Página 1 dos resultados de 2324 itens digitais encontrados em 0.023 segundos

Timing of renal replacement therapy and clinical outcomes in critically ill patients with severe acute kidney injury

BAGSHAW, Sean M.; UCHINO, Shigehiko; BELLOMO, Rinaldo; MORIMATSU, Hiroshi; MORGERA, Stanislao; SCHETZ, Miet; TAN, Ian; BOUMAN, Catherine; MACEDO, Ettiene; GIBNEY, Noel; TOLWANI, Ashita; STRAATEN, Heleen M. Oudemans-van; RONCO, Claudio; KELLUM, John A.; BE
Fonte: W B SAUNDERS CO-ELSEVIER INC Publicador: W B SAUNDERS CO-ELSEVIER INC
Tipo: Artigo de Revista Científica
Português
Relevância na Pesquisa
36.819197%
Purpose: The aim of this study is to evaluate the relationship between timing of renal replacement therapy (RRT) in severe acute kidney injury and clinical outcomes. Methods: This was a prospective multicenter observational study conducted at 54 intensive care units (ICUs) in 23 countries enrolling 1238 patients. Results: Timing of RRT was stratified into ""early"" and ""late"" by median urea and creatinine at the time RRT was started. Timing was also categorized temporally from ICU admission into early (<2 days), delayed (2-5 days), and late (>5 days). Renal replacement therapy timing by serum urea showed no significant difference in crude (63.4% for urea <= 24.2 mmol/L vs 61.4% for urea >24.2 mmol/L; odds ratio [OR], 0.92; 95% confidence interval [CI], 0.73-1.15; P = .48) or covariate-adjusted mortality (OR, 1.25; 95% CI, 0.91-1.70; P = .16). When stratified by creatinine, late RRT was associated with lower crude (53.4% for creatinine >309 mu mol/L vs 71.4% for creatinine <= 309 mu mol/L; OR, 0.46; 95% CI, 0.36-0.58; P < .0001) and covariate-adjusted mortality (OR, 0.51; 95% CI, 0.37-0.69; P < .001).However, for timing relative to ICU admission, late RRT was associated with greater crude (72.8% vs 62.3% vs 59%, P < .001) and covariate-adjusted mortality (OR...

Adrenalectomy counteracts the local modulation of astroglial fibroblast growth factor system without interfering with the pattern of 6-OHDA-induced dopamine degeneration in regions of the ventral midbrain

CHADI, Gerson; SILVA, Camila; MAXIMINO, Jessica Ruivo; FUXE, Kjell; SILVA, Gilberto Ochman da
Fonte: ELSEVIER SCIENCE BV Publicador: ELSEVIER SCIENCE BV
Tipo: Artigo de Revista Científica
Português
Relevância na Pesquisa
36.930989%
The present study investigated the effects of bilateral adrenalectomy (ADX) on the synthesis of basic fibroblast growth factor (bFGF, FGF-2) mRNA and on the expression of its FGF receptor subtype-2 (FGFR2) mRNA after a 6-hydroxydopamine (6-OHDA)-induced lesion of nigrostriatal dopamine system. In previous papers we have demonstrated that corticosterone increases FGF-2 immunoreactivity mainly in the astrocytes of the substantia nigra [Chadi, G., Rosen, L., Cintra, A., Tinner, B., Zoli, M., Pettersson, R.F., Fuxe, K., 1993b. Corticosterone increases FGF-2 (bFGF) immunoreactivity in the substantia nigra of the rat. Neuroreport 4, 783-786.] and that 6-OHDA injected in the ventral midbrain upregulates FGF-2 synthesis in reactive astrocytes in the ascending dopamine pathways [Chadi, G., Cao, Y., Pettersson, R.F., Fuxe, K., 1994. Temporal and spatial increase of astroglial basic fibroblast growth factor synthesis after 6-hydroxydopamine-induced degeneration of the nigrostriatal dopamine neurons. Neuroscience 61, 891-910.]. Rats were adrenalectomized and received a 6-OHDA stereotaxical injection in the ventral midbrain 2 days later. Seven days after the dopamine lesion, Western blot analysis showed a decreased level of tyrosine hydroxylase in the lesioned side of the midbrain...

Keratinocyte growth factor: a new mesothelial targeted therapy to reduce postoperative pericardial adhesions

LOPES, Jackson B.; DALLAN, Luis A. O.; CAMPANA-FILHO, Sergio P.; LISBOA, Luiz A. F.; GUTIERREZ, Paulo S.; MOREIRA, Luiz Felipe R.; OLIVEIRA, Sergio A.; STOTF, Noedir A. G.
Fonte: ELSEVIER SCIENCE BV Publicador: ELSEVIER SCIENCE BV
Tipo: Artigo de Revista Científica
Português
Relevância na Pesquisa
36.632227%
Background: Several methods have been utilized to prevent pericardial and retrosternal adhesions, but none of them evaluated the mesothelial regenerative hypothesis. There are evidences that the mesothelial trauma reduces pericardial fibrinolytic capability and induces an adhesion process. Keratinocyte growth factor (KGF) has proven to improve mesothelial cells proliferation. This study investigated the influence of keratinocyte growth factor in reducing post-surgical adhesions. Methods: Twelve pigs were operated and an adhesion protocol was employed. Following a stratified randomization, the animals received a topical application of KGF or saline. At 8 weeks, intrapericardial adhesions were evaluated and a severity score was established. The time spent to dissect the adhesions and the amount of sharp dissection used, were recorded. Histological sections were stained with sirius red and morphometric analyses were assessed with a computer-assisted image analysis system. Results: The severity score was lower in the KGF group than in the control group (11.5 vs 17, p = 0.005). The dissection time was lower in the KGF group (9.2 +/- 1.4 min vs 33.9 +/- 9.2 min, p = 0.004) and presented a significant correlation with the severity score (r = 0.83...

Expression of VEGF and collagen using a latex biomembrane as bladder replacement in rabbits

Alonso Domingos, André Luis; Garcia, Sergio Britto; Bessa, Jose de, Jr.; Cassini, Marcelo Ferreira; Fernandes Molina, Carlos Augusto; Tucci Junior, Silvio
Fonte: BRAZILIAN SOC UROL; RIO DE JANEIRO Publicador: BRAZILIAN SOC UROL; RIO DE JANEIRO
Tipo: Artigo de Revista Científica
Português
Relevância na Pesquisa
36.722893%
Objective: To investigate the VEGF expression and collagen deposition using a latex biomembrane as bladder replacement in rabbits. Materials and Methods: After partial cystectomy, a patch of a non-vulcanized latex biomembrane (2 x 2 cm) was sewn to the bladder of rabbits with 5/0 monofilament polydioxanone sulfate sutures in a watertight manner. Groups of 5 animals were killed at 15, 45 and 90 days after surgery and the bladder was removed. Sections of 5 mu m were cut and stained with picrosirius-red in order to estimate the amount of extracellular matrix in the graft. To confirm the presence of VEGF in tissues, protein expression was determined by immunohistochemistry. Results: No death, urinary leakage or graft extrusion occurred in any group. All bladders showed a spherical shape. A progressive reduction in the amount of collagen occurred in the graft area and was negatively and linearly correlated with time (p < 0.001). VEGF expression was higher in grafted areas when compared to controls at 15 and 45 days after surgery and decreased with time (p < 0.001). Conclusion: The latex biomembrane as a matrix for partial bladder replacement in rabbits promotes temporary collagen deposition and stimulates the angiogenic process.

Estrutura cristalográfica do inibidor de tripsina purificada de sementes de Enterolobium contortisiloquum e modelagem molecular de seus complexos com tripsina, trombina e fator Xa.; Crystallographic structure of the trypsin inhibitor purified from Enterolobium contortisiliquum seeds and the molecular modeling of its complexes with trypsin, trombin and Xa factor.

Bonfadini, Marcos Roberto
Fonte: Biblioteca Digitais de Teses e Dissertações da USP Publicador: Biblioteca Digitais de Teses e Dissertações da USP
Tipo: Tese de Doutorado Formato: application/pdf
Publicado em 19/12/2003 Português
Relevância na Pesquisa
36.681135%
Esse trabalho teve como objetivo a determinação da estrutura tridimensional do inibidor de tripsina purificado de sementes de Enterolobium contortisiliquum (EcTI) e a modelagem molecular dos complexos EcTItripsina, EcTI-quimotripsina , EcTI-trombina, EcTI-fator Xa, e suas análises. O EcTI possui 19kDa de peso molecular inibe tripsina, quimotripsina, calicreína plasmática humana, plasmina humana e fator Xlla, mas não inibe fator Xa e ativador de plasminogênio. Monocristais apropriados à coleta de dados de difração de raios-X foram obtidos na condição 50 do fatorial da Hampton (PEG8000 - 0,5M, LiSO4 - 0,5M) através da técnica de acupuntura em gel à temperatura constante de 15°C após três semanas. O grupo espacial encontrado foi o P21 com uma molécula na unidade assimétrica. Os dados de difração foram coletados num detetor de placas de imagem MAR345 na linha de Cristalografia de Proteínas (PCr) no Laboratório Nacional de Luz Síncrotron (LNLS) em Campinas até uma resolução de 1,96Å, completeza de 87% e Rsym=10,3%. A estrutura foi resolvida por Substituição Molecular tendo-se como molde a estrutura do inibidor de tripsina proveniente de Erythrina caffra que apresenta 39% de identidade seqüencial com a seqüência primária do EcTI. Divergências entre a seqüência primária esperada e a observada no mapa de densidade eletrônica levaram à suposição da existência de isoformas para este inibidor. Acatando esta hipótese e supondo que a isoforma cristalizada era diferente da isoforma cuja seqüência foi publicada...

Metodologia para estimar a linha de base de projeto MDL conectado a sistema elétrico: uma abordagem prospectiva.; Methodology to estimate the baseline emissions by a grid connected CDM project activity: a forecasting approach.

Reis, Tereza Virginia Mousinho
Fonte: Biblioteca Digitais de Teses e Dissertações da USP Publicador: Biblioteca Digitais de Teses e Dissertações da USP
Tipo: Tese de Doutorado Formato: application/pdf
Publicado em 14/05/2009 Português
Relevância na Pesquisa
37.009626%
Essa pesquisa tem como objetivo propor um novo referencial metodológico para estimar a linha de base para projetos de MDL a serem conectados ao sistema interligado nacional SIN, a partir de uma visão do mix futuro das fontes energéticas que serão responsáveis pelas gerações de energia, nos próximos dez anos. Objetiva também aplicar essa nova abordagem para calcular as emissões deslocadas pelas atividades de projetos de MDL, através do cálculo do fator de substituição, medido em tCO2/MWh. Este fator estima a redução das emissões decorrente da substituição de parte da energia gerada pelas usinas térmicas convencionais, pela entrada no sistema de usinas que geram energia limpa e/ou pela redução da demanda agregada do sistema elétrico pela implementação de programas/medidas de eficiência energética pelo lado da demanda Para tanto, usando um modelo que simula o equilíbrio entre a oferta elétrica e os requisitos de energia previstos para o horizonte de 10 anos de energia calcula-se, inicialmente, as emissões dos GEE do sistema elétrico sem considerar a entrada do projeto de MDL. Na seqüência, as emissões do sistema elétrico são novamente calculadas, considerando a entrada do projeto MDL. Atualmente a linha de base do SIN é calculada...

Perfil estrutural e molecular do lobo ventral da próstata de ratos senis (Sprague-Dawley) com e sem reposição de hormônios esteróides; Structural and molecular features of ventral prostate from senile rats (Sprague-Dawley) submitted or not steroid hormone replacement

Fabio Montico
Fonte: Biblioteca Digital da Unicamp Publicador: Biblioteca Digital da Unicamp
Tipo: Dissertação de Mestrado Formato: application/pdf
Publicado em 22/02/2011 Português
Relevância na Pesquisa
37.293208%
A reposição androgênica representa uma alternativa para minimizar os efeitos prejudiciais do desequilíbrio hormonal em homens senis, embora seus efeitos sobre o desenvolvimento de doenças prostáticas ainda seja assunto controvertido. Assim, o objetivo deste estudo foi caracterizar aspectos estruturais e moleculares do lobo ventral da próstata de ratos senis frente à reposição de hormônios esteróides, relacionando as alterações decorrentes da terapia hormonal a possíveis condições de lesões prostáticas. Ratos machos (Sprague- Dawley) foram divididos em um grupo Jovem (JOV) (4 meses), que recebeu óleo de amendoim (5 mL/Kg, s.c.), e grupos senis (10 meses), submetidos aos tratamentos: grupo Senil (SEN): óleo de amendoim (5 mL/Kg, s.c.); grupo Testosterona (TEST): cipionato de testosterona (5 mg/Kg, s.c.); grupo Estrógeno (EST): 17?-estradiol (25 ?g/Kg, s.c.); grupo Castrado (CAS): castração cirúrgica; grupo Castrado-Testosterona (CT): castração e após 30 dias tratamento similar ao grupo TEST; grupo Castrado-Estrógeno (CE): castração e após 30 dias tratamento similar ao grupo EST. Após 30 dias de tratamento, foram coletadas amostras de sangue, para dosagens hormonais séricas, e do lobo ventral, para análises em microscopias de luz e eletrônica de transmissão...

Prevalence and risk factors for periprosthetic fracture in older recipients of total hip replacement: a cohort study

Katz, Jeffrey N; Wright, Elizabeth A; Polaris, Julian JZ; Harris, Mitchel B; Losina, Elena
Fonte: BioMed Central Publicador: BioMed Central
Tipo: Artigo de Revista Científica
Português
Relevância na Pesquisa
36.967178%
Background: The growing utilization of total joint replacement will increase the frequency of its complications, including periprosthetic fracture. The prevalence and risk factors of periprosthetic fracture require further study, particularly over the course of long-term follow-up. The objective of this study was to estimate the prevalence and risk factors for periprosthetic fractures occurring in recipients of total hip replacement. Methods: We identified Medicare beneficiaries who had elective primary total hip replacement (THR) for non-fracture diagnoses between July 1995 and June 1996. We followed them using Medicare Part A claims data through 2008. We used ICD-9 codes to identify periprosthetic femoral fractures occurring from 2006–2008. We used the incidence density method to calculate the annual incidence of these fractures and Cox proportional hazards models to identify risk factors for periprosthetic fracture. We also calculated the risk of hospitalization over the subsequent year. Results: Of 58,521 Medicare beneficiaries who had elective primary THR between July 1995 and June 1996, 32,463 (55%) survived until January 2006. Of these, 215 (0.7%) developed a periprosthetic femoral fracture between 2006 and 2008. The annual incidence of periprosthetic fracture among these individuals was 26 per 10...

Microarray gene expression profiling of osteoarthritic bone suggests altered bone remodelling, WNT and transforming growth factor-β/bone morphogenic protein signalling; Microarray gene expression profiling of osteoarthritic bone suggests altered bone remodelling, WNT and transforming growth factor-beta/bone morphogenic protein signalling

Hopwood, B.; Tsykin, A.; Findlay, D.; Fazzalari, N.
Fonte: BioMed Central Ltd. Publicador: BioMed Central Ltd.
Tipo: Artigo de Revista Científica
Publicado em //2007 Português
Relevância na Pesquisa
36.593665%
Osteoarthritis (OA) is characterized by alterations to subchondral bone as well as articular cartilage. Changes to bone in OA have also been identified at sites distal to the affected joint, which include increased bone volume fraction and reduced bone mineralization. Altered bone remodelling has been proposed to underlie these bone changes in OA. To investigate the molecular basis for these changes, we performed microarray gene expression profiling of bone obtained at autopsy from individuals with no evidence of joint disease (control) and from individuals undergoing joint replacement surgery for either degenerative hip OA, or fractured neck of femur (osteoporosis [OP]). The OP sample set was included because an inverse association, with respect to bone density, has been observed between OA and the low bone density disease OP. Compugen human 19K-oligo microarray slides were used to compare the gene expression profiles of OA, control and OP bone samples. Four sets of samples were analyzed, comprising 10 OA-control female, 10 OA-control male, 10 OA-OP female and 9 OP-control female sample pairs. Print tip Lowess normalization and Bayesian statistical analyses were carried out using linear models for microarray analysis, which identified 150 differentially expressed genes in OA bone with t scores above 4. Twenty-five of these genes were then confirmed to be differentially expressed (P < 0.01) by real-time PCR analysis. A substantial number of the top-ranking differentially expressed genes identified in OA bone are known to play roles in osteoblasts...

Is physical activity a risk factor for primary knee or hip replacement due to osteoarthritis? A prospective cohort study

Wang, Yuanyuan; Simpson, Julie Anne; Wluka, Anita E.; Teichtahl, Andrew J.; English, Dallas R.; Giles, Graham G.; Graves, Stephen Ellis; Cicuttini, Flavia M.
Fonte: J Rheumatol Publ Co Publicador: J Rheumatol Publ Co
Tipo: Artigo de Revista Científica
Publicado em //2011 Português
Relevância na Pesquisa
37.035884%
Objective. To estimate prospectively any association between measures of physical activity and the risk of either primary knee or hip replacement due to osteoarthritis (OA). Methods. Eligible subjects (n = 39,023) were selected from participants in a prospective cohort study recruited 1990–1994. Primary knee and hip replacement for OA during 2001–2005 was determined by linking the cohort records to the National Joint Replacement Registry. A total physical activity level was computed, incorporating both intensity and frequency for different forms of physical activity obtained by questionnaire at baseline attendance. Results. There was a dose-response relationship between total physical activity level and the risk of primary knee replacement [hazards ratio (HR) 1.04, 95% CI 1.01–1.07 for an increase of 1 level in total physical activity]. Although vigorous activity frequency was associated with an increased risk of primary knee replacement (HR 1.42, 95% CI 1.08–1.86) for 1–2 times/week and HR 1.24 (95% CI 0.90–1.71) for ≥ 3 times/week), the p for trend was marginal (continuous HR 1.08, 95% CI 1.00–1.16, p = 0.05). The frequency of less vigorous activity or walking was not associated with the risk of primary knee replacement...

Incidence of total knee and hip replacement for osteoarthritis in relation to circulating sex steroid hormone concentrations in women

Hussain, S.M.; Cicuttini, F.M.; Bell, R.J.; Robinson, P.J.; Davis, S.R.; Giles, G.G.; Graves, S.; Milne, R.L.; Wang, Y.
Fonte: Wiley Publicador: Wiley
Tipo: Artigo de Revista Científica
Publicado em //2014 Português
Relevância na Pesquisa
37.051277%
OBJECTIVE: The increased prevalence of osteoarthritis (OA) in postmenopausal women suggests that changes in either circulating sex steroid concentrations or the tissue response to sex steroids may have a role in the pathogenesis of OA. The aim of this study was to examine whether circulating sex steroid concentrations are associated with the incidence of total knee and total hip replacement for OA. METHODS: Study subjects (n = 2,621; all women) were recruited in 1990-1994 from the Melbourne Collaborative Cohort Study (MCCS). Circulating sex steroid concentrations were measured in blood samples obtained from the women at the time of recruitment. The incidence of total knee and total hip replacement for OA during 2001-2011 was determined by linking the MCCS records to the Australian Orthopaedic Association National Joint Replacement Registry. RESULTS: During the followup period, 115 women had undergone total knee replacement and 99 had undergone total hip replacement for OA. Greater log-transformed concentrations of estradiol were associated with a lower incidence of knee replacement (hazard ratio [HR] 0.70, 95% confidence interval [95% CI] 0.50-0.96), and greater log-transformed concentrations of androstenedione were associated with a lower incidence of hip replacement (HR 0.70...

Prognostische Relevanz einer leicht- bis mittelgradigen pulmonalen Hypertonie bei Patienten mit hochgradiger Aortenklappenstenose vor konventionellem Aortenklappenersatz; Prognostic relevance of mild-to-moderate pulmonary hypertension in patients with severe aortic valve stenosis undergoing surgical aortic valve replacement

Woernle, Barbara Raphaela
Fonte: Universidade de Tubinga Publicador: Universidade de Tubinga
Tipo: Dissertação
Português
Relevância na Pesquisa
37.212483%
Die Aortenklappenstenose stellt mit einer Prävalenz von 2,5% bei Patienten jenseits des 65. Lebensjahres das häufigste erworbene Herzklappenvitium in der westlichen Welt dar. Die effektive Therapie der Aortenklappenstenose besteht im operativen oder katheterinterventionellen Aortenklappenersatz. Die Wahl des optimalen Zeitpunktes des Aortenklappenersatz stellt jedoch trotz Vorliegen etablierter Risikofaktoren, vor allem bei älteren oligosymptomatischen Patienten eine Herausforderung im klinischen Alltag dar. Andererseits verstirbt ein kleiner, aber relevanter Anteil an Patienten trotz primär erfolgreichem Aortenklappenersatz. Daher ist die Identifikation von sensitiven Risikoparametern bei Patienten mit Aortenklappenstenose von großem klinischen Wert. Im Verlauf der Aortenklappenstenose kommt es bereits in frühen Stadien durch Obstruktion der Klappe, Steigerung der Nachlast und Erhöhung des linksventrikulären Füllungsdruckes zu einer Zunahme des pulmonalen Drucks. Zunächst erfolgt ein passiver Rückstau in die Lungengefäße, später entwickelt sich eine eigenständige, fixierte pulmonalarterielle Hypertonie. Ein bereits leicht- bis mittelgradiger Anstieg des systolischen pulmonalarteriellen Drucks könnte somit ein subklinisches Zeichen einer beginnenden Dekompensation bei der Aortenklappenstenose darstellen...

Cenomanian transgression in the Basque-Cantabrian Basin (northern Spain) and associated faunal replacement

Cavin, Lionel; Bermúdez Rochas, David Didier; López-Horgue, Mikel A.; Poyato-Ariza, Francisco J.
Fonte: Universidad Complutense; Consejo Superior de Investigaciones Científicas (CSIC) Publicador: Universidad Complutense; Consejo Superior de Investigaciones Científicas (CSIC)
Tipo: info:eu-repo/semantics/article; publishedVersion
Português
Relevância na Pesquisa
36.819197%
Abstract:The available data concerning the environmental changes and faunal replacements that occurred during the Cenomanian marine transgression in the North of Iberia are integrated and discussed on the basis of new evidence from the invertebrate and vertebrate fossil record. New stratigraphical data and the reassessment of known stratigraphic sections support the correlation of the Cenomanian carbonate-ramp successions from the Iberian margin to the centre of the Basque-Cantabrian Basin during a major transgressive episode. This new stratigraphical framework is the key to understand the changing oceanographic conditions in the area that resulted from a progressive inundation of the Iberian continental platform. This transgression seems to have triggered major faunal replacements in this particular geographic area, starting out around the Albian-Cenomanian transition. Ammonite faunal replacement led to a new radiation of this group that spread out rapidly until their new decline around the Cenomanian-Turonian boundary. A new record of Calycoceras (Newboldiceras) asiaticum spinosum and the first record of a Pachyrhizodontidae indet. (Actinopterygii, Teleostei, Crossognathiformes) from the Iberian Peninsula are reported here from the Cenomanian basal units of the major Late Cretaceous transgressive episode. The two new specimens come from the same level in an outer marine ramp succession near Amurrio...

An examination of the USMC Combat Active Replacement Factor (CARF) determination system

Lindsay, Glenn F.
Fonte: Monterey, California. Naval Postgraduate School Publicador: Monterey, California. Naval Postgraduate School
Tipo: Relatório
Português
Relevância na Pesquisa
67.15354%
Combat Active Replacement Factors, or CARFs, are logistics planning factors currently used by the U.S. Marine Corps as estimates of equipment losses in future conflicts. Adapted Army replacement factors are currently a prime source for CARF values, but verification of these values is difficult. This report examines two alternate means of estimating CARF values for comparative purposes. The first employs mean-time-to-loss estimates for various equipment types, and several scenario-oriented models are given for mapping these values into CARFs. Professional military judgement provides another way of estimating CARF values, and a procedure is given by which the judgment of many experts can be aggregated to provide CARF information. A demonstraction of the procedure is given, employing actual data from twenty-three judges who rated 'chance of loss' for twenty-one equipment types. Keywords: Replacement factor, combat losses, scaling; Naval Postgraduate School, Monterey, CA; http://archive.org/details/examinationofusm00lind; NA

Use of routine hospital morbidity data together with weight and height of patients to predict in-hospital complications following total joint replacement

Mnatzaganian, G.; Ryan, P.; Norman, P.; Davidson, D.; Hiller, J.
Fonte: BioMed Central Ltd. Publicador: BioMed Central Ltd.
Tipo: Artigo de Revista Científica
Publicado em //2012 Português
Relevância na Pesquisa
36.819197%
BACKGROUND: Routinely collected data such as hospital morbidity data (HMD) are increasingly used in studying clinical outcomes among patients undergoing total joint replacement (TJR). These data are readily available and cover large populations. However, since these data were not originally collected for the purpose of health research, a rigorous assessment of their quality is required. We assessed the accuracy of the diagnosis of obesity in HMD and evaluated whether the augmentation of HMD with actual weight and height of patients could improve their ability to predict major in-hospital complications following total joint replacement in men. METHODS: The electronic records of 857 participants in the Health In Men Study (HIMS) who had had TJR were linked with Western Australia HMD. HMD-recorded diagnosis of obesity was validated using the actual weight and height obtained from HIMS. In-hospital major complications were modelled using multivariable logistic regressions that either included the actual weight and height or HMD-recorded obesity. Model discrimination was calculated using area under ROC curve. RESULTS: The HMD failed to detect 70% of the obese patients. Only 64 patients (7.5%) were recorded in HMD as obese although 216 (25%) were obese [BMI: ≥30kg/m2] (sensitivity: 0.2...

Caracterización y ajuste del factor de magnificación para radiología digital de cadera

Bravo, Flavio; Salazar, Santiago
Fonte: Facultad de Medicina Publicador: Facultad de Medicina
Tipo: info:eu-repo/semantics/bachelorThesis; info:eu-repo/semantics/acceptedVersion Formato: application/pdf
Publicado em 29/01/2014 Português
Relevância na Pesquisa
37.115337%
Introducción. Las imágenes obtenidas mediante rayos X, determinan una conducta clínica en ortopedia y son analizadas por parte del cirujano en el momento previo a realizar un acto quirúrgico. El planeamiento pre quirúrgico basado en radiografías de cadera, permite predecir el tamaño de los componentes protésicos a utilizar en un reemplazo de cadera. Con el advenimiento de las radiografías digitales, existe la falsa percepción de que estas tienen corregido el factor de magnificación. La corrección de dicho factor requiere un protocolo de calibración de imágenes, aún no implementado en la Fundación Santa Fe de Bogotá (FSFB). Como consecuencia, las radiografías de cadera actualmente resultan magnificadas. Materiales y métodos. Fueron seleccionados 73 pacientes con reemplazo articular total de la cadera intervenidos en la FSFB. Para cada paciente, se estableció la dimensión de la cabeza protésica en la radiografía de cadera obtenida mediante el sistema de radiología digital (PACS-IMPAX) y su tamaño fue comparado con el de la cabeza femoral implantada. Resultados. La concordancia entre los dos observadores al medir la dimensión radiológica de los componentes protésicos fue excelente y el coeficiente de magnificación promedio de 1.2 (20%). Este será introducido al PACS-IMPAX para ajustar el tamaño definitivo de la radiografía. Conclusión. El ajuste del PACS-IMPAX permite obtener radiografías en las cuales se refleja con mayor precisión el tamaño de los segmentos anatómicos y de los componentes protésicos.; Urosario; Introduction. The images obtained by X-ray determinate decision-making for orthopedic surgeons. These are analyzed prior a surgical procedure. The preoperative planning is based on radiographs of the hip...

Selective expression of insulin-like growth factor II in the songbird brain.

Holzenberger, M; Jarvis, ED; Chong, C; Grossman, M; Nottebohm, F; Scharff, C
Fonte: Universidade Duke Publicador: Universidade Duke
Tipo: Artigo de Revista Científica Formato: 6974 - 6987
Publicado em 15/09/1997 Português
Relevância na Pesquisa
37.04892%
Neuronal replacement occurs in the forebrain of juvenile and adult songbirds. To address the molecular processes that govern this replacement, we cloned the zebra finch insulin-like growth factor II (IGF-II) cDNA, a factor known to regulate neuronal development and survival in other systems, and examined its expression pattern by in situ hybridization and immunocytochemistry in juvenile and adult songbird brains. The highest levels of IGF-II mRNA expression occurred in three nuclei of the song system: in the high vocal center (HVC), in the medial magnocellular nucleus of the neostriatum (mMAN), which projects to HVC, and to a lesser extent in the robust nucleus of the archistriatum (RA), which receives projections from HVC. IGF-II mRNA expression was developmentally regulated in zebra finches. In canary HVC, monthly changes in IGF-II mRNA expression covaried with previously reported monthly differences in neuron incorporation. Combining retrograde tracers with in situ hybridization and immunocytochemistry, we determined that the HVC neurons that project to area X synthesize the IGF-II mRNA, whereas the adjacent RA-projecting neurons accumulate the IGF-II peptide. Our findings raise the possibility that within HVC IGF-II acts as a paracrine signal between nonreplaceable area X-projecting neurons and replaceable RA-projecting neurons...

The Effects of fluctuations in solid ink density on color variation for conventional and grey component replacement separations when printing process color on newsprint

Pawlow, Eric Matthew
Fonte: Rochester Instituto de Tecnologia Publicador: Rochester Instituto de Tecnologia
Tipo: Tese de Doutorado
Português
Relevância na Pesquisa
36.722893%
A color separation technique known as Gray Component Replacement, or GCR has been an option available to high-end drum scanner operators for the past eight years. Recently, GCR has been made available by lower-end color system vendors as well. GCR consists of removing the least predominant process color ink in a unit area, reducing the remaining colored inks by the same amount and replacing the "gray component" of the color with black ink. One of the reported benefits of the GCR technique is that more consistency can be realized during a pressrun. If this is in fact true, the first publication printers who would surely utilize the technique would be newspapers. The problem of consistency is particularly acute for newspapers. There are a number of reasons for this, but the primary ones relate to the types of materials used. Newspapers use the cheapest paper and ink and in many cases, they print with old or poorly maintained presses. They would surely welcome any process that offered better reproductive quality and more consistency, provided the investment was justifiable. Since their present color separation systems allow for the use of GCR in the majority of cases, its potential in the area of newspaper printing was investigated in this study. One factor determining consistency during a pressrun is the control of ink film thickness. As ink film thickness fluctuates...

Identification of a new mutation (Gly420Ser), distal to the active site, that leads to factor XIII deficiency

Kangsadalampai, Sasichai; Yenchitsomanus, Pathai; Chelvanayagam, Gareth; Sawasdee, Nunghathai; Laosombat, Vichai; Board, Philip
Fonte: Munksgaard International Publishers Publicador: Munksgaard International Publishers
Tipo: Artigo de Revista Científica
Português
Relevância na Pesquisa
36.710864%
The molecular defects of the factor XIII A subunit gene were studied in a patient with factor XIII deficiency. Mutation analysis was performed on amplified DNA from each exon of this gene by single-strand conformation polymorphism (SSCP) and DNA sequencing techniques. A substitution of guanine by adenine at nucleotide 1258 in exon 10 of the coagulation factor XIII A subunit gene has been identified in the patient. The mutation results in the replacement of Gly420 by Ser in the core domain of the enzyme. Restriction enzyme analysis of amplified exon 10 DNA confirmed that the patient was homozygous for this mutation. A family study revealed that the mutation was inherited from both parents, who were first cousins. The potential effects of the mutation were predicted by molecular modeling of the amino acid substitution within the coordinates of the crystal structure. The substitution occurred within the core domain of the enzyme at a residue completely conserved among all known members of the transglutaminase family. The model of the mutant protein suggests that although the substitution of Gly420 by Ser causes only minor readjustment of the residues and does not appear to be particularly deleterious in terms of structure, the mutation is...

The effect of joint line restoration on kneeling ability after primary total knee replacement

Hassaballa,MA; Gbejuade,HO; Porteous,AJ; Murray,JR
Fonte: SA Orthopaedic Journal Publicador: SA Orthopaedic Journal
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/01/2012 Português
Relevância na Pesquisa
36.722893%
BACKGROUND: Total knee replacement (TKR) surgery has become one of the commonest orthopaedic procedures undertaken. Pain relief and restoration of function are two major expectations following knee arthroplasty. Kneeling is a knee function required for many types of occupation and activities of daily living, making its restoration following knee arthroplasty essential. Restoration of joint line position is a surgical factor that has been reported to have an important impact on functional outcome after TKR. MATERIALS AND METHODS: We reviewed 100 (43 males and 57 females; with a mean patient age of 71 years) consecutive cemented Kinemax Plus TKRs (Stryker, Newbury, UK) performed in our unit with a minimum follow-up of two years. Joint line measurements were made on the pre-operative and post-operative X-rays. The kneeling ability component of the Oxford Knee Score questionnaire was analysed for all patients. The pre- and post-operative Oxford Knee Scores were prospectively recorded. Patients' ranges of movement (ROM) were measured. RESULTS: The mean pre-operative ROM for the group was 82° (std ± 15). Post-operatively, the mean ROM for the whole group was 109° (std ± 8). A joint line within ± 5 mm of the pre-operative measurement was considered 'restored' and more than 5 mm was considered 'elevated. Seventy-five per cent of patients had the joint line restored within 5 mm of their native joint line post-operatively. The mean ROM for restored and elevated groups was 116° and 108° respectively. This difference was statistically significant (P < 0.01). However...