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On molecular chirality within naturally occurring secondary organic aerosol particles from the central Amazon Basin

MARTINEZ, Imee Su; PETERSON, Mark D.; EBBEN, Carlena J.; HAYES, Patrick L.; Artaxo Netto, Paulo Eduardo; MARTIN, Scot T.; GEIGER, Franz M.
Fonte: ROYAL SOC CHEMISTRY Publicador: ROYAL SOC CHEMISTRY
Tipo: Artigo de Revista Científica
Português
Relevância na Pesquisa
46.26%
In this perspectives article, we reflect upon the existence of chirality in atmospheric aerosol particles. We then show that organic particles collected at a field site in the central Amazon Basin under pristine background conditions during the wet and dry seasons consist of chiral secondary organic material. We show how the chiral response from the aerosol particles can be imaged directly without the need for sample dissolution, solvent extraction, or sample preconcentration. By comparing the chiral-response images with optical images, we show that chiral responses always originate from particles on the filter, but not all aerosol particles produce chiral signals. The intensity of the chiral signal produced by the size resolved particles strongly indicates the presence of chiral secondary organic material in the particle. Finally, we discuss the implications of our findings on chiral atmospheric aerosol particles in terms of climate-related properties and source apportionment.; Northwestern Initiative for Sustainability and Energy at Northwestern (ISEN); National Science Foundation NSF; Achievement Rewards for College Scientists (ARCS); Schlumberger Oilfield Chemical Products, LLC; FAPESP; CNPq; Office of Science (BES), U.S. Department of Energy (DOE)[DE-FG02-08ER64529]; National Science Foundation Atmospheric Chemistry division[NSF ATM-0533436]; Division of Chemistry[CHE-0937460]; Irving M

Visualização e modelagem no ensino de química orgânica: a visão de professores em um curso de formação continuada; Visualization and Modeling in Organic Chemistry instruction: teachers´views on a continuing education course

Mantovani, Vivian Lopes
Fonte: Biblioteca Digitais de Teses e Dissertações da USP Publicador: Biblioteca Digitais de Teses e Dissertações da USP
Tipo: Dissertação de Mestrado Formato: application/pdf
Publicado em 10/06/2013 Português
Relevância na Pesquisa
56.19%
Essa dissertação está baseada em uma pesquisa qualitativa, em que procuramos conhecer e analisar como professores em um curso de formação continuada, onde são utilizadas ferramentas visuais e modelos, receberiam esse tipo de informação e se esse modo de exposição poderia afetar a maneira como pensam a sua prática docente. Percebe-se que o papel dos modelos e da utilização de ferramentas que favoreçam a visualização tem crescido nas últimas décadas, fato observado pela quantidade de trabalhos envolvendo tal temática. Dessa maneira, os cursos de formação continuada podem ser bastante proveitosos, na tentativa de preparar o professor para a utilização crítica dessas ferramentas e modelos, bem como servirem como momentos de reflexão sobre a própria prática docente. Nesse sentido, foram acompanhadas pela pesquisadora as aulas de Química Orgânica de um curso de pós-graduação Lato Sensu. Foi aplicado um questionário no início das aulas, com o objetivo de identificar o perfil dos alunos, suas expectativas, seus conhecimentos prévios acerca de alguns conceitos trabalhados nessa tese. As aulas foram acompanhadas, visando-se perceber a interação da docente e dos alunos com as ferramentas visuais utilizadas. Além disso...

Processos de ensino e aprendizagem de conceitos de química orgânica sob um olhar da semiótica peirceana; The teaching and learning processes of organic chemistry concepts in the Peirce semiotics perspective.

Wartha, Edson José
Fonte: Biblioteca Digitais de Teses e Dissertações da USP Publicador: Biblioteca Digitais de Teses e Dissertações da USP
Tipo: Tese de Doutorado Formato: application/pdf
Publicado em 09/08/2013 Português
Relevância na Pesquisa
66.33%
Este estudo objetiva aproximar as Ciências Cognitivas da Semiótica Peirceana, na tentativa de compreender as dificuldades dos alunos na apropriação dos processos de representação nas disciplinas de Química Orgânica. Nesse sentido, pretende-se identificar e analisar como ocorrem os processos de percepção, interpretação e construção de representações no ensino e aprendizagem de Química Orgânica. No presente trabalho, delimitou-se a sala de aula como núcleo de uma rede de atividades para a formulação de situações de estudo. A justificativa por essa opção reside na oportunidade que esse locus fornece como meio de intercomunicação, no qual o professor apreende as participações de cada aluno em relação a um conjunto de atividades propostas ou negociadas, que são interpretadas como relações entre signos, objetos e interpretantes. Com base nos resultados da pesquisa, pode-se afirmar que a Semiótica Peirceana tem muito a contribuir na compreensão dos processos de ensino e aprendizagem de conceitos da Química Orgânica, principalmente no que se refere à importância da aquisição de sua linguagem específica no processo de elaboração conceitual. Foi possível identificar dificuldades de ensino e de aprendizagem na disciplina de Química Orgânica...

Estudo de casos : uma proposta para o ensino de química orgânica no ensino médio; Case study: a proposal for organic chemistry teaching in high school

Alba, Juliana
Fonte: Universidade Federal do Rio Grande do Sul Publicador: Universidade Federal do Rio Grande do Sul
Tipo: Trabalho de Conclusão de Curso Formato: application/pdf
Português
Relevância na Pesquisa
56.11%
Este trabalho consiste no relato da experiência da aplicação do método de Estudo de Casos. Essa metodologia foi aplicada em uma turma de segundo ano do Ensino Médio de uma escola pública de Porto Alegre para o estudo das funções orgânicas, por meio do tema “Medicamentos”. Foram utilizados instrumentos de coleta de dados, antes e depois da realização das atividades, a fim de avaliar a contribuição do método para o aprendizado dos conceitos de química orgânica, desenvolvimento de habilidades e capacidade de tomada de decisão dos alunos.; This work is a report on the experience of applying the Case Studies method. This methodology was applied in a class of second year of high school in a public school in Porto Alegre for the study of organic functions by means of the theme “Medicaments”. Instruments were used to collect data, before and after the implementation of activities, in order to access the contribution of the method for learning organic chemistry concepts, development of skills and capacity for decision making of students.

The contributions of Henri Victor Regnault in the context of organic chemistry of the first half of the nineteenth century

Reif-Acherman,Simón
Fonte: Sociedade Brasileira de Química Publicador: Sociedade Brasileira de Química
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/01/2012 Português
Relevância na Pesquisa
56.18%
A very little known aspect of the scientific career of Regnault is his contribution to the emerging organic chemistry in the first half of the nineteenth century. The purpose of this article is not only to describe two of his most important researches in this field, as were the discovery of two series of halogenated derivates of certain organic compounds and the precise identification of some of the then recently discovered alkaloids, but also the main features that identified his research method. With the involvement in these subjects, Regnault unintentionally positioned himself in the midst of some of the polemics about the classification of organic compounds that characterized this age of science.

Biomassa em aula prática de Química Orgânica Verde: cravo-da-índia como fonte simultânea de óleo essencial e de furfural

Cunha,Silvio; Lustosa,Danilo Machado; Conceição,Nathan Dias; Fascio,Miguel; Magalhães,Vinícius
Fonte: Sociedade Brasileira de Química Publicador: Sociedade Brasileira de Química
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/01/2012 Português
Relevância na Pesquisa
46.26%
This work presents an optimized integrated experiment for isolation of clove bud essential oil, rich in eugenol, and subsequent utilization of the solid residue for furfural synthesis. The operationally simple laboratory protocols and utilization of water as a solvent in both operations, plus the use of biomass as the starting material for preparation of versatile intermediates in organic synthesis, make the experiments attractive for undergraduate experimental organic chemistry courses in the context of green chemistry. In addition, this is the first description of the use of biomass (clove bud) in the simultaneous preparation of two chemical feedstocks, eugenol and furfural, on experimental organic chemistry courses.

Minimal Impact of Organic Chemistry Prerequisite on Student Performance in Introductory Biochemistry

Wright, Robin; Cotner, Sehoya; Winkel, Amy
Fonte: American Society for Cell Biology Publicador: American Society for Cell Biology
Tipo: Artigo de Revista Científica
Publicado em //2009 Português
Relevância na Pesquisa
46.33%
Curriculum design assumes that successful completion of prerequisite courses will have a positive impact on student performance in courses that require the prerequisite. We recently had the opportunity to test this assumption concerning the relationship between completion of the organic chemistry prerequisite and performance in introductory biochemistry. We found no statistically significant differences between average biochemistry grades or grade distribution among students with or without the organic chemistry prerequisite. However, students who had not completed the organic chemistry prerequisite before biochemistry were more likely to withdraw from the course than those who had completed the prerequisite. In contrast to the lack of correlation between performance in biochemistry and completion of organic chemistry, we observed a strong, highly significant positive relationship between cumulative GPA and the biochemistry grade. Our data suggest that excluding students without organic chemistry would have less positive impact on student success in biochemistry than would providing additional support for all students who enroll in biochemistry with a cumulative GPA below 2.5.

Professional Versus Non-professional Track Student Involvement in Organic Chemistry WorkshopsBy

Bourque, Nikita ; Hunter, Chad
Fonte: Universidade de Rochester Publicador: Universidade de Rochester
Tipo: Conferência ou Objeto de Conferência
Português
Relevância na Pesquisa
66.14%
poster, Organic Chemistry/CAS 352 student leader training seminar

Assessment of the “Content-First” Approach in College-Level Organic Chemistry Workshops

DeMars, Matthew ; Kaufman, Matthew ; Wasser, Bradley
Fonte: Universidade de Rochester Publicador: Universidade de Rochester
Tipo: Conferência ou Objeto de Conferência
Português
Relevância na Pesquisa
66.14%
poster, Organic Chemistry/CAS 352 student leader training seminar

Application of Biomarkers and Compound Specific Stable Isotopes for the Assessment of Hydrology as a Driver of Organic Matter Dynamics in the Everglades Ecosystem

He, Ding
Fonte: FIU Digital Commons Publicador: FIU Digital Commons
Tipo: Artigo de Revista Científica Formato: application/pdf
Português
Relevância na Pesquisa
46.3%
The Everglades is a sub-tropical coastal wetland characterized among others by its hydrological features and deposits of peat. Formation and preservation of organic matter in soils and sediments in this wetland ecosystem is critical for its sustainability and hydrological processes are important divers in the origin, transport and fate of organic matter. With this in mind, organic matter dynamics in the greater Florida Everglades was studied though various organic geochemistry techniques, especially biomarkers, bulk and compound specific δ13C and δD isotope analysis. The main objectives were focused on how different hydrological regimes in this ecosystem control organic matter dynamics, such as the mobilization of particulate organic matter (POM) in freshwater marshes and estuaries, and how organic geochemistry techniques can be applied to reconstruct Everglades paleo-hydrology. For this purpose organic matter in typical vegetation, floc, surface soils, soil cores, and estuarine suspended particulates were characterized in samples selected along hydrological gradients in the Water Conservation Area 3, Shark River Slough and Taylor Slough. This research focused on three general themes: (1) Assessment of the environmental dynamics and source-specific particulate organic carbon export in a mangrove-dominated estuary. (2) Assessment of the origin...

Identification of the difficulties in teaching and learning of introductory organic chemistry in Ireland and the development of a second-level intervention programme to address these

O'Dwyer, Anne
Fonte: University of Limerick Publicador: University of Limerick
Tipo: info:eu-repo/semantics/doctoralThesis; all_ul_research; ul_published_reviewed; ul_theses_dissertations
Português
Relevância na Pesquisa
56.5%
peer-reviewed; This project involved the effective implementation of Chemistry Education Research (CER) into classroom practice. The project was carried out in two cycles. Cycle One of the project involved two investigations: one at second-level and one at third-level. Cycle Two involved the development, implementation and evaluation of an intervention in the Irish second-level schools programme to address the issues identified in Cycle One. The difficulties of organic chemistry have been investigated and researched in many other countries. However, there has been no explicit research carried out investigating the difficulties experienced by novices learning organic chemistry in Ireland. This Action Research project involved an investigation of the difficulties experienced by those learning organic chemistry at second-level and at introductory third-level in Ireland. The second-level study involved the completion of questionnaires by chemistry teachers in 73 Second-Level schools and pupils in 35 second-level schools teaching Leaving Certificate Chemistry in Ireland. At third-level, questionnaires were completed by lecturers in 12 different third-level Irish institutions and to students in three different Institutions. These questionnaires provided an insight into the teaching and learning of organic chemistry. It was found that those teaching and learning organic chemistry at second-level and third-level experience many common topics as difficult: IUPAC nomenclature; functional groups; characteristics of organic compounds; reaction types; reaction mechanisms and practical work. Organic chemistry accounts for a substantial amount of the Leaving Certificate Chemistry syllabus (20%) and examination (25%). Using the findings from Cycle One and those from CER...

How Learning Styles, Chemistry Attitudes and Experiences, Confidence, and Demographics Correlate with Academic Success in First and Second Year Chemistry Courses

Ilnicki-Stone, Elizabeth
Fonte: Brock University Publicador: Brock University
Português
Relevância na Pesquisa
56.24%
At Brock University, the Faculty of Mathematics and Science currently has one of the highest percentages of students on academic probation, with many students reporting the most difficulty with Introductory Chemistry in first year and Organic Chemistry in second year. To identify strategies to improve students' performance and reduce the number of students on academic probation, a multi-year research project was undertaken involving several chemistry courses. Students were asked to complete three questionnaires, and provide consent to obtain their final Chemistry grade from the Registrar's Office. Research began at the end of the 2007-08 academic year with CHEM IPOO, and in the 2008-09 academic year, students in the larger CHEM IF92 Introductory Chemistry course were invited to participate in this research near the beginning of the academic year. Students who went on to take second year Organic and Analytical Chemistry were asked to complete these questionnaires in each second year course. The three questionnaires included the Kolb Learning Styles Inventory (Kolb, 1984) modified to include specific reference to Chemistry in each question, Dalgety, ColI, and Jones' (2002) Chemistry Attitudes and Experiences Questionnaire (CAEQ)...

Host-guest chemistry between cucurbit[7]uril and neutral and cationic guests

WYMAN, IAN
Fonte: Quens University Publicador: Quens University
Tipo: Tese de Doutorado Formato: 7145551 bytes; application/pdf
Português
Relevância na Pesquisa
46.28%
This thesis describes the host-guest chemistry between cucurbit[7]uril (CB[7]) and various series of guests, including neutral polar organic solvents, bis(pyridinium)alkane dications, local anaesthetics, acetylcholine analogues, as well as succinylcholine and decamethonium analogues, in aqueous solution. A focus of this thesis is the effects of varying the chemical structures within different series of guests upon the nature of the host-guest chemistry, such as the relative position and orientation of the guest relative to the CB[7] cavity, and the strengths of the binding affinities. The binding affinities of polar organic solvents with CB[7] depend upon the hydrophobic effect and dipole-quadrupole interactions. The polar guests align themselves so that their dipole moment is perpendicular to the quadrupole moment of CB[7]. The binding strengths of acetone and acetophenone to CB[7] decrease in the presence of alkali metals. Discrete 1:1 and 2:1 host-guest complexes are formed between CB[7] and a series of bis(pyridinium)alkane guests. In most cases the CB[7] initially occupies the aliphatic linker when the 1:1 complex is formed and migrates to the terminal regions as the second CB[7] is added. When bulky, hydrophobic tert-butyl substituents are present...

The study of organic crystals by atomic force microscopy

Chow, Ernest Ho Hin
Fonte: University of Cambridge; Department of Chemistry Publicador: University of Cambridge; Department of Chemistry
Tipo: Thesis; doctoral; PhD
Português
Relevância na Pesquisa
46.32%
Organic crystals are found in everyday goods such as foods, drugs, dyes, and agricultural products. To better understand the solid-state behaviour of organic crystals, the study of their surfaces is crucial, as several reactions occur at the interface between the crystal surface and its immediate environment. While atomic force microscopy (AFM) is a useful tool for studying surfaces, it is not a common technique for studying organic crystals. The rst part of this report aims to address problems of imaging organic crystals by AFM which arise from the nature of the imaging technique and the material property of organic crystals. Methods of detecting and predicting the likelihood of the problems encountered in imaging organic crystals are suggested in order for a more accurate interpretation of the information obtained by this technique. The e ect of humidity on aspirin crystal surfaces is then investigated by AFM. The growth of new features on the surface is believed to be a result of the hydrolysis of aspirin molecules. Mechanisms are suggested based on the observed surface response of aspirin, where surface defects and the mobility of surface molecules are believed to be important factors a ecting reactivity. The last section investigates the solid-state photochemical reaction of anthracene...

Where is physical organic chemistry going?

Roberts, John D.
Fonte: International Union of Pure and Applied Chemistry Publicador: International Union of Pure and Applied Chemistry
Tipo: Article; PeerReviewed Formato: application/pdf
Publicado em /02/1997 Português
Relevância na Pesquisa
56.3%
John D. Roberts graduated from the University of California at Los Angeles with an A. B. (hons) degree in 1941 and the Ph. D. degree in 1944. His academic career began in 1945, as Instructor at UCLA. In 1945-1946 he was National Research Council Fellow and Instructor at Harvard. He went to MIT in 1946 as an Instructor, was Assistant Professor in 1947 and Associate Professor in 1950. In 1953 he became Professor of Organic Chemistry at Caltech and in 1972 Institute Professor of Chemistry. He is now Institute Professor of Chemistry, Emeritus and Lecturer. He is a member of the National Academy of Sciences (1956) and the American Philosophical Society (1974). He received the Welch Award (1990, with W. E. Doering), the National Medal of Science (1990), and the ACS Arthur C. Cope Award (1994). Since 1939 his research has been concerned with the mechanisms of organic reactions and the chemistry of small-ring compounds. His current work involves applications of nuclear magnetic resonance spectroscopy to physical organic chemistry.

Organic chemistry: methane to macromolecules

Roberts, John D.; Stewart, Ross; Caserio, Marjorie C.
Fonte: W. A. Benjamin, Inc. Publicador: W. A. Benjamin, Inc.
Tipo: Book; NonPeerReviewed Formato: application/pdf
Publicado em //1971 Português
Relevância na Pesquisa
46.39%
The success achieved by this book's forerunners, Basic Principles of Organic Chemistry and Modern Organic Chemistry, was to a considerable extent due to the rigor with which the subject of organic chemistry was presented. In the present work we have tried to paint an interesting, relevant, and up-to-date picture of organic chemistry while retaining the rigorous approach of the earlier books. Organic chemistry sometimes appears to be enormously complex to the beginning student, particularly if he must immediately grapple with the subjects of structural isomerism and nomenclature. We have attempted to avoid this difficulty in the following way. Chapter 1 briefly relates carbon to its neighbors in the Periodic Table and reviews some fundamental concepts. Chapter 2 deals with the four C1 and C2 hydrocarbons-methane, ethane, ethene, and ethyne-and discusses their conformational and configurational properties and some of their chemical reactions. The reader thus makes an acquaintance with the properties of some important organic compounds before dealing in an open-ended way with families of compounds-alkanes, alcohols, etc. A heavy emphasis on spectroscopy is retained but the subject is introduced somewhat later than in the earlier books. Important additions are chapters dealing with enzymic processes and metabolism and with cyclization reactions. Many of the exercises of the earlier books have been retained and have been supplemented with drill-type problems. It seems a shame to burden the mind of the beginning student with trivial names...

Basic Principles of Organic Chemistry, second edition

Roberts, John D.; Caserio, Marjorie C.
Fonte: W. A. Benjamin, Inc. Publicador: W. A. Benjamin, Inc.
Tipo: Book; NonPeerReviewed Formato: application/pdf; application/pdf; application/pdf; application/pdf; application/pdf; application/pdf; application/pdf; application/pdf; application/pdf; application/pdf; application/pdf; application/pdf; application/pdf; application/pdf; application/pdf;
Publicado em 15/05/1977 Português
Relevância na Pesquisa
46.42%
PREFACE: No period in the history of organic chemistry has been as dynamic and productive of research accomplishment as the twelve years between the completion of the first and present editions of this textbook. New reagents, new reactions, and extraordinary syntheses have been manifold. New techniques and new instruments for analysis and determination of structures, improved methods for theoretical calculations, as well as new junctures with physical, inorganic, and biochemistry, have made organic chemistry an enormously vital discipline. But along with this "best of times," there is a "worst of times" coming from the recognition that many widely used organic compounds are more toxic than previously suspected. Some are carcinogenic; some may be destroying the ozone layer in the upper atmosphere, which protects all life from the sun's strong ultraviolet radiation; others are concentrated and persist in living tissue to as yet unknown effect. Nonetheless, our society has come to depend on synthetic organic chemicals, and we may ponder the fact that in just a few years the petroleum that makes so many useful organic compounds easily available will be in very short supply throughout the world. It has been a real challenge for us to try to cover the elements of modern organic chemistry with sufficient breadth to anticipate the interests and needs of the future chemists...

"Thin Layer Chromatography" Video Lecture and Learning Motivation in Organic Chemistry Laboratory Classes of Chemistry, Chemical Engineering and Pharmacy courses - UFF; A Videoaula “Cromatografia em Camada Delgada” e a Motivação da Aprendizagem nas Disciplinas Experimentais de Química Orgânica dos Cursos de Química, Engenharia Química e Farmácia da UFF

Carlos Magno R. Ribeiro; Universidade Federal Fluminense; Alessandra Leda Valverde; Universidade Federal Fluminense; Mariana M. J. Ribeiro; Universidade Federal Fluminense; Thiago S. G. Souza; Universidade Federal Fluminense; Thayssa S. F. Fagundes; Unive
Fonte: Revista Virtual de Química Publicador: Revista Virtual de Química
Tipo: ; Formato: binary/octet-stream; video/x-msvideo
Publicado em 27/05/2015 Português
Relevância na Pesquisa
56.3%
This paper describes the methodological approach followed in preparation, implementation and evaluation of the video tutorial "Thin Layer Chromatography", performed by 3 professors, 4 undergraduate and 1 PhD teaching assistants students, all of them from the Organic Chemistry Department of the Universidade Federal Fluminense (UFF). Alongside to video preparation, a survey with 127 undergraduate students (Chemistry, Chemical Engineering and Pharmacy courses) enrolled in 14 different Organic Chemistry laboratory classes was conduct along 2013, seeking to know the types of resources textbooks they had access in elementary, middle and high schools, as well as their frequency of use. Similarly, there was a survey with 6 instructors who taught these subjects also in 2013, seeking to ascertain the types of educational resources used in their undergraduate classes, as well as its frequency of use. Results indicated that the most common teaching resources in elementary, middle and high schools were the blackboard and chalk, and rarely videos, games and library visits. These answers were in agreement with the undergraduate professor’s ones. After the initial research, tutorial video class was applied in 9 of 14 Organic Chemistry laboratory classes mentioned above.  To assess the helpfulness of the tutorial...

James Moir as Organic Chemist

Loyson,Peter
Fonte: South African Journal of Chemistry Publicador: South African Journal of Chemistry
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/01/2014 Português
Relevância na Pesquisa
66.29%
James Moir played a leading role in the South African Chemical Institute and was a pioneering organic chemist in South Africa during the early 1900s. He published widely on various organic topics but was especially noted for his work on the relationship between the colour of an organic substance and its chemical structure or constitution. After some initial research work in Scotland and London dealing with amarine and diacetonitrile, he arrived in South Africa in 1902. He first worked on derivatives of diphenol, oxidation products of benzidine, diphenylquinone and other compounds. His immense study of colour covered the years 1916-1929. He put forward theories on colour, which he applied to a whole range of phthaleins and related compounds, in order to see the effect of substitution on the spectrum of the compound. He introduced his numerical solution of colour, by which he could predict the band centre of absorption of many compounds. He applied this to a variety of different dyes and substituted products of phenolphthalein and fluorescein, relating colour to structure. He also studied the factors responsible for organic fluorescence, and doubly-linked diphenylene compounds. Finally he studied the structure of various flower pigments. This article explores his research output in the field of organic chemistry.

An inquiry-based practical curriculum for organic chemistry as preparation for industry and postgraduate research

Pilcher,Lynne A.; Riley,Darren L.; Mathabathe,Kgadi C.; Potgieter,Marietjie
Fonte: South African Journal of Chemistry Publicador: South African Journal of Chemistry
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/01/2015 Português
Relevância na Pesquisa
76.19%
This paper describes the development of a new practical curriculum for third-year organic chemistry to replace the recipe-based approach typically used in undergraduate teaching laboratories. The new curriculum consists of an inquiry-based project set in a simulated industrial context preceded by two scaffolding experiments to prepare students for the task. The industrial project requires students to evaluate experimentally three multi-step synthetic routes to a given target based on cost, technical challenge and environmental impact in order to make a recommendation as to which route the 'company' should use to synthesize the compound. The project equips students with technical skills suitable for both postgraduate research and industry, and develops metacognition and understanding through the use of the jig-saw cooperative learning strategy and reflection. The students were found to engage with the practical work at a deep intellectual level, demonstrating that contextualized inquiry-based laboratory teaching afforded an improved quality of learning. In addition, the reported practical curriculum made a difficult subject accessible and even popular, to some measure grew the students' ability in all desired graduate attributes and resulted in the establishment of a professional identity for individual students.