esteira ergométrica antes e após 12 semanas de intervenção para determinação do consumo de oxigênio de pico (VO2pico), reserva cronotrópica (RC) e a frequência cardíaca de recuperação no primeiro (deltaFCR1) e segundo minuto (deltaFCR2) após exercício. RESULTADOS: Os pacientes com LES-J que não realizaram treinamento físico aeróbio não apresentaram alteração em qualquer dos parâmetros cardiorrespiratórios analisados (p > 0...

Efeitos da reabilitação cardiopulmonar sobre o tempo de tolerância ao exercício e a cinética do consumo de oxigênio em cardiopatas isquêmicos; Effects of cardiopulmonary rehabilitation in exercise tolerance time and oxygen kinetics in ischemic heart disease

Hossri, Carlos Alberto Cordeiro
Fonte: Biblioteca Digitais de Teses e Dissertações da USP Publicador: Biblioteca Digitais de Teses e Dissertações da USP
Tipo: Tese de Doutorado Formato: application/pdf
Publicado em 01/10/2014 Português
Relevância na Pesquisa
66.35%
Introdução: A reabilitação cardiopulmonar e metabólica (RCPM) é uma importante estratégia no tratamento da insuficiência cardíaca isquêmica. Entretanto, os seus principais mecanismos de melhora e as correlações com aumento na capacidade de exercício e menos sintomas ainda não estão totalmente esclarecidos. Objetivos: Investigar os efeitos de um programa multidisciplinar de RCPM sobre o tempo de tolerância ao esforço (TLim) e a resposta da fase rápida (fase II) da cinética do consumo de oxigênio (variável relacionada ao desempenho oxidativo muscular) em cardiopatas isquêmicos. Adicionalmente, avaliar as variáveis cardiovasculares, ventilatórias e metabólicas nos TCPE máximo (TRIM) e de endurance (TSCC), além da composição corporal pela bioimpedância elétrica, fração de ejeção (FE) e qualidade de vida. Métodos: Cento e seis pacientes com cardiopatia isquêmica encaminhados ao PRCPM foram submetidos ao TRIM em esteira rolante e, após intervalo de 1 a 7 dias, ao TSCC, com 80% da carga atingida no TRIM. Trinta e sete (37) pacientes foram excluídos, 31 por adesão < 50% às sessões de treinamento, 3 com IMC> 35kg.m-2 e 3 com FE<35%. Após 12 semanas de RCPM, 69 pacientes foram ressubmetidos aos mesmos testes e analisados os efeitos sobre o TLim...

Efeitos da respiração bucal e da projeção anterior da cabeça na força muscular respiratória e na capacidade de exercício em crianças e adolescentes; Effects of mouth breathing and forward head posture in the respiratory muscle strength and exercise capacity in children and adolescents

Renata Tiemi Okuro
Fonte: Biblioteca Digital da Unicamp Publicador: Biblioteca Digital da Unicamp
Tipo: Dissertação de Mestrado Formato: application/pdf
Publicado em 06/01/2012 Português
Relevância na Pesquisa
56.23%
Introdução: A respiração bucal em crianças é associada a alterações posturais. A principal compensação postural é a projeção anterior da cabeça. A diminuição da força muscular respiratória, menor expansibilidade torácica, prejuízo da ventilação pulmonar e repercussões na capacidade de exercício podem ser decorrentes destas alterações, tanto do modo respiratório como da postura. As relações entre estas variáveis são pouco exploradas na literatura. Objetivo: avaliar a tolerância ao exercício submáximo e a força muscular respiratória em relação à postura da cabeça e tipo respiratório (respiradores nasais-RN e respiradores bucais-RB) em crianças e adolescentes. Método: Estudo analítico transversal com grupo controle no qual foram incluídas crianças de 8 a 12 anos com diagnóstico clínico otorrinolaringológico de RB, recrutadas do Ambulatório do Respirador Bucal de um Hospital Universitário, no período de janeiro de 2010 a janeiro de 2011. Crianças obesas, asmáticas, com doenças respiratórias crônicas, distúrbios neurológicos, ortopédicos e cardiopatas foram excluídas. Todos os participantes foram submetidos à avaliação postural, medidas das pressões respiratórias máximas (pressão inspiratória máxima - PImáx e pressão expiratória máxima - PEmáx)...

Effect of L-carnitine on exercise performance in patients with mitochondrial myopathy

Gimenes,A.C.; Bravo,D.M.; Nápolis,L.M.; Mello,M.T.; Oliveira,A.S.B.; Neder,J.A.; Nery,L.E.
Fonte: Associação Brasileira de Divulgação Científica Publicador: Associação Brasileira de Divulgação Científica
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/04/2015 Português
Relevância na Pesquisa
56.37%
Exercise intolerance due to impaired oxidative metabolism is a prominent symptom in patients with mitochondrial myopathy (MM), but it is still uncertain whether L-carnitine supplementation is beneficial for patients with MM. The aim of our study was to investigate the effects of L-carnitine on exercise performance in MM. Twelve MM subjects (mean age±SD=35.4±10.8 years) with chronic progressive external ophthalmoplegia (CPEO) were first compared to 10 healthy controls (mean age±SD=29±7.8 years) before they were randomly assigned to receive L-carnitine supplementation (3 g/daily) or placebo in a double-blind crossover design. Clinical status, body composition, respiratory function tests, peripheral muscle strength (isokinetic and isometric torque) and cardiopulmonary exercise tests (incremental to peak exercise and at 70% of maximal), constant work rate (CWR) exercise test, to the limit of tolerance [Tlim]) were assessed after 2 months of L-carnitine/placebo administration. Patients with MM presented with lower mean height, total body weight, fat-free mass, and peripheral muscle strength compared to controls in the pre-test evaluation. After L-carnitine supplementation, the patients with MM significantly improved their Tlim (14±1.9 vs 11±1.4 min) and oxygen consumption ( V ˙ O 2 ) at CWR exercise...

Influence of noninvasive ventilation by BiPAP® on exercise tolerance and respiratory muscle strength in chronic obstructive pulmonary disease patients (COPD)

Costa,Dirceu; Toledo,Andreza; Silva,Audrey Borghi e; Sampaio,Luciana Maria Malosá
Fonte: Escola de Enfermagem de Ribeirão Preto / Universidade de São Paulo Publicador: Escola de Enfermagem de Ribeirão Preto / Universidade de São Paulo
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/06/2006 Português
Relevância na Pesquisa
66.32%
This study aimed to assess the effect of BiPAP®, by nasal mask, on exercise tolerance and respiratory muscle strength in patients with a clinical and spirometric diagnosis of moderate/severe COPD (FEV1 < 60% of predicted). Ten patients of 59.4±8.9 years old, with FEV1/FVC <70% of predicted level, were treated with 30 minutes of BiPAP® (IPAP:10 and 15 cmH2O; EPAP:4 cmH2O), three days per week, during two months. Before and after the treatment, spirometry, inspiratory (MIP) and expiratory (MEP) muscle strength and the distance walked in six minutes (6MWT) were measured. We observed a significant increase (Wilcoxon, p<0.05) in the mean values of MIP (from -55±17 to -77±19, respectively), MEP (from 75±20 to 109±36, respectively) and walking distance (from 349±67 to 448±75). Based on these results, we concluded that BiPAP® improves respiratory muscle strength and exercise tolerance in these COPD patients.

Noninvasive ventilation and exercise tolerance in heart failure: A systematic review and meta-analysis

Bündchen,Daiana C.; Gonzáles,Ana I.; Noronha,Marcos De; Brüggemann,Ana K.; Sties,Sabrina W.; Carvalho,Tales De
Fonte: Associação Brasileira de Pesquisa e Pós-Graduação em Fisioterapia Publicador: Associação Brasileira de Pesquisa e Pós-Graduação em Fisioterapia
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/10/2014 Português
Relevância na Pesquisa
56.3%
Background: Patients with heart failure (HF) usually develop exercise intolerance. In this context, noninvasive ventilation (NIV) can help to increase physical performance. Objective: To undertake a systematic review and meta-analysis of randomized controlled trials that evaluated the effects of NIV on exercise tolerance in patients with HF. Method: Search Strategy: Articles were searched in the following databases: Physiotherapy Evidence Database (PEDro), Scientific Electronic Library Online (SciELO), and MEDLINE. Selection Criteria: This review included only randomized controlled trials involving patients with HF undergoing NIV, with or without other therapies, that used exercise tolerance as an outcome, verified by the distance travelled in the six-minute walk test (6MWT), VO2peak in the cardiopulmonary test, time spent in testing, and dyspnea. Data Collection and Analysis: The methodological quality of the studies was rated according to the PEDro scale. Data were pooled in fixed-effect meta-analysis whenever possible. Results: Four studies were selected. A meta-analysis including 18 participants showed that the use of NIV prior to the 6MWT promoted increased distance, [mean difference 65.29 m (95% CI 38.80 to 91.78)]. Conclusions: The use of NIV prior to the 6MWT in patients with HF may promote increased distance. However...

Can bronchodilators improve exercise tolerance in COPD patients without dynamic hyperinflation?

Scuarcialupi,Maria Enedina Aquino; Berton,Danilo Cortozi; Cordoni,Priscila Kessar; Squassoni,Selma Denis; Fiss,Elie; Neder,José Alberto
Fonte: Sociedade Brasileira de Pneumologia e Tisiologia Publicador: Sociedade Brasileira de Pneumologia e Tisiologia
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/04/2014 Português
Relevância na Pesquisa
66.44%
OBJECTIVE: To investigate the modulatory effects that dynamic hyperinflation (DH), defined as a reduction in inspiratory capacity (IC), has on exercise tolerance after bronchodilator in patients with COPD. METHODS: An experimental, randomized study involving 30 COPD patients without severe hypoxemia. At baseline, the patients underwent clinical assessment, spirometry, and incremental cardiopulmonary exercise testing (CPET). On two subsequent visits, the patients were randomized to receive a combination of inhaled fenoterol/ipratropium or placebo. All patients then underwent spirometry and submaximal CPET at constant speed up to the limit of tolerance (Tlim). The patients who showed ΔIC(peak-rest) < 0 were considered to present with DH (DH+). RESULTS: In this sample, 21 patients (70%) had DH. The DH+ patients had higher airflow obstruction and lower Tlim than did the patients without DH (DH-). Despite equivalent improvement in FEV1 after bronchodilator, the DH- group showed higher ΔIC(bronchodilator-placebo) at rest in relation to the DH+ group (p < 0.05). However, this was not found in relation to ΔIC at peak exercise between DH+ and DH- groups (0.19 ± 0.17 L vs. 0.17 ± 0.15 L, p > 0.05). In addition...

Exercise capacity, respiratory mechanics and posture in mouth breathers

Okuro,Renata Tiemi; Morcillo,André Moreno; Sakano,Eulália; Schivinski,Camila Isabel Santos; Ribeiro,Maria Ângela Gonçalves Oliveira; Ribeiro,José Dirceu
Fonte: Associação Brasileira de Otorrinolaringologia e Cirurgia Cervicofacial Publicador: Associação Brasileira de Otorrinolaringologia e Cirurgia Cervicofacial
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/10/2011 Português
Relevância na Pesquisa
56.2%
Chronic and persistent mouth or oral breathing (OB) has been associated with postural changes. Although posture changes in OB causes decreased respiratory muscle strength, reduced chest expansion and impaired pulmonary ventilation with consequences in the exercise capacity, few studies have verified all these assumptions. OBJECTIVE: To evaluate exercise tolerance, respiratory muscle strength and body posture in oral breathing (OB) compared with nasal breathing (NB) children. MATERIAL AND METHOD: A cross-sectional contemporary cohort study that included OB and NB children aged 8-11 years old. Children with obesity, asthma, chronic respiratory diseases, neurological and orthopedic disorders, and cardiac conditions were excluded. All participants underwent a postural assessment, maximal inspiratory pressure (MIP), maximal expiratory pressure (MEP), the six-minute walk test (6MWT), and otorhinolaryngologic evaluation. RESULTS: There were 107 children (45 OB and 62 NB). There was an association between abnormal cervical posture and breathing pattern: 36 (80.0%) OB and 30 (48.4%) NB presented abnormal head posture (OR=4.27 [95% CI: 1.63-11,42], p<0.001). The mean MIP and MEP were lower in OB (p=0.003 and p=0.004). CONCLUSION: OB children had cervical spine postural changes and decreased respiratory muscle strength compared with NB.

Four weeks of blood flow restricted training increases time to exhaustion at severe intensity cycling exercise

Corvino,Rogério Bulhões; Oliveira,Mariana Fernandes Mendes de; Santos,Rafael Penteado dos; Denadai,Benedito Sérgio; Caputo,Fabrizio
Fonte: Universidade Federal de Santa Catarina Publicador: Universidade Federal de Santa Catarina
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/10/2014 Português
Relevância na Pesquisa
56.29%
The present study aimed to verify the effects of 4 weeks of low-intensity blood flow restricted (BFR) training on time to exhaustion (Tlim) at severe-intensity exercise. Thirteen physically active subjects (23 ± 3.4 years; 70.6 ± 7.8 kg; 170.9 ± 10 cm) were assigned to one of two groups: low-intensity interval training with (BFR, n=9) or without (CON, n=4) blood flow restricted. The interval training sessions consisted of 2 sets of 5-8 × 2-min intervals at 30% of peak power output (Ppeak) obtained during incremental exercise for LOW and BFR, separated by 1min of rest. For BFR a cuff was inflated (140-200mmHg) during the exercise bouts and deflated during rest intervals. The pressure was increased 20mmHg after three completed sessions, thus, in the last week the pressure applied was 200mmHg. Before and after 4 weeks intervention period, all subjects completed an incremental exercise until exhaustion and one-step transition to a severe-intensity work rate (110%Ppeak). The results revealed that BFR (Pre: 227 ± 44s vs. Post: 338 ± 76s), but not CON (Pre: 236 ± 24s vs. Post: 212 ± 26s), increase significantly Tlim at 110%Ppeak. It can be concluded that 4 weeks of BFR training, but not CON, increased the exercise tolerance at severe intensity domain. Therefore...

Glucose kinetics and exercise tolerance in mice lacking the GLUT4 glucose transporter

Fueger, Patrick T; Li, Candice Y; Ayala, Julio E; Shearer, Jane; Bracy, Deanna P; Charron, Maureen J; Rottman, Jeffrey N; Wasserman, David H
Fonte: Blackwell Science Inc Publicador: Blackwell Science Inc
Tipo: Artigo de Revista Científica
Português
Relevância na Pesquisa
56.39%
The absence of GLUT4 severely impairs basal glucose uptake in vivo, but does not alter glucose homeostasis or circulating insulin. Glucose uptake in isolated contracting skeletal muscle (MGU) is also impaired by the absence of GLUT4, and onset of muscle fatigue is hastened. Whether the body can compensate and preserve glucose homeostasis during exercise, as it does in the basal state, is unknown. One aim was to test the effectiveness of glucoregulatory compensation for the absence of GLUT4 in vivo. The absence of GLUT4 was also used to further define the role of hexokinase (HK) II, which catalyses glucose phosphorylation after it is transported in the cell. HK II increases MGU during exercise, as well as exercise endurance. In the absence of GLUT4, HK II expression will not affect MGU. A second aim was to test whether, in the absence of GLUT4, HK II retains its ability to increase exercise endurance. Wild-type (WT), GLUT4 null (GLUT4−/−), and GLUT4 null overexpressing HK II (GLUT4−/−HKTg) mice were studied using a catheterized mouse model that allows blood sampling and isotope infusions during treadmill exercise. The impaired capacity of working muscle to take up glucose in GLUT4−/− is partially offset by an exaggerated increase in the glucagon: insulin ratio...

Cardiorespiratory fitness adaptations to exercise in sedentary men

Clarke, Gregory John
Fonte: Quens University Publicador: Quens University
Tipo: Tese de Doutorado
Português
Relevância na Pesquisa
56.58%
Cardiorespiratory Fitness (CRF) classically measured by maximal oxygen consumption (VO2max), is a strong predictor of morbidity and mortality. However, there is substantial inter-individual variation in CRF response with exercise training. Several lines of evidence suggest that the measurement of CRF using VO2peak alone may be masking some of the submaximal cardiorespiratory adaptations, such as exercise tolerance, that occur as a result of regular physical activity. Our goal is to assess the relationship between changes in CRF and exercise tolerance in inactive men of varying age. We studied 25 inactive men between the ages of 30 and 60 years ([mean (SD)] age = 44.3 (9.1)) from Kingston, Canada. Participants completed 4 weeks of moderate intensity exercise in accordance with the Canadian Physical Activity Guidelines. All measurements were obtained at baseline and post exercise. CRF was assessed using a maximal, graded treadmill test. Exercise tolerance was assessed using a 12 minute time trial on a treadmill, where participants were instructed to cover as much distance as possible through self-selection of speed. Twenty four hour physical activity data was obtained at baseline and during the final week of exercise using accelerometry. In a secondary analysis...

Influence of Caffeine on Exercising Muscle Blood Flow and Exercise Tolerance in Type II Diabetes

POITRAS, VERONICA
Fonte: Quens University Publicador: Quens University
Tipo: Tese de Doutorado Formato: 3530486 bytes; application/pdf
Português
Relevância na Pesquisa
56.45%
BACKGROUND: Exercise is a critical treatment modality in persons with Type II Diabetes Mellitus (T2DM), however people with this disease experience chronic fatigue and a decreased exercise capacity, which affects their ability or willingness to participate in physical activity. Studies suggest that this exercise intolerance may be partly due to a reduced exercising muscle blood flow (MBF), and in particular to a reduced ability of red blood cells (RBCs) to evoke ATP-mediated vasodilation and an increase in MBF as they traverse areas of high O2 demand. Additional evidence suggests that caffeine may attenuate this impairment by enhancing the release of ATP from RBCs. HYPOTHESIS: Persons with T2DM would have reduced Forearm Blood Flow (FBF), oxygen consumption (VO2), and exercise tolerance responses to exercise compared to control (CON) subjects, and caffeine would attenuate these impairments. METHODS: T2DM (n = 4) and CON (n = 4) participants performed rhythmic forearm handgrip exercise at an intensity equivalent to 17.5 kg until “task failure” or 20 minutes of exercise was reached, after having consumed either a caffeine (5mg/kg; Caff) or placebo (Pl) capsule. FBF (Doppler and Echo ultrasound of the brachial artery), VO2 and lactate efflux (deep venous blood sampling)...

Impact of CPAP on physical exercise tolerance and sympathetic-vagal balance in patients with chronic heart failure

Reis,Hugo V.; Borghi-Silva,Audrey; Catai,Aparecida M.; Reis,Michel S.
Fonte: Associação Brasileira de Pesquisa e Pós-Graduação em Fisioterapia Publicador: Associação Brasileira de Pesquisa e Pós-Graduação em Fisioterapia
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/06/2014 Português
Relevância na Pesquisa
66.44%
Background: Chronic heart failure (CHF) leads to exercise intolerance. However, non-invasive ventilation is able to improve functional capacity of patients with CHF. Objectives: The aim of this study was to evaluate the effectiveness of continuous positive airway pressure (CPAP) on physical exercise tolerance and heart rate variability (HRV) in patients with CHF. Method : Seven men with CHF (62±8 years) and left ventricle ejection fraction of 41±8% were submitted to an incremental symptom-limited exercise test (IT) on the cicloergometer. On separate days, patients were randomized to perform four constant work rate exercise tests to maximal tolerance with and without CPAP (5 cmH2O) in the following conditions: i) at 50% of peak work rate of IT; and ii) at 75% of peak work rate of IT. At rest and during these conditions, instantaneous heart rate (HR) was recorded using a cardiofrequencimeter and HRV was analyzed in time domain (SDNN and RMSSD indexes). For statistical procedures, Wilcoxon test or Kruskall-Wallis test with Dunn's post-hoc were used accordingly. In addition, categorical variables were analysed through Fischer's test (p<0.05). Results: There were significant improvements in exercise tolerance at 75% of peak work rate of IT with CPAP (405±52 vs. 438±58 s). RMSSD indexes were lower during exercise tests compared to CPAP at rest and with 50% of peak work rate of IT. Conclusion: These data suggest that CPAP appears to be a useful strategy to improve functional capacity in patients with CHF. However...

Importance of heart rate analysis in exercise tolerance test

Herdy,Artur Haddad; Fay,Carlos Eduardo Schio; Bornschein,Christian; Stein,Ricardo
Fonte: Sociedade Brasileira de Medicina do Exercício e do Esporte Publicador: Sociedade Brasileira de Medicina do Exercício e do Esporte
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/08/2003 Português
Relevância na Pesquisa
56.38%
After many years away from the limelights, at the beginning of this century, exercise tolerance testing has earned back an important position in international medical journals. The different sorts of information derived from a variety of studies based on it have shown us that this propedeutic method has a highly valuable prognostic impact. Because of its low cost and easy applicability, the exercise testing reinforces its position in the clinical practice of the cardiologist. In the early 70's, research relating the influence of the autonomic nervous system in heart rate behavior in all phases of an exercise tolerance testing began. Ever since, a number of hypotheses tried to clarify which would be the mechanisms related to the chronotropic response during effort and its performance in the recovery period. In this updating article the authors deal with an important data referring to the chronotropic deficit and the abnormal heart rate recovery, commenting on the prognostic implication of keeping the focus on the potential of its clinical impact. In other words, approaches that can be used whenever there is someone performing a monitored exercise tolerance testing.

Efficacy of noninvasive ventilation support on the increase of exercise tolerance in patients with heart failure: a systematic review

Carvalho,Larissa de Andrade; Rattes,Catarina; Brandão,Daniella Cunha; Andrade,Armèle Dornelas de
Fonte: Universidade de São Paulo Publicador: Universidade de São Paulo
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/12/2014 Português
Relevância na Pesquisa
56.3%
The aim of this study was evaluate the efficacy of noninvasive ventilation (NIV) on improving exercise tolerance of patients with heart failure (HF). A systematic review was performed in PubMed/MEDLINE, LILACS, Cochrane, CINAHL, Scopus and Web of Science for randomized and quasi-randomized clinical trials, without language and year of publication restrictions. Descriptors were defined as 'heart failure', 'noninvasive ventilation', 'positive-pressure respiration', 'interactive ventilatory support', 'exercise test' in addition to the keywords 'BIPAP', 'CPAP', 'IPAP', 'EPAP', 'NIV' and their Portuguese equivalents. Studies comparing NIV with one or two pressure levels to groups without intervention, other physiotherapy modalities without positive pressure or a sham group were included. Four studies were selected, including HF patients of various etiologies, considering the staging classification of New York Heart Association. Any included work realized the allocation concealment, all studies participants underwent blinding, but only two trials performed assessors blinding. None of the studies have described an intention to treat analysis and did not use appropriate statistical methods. All selected trials assessed functional capacity and in only two...

Influência da ventilação não invasiva por meio do BiPAP® sobre a tolerância ao exercício físico e força muscular respiratória em pacientes com doença pulmonar obstrutiva crônica (DPOC); Influencia de la ventilación no evasiva mediante el BiPAP® sobre la tolerancia al ejercicio físico y fuerza muscular respiratoria en pacientes con enfermedad pulmonar obstrutiva crónica (EPOC); Influence of noninvasive ventilation by BiPAP® on exercise tolerance and respiratory muscle strength in chronic obstructive pulmonary disease patients (COPD)

Costa, Dirceu; Toledo, Andreza; Silva, Audrey Borghi e; Sampaio, Luciana Maria Malosá
Fonte: Universidade de São Paulo. Escola de Enfermagem de Ribeirão Preto Publicador: Universidade de São Paulo. Escola de Enfermagem de Ribeirão Preto
Tipo: info:eu-repo/semantics/article; info:eu-repo/semantics/publishedVersion; Formato: application/pdf; application/pdf
Publicado em 01/06/2006 Português
Relevância na Pesquisa
66.23%
O objetivo deste estudo foi avaliar o efeito do BiPAP®, através de máscara nasal, na tolerância ao exercício físico e no desempenho muscular respiratório em pacientes com diagnóstico clínico e espirométrico de DPOC, moderado/grave (VEF1 < 60% do previsto). Com VEF1/CVF; El objetivo de esto estudio fue evaluar el efecto del BiPAP®, por medio de la máscara nasal, sobre la tolerancia al ejercicio físico y el desempeño muscular respiratorio en pacientes con diagnosis clínico y espirométrico de EPOC moderada/grave (VEF1 < 60% del previsible). Con VEF1/CVF; This study aimed to assess the effect of BiPAP®, by nasal mask, on exercise tolerance and respiratory muscle strength in patients with a clinical and spirometric diagnosis of moderate/severe COPD (FEV1 < 60% of predicted). Ten patients of 59.4±8.9 years old, with FEV1/FVC

Four weeks of blood flow restricted training increases time to exhaustion at severe intensity cycling exercise; Quatro semanas de treinamento com restrição de fluxo sanguíneo aumenta o tempo de exaustão em exercício severo no ciclismo

Corvino, Rogério Bulhões; State University of Santa Catarina; Oliveira, Mariana Fernandes Mendes de; State University of Santa Catarina. Federal University of Santa Catarina.; Santos, Rafael Penteado dos; State University of Santa Catarina; Denadai, Ben
Fonte: Universidade Federal de Santa Catarina. Florianópolis, SC. Brasil Publicador: Universidade Federal de Santa Catarina. Florianópolis, SC. Brasil
Tipo: info:eu-repo/semantics/article; info:eu-repo/semantics/publishedVersion; "Avaliado por Pares",; Original paper; Avaliado por Pares; Artigos Originais Formato: application/pdf
Publicado em 01/08/2014 Português
Relevância na Pesquisa
56.29%
http://dx.doi.org/10.5007/1980-0037.2014v16n5p570 The present study aimed to verify the effects of 4 weeks of low-intensity blood flow restricted (BFR) training on time to exhaustion (Tlim) at severe-intensity exercise. Thirteen physically active subjects (23 ± 3.4 years; 70.6 ± 7.8 kg; 170.9 ± 10 cm) were assigned to one of two groups: low-intensity interval training with (BFR, n=9) or without (CON, n=4) blood flow restricted. The interval training sessions consisted of 2 sets of 5-8 × 2-min intervals at 30% of peak power output (Ppeak) obtained during incremental exercise for LOW and BFR, separated by 1min of rest. For BFR a cuff was inflated (140-200mmHg) during the exercise bouts and deflated during rest intervals. The pressure was increased 20mmHg after three completed sessions, thus, in the last week the pressure applied was 200mmHg. Before and after 4 weeks intervention period, all subjects completed an incremental exercise until exhaustion and one-step transition to a severe-intensity work rate (110%Ppeak). The results revealed that BFR (Pre: 227 ± 44s vs. Post: 338 ± 76s), but not CON (Pre: 236 ± 24s vs. Post: 212 ± 26s), increase significantly Tlim at 110%Ppeak. It can be concluded that 4 weeks of BFR training, but not CON...