Página 1 dos resultados de 27 itens digitais encontrados em 0.011 segundos

O efeito dos estanóis vegetais na dislipidemia dos indivíduos infectados pelo VIH

Lopes, Joana Patrícia Faria Pinho
Fonte: Porto : edição de autor Publicador: Porto : edição de autor
Tipo: Dissertação
Português
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Resumo da dissertação:Objectivos: Uma grande percentagem de indivíduos infectados pelo VIH submetidos a terapia anti-retrovírica altamente activa (HAART) desenvolve dislipidemia. Estudos em outras populações revelam que o consumo de fitoesteróis/fitoestanóis consegue reduzir os níveis séricos de colesterol-LDL. O objectivo deste estudo foi avaliar o efeito da ingestão de fitoestanóis, sob a forma de leite fermentado, associada à dieta e à prática de exercício físico habituais, no nível sérico de colesterol-LDL de indivíduos VIH positivos, submetidos a um esquema de anti-retrovíricos, com dislipidemia, a fazer ou não antidislipidémico. Métodos: Foi conduzido um estudo experimental, randomizado, cruzado, não cego com a duração de 12 semanas, em 16 indivíduos infectados pelo VIH, com níveis de colesterol-LDL: 100mg/dl, que consumiram um leite fermentado com 2g/dia de fitoestanóis durante 30 dias. Foram recolhidos dados analíticos, antropométricos e relativos à actividade física habitual e aos hábitos alimentares nas semanas 0, 4,8 e 12. Resultados: Foram avaliados 9 homens e 7 mulheres, com uma média de idade de 51 anos. 75% dos indivíduos estavam submetidos a 2 inibidores nucleosídeos da transcriptase reversa e 1 inibidor não nucleosídeo da transcriptase reversa. Metade dos indivíduos fazia antidislipidémicos. 50% dos indivíduos apresentavam peso normal...

Evaluation of Phytosterols in Milk and Yogurts Used as Functional Foods in Portu

Saraiva, David; Castilho, M. Conceição; Martins, M. Rosário; Noronha da Silveira, M. Irene; Ramos, Fernando
Fonte: Springer Publicador: Springer
Tipo: Artigo de Revista Científica
Português
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The early development of cardiovascular diseases, one of the major death causes in Europe, is clearly associated with high plasmatic cholesterol levels. However, it is demonstrated that the ingestion of phytosterols enriched milk and yogurts could reduce cholesterolemia. The purpose of the present work was to assess the commercially available phytosterols-enriched milk and yogurts. As such, the available three milk and seven yogurt presentations in Portuguese market were collected during 2008 and analyzed through gas chromatography coupled with mass detection. All the analyzed milk samples were in agreement with the proportion established by the European Commission, with β-sitosterol as the more abundant phytosterol. However, and contrarily to milk, the different yogurt manufacturers had different options in the phytosterols added to the dairy foods commercialized.

Role and health benefits of different functional food components

Guiné, Raquel; Lima, Maria; Barroca, Maria
Fonte: Instituto Politécnico de Viseu Publicador: Instituto Politécnico de Viseu
Tipo: Artigo de Revista Científica
Publicado em /11/2009 Português
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Functional food components are potentially beneficial components found naturally in foods or added to them as functional ingredients, and include carotenoids, dietary fiber, fatty acids, flavonoids, isothiocyanates, phenolic acids, plant stanols and sterols, polyols, prebiotics and probiotics, phytoestrogens, soy protein, vitamins and minerals. At present, professionals are recognizing that some functional components of foods have a major role in health enhancement. In fact, the big importance of these “bioactives” present in many foods, either naturally or added, has lead many scientists of different fields to conduct studies aimed for establishing the scientific basis that supports and validates the benefits of a particular food or component for the human health. It appears that people should strive to consume a wide variety of foods such as to assure the ingestion of compounds such as carotenoids, fiber, flavonoids, specific fatty acids, minerals, prebiotics and probiotics, phytoestrogens, soy protein and vitamins, among others, in order to reduce the risk of developing some diseases, or even to help curing others. In the present work...

Expression and Chloroplast Targeting of Cholesterol Oxidase in Transgenic Tobacco Plants

Corbin, David R.; Grebenok, Robert J.; Ohnmeiss, Thomas E.; Greenplate, John T.; Purcell, John P.
Fonte: American Society of Plant Physiologists Publicador: American Society of Plant Physiologists
Tipo: Artigo de Revista Científica
Publicado em /07/2001 Português
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Cholesterol oxidase represents a novel type of insecticidal protein with potent activity against the cotton boll weevil (Anthonomus grandis grandis Boheman). We transformed tobacco (Nicotiana tabacum) plants with the cholesterol oxidase choM gene and expressed cytosolic and chloroplast-targeted versions of the ChoM protein. Transgenic leaf tissues expressing cholesterol oxidase exerted insecticidal activity against boll weevil larvae. Our results indicate that cholesterol oxidase can metabolize phytosterols in vivo when produced cytosolically or when targeted to chloroplasts. The transgenic plants exhibiting cytosolic expression accumulated low levels of saturated sterols known as stanols, and displayed severe developmental aberrations. In contrast, the transgenic plants expressing chloroplast-targeted cholesterol oxidase maintained a greater accumulation of stanols, and appeared phenotypically and developmentally normal. These results are discussed within the context of plant sterol distribution and metabolism.

Plant Sterols and Stanols: Their Role in Health and Disease

Patel, Shailendra B.
Fonte: PubMed Publicador: PubMed
Tipo: Artigo de Revista Científica
Publicado em /04/2008 Português
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Mammalian physiological processes, and likely any organism with a biliary tree, can distinguish between dietary cholesterol and non-cholesterols, retaining very little of the non-cholesterol in their bodies. Historically, the distinction between plant sterols and cholesterol has been known about for a century or more. That plants sterols were not ‘absorbed’ has been investigated for almost half a century. Indeed, the oral of plant sterols in gram quantities was shown to interfere with cholesterol absorption and is one of the oldest pharmacological therapies for hypercholesterolemia. Although the basis for the latter was shown to be caused by exclusion of cholesterol from intestinal micelles by plant sterols, it was not until the identification of the a rare genetic disease, sitosterolemia, first described in 1974, that led to the hypothesis that specific molecular mechanism(s) governed both the entry and excretion of sterols by the body. This talk will cover the physiology of dietary sterol metabolism, genetics and pathophysiology of sitosterolemia. Additionally, the role of plant sterols in normal and abnormal metabolism in humans as well as selected animal models will be discussed.

TLR2 Activation Is Essential to Induce a Th1 Shift in Human Peripheral Blood Mononuclear Cells by Plant Stanols and Plant Sterols

Brüll, Florence; Mensink, Ronald P.; van den Hurk, Karin; Duijvestijn, Adriaan; Plat, Jogchum
Fonte: American Society for Biochemistry and Molecular Biology Publicador: American Society for Biochemistry and Molecular Biology
Tipo: Artigo de Revista Científica
Português
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Plant sterols may induce a Th1 shift in humans. However, whether plant stanols have similar effects as well as the underlying mechanism are unknown. We have now shown that (like sitosterol) sitostanol, both 4-desmethylsterols, induces a Th1 shift when added in vitro at physiological concentrations to human PBMCs. This conclusion was based on a higher IFNγ production, with no change in the production of IL-4 and IL-10. α-Amyrin, a 4.4-dimethylsterol, had comparable effects. Because 4.4-dimethylsterols cannot activate transcription factor LXR, this finding indicates that LXR activation was not involved. Sitosterol and sitostanol did not alter the production of IL-12 and IL-18 in PBMCs as well as in monocyte-derived U937 cells, suggesting that plant sterols directly affect T-helper cells, without activating APCs. However, in PBMCs treated with a TLR2 blocker (T2.5), IFNγ production was completely inhibited, whereas blocking TLR4 with HTA125 had no such effect. To confirm these findings, PBMCs from TLR2−/− mice were cultured in the presence of sitosterol and sitostanol. In these cells, no Th1 shift was observed. Our results, therefore, indicate that TLR2 activation is essential to induce a Th1 shift in human PBMCs by plant stanols and plant sterols.

Phytosterols and phytosterolemia: gene–diet interactions

Izar, Maria C.; Tegani, Daniela M.; Kasmas, Soraia H.; Fonseca, Francisco A.
Fonte: Springer-Verlag Publicador: Springer-Verlag
Tipo: Artigo de Revista Científica
Português
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Phytosterol intake is recommended as an adjunctive therapy for hypercholesterolemia, and plant sterols/stanols can reduce cholesterol absorption at the intestinal lumen through the Niemann-Pick C1 Like 1 (NPC1L1) transporter pathway by competitive solubilization in mixed micelles. Phytosterol absorption is of less magnitude than cholesterol and is preferably secreted in the intestinal lumen by ABCG5/G8 transporters. Therefore, plasma levels of plant sterols/stanols are negligible compared with cholesterol, under an ordinary diet. The mechanisms of cholesterol and plant sterols absorption and the whole-body pool of sterols are discussed in this chapter. There is controversy about treatment with statins inducing further increase in plasma non-cholesterol sterols raising concerns about the safety of supplementation of plant sterols to such drugs. In addition, increase in plant sterols has also been reported upon consumption of plant sterol–enriched foods, regardless of other treatments. Rare mutations on ABCG5/G8 transporters affecting cholesterol/non-cholesterol extrusion, causing sitosterolemia with xanthomas and premature atheroslerotic disease are now known, and cholesterol/plant sterols absorption inhibitor, ezetimibe, emerges as the drug that reduces phytosterolemia and promotes xanthoma regression. On the other hand...

A Review of the Rationale for Additional Therapeutic Interventions to Attain Lower LDL-C When Statin Therapy Is Not Enough

Shanes, Jeffrey G.
Fonte: Current Science Inc. Publicador: Current Science Inc.
Tipo: Artigo de Revista Científica
Português
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Statins alone are not always adequate therapy to achieve low-density lipoprotein (LDL) goals in many patients. Many options are available either alone or in combination with statins that makes it possible to reach recommended goals in a safe and tolerable fashion for most patients. Ezetimibe and bile acid sequestrants reduce cholesterol transport to the liver and can be used in combination. Niacin is very effective at lowering LDL, beyond its ability to raise high-density lipoprotein and shift LDL particle size to a less atherogenic type. When statins cannot be tolerated at all, red yeast rice can be used if proper formulations of the product are obtained. Nutrients can also be added to the diet, including plant stanols and sterols, soy protein, almonds, and fiber, either individually or all together as a portfolio diet. A clear understanding of how each of these strategies works is essential for effective results.

P02.88. Powdered Red Yeast Rice and Plant Stanols and Sterols to lower cholesterol

Feuerstein, J; Bjerke, W
Fonte: BioMed Central Publicador: BioMed Central
Tipo: Artigo de Revista Científica
Publicado em 12/06/2012 Português
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Lipid-altering effects of a dietary supplement tablet containing free plant sterols and stanols in men and women with primary hypercholesterolaemia: a randomized, placebo-controlled crossover trial

Maki, Kevin C; Lawless, Andrea L; Reeves, Matthew S; Dicklin, Mary R; Jenks, Belinda H; Shneyvas, ED; Brooks, James R
Fonte: Informa Healthcare Publicador: Informa Healthcare
Tipo: Artigo de Revista Científica
Publicado em /06/2012 Português
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This randomized, placebo-controlled, crossover trial assessed the lipid-altering efficacy of a dietary supplement (tablet form) providing 1.8g/day free (non-esterified) plant sterols and stanols versus placebo for 6 weeks as part of a therapeutic lifestyle changes (TLC) diet in 32 men and women with primary hypercholesterolaemia. Mean ± SE baseline (end of a 5-week TLC diet lead-in) lipid concentrations (mmol/1) were total cholesterol (TC), 5.88 ± 0.08; non-high-density lipoprotein cholesterol (non-HDL-C), 4.71 ± 0.09; low-density lipoprotein cholesterol (LDL-C), 4.02 ± 0.08; HDL-C, 1.17 ± 0.06 and triglycerides (TGs), 1.51 ± 0.12. Differences from control in responses (plant sterol/stanol — control) were significant (p < 0.05) for LDL-C (− 4.9%), non-HDL-C (− 3.6%) and TC (− 2.8%). HDL-C and TG responses were not significantly different between treatment conditions. These results indicate that 1.8g/day free plant sterols/stanols administered in a tablet produced favourable lipoprotein lipid changes in men and women with hypercholesterolaemia.

Dose-dependent LDL-cholesterol lowering effect by plant stanol ester consumption: clinical evidence

Laitinen, Kirsi; Gylling, Helena
Fonte: BioMed Central Publicador: BioMed Central
Tipo: Artigo de Revista Científica
Publicado em 22/10/2012 Português
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Elevated serum lipids are linked to cardiovascular diseases calling for effective therapeutic means to reduce particularly LDL-cholesterol (LDL-C) levels. Plant stanols reduce levels of LDL-C by partly blocking cholesterol absorption. Accordingly the consumption of foods with added plant stanols, typically esterified with vegetable oil fatty acids in commercial food products, are recommended for lowering serum cholesterol levels. A daily intake of 1.5 to 2.4 g of plant stanols has been scientifically evaluated to lower LDL-C by 7 to 10% in different populations, ages and with different diseases. Based on earlier studies, a general understanding is that no further reduction may be achieved in intakes in excess of approximately 2.5 g/day. Recent studies however suggest that plant stanols show a continuous dose–response effect in serum LDL-C lowering. This review discusses the evidence for a dose-effect relationship between plant stanol ester consumption and reduction of LDL-C concentrations with daily intakes of plant stanols of 4 g/day or more. We identified five such studies and the overall data demonstrate a linear dose-effect relationship with the most pertinent LDL-Cholesterol lowering outcome, 18%, achieved by a daily intake of 9 to 10 g of plant stanols. Along with reduction in LDL-C...

Low-Fat Nondairy Minidrink Containing Plant Stanol Ester Effectively Reduces LDL Cholesterol in Subjects with Mild to Moderate Hypercholesterolemia as Part of a Western Diet

Hallikainen, Maarit; Olsson, Johan; Gylling, Helena
Fonte: Hindawi Publishing Corporation Publicador: Hindawi Publishing Corporation
Tipo: Artigo de Revista Científica
Português
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The cholesterol-lowering efficacy of plant stanol ester (STAEST) added to fat- or milk-based products is well documented. However, their efficacy when added to nondairy liquid drinks is less certain. Therefore, we have investigated the cholesterol-lowering efficacy of STAEST added to a soymilk-based minidrink in the hypercholesterolemic subjects. In a randomized, double-blind, placebo-controlled parallel study, the intervention group (n = 27) consumed 2.7 g/d of plant stanols as the ester in soymilk-based minidrink (65 mL/d) with the control group (n = 29) receiving the same drink without added plant stanols once a day with a meal for 4 weeks. Serum total, LDL, and non-HDL cholesterol concentrations were reduced by 8.0, 11.1, and 10.2% compared with controls (P < 0.05 for all). Serum plant sterol concentrations and their ratios to cholesterol declined by 12–25% from baseline in the STAEST group while the ratio of campesterol to cholesterol was increased by 10% in the controls (P < 0.05 for all). Serum precursors of cholesterol remained unchanged in both groups. In conclusion, STAEST-containing soymilk-based low-fat minidrink consumed once a day with a meal lowered LDL and non-HDL cholesterol concentrations without evoking any side effects in subjects consuming normal Western diet. The clinical trial registration number is NCT01716390.

LDL-cholesterol-lowering effect of plant sterols and stanols across different dose ranges: a meta-analysis of randomised controlled studies

Ras, Rouyanne T.; Geleijnse, Johanna M.; Trautwein, Elke A.
Fonte: Cambridge University Press Publicador: Cambridge University Press
Tipo: Artigo de Revista Científica
Português
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Phytosterols (PS, comprising plant sterols and plant stanols) have been proven to lower LDL-cholesterol concentrations. The dose–response relationship for this effect has been evaluated in several meta-analyses by calculating averages for different dose ranges or by applying continuous dose–response functions. Both approaches have advantages and disadvantages. So far, the calculation of averages for different dose ranges has not been done for plant sterols and stanols separately. The objective of the present meta-analysis was to investigate the combined and separate effects of plant sterols and stanols when classified into different dose ranges. Studies were searched and selected based on predefined criteria. Relevant data were extracted. Average LDL-cholesterol effects were calculated when studies were categorised by dose, according to random-effects models while using the variance as weighing factor. This was done for plant sterols and stanols combined and separately. In total, 124 studies (201 strata) were included. Plant sterols and stanols were administered in 129 and fifty-nine strata, respectively; the remaining used a mix of both. The average PS dose was 2·1 (range 0·2–9·0) g/d. PS intakes of 0·6–3·3 g/d were found to gradually reduce LDL-cholesterol concentrations by...

Plant Sterols, Stanols, and Sitosterolemia

Ajagbe, Bridget O.; Othman, Rgia A.; Myrie, Semone B.
Fonte: PubMed Publicador: PubMed
Tipo: Artigo de Revista Científica
Português
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Phytosterolemia (sitosterolemia) is a rare autosomal recessive sterol storage disease caused by mutations in either of the adenosine triphosphate (ATP) binding cassette transporter genes; (ABC)G5 or ABCG8, leading to impaired elimination of plant sterols and stanols, with their increased accumulation in the blood and tissues. Thus the disease is characterized by substantially elevated serum plant sterols and stanols, with moderate to high plasma cholesterol levels, and increased risk of premature atherosclerosis. Hematologic abnormalities including macrothrombocytopenia, stomatocytosis and hemolysis are frequently observed in sitosterolemia patients. Currently, ezetimibe, a sterol absorption inhibitor, is used as the routine treatment for sitosterolemia, with reported improvement in plant sterol levels and hemolytic parameters. This review summarizes the research related to the health impact of plant sterols and stanols on sitosterolemia.

Plant sterol and stanols - comparison and contrasts. Sterols versus stanols in cholesterol-lowering: is there a difference?

Clifton, P.
Fonte: Elsevier Science Ireland Ltd Publicador: Elsevier Science Ireland Ltd
Tipo: Artigo de Revista Científica
Publicado em //2002 Português
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http://www.elsevier.com/wps/find/journaldescription.cws_home/522790/description#description; Peter Clifton

Serum Cholesterol Reduction Efficacy of Biscuits with Added Plant Stanol Ester

Kriengsinyos, Wantanee; Wangtong, Ajima; Komindr, Surat
Fonte: Hindawi Publishing Corporation Publicador: Hindawi Publishing Corporation
Tipo: Artigo de Revista Científica
Português
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This study's aim was to test the low-density lipoprotein cholesterol- (LDL-c-) lowering efficacy of biscuits containing 2 g of plant stanols, which corresponded to 3.4 g of plant stanol esters. The biscuit is a new food format that can be consumed as a snack. In a double-blind, placebo-controlled parallel design study, 119 mildly to moderately hypercholesterolemic volunteers were randomized to plant stanol or control groups. Subjects were comparable in age, gender, lipid profiles, and body mass index. They consumed a control biscuit once a day for a two-week period, followed by a four-week intervention period that either had a plant stanol ester biscuit or a control. During the habitual diet, one biscuit per day was consumed at any time that subjects wished. Serum lipid profiles were measured at the first day of run-in, at baseline, and at the study's end. Compared to the control, the total cholesterol (TC), LDL-c, and the LDL-to-high-density lipoprotein (LDL/HDL) ratio had serum reductions of 4.9%, 6.1%, and 4.3%, respectively, and were observed after 4 weeks of biscuit consumption with added plant stanols (P < 0.05). A significantly higher reduction in LDL-c (8.9%) and LDL/HDL ratio (11.4%) was measured in those taking a plant stanol biscuit with a meal compared to those who consumed a plant stanol biscuit without other food. In conclusion...

Optimal Use of Plant Stanol Ester in the Management of Hypercholesterolemia

Rosin, Susanna; Ojansivu, Ilkka; Kopu, Aino; Keto-Tokoi, Malin; Gylling, Helena
Fonte: Hindawi Publishing Corporation Publicador: Hindawi Publishing Corporation
Tipo: Artigo de Revista Científica
Português
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Plant stanol ester is a natural compound which is used as a cholesterol-lowering ingredient in functional foods and food supplements. The safety and efficacy of plant stanol ester have been confirmed in more than 70 published clinical studies and the ingredient is a well-established and widely recommended dietary measure to reduce serum cholesterol. Daily intake of 2 g plant stanols as plant stanol ester lowers LDL-cholesterol by 10%, on average. In Europe, foods with added plant stanol ester have been on the market for 20 years, and today such products are also available in many Asian and American countries. Despite the well-documented efficacy, the full potential in cholesterol reduction may not be reached if plant stanol ester is not used according to recommendations. This review therefore concentrates on the optimal use of plant stanol ester as part of dietary management of hypercholesterolemia. For optimal cholesterol lowering aiming at a lower risk of cardiovascular disease, plant stanol ester should be used daily, in sufficient amounts, with a meal and in combination with other recommended dietary changes.

Plant sterols, marine-derived omega-3 fatty acids and other functional ingredients: a new frontier for treating hyperlipidemia

Marinangeli, Christopher PF; Jones, Peter JH
Fonte: BioMed Central Publicador: BioMed Central
Tipo: Artigo de Revista Científica
Publicado em 28/09/2010 Português
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As hyperlipidemia, including hypercholesterolemia (HC) and hypertriglyceridemia (HTN), continue to challenge North America's healthcare systems, patients continue to seek efficacious and safe natural therapies that complement pharmaceutical interventions. However, despite the ever-growing body of research supporting the use of functional foods and nutraceuticals (FFN) for the prevention and treatment of hyperlipidemia, reception amongst the medical community regarding the implementation of FFN into clinical guidelines continues to lag. Research demonstrates that specific FFN target and modulate molecular processes that perpetuate hyperlipidemia. In addition, studies consistently demonstrate that combining certain FFN such as marine-derived omega-3 fatty acids or plant sterols/stanols with statins enhances triglyceride and cholesterol-lowering efficacy, respectively. Thus, the purpose of this commentary is to contend that efficacious FFN not only reduce HC and HTG but also boost the lipid-lowering effects of pharmaceutical hypolipidemic medications. Finally, this editorial aims to challenge current medical guidelines to emphasize efficacious FFN during all stages of treatment of hyperlipidemias as adjuncts to pharmacotherapy.

Food Sources and Chemistry of Plant Sterols and Stanols

Guiné, Raquel
Fonte: Instituto Politécnico de Viseu Publicador: Instituto Politécnico de Viseu
Tipo: Parte de Livro
Publicado em //2015 Português
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A wide range of plants have phytosterols in their composition, both strerols and stanols, being however the stanols present in considerably smaller quantities when compared to sterols. Among the most abundant plant sterols are sitosterol, campesterol and stigmasterol. As to plant stanols, they are present in the diet in small amounts, being one of the most important the sitostanol. Some food sources that are rich in phytosterols include for example: fruits, vegetables, nuts, seeds, cereals, legumes and vegetable oils. It is therefore important to know what are the food sources of these bioactive compounds and what amounts are present. This is one of the goals of the present chapter, which aims to revise the most recent scientific literature to look for updates regarding the food sources of phytosterols, as a complement to the information more generally available. Both stanols and sterols are essential components of plant cell membranes and structurally resemble cholesterol. In fact, cholesterol is also a sterol, but, unlike plant sterols, it is predominantly of animal origin, being synthesized in the human liver. Because the bioactive effects of phytosterols are much associated to their chemical structure, also this aspect is addressed in the present chapter...

Efectos de los esteroles y estanoles vegetales en el metabolismo enterohepático del colesterol y los triglicéridos

Méndez González, Jesús
Fonte: [Barcelona] : Universitat Autònoma de Barcelona, Publicador: [Barcelona] : Universitat Autònoma de Barcelona,
Tipo: Tesis i dissertacions electròniques; info:eu-repo/semantics/doctoralThesis Formato: application/pdf
Publicado em //2014 Português
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Los esteroles vegetales son los análogos del colesterol en los vegetales. Comparten su misma estructura y se diferencian únicamente por sus cadenas laterales. Los estanoles vegetales proceden de la saturación del doble enlace en el anillo. Desde los años 90, tanto los esteroles como los estanoles vegetales están aprobados como alimentos funcionales para disminuir las concentraciones de colesterol total y de LDL. Aunque su mecanismo de acción no es aún del todo conocido, se estima que 2g/día de esteroles vegetales disminuyen el colesterol de LDL en aproximadamente un 10%. Sin embargo, se están desarrollando nuevas formas y combinaciones para aumentar esta eficacia. El primer trabajo de la presente tesis estudia el comportamiento y acción de una de ellas, el llamado FM-VP4. FM-VP4 es un compuesto sintético derivado del sitostanol y campestanol que ha mostrado una acción hipocolesterolemiante mayor que la de sus componentes aislados. Sin embargo, su mecanismo de acción es todavía desconocido. En este trabajo se estudió la capacidad de FM-VP4 para alterar la homeostasis del colesterol en ratones, fundamentalmente a nivel hepático e intestinal. Como conclusiones, se pudo establecer que FM-VP4 redujo con gran eficacia la absorción intestinal de colesterol...