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## Nonlinear effects generation in suspended core chalcogenide fibre

El-Amraoui, M.; Duhant, M.; Desevedavy, F.; Renard, W.; Canat, G.; Gadret, G.; Jules, J. C.; Fatome, J.; Kibler, B.; Renversez, G.; Troles, J.; Brilland, L.; Messaddeq, Y.; Smektala, F.
Tipo: Conferência ou Objeto de Conferência
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In this work we report our achievements in the elaboration and optical characterizations of low-losses suspended core optical fibers elaborated from As2S3 glass. For preforms elaboration, alternatively to other processes like the stack and draw or extrusion, we use a process based on mechanical drilling. The drawing of these drilled performs into fibers allows reaching a suspended core geometry, in which a 2 μm diameter core is linked to the fiber clad region by three supporting struts. The different fibers that have been drawn show losses close to 0.9 dB/m at 1.55 μm. The suspended core waveguide geometry has also an efficient influence on the chromatic dispersion and allows its management. Indeed, the zero dispersion wavelength, which is around 5 μm in the bulk glass, is calculated to be shifted towards around 2μm in our suspended core fibers. In order to qualify their nonlinearity we have pumped them at 1.995 μm with the help of a fibered ns source. We have observed a strong non linear response with evidence of spontaneous Raman scattering and strong spectral broadening. © 2011 SPIE.

## Antibodies against non-structural c100/3 and structural core antigen of hepatitis C virus (HCV) in hemodialysis patients

Yoshida,C.F.T.; Takahashi,Y.; Vanderborght,B.O.M.; Rouzere,C.D.; França,M.S.; Takahashi,C.; Takamizawa,A.; Yoshida,I.; Schatzmayr,H.G.
Fonte: Instituto de Medicina Tropical Publicador: Instituto de Medicina Tropical
Tipo: Artigo de Revista Científica Formato: text/html
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Two groups of patients undergoing hemodialysis (HD) maintenance were evaluated for their antibody response to non-structural c100/3 protein and structural core protein of hepatitis C virus (HCV). Forty-six patients (Group 1) never presented liver abnormalities during HD treatment, while 52 patients (Group 2) had either current or prior liver enzyme elevations. Prevalence rates of 32.6% and 41.3% were found for anti-c100/3 and anti-HCV core antibodies, respectively, in patients with silent infections (Group 1). The rate of anti-c100/3 in patients of Group 2 was 71.15% and reached 86.5% for anti-HCV core antibodies. The recognition of anti-c100/3 and anti-core antibodies was significantly higher in Group 2 than in Group 1. A line immunoassay composed of structural and non-structural peptides was used as a confirmation assay. HBV infection, measured by the presence of anti-HBc antibodies, was observed in 39.8% of the patients. Six were HBsAg chronic carriers and 13 had naturally acquired anti-HBs antibodies. The duration of HD treatment was correlated with anti-HCV positivity. A high prevalence of 96.7% (Group 2) was found in patients who underwent more than 5 years of treatment. Our results suggest that anti-HCV core ELISA is more accurate for detecting HCV infection than anti-c100/3. Although the risk associated with the duration of HD treatment and blood transfusion was high...

## Increased frequency of aberrant V(D)J recombination products in core RAG-expressing mice

Talukder, Sadiqur R.; Dudley, Darryll D.; Alt, Frederick W.; Takahama, Yousuke; Akamatsu, Yoshiko
Fonte: Oxford University Press Publicador: Oxford University Press
Tipo: Artigo de Revista Científica
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RAG1 and RAG2 play a central role in V(D)J recombination, a process for antigen receptor gene assembly. The truncated ‘core’ regions of RAGs are sufficient to catalyze the recombination reaction, although with lower joining efficiency than full-length proteins. To investigate the role of the non-core regions of RAGs in the end-joining phase of antigen receptor rearrangement, we analyzed recombination products isolated from core RAG1 and core RAG2 knock-in mice. Here, we report that the truncation of RAGs increases the frequency of aberrant recombination in vivo. Signal joints (SJs) associated with V-to-D recombination of core RAG1 knock-in mice were normal, whereas those of core RAG2 knock-in mice were highly imprecise, containing large deletions and additions, and in some cases coding sequences. In contrast, we found an elevated level of imprecise D-to-J associated SJs for both core RAG1- and RAG2-expressing mice. Likewise, sequences of coding joints (CJs) were also affected by the expression of core RAGs. Finally, sequences found at the junctions of rearranged T-cell receptor loci were highly influenced by differences in rearranging recombination signal sequence pairs. We provide the first evidence that the non-core regions of RAGs have critical functions in the proper assembly and resolution of recombination intermediates in endogenous antigen receptor loci.

## A pseudoknot in the 3′ non-core region of the glmS ribozyme enhances self-cleavage activity

WILKINSON, SARA R.; BEEN, MICHAEL D.
Tipo: Artigo de Revista Científica
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The recently described glmS ribozyme is a self-cleaving RNA sequence found in the 5′ noncoding region of the transcript of the gene for glucosamine-6-phosphate (GlcN6P) synthase in many Gram-positive bacteria. This ribozyme is associated with the GlcN6P riboswitch, and ribozyme activity in response to binding of the metabolite, GlcN6P, is proposed to effect levels of gene expression. The previously defined core sequence of the GlcN6P-dependent ribozyme contained fewer than 80 nt of contiguous sequence, but a sequence containing conserved secondary structural features and encompassing the core was twice as long. Structural elements outside of the ribozyme core could contribute to ribozyme activity or participate in gene regulation as part of the expression platform or both. Here, a 174-nt transcript containing the Bacillus anthracis glmS ribozyme was used to examine the contribution of part of the non-core sequence to in vitro cleavage activity. The loop portion of hairpin loop 3, located just 3′ of the ribozyme core, can potentially pair with a sequence ~80 nt downstream to form a pseudoknot tertiary interaction. Disruptive and compensatory mutations in the two duplex regions of the pseudoknot had effects on in vitro cleavage rates that support a role for the pseudoknot in enhanced ribozyme activity. Cleavage activity became less sensitive to disruptive mutations in the pseudoknot as MgCl2 concentrations were raised from 2.5 to 10 mM...

## Non-core Region Modulates Interleukin-11 Signaling Activity: GENERATION OF AGONIST AND ANTAGONIST VARIANTS*

Yanaka(谷, Saeko, 中冴子); Sano(佐, Emiko, 野恵海子); Naruse(成, Norio, 瀬紀男); Miura(三, Kin-ichiro, 浦謹一郎); Futatsumori-Sugai(二, Mutsumi, ツ森ー菅井睦美); Caaveiro, Jose M. M.; Tsumoto(津, Kouhei, 本浩平)
Fonte: American Society for Biochemistry and Molecular Biology Publicador: American Society for Biochemistry and Molecular Biology
Tipo: Artigo de Revista Científica
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Human interleukin-11 (hIL-11) is a pleiotropic cytokine administered to patients with low platelet counts. From a structural point of view hIL-11 belongs to the long-helix cytokine superfamily, which is characterized by a conserved core motif consisting of four α-helices. We have investigated the region of hIL-11 that does not belong to the α-helical bundle motif, and that for the purpose of brevity we have termed “non-core region.” The primary sequence of the interleukin was altered at various locations within the non-core region by introducing glycosylation sites. Functional consequences of these modifications were examined in cell-based as well as biophysical assays. Overall, the data indicated that the non-core region modulates the function of hIL-11 in two ways. First, the majority of muteins displayed enhanced cell-stimulatory properties (superagonist behavior) in a glycosylation-dependent manner, suggesting that the non-core region is biologically designed to limit the full potential of hIL-11. Second, specific modification of a predicted mini α-helix led to cytokine inactivation, demonstrating that this putative structural element belongs to site III engaging a second copy of cell-receptor gp130. These findings have unveiled new and unexpected elements modulating the biological activity of hIL-11...

## The Non-core Subunit eIF3h of Translation Initiation Factor eIF3 Regulates Zebrafish Embryonic Development

Choudhuri, Avik; Evans, Todd; Maitra, Umadas
Tipo: Artigo de Revista Científica
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Eukaryotic translation initiation factor eIF3, that plays a central role in translation initiation, consists of five core subunits that are present in both the budding yeast and higher eukaryotes. However, higher eukaryotic eIF3 contains additional (non-core) subunits that are absent in the budding yeast. We investigated the role of one such non-core eIF3 subunit eIF3h, encoded by two distinct genes – eif3ha and eif3hb, as a regulator of embryonic development in zebrafish. Both eif3h genes are expressed during early embryogenesis, and display overlapping yet distinct and highly dynamic spatial expression patterns. Loss of function analysis using specific morpholino oligomers indicates that each isoform has specific as well as redundant functions during early development. The morphant phenotypes correlate with their spatial expression patterns, indicating that eif3h regulates development of the brain, heart, vasculature, and lateral line. These results indicate that the non-core subunits of eIF3 regulate specific developmental programs during vertebrate embryogenesis.

## Non-Core RAG1 Regions Promote Vβ Rearrangements and αβ T Cell Development by Overcoming Inherent Inefficiency of Vβ Recombination Signal Sequences

Horowitz, Julie E.; Bassing, Craig H.
Tipo: Artigo de Revista Científica
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The RAG proteins are comprised of core endonuclease domains and non-core regions that modulate endonuclease activity. Mutation or deletion of non-core RAG regions in humans causes immunodeficiency and altered TCR repertoire, and mice expressing core but not full-length Rag1 (Rag1C/C) or Rag2 (Rag2C/C) exhibit lymphopenia, reflecting impaired V(D)J recombination and lymphocyte development. Rag1C/C mice display reduced D-to-J and V-to-DJ rearrangements of TCRβ and IgH loci, while Rag2C/C mice show decreased V-to-DJ rearrangements and altered Vβ/VH repertoire. Since Vβs/VHs only recombine to DJ complexes, the Rag1C/C phenotype could reflect roles for non-core RAG1 regions in promoting recombination during only the D-to-J step or during both steps. Here, we demonstrate that a pre-assembled TCRβ gene, but not a pre-assembled DβJβ complex or the pro-survival BCL2 protein, completely rescues αβ T cell development in Rag1C/C mice. We find that Rag1C/C mice exhibit altered Vβ utilization in Vβ-to-DJβ rearrangements, increased usage of 3’Jα gene segments in Vα-to-Jα rearrangements, and abnormal changes in Vβ repertoire during αβ TCR selection. Inefficient Vβ/VH recombination signal sequences (RSSs) have been hypothesized to cause impaired V-to-DJ recombination on the background of a defective recombinase as in core-Rag mice. We show that replacement of the Vβ14 RSS with a more efficient RSS increases Vβ14 recombination and rescues αβ T cell development in Rag1C/C mice. Our data indicate that non-core RAG1 regions establish a diverse TCR repertoire by overcoming Vβ RSS inefficiency to promote Vβ recombination and αβ T cell development...

## 16S rRNA Amplicon Sequencing Demonstrates that Indoor-Reared Bumblebees (Bombus terrestris) Harbor a Core Subset of Bacteria Normally Associated with the Wild Host

Meeus, Ivan; Parmentier, Laurian; Billiet, Annelies; Maebe, Kevin; Van Nieuwerburgh, Filip; Deforce, Dieter; Wäckers, Felix; Vandamme, Peter; Smagghe, Guy
Fonte: Public Library of Science Publicador: Public Library of Science
Tipo: Artigo de Revista Científica
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A MiSeq multiplexed 16S rRNA amplicon sequencing of the gut microbiota of wild and indoor-reared Bombus terrestris (bumblebees) confirmed the presence of a core set of bacteria, which consisted of Neisseriaceae (Snodgrassella), Orbaceae (Gilliamella), Lactobacillaceae (Lactobacillus), and Bifidobacteriaceae (Bifidobacterium). In wild B. terrestris we detected several non-core bacteria having a more variable prevalence. Although Enterobacteriaceae are unreported by non next-generation sequencing studies, it can become a dominant gut resident. Furthermore the presence of some non-core lactobacilli were associated with the relative abundance of bifidobacteria. This association was not observed in indoor-reared bumblebees lacking the non-core bacteria, but having a more standardized microbiota compared to their wild counterparts. The impact of the bottleneck microbiota of indoor-reared bumblebees when they are used in the field for pollination purpose is discussed.

## Characterization of Carotid Plaques with Ultrasound Non-Invasive Vascular Elastography (NIVE) : Feasibility and Correlation with High-Resolution Magnetic Resonance Imaging

Naïm, Cyrille
Fonte: Université de Montréal Publicador: Université de Montréal
Tipo: Thèse ou Mémoire numérique / Electronic Thesis or Dissertation
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L’accident vasculaire cérébral (AVC) est une cause principale de décès et de morbidité dans le monde; une bonne partie des AVC est causée par la plaque d’athérosclérose carotidienne. La prévention de l’AVC chez les patients ayant une plaque carotidienne demeure controversée, vu les risques et bénéfices ambigus associés au traitement chirurgical ou médical. Plusieurs méthodes d’imagerie ont été développées afin d’étudier la plaque vulnérable (dont le risque est élevé), mais aucune n’est suffisamment validée ou accessible pour permettre une utilisation comme outil de dépistage. L’élastographie non-invasive vasculaire (NIVE) est une technique nouvelle qui cartographie les déformations (élasticité) de la plaque afin de détecter les plaque vulnérables; cette technique n’est pas encore validée cliniquement. Le but de ce projet est d’évaluer la capacité de NIVE de caractériser la composition de la plaque et sa vulnérabilité in vivo chez des patients ayant des plaques sévères carotidiennes, en utilisant comme étalon de référence, l’imagerie par résonance magnétique (IRM) à haute-résolution. Afin de poursuivre cette étude, une connaissance accrue de l’AVC, l’athérosclérose...

## No More Ping-Pong: The Need for Article III Status in Bankruptcy After Stern v. Marshall

Brown, Latoya C.
Tipo: Artigo de Revista Científica
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“Unfortunately, Stern v. Marshall has become the mantra of every litigant who, for strategic or tactical reasons, would rather litigate somewhere other than the bankruptcy court.” I. INTRODUCTION Quite aptly, the United States Supreme Court borrowed the words of Charles Dickens to describe the life of the case that ultimately resulted in Stern v. Marshall : “This suit has, in the curse of time, become so complicated, that . . . no two . . . lawyers can talk about it for five minutes, without coming to a total disagreement as to all the premises.’” Ironically, even after the Court’s decision, the “curse” has continued and many, especially those of the bankruptcy bar, are in disagreement as to the ultimate outcome and unforeseen consequences of Stern. The “big fuss” arose out of the Court’s holding that bankruptcy courts do not have constitutional authority to enter final judgment on a state law counterclaim “that is not resolved in the process of ruling on a creditor’s proof of claim.” The Court stated that common law claims, as well as suits in equity and admiralty, fall within the province of Article III courts, and Congress cannot “chip away at the authority of the judicial branch” by enacting statutes delegating such power to non-Article III judges. The Constitution grants judicial power to courts whose judges enjoy tenure during good behavior and salary protections. Article III provisions are safeguards against intrusion by other branches of government and they ensure that judicial decisions are being made with “[c]lear heads . . . and honest hearts.” A different outcome would have been likely if the case involved a ‘public right’ because the Court has recognized that Congress has the authority to adjudicate in suits involving that exception. The public rights exception applies in cases where a “right is integrally related to particular federal government action.” Other than the obvious limiting effect that Stern will have on bankruptcy courts with regards to adjudicating common law claims...

## The core of a class of non-atomic games which arise in economic applications

Einy, Ezra; Moreno, Diego; Shitovitz, Benyamin
Tipo: Artigo de Revista Científica Formato: application/pdf
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We study the core of a non-atomic game v which is uniformly continuous with respect to the DNA-topology and continuous at the grand coalition. Such a game has a unique DNA-continuous extension on the space B 1 of ideal sets. We show that if the extension is concave then the core of the game v is non-empty iff is homogeneous of degree one along the diagonal of B 1. We use this result to obtain representation theorems for the core of a non-atomic game of the form v=f where μ is a finite dimensional vector of measures and f is a concave function. We also apply our results to some non-atomic games which occur in economic applications.

## The core of a class of non-atomic games which arise in economic applications

Einy, Ezra; Moreno, Diego; Shitovitz, Benyamin
Tipo: Trabalho em Andamento Formato: application/pdf
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We prove a representation theorem for the core of a non-atomic game of the form v = fOil, where Il is a finite dimensional vector of non-atomic measures and f is a non-decreasing continuous concave function on the range of Il. The theorem is stated in terms of the sub gradients of the function f. As a consequence of this theorem we show that the game v is balanced (i. e., has a non-empty core) iff the function f is homogeneous of degree one along the diagonal of the range of Il, and it is totally balanced (i.e., every subgame of v has a non-empty core) iff the function f is homogeneous of degree one in the entire range of Il. We also apply our results to some non-atomic games which occur in economic applications.

## Associations between parenting styles and nutrition knowledge and 2-5-year-old children's fruit, vegetable and non-core food consumption

Peters, J.; Dollman, J.; Petkov, J.; Parletta, N.
Fonte: Cambridge University Press (CUP) Publicador: Cambridge University Press (CUP)
Tipo: Artigo de Revista Científica
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OBJECTIVE: During the early years, parents have a major influence on children’s diets and developing food choices. We investigated parenting styles as predictors of 2–5-year-old children’s diets and whether general nutrition knowledge (GNK) mediated these influences. DESIGN: Cross-sectional research. Questionnaires measured demographic and lifestyle variables, family environment, parenting styles and feeding practices, child diet and GNK. Regression models tested GNK as a mediator of relationships between parenting variables and child diet (fruit/vegetable and non-core food consumption), controlling for confounders and family environment. SETTING: Questionnaires were completed by main caregivers at home. SUBJECTS: Parents of children aged 2–5 years (n 269). RESULTS: Higher child fruit/vegetable consumption was associated with lower overreactive parenting and restriction, higher authoritative parenting and dining together as a family; with lax parenting approaching statistical significance (P50?083) and 19% of variance explained by the model. GNK was not a significant predictor. Conversely, non-core food consumption was associated with higher over-reactive and lax parenting as well as child age, increased takeaway food consumption and higher television viewing; GNK had a small effect (P = 0.043) and 28% of variance was explained by the model. GNK was a significant mediator only for authoritative parenting on non-core food (effect = -0.005). CONCLUSIONS: These findings highlight that young children’s diets may be improved by interventions targeting a range of positive and supportive parenting practices in conjunction with nutrition knowledge education for parents of young children. Further insights will come from closer attention to the nature and role of restrictive feeding practices v. laxness and longitudinal research.; Jacqueline Peters...

## Firm Location and the Determinants of Exporting in Developing Countries

Farole, Thomas; Winkler, Deborah
Fonte: Banco Mundial Publicador: Banco Mundial
Tipo: Publications & Research :: Policy Research Working Paper
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Using a cross-section of more than 40,000 manufacturing and services firms in 79 developing countries from the World Bank's Enterprise Surveys Database, this paper assesses how firm location determines the likelihood and extent of exporting in developing countries. Descriptive statistics confirm higher export participation (but not intensity) for firms in core versus non-core regions, despite the finding that firms in the core assess many aspects of the investment climate more negatively. Results from a probit model show that, in addition to firm-specific characteristics, both regional investment climate and agglomeration factors have a significant impact on export participation. Specifically, customs clearance and electricity quality matter for export participation for manufacturing firms. Although localization economies and export spillovers are associated with increased exporting, the opposite is found for urbanization economies for both manufacturing and services firms. The analysis finds that firm-level determinants of exporting matter more for firms located in non-core regions...

## RAG2's non-core domain contributes to the ordered regulation of V(D)J recombination

Curry, John D.; Schlissel, Mark S.
Fonte: Oxford University Press Publicador: Oxford University Press
Tipo: Artigo de Revista Científica
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Variable (diversity) joining [V(D)J] recombination of immune gene loci proceeds in an ordered manner with D to J portions recombining first and then an upstream V joins that recombinant. We present evidence that the non-core domain of recombination activating gene (RAG) protein 2 is involved in the regulation of recombinatorial order. In mice lacking the non-core domain of RAG2 the ordered rearrangement is disturbed and direct V to D rearrangements are 10- to 1000-times increased in tri-partite immune gene loci. Some forms of inter-chromosomal translocations between TCRβ and TCRδ D gene segments are also increased in the core RAG2 animals as compared with their wild-type (WT) counterparts. In addition, the concise use of proper recombination signal sequences (RSSs) appears to be disturbed in the core RAG2 mice as compared with WT RAG2 animals.

## COrE (Cosmic Origins Explorer) A White Paper

The COrE Collaboration; Armitage-Caplan, C.; Avillez, M.; Barbosa, D.; Banday, A.; Bartolo, N.; Battye, R.; Bernard, JP.; de Bernardis, P.; Basak, S.; Bersanelli, M.; Bielewicz, P.; Bonaldi, A.; Bucher, M.; Bouchet, F.; Boulanger, F.; Burigana, C.; Camus,
Tipo: Artigo de Revista Científica
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COrE (Cosmic Origins Explorer) is a fourth-generation full-sky, microwave-band satellite recently proposed to ESA within Cosmic Vision 2015-2025. COrE will provide maps of the microwave sky in polarization and temperature in 15 frequency bands, ranging from 45 GHz to 795 GHz, with an angular resolution ranging from 23 arcmin (45 GHz) and 1.3 arcmin (795 GHz) and sensitivities roughly 10 to 30 times better than PLANCK (depending on the frequency channel). The COrE mission will lead to breakthrough science in a wide range of areas, ranging from primordial cosmology to galactic and extragalactic science. COrE is designed to detect the primordial gravitational waves generated during the epoch of cosmic inflation at more than $3\sigma$ for $r=(T/S)>=10^{-3}$. It will also measure the CMB gravitational lensing deflection power spectrum to the cosmic variance limit on all linear scales, allowing us to probe absolute neutrino masses better than laboratory experiments and down to plausible values suggested by the neutrino oscillation data. COrE will also search for primordial non-Gaussianity with significant improvements over Planck in its ability to constrain the shape (and amplitude) of non-Gaussianity. In the areas of galactic and extragalactic science...

## Elasticity-driven attraction between Abrikosov vortices in high-$\kappa$ superconductors: Leading role of a non-core contribution

Cano, A.; Levanyuk, A. P.; Minyukov, S. A.
Tipo: Artigo de Revista Científica
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We show that the strain-induced attraction between Abrikosov vortices has a non-core contribution overlooked up until now. This contribution is an example of the universal mechanism of soliton attraction in solids revealed in [Phys. Rev. B {\bf 66}, 14111 (2002)]. The resulting interaction energy is larger than that due to the vortex cores at least by a factor $\ln ^2 \kappa$. Consequently, the non-core contribution must be included, for instance, in discussions about the orientation of vortex lattices with respect to the crystal axes. It is shown to be also important when interpreting the thermal anomalies of the transition between superconducting and mixed states.; Comment: RevTeX4, 5 pages

## Understanding the Dynamical State of Globular Clusters: Core-Collapsed vs Non Core-Collapsed

Chatterjee, Sourav; Umbreit, Stefan; Fregeau, John M.; Rasio, Frederic A.
Tipo: Artigo de Revista Científica
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We study the dynamical evolution of globular clusters using our H\'enon-type Monte Carlo code for stellar dynamics including all relevant physics such as two-body relaxation, single and binary stellar evolution, Galactic tidal stripping, and strong interactions such as physical collisions and binary mediated scattering. We compute a large database of several hundred models starting from broad ranges of initial conditions guided by observations of young and massive star clusters. We show that these initial conditions very naturally lead to present day clusters with properties including the central density, core radius, half-light radius, half-mass relaxation time, and cluster mass, that match well with those of the old Galactic globular clusters. In particular, we can naturally reproduce the bimodal distribution in observed core radii separating the "core-collapsed" vs the "non core-collapsed" clusters. We see that the core-collapsed clusters are those that have reached or are about to reach the equilibrium "binary burning" phase. The non core-collapsed clusters are still undergoing gravo-thermal contraction.; Comment: 42 pages, 12 figures, 1 table, submitted to MNRAS

## State Leaders in Providing Common Core-Aligned Instructional Materials

Fago, Cassandra
Tipo: Masters' project