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Downregulation of microRNA-132 by DNA hypermethylation is associated with cell invasion in colorectal cancer

Qin, Jun; Ke, Jing; Xu, Junfei; Wang, Feiran; Zhou, Youlang; Jiang, Yasu; Wang, Zhiwei
Fonte: Dove Medical Press Publicador: Dove Medical Press
Tipo: Text
Publicado em 07/12/2015 Português
microRNAs (miRNAs) are small, noncoding RNAs that are involved in many biological processes, and aberrant regulation of miRNAs is always associated with cancer progression and development. Abnormal expression of miRNA-132 (miR-132) has been found in some types of cancer, but the effects and potential mechanisms of miR-132 in colorectal cancer (CRC) have not been explored to date. In this study, quantitative real-time polymerase chain reaction was used to investigate the level of miR-132 in CRC tissues and their paired adjacent normal tissues. Bioinformatics analysis indicated that the mechanism underlying the tumor suppressor role of miR-132 in CRC cells may play a role in tumor suppression by targeting paxillin. Furthermore, methylation-specific polymerase chain reaction was performed to evaluate the methylation status of the miR-132 regulatory region. A DNA methyltransferase inhibitor, 5-aza-2′-deoxycytidine, was used to activate the expression of miR-132 in CRC cells in vitro. Downregulation of miR-132 may occur as a result of hypermethylation and implies a poor prognosis in CRC; therefore, triggering miR-132 reexpression by using DNA methyltransferase inhibitors may be a potential molecular therapeutic target for CRC.

Joining the patient on the path to customized prophylaxis: one hemophilia team explores the tools of engagement

Gue, Deborah; Squire, Sandra; McIntosh, Kam; Bartholomew, Claude; Summers, Nicole; Sun, Haowei; Yang, Ming; Jackson, Shannon
Fonte: Dove Medical Press Publicador: Dove Medical Press
Tipo: Text
Publicado em 07/12/2015 Português

Crosstalk with cancer-associated fibroblasts induces resistance of non-small cell lung cancer cells to epidermal growth factor receptor tyrosine kinase inhibition

Choe, Chungyoul; Shin, Yong-Sung; Kim, Changhoon; Choi, So-Jung; Lee, Jinseon; Kim, So Young; Cho, Yong Beom; Kim, Jhingook
Fonte: Dove Medical Press Publicador: Dove Medical Press
Tipo: Text
Publicado em 07/12/2015 Português
Although lung cancers with activating mutations in the epidermal growth factor receptor (EGFR) are highly sensitive to selective EGFR tyrosine kinase inhibitors (TKIs), these tumors invariably develop acquired drug resistance. Host stromal cells have been found to have a considerable effect on the sensitivity of cancer cells to EGFR TKIs. Little is known, however, about the signaling mechanisms through which stromal cells contribute to the response to EGFR TKI in non-small cell lung cancer. This work examined the role of hedgehog signaling in cancer-associated fibroblast (CAF)-mediated resistance of lung cancer cells to the EGFR TKI erlotinib. PC9 cells, non-small cell lung cancer cells with EGFR-activating mutations, became resistant to the EGFR TKI erlotinib when cocultured in vitro with CAFs. Polymerase chain reaction and immunocytochemical assays showed that CAFs induced epithelial to mesenchymal transition phenotype in PC9 cells, with an associated change in the expression of epithelial to mesenchymal transition marker proteins including vimentin. Importantly, CAFs induce upregulation of the 7-transmembrane protein smoothened, the central signal transducer of hedgehog, suggesting that the hedgehog signaling pathway is active in CAF-mediated drug resistance. Indeed...

Association between MDM2 SNP309 T>G polymorphism and the risk of bladder cancer: new data in a Chinese population and an updated meta-analysis

Xie, Linguo; Sun, Yan; Chen, Tao; Tian, Dawei; Li, Yujuan; Zhang, Yu; Ding, Na; Shen, Zhonghua; Xu, Hao; Nian, Xuewu; Sha, Nan; Han, Ruifa; Hu, Hailong; Wu, Changli
Fonte: Dove Medical Press Publicador: Dove Medical Press
Tipo: Text
Publicado em 07/12/2015 Português

Ocular hypertension and hypotony as determinates of outcomes in uveitis

Aman, Rabia; Engelhard, Stephanie B; Bajwa, Asima; Patrie, James; Reddy, Ashvini K
Fonte: Dove Medical Press Publicador: Dove Medical Press
Tipo: Text
Publicado em 07/12/2015 Português

Impact of volume expansion on the efficacy and pharmacokinetics of liposome bupivacaine

Hadzic, Admir; Abikhaled, John A; Harmon, William J
Fonte: Dove Medical Press Publicador: Dove Medical Press
Tipo: Text
Publicado em 07/12/2015 Português
Liposome bupivacaine is a prolonged-release liposomal formulation of bupivacaine indicated for single-dose infiltration into the surgical site to produce postsurgical analgesia of longer duration than traditional local anesthetics. This review summarizes the available data on how volume expansion may impact the analgesic efficacy of liposome bupivacaine. The Phase II and III clinical studies that involved surgical site administration of liposome bupivacaine at various concentrations in different surgical settings revealed no apparent concentration–efficacy relationship. A single-center, prospective study comparing the efficacy of transversus abdominis plane infiltration with liposome bupivacaine administered in a lower (266 mg/40 mL) vs a higher (266 mg/20 mL) dose concentration in subjects undergoing robotic-assisted laparoscopic prostatectomy also reported similar postsurgical pain intensity scores and opioid usage in both treatment groups. The pharmacokinetic profile of liposome bupivacaine following subcutaneous injections in rats was unaltered by differences in drug concentration, dose, or injection volume within the ranges tested. Volume expansion of liposome bupivacaine to a total volume of 300 mL or less does not appear to impact its clinical efficacy or pharmacokinetic profile...

Outcome of therapeutic penetrating keratoplasty in a tertiary eye care center in Nepal

Bajracharya, Leena; Gurung, Reeta
Fonte: Dove Medical Press Publicador: Dove Medical Press
Tipo: Text
Publicado em 07/12/2015 Português

Integrating complementary/alternative medicine into primary care: evaluating the evidence and appropriate implementation

Wainapel, Stanley F; Rand, Stephanie; Fishman, Loren M; Halstead-Kenny, Jennifer
Fonte: Dove Medical Press Publicador: Dove Medical Press
Tipo: Text
Publicado em 07/12/2015 Português
The frequency with which patients utilize treatments encompassed by the term complementary/alternative medicine (CAM) is well documented. A number of these therapies are beginning to be integrated into contemporary medical practice. This article examines three of them: osteopathic manipulation, yoga, and acupuncture, with a focus on their physiological effects, efficacy in treating medical conditions commonly encountered by practitioners, precautions or contraindications, and ways in which they can be incorporated into clinical practice. Physicians should routinely obtain information about use of CAM as part of their patient history and should consider their role based on physiological effects and clinical research results.

Fractional flow reserve-guided percutaneous coronary intervention: where to after FAME 2?

van de Hoef, Tim P; Meuwissen, Martijn; Piek, Jan J
Fonte: Dove Medical Press Publicador: Dove Medical Press
Tipo: Text
Publicado em 03/12/2015 Português
Fractional flow reserve (FFR) is a well-validated clinical coronary physiological parameter derived from the measurement of coronary pressures and has drastically changed revascularization decision-making in clinical practice. Nonetheless, it is important to realize that FFR is a coronary pressure-derived estimate of coronary blood flow impairment. It is thereby not the same as direct measures of coronary flow impairment that determine the occurrence of signs and symptoms of myocardial ischemia. This consideration is important, since the FAME 2 study documented a limited discriminatory power of FFR to identify stenoses that require revascularization to prevent adverse events. The physiological difference between FFR and direct measures of coronary flow impairment may well explain the findings in FAME 2. This review aims to address the physiological background of FFR, its ambiguities, and its consequences for the application of FFR in clinical practice, as well as to reinterpret the diagnostic and prognostic characteristics of FFR in the light of the recent FAME 2 trial outcomes.

Psychological changes in alcohol-dependent patients during a residential rehabilitation program

Giorgi, Ines; Ottonello, Marcella; Vittadini, Giovanni; Bertolotti, Giorgio
Fonte: Dove Medical Press Publicador: Dove Medical Press
Tipo: Text
Publicado em 07/12/2015 Português

Patient experiences with self-monitoring renal function after renal transplantation: results from a single-center prospective pilot study

van Lint, Céline L; van der Boog, Paul JM; Wang, Wenxin; Brinkman, Willem-Paul; Rövekamp, Ton JM; Neerincx, Mark A; Rabelink, Ton J; van Dijk, Sandra
Fonte: Dove Medical Press Publicador: Dove Medical Press
Tipo: Text
Publicado em 07/12/2015 Português

A 9-year Trend in the Prevalence of Allergic Disease Based on National Health Insurance Data

Yoo, Byoungin; Park, Yoonhyung; Park, Kwanjun; Kim, Hoseob
Fonte: Korean Society for Preventive Medicine Publicador: Korean Society for Preventive Medicine
Tipo: Text
Português

Implementation of Quaternary Prevention in the Korean Healthcare System: Lessons From the 2015 Middle East Respiratory Syndrome Coronavirus Outbreak in the Republic of Korea

Bae, Jong-Myon
Fonte: Korean Society for Preventive Medicine Publicador: Korean Society for Preventive Medicine
Tipo: Text
Português
Quaternary prevention should be implemented to minimize harm to patients because the ultimate goal of medicine is to prevent disease and promote health. Primary care physicians have a major responsibility in quaternary prevention, and the establishment of clinical epidemiology as a distinct field of study would create a role charged with minimizing patient harm arising from over-medicalization.

Current Status of Infection Prevention and Control Programs for Emergency Medical Personnel in the Republic of Korea

Oh, Hyang Soon; Uhm, Dong Choon
Fonte: Korean Society for Preventive Medicine Publicador: Korean Society for Preventive Medicine
Tipo: Text
Português

A New Measure for Assessing the Public Health Response to a Middle East Respiratory Syndrome Coronavirus Outbreak

Cho, Sung-il
Fonte: Korean Society for Preventive Medicine Publicador: Korean Society for Preventive Medicine
Tipo: Text
Português
Contact monitoring is an essential component of the public health response to a Middle East respiratory syndrome coronavirus outbreak, and is required for an effective quarantine to contain the epidemic. The timeliness of a quarantine is associated with its effectiveness. This paper provides a conceptual framework to describe the process of contact monitoring, and proposes a new measure called the “timely quarantined proportion” as a tool to assess the adequacy of a public health response.

Determinants of Poor Self-rated Health in Korean Adults With Diabetes

Lee, Hwi-Won; Song, Minkyo; Yang, Jae Jeong; Kang, Daehee
Fonte: Korean Society for Preventive Medicine Publicador: Korean Society for Preventive Medicine
Tipo: Text
Português

Structural Factors of the Middle East Respiratory Syndrome Coronavirus Outbreak as a Public Health Crisis in Korea and Future Response Strategies

Kim, Dong-Hyun
Fonte: Korean Society for Preventive Medicine Publicador: Korean Society for Preventive Medicine
Tipo: Text
Português
The recent Middle East respiratory syndrome coronavirus (MERS-CoV) outbreak has originated from a failure in the national quarantine system in the Republic of Korea as most basic role of protecting the safety and lives of its citizens. Furthermore, a number of the Korean healthcare system’s weaknesses seem to have been completely exposed. The MERS-CoV outbreak can be considered a typical public health crisis in that the public was not only greatly terrorized by the actual fear of the disease, but also experienced a great impact to their daily lives, all in a short period of time. Preparedness for and an appropriate response to a public health crisis require comprehensive systematic public healthcare measures to address risks comprehensively with an all-hazards approach. Consequently, discussion regarding establishment of post-MERS-CoV improvement measures must focus on the total reform of the national quarantine system and strengthening of the public health infrastructure. In addition, the Korea Centers for Disease Control and Prevention must implement specific strategies of action including taking on the role of “control tower” in a public health emergency, training of Field Epidemic Intelligence Service officers, establishment of collaborative governance between central and local governments for infection prevention and control...

Hormonal Replacement Therapy and the Risk of Lung Cancer in Women: An Adaptive Meta-analysis of Cohort Studies

Bae, Jong-Myon; Kim, Eun Hee
Fonte: Korean Society for Preventive Medicine Publicador: Korean Society for Preventive Medicine
Tipo: Text
Português

Factors Determining Children’s Private Health Insurance Enrolment and Healthcare Utilization Patterns: Evidence From the 2008 to 2011 Health Panel Data

Shin, Jawoon; Lee, Tae-Jin; Cho, Sung-il; Choe, Seung Ah
Fonte: Korean Society for Preventive Medicine Publicador: Korean Society for Preventive Medicine
Tipo: Text
Português

The Relationship of Socioeconomic and Behavioral Risk Factors With Trends of Overweight in Korea

Shin, Jin Hee; Dupre, Matthew E.; Østbye, Truls; Murphy, Gwen; Silberberg, Mina
Fonte: Korean Society for Preventive Medicine Publicador: Korean Society for Preventive Medicine
Tipo: Text
Português