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The neuroprotective effect of pituitary adenylate cyclase-activating polypeptide on cerebellar granule cells is mediated through inhibition of the CED3-related cysteine protease caspase-3/CPP32

Vaudry, David; Gonzalez, Bruno J.; Basille, Magali; Pamantung, Tommy F.; Fontaine, Marc; Fournier, Alain; Vaudry, Hubert
Fonte: The National Academy of Sciences Publicador: The National Academy of Sciences
Tipo: Artigo de Revista Científica
Publicado em 21/11/2000 Português
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Caspase-3 knockout mice exhibit thickening of the internal granule cell layer of the cerebellum. Concurrently, it has been shown that intracerebral injection of pituitary adenylate cyclase-activating polypeptide (PACAP) induces a transient increase of the thickness of the cerebellar cortex. In the present study, we have investigated the possible effect of PACAP on caspase activity in cultured cerebellar granule cells from 8-day-old rat. Incubation of granule neurons with PACAP for 24 h promoted cell survival and prevented DNA fragmentation. Exposure of cerebellar granule cells to the specific caspase-3 inhibitor N-benzyloxycarbonyl-Asp-Glu-Val-Asp fluoromethylketone (Z-DEVD-FMK) for 24 h markedly enhanced cell survival and inhibited apoptotic cell death. Time-course studies revealed that PACAP causes a prolonged inhibition of caspase-3 activity without affecting caspase-1. Administration of graded concentrations of PACAP for 3 h induced a dose-dependent inhibition of caspase-3 activity. Incubation of granule cells with both dibutyryl-cAMP (dbcAMP) and phorbol 12-myristate 13-acetate (PMA) mimicked the inhibitory effect of PACAP on caspase-3. Cotreatment of cultured neurons with the protein kinase A inhibitor H89 and the protein kinase C inhibitor chelerythrine abrogated the effect of PACAP on caspase-3 activity. In contrast...

Outreach NPS Office San Diego Quarterly Newsletter / December 2012

Fonte: Escola de Pós-Graduação Naval Publicador: Escola de Pós-Graduação Naval
Tipo: Periódico
Português
Relevância na Pesquisa
16.67%
This newsletter presents topics of interest to NPS Distance Learning students.

Outreach NPS Office San Diego Quarterly Newsletter / August 2008

Fonte: Monterey, California. Naval Postgraduate School; Fleet Concentration Area, PME Outreach Publicador: Monterey, California. Naval Postgraduate School; Fleet Concentration Area, PME Outreach
Tipo: Periódico
Português
Relevância na Pesquisa
16.67%
This newsletter presents topics of interest to NPS Distance Learning students.

Outreach NPS Office San Diego Quarterly Newsletter / December 2008

Fonte: Monterey, California. Naval Postgraduate School; Fleet Concentration Area, PME Outreach Publicador: Monterey, California. Naval Postgraduate School; Fleet Concentration Area, PME Outreach
Tipo: Periódico
Português
Relevância na Pesquisa
16.67%
This newsletter presents topics of interest to NPS Distance Learning students.

Outreach NPS Office San Diego Quarterly Newsletter / December 2009

Fonte: Monterey, California. Naval Postgraduate School; Center for Educational Design, Development and Distribution (CED3) Publicador: Monterey, California. Naval Postgraduate School; Center for Educational Design, Development and Distribution (CED3)
Tipo: Periódico
Português
Relevância na Pesquisa
27.3%
This newsletter presents topics of interest to NPS Distance Learning students.

Outreach NPS Office San Diego Quarterly Newsletter / June 2009

Fonte: Monterey, California. Naval Postgraduate School; Center for Educational Design, Development and Distribution (CED3) Publicador: Monterey, California. Naval Postgraduate School; Center for Educational Design, Development and Distribution (CED3)
Tipo: Periódico
Português
Relevância na Pesquisa
27.3%
This newsletter presents topics of interest to NPS Distance Learning students.

Outreach NPS Office San Diego Quarterly Newsletter / March 2009

Fonte: Monterey, California. Naval Postgraduate School; Center for Educational Design, Development and Distribution (CED3) Publicador: Monterey, California. Naval Postgraduate School; Center for Educational Design, Development and Distribution (CED3)
Tipo: Periódico
Português
Relevância na Pesquisa
27.3%
This newsletter presents topics of interest to NPS Distance Learning students.

Outreach NPS Office San Diego Quarterly Newsletter / September 2009

Fonte: Monterey, California. Naval Postgraduate School; Center for Educational Design, Development and Distribution (CED3) Publicador: Monterey, California. Naval Postgraduate School; Center for Educational Design, Development and Distribution (CED3)
Tipo: Periódico
Português
Relevância na Pesquisa
27.3%
This newsletter presents topics of interest to NPS Distance Learning students.

Outreach NPS Office San Diego Quarterly Newsletter / June 2010

Fonte: Monterey, California. Naval Postgraduate School; Center for Educational Design, Development and Distribution (CED3) Publicador: Monterey, California. Naval Postgraduate School; Center for Educational Design, Development and Distribution (CED3)
Tipo: Periódico
Português
Relevância na Pesquisa
27.3%
This newsletter presents topics of interest to NPS Distance Learning students.

Outreach NPS Office San Diego Quarterly Newsletter / March 2010

Fonte: Monterey, California. Naval Postgraduate School; Center for Educational Design, Development and Distribution (CED3) Publicador: Monterey, California. Naval Postgraduate School; Center for Educational Design, Development and Distribution (CED3)
Tipo: Periódico
Português
Relevância na Pesquisa
27.3%
This newsletter presents topics of interest to NPS Distance Learning students.

Outreach NPS Office San Diego Quarterly Newsletter / January 2011

Fonte: Monterey, California. Naval Postgraduate School; Center for Educational Design, Development and Distribution (CED3) Publicador: Monterey, California. Naval Postgraduate School; Center for Educational Design, Development and Distribution (CED3)
Tipo: Periódico
Português
Relevância na Pesquisa
27.3%
This newsletter presents topics of interest to NPS Distance Learning students.

International Maritime Security Program [video]

Naval Postgraduate School (U.S.)
Fonte: Monterey, California: Naval Postgraduate School Publicador: Monterey, California: Naval Postgraduate School
Tipo: Vídeo
Português
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An introduction to the Maritime Security Program at the Naval Postgraduate School. Produced by CED3

Outreach NPS Office San Diego Quarterly Newsletter / March 2009

Fonte: Monterey, California, Naval Postgraduate School Publicador: Monterey, California, Naval Postgraduate School
Tipo: Newsletter
Português
Relevância na Pesquisa
16.67%
This newsletter presents topics of interest to NPS Distance Learning students.

Outreach NPS Office San Diego Quarterly Newsletter / June 2009

Fonte: Monterey, California, Naval Postgraduate School Publicador: Monterey, California, Naval Postgraduate School
Tipo: Newsletter
Português
Relevância na Pesquisa
16.67%
This newsletter presents topics of interest to NPS Distance Learning students.

Outreach NPS San Diego Office Quarterly Newsletter / September 2009

Fonte: Monterey, California, Naval Postgraduate School Publicador: Monterey, California, Naval Postgraduate School
Tipo: Newsletter
Português
Relevância na Pesquisa
16.67%
This newsletter presents topics of interest to NPS Distance Learning students

Outreach NPS San Diego Office Quarterly Newsletter / December 2009

Fonte: Monterey, California, Naval Postgraduate School Publicador: Monterey, California, Naval Postgraduate School
Tipo: Newsletter
Português
Relevância na Pesquisa
16.67%
This newsletter presents topics of interest to NPS Distance Learning students.

Outreach NPS San Diego Office Quarterly Newsletter / March 2010

Fonte: Monterey, California, Naval Postgraduate School Publicador: Monterey, California, Naval Postgraduate School
Tipo: Newsletter
Português
Relevância na Pesquisa
16.67%
This newsletter presents topics of interest to NPS Distance Learning students.

Outreach NPS San Diego Office Quarterly Newsletter / June 2010

Fonte: Monterey, California, Naval Postgraduate School Publicador: Monterey, California, Naval Postgraduate School
Tipo: Newsletter
Português
Relevância na Pesquisa
16.67%
This newsletter presents topics of interest to NPS Distance Learning students

Distance Learning Handbook for Students

The Center for Educational Design, Development, and Distribution (CED3)
Fonte: Monterey, California: Naval Postgraduate School. Publicador: Monterey, California: Naval Postgraduate School.
Tipo: Livro
Português
Relevância na Pesquisa
27.3%
Handbook for Distance learning students produced by CED3.

Quick Start Guide for Distance Learning Faculty

CED3
Fonte: Monterey, California: Naval Postgraduate School Publicador: Monterey, California: Naval Postgraduate School
Tipo: Livro
Português
Relevância na Pesquisa
27.3%
Handbook includes information about: Academics, admissions, learning management, course delivery, learning etchnologies, etc. Produced by: The Center for Educational Design, Development, and Distribution (CED3).